YvonneDoID:1202653759 JazmineMayberryID:1202908403 BuildAPathogenOutline

1.AlteringtheImmuneResponse a.PoisoningTHelperCells i. PathogenpresentsCD3LYEtomakeTcrCD3LYEcomplex(LYEisa toxinthatinterfereswithcytokinesabilitytodestroyinfectedcells.

ii. LYEinfectedTcellsdonotterminateinfectedcells.Theyinducedivision ofinfectedcells. iii. Source1:Beissert, S., Schwarz, A., & Schwarz, T. (2006). Regulatory T
Cells.Journal Of Investigative Dermatology, 126(1), 15-24. doi:10.1038/sj.jid.5700004

b.ChangingSignalsforTCells i.PathogenproducesLYEsecretingpeptidesthatareprocessedtothecell surfacewithMHCI. ii.CD8onTcellgetsinfectedwithLYE iii.SecondsignalofTcellbecomeCD28B7LYE,whichcausesinfectedcell todivide. iv.Source2:Mller, A., & Saino, N. (2004). Immune response and survival.
Oikos,104(2), doi:10.1111/j.0030-1299.2004.12844.x

2.SpreadofDisease a. Howthebacteriacausesdisease i.Secreteexotoxins ii.Secondmessengerpathwaydisrupters iii.ABsubunit iv.ADPribosyltransferase

b. Wherethebacteriacausesdisease i.Usuallyingestedorallythroughfood ii.Startsinthegastrointestinalregion iii.Mayinfectthebloodfromthereandspreadtootherorgansthroughtheblood

3.Epidemiology a.MethodsofSpreading i.Spreadbycontactofuninfectedindividualwithbodyfluidsofinfectedindividual ii.Spreadbymosquitoesandflies iii.Spreadbyinsects,fecesonfoodorinbeverages b.Prevalentareas i.Tropicalareas ii.Thirdworldcountries iii.Hospitals 4.VaccinationandTreatment a.Vaccination i.weakenedformofthebacteriainjectedintotheindividual ii.AbbasD,LichtmanA,PoberJ.CellularandMolecularImmunology.2ed. Philadelphia:W.B.SaundersCo.1994. b.Treatment i.antibioticsTheGreekwordantimeans"against",andtheGreekwordbios means"life" ii.lysecellsbydestroyingcellwalls

iii.interfereswiththebacteriasabilitytoformcellwalls iv.AtkinsonW,WolfeC,HumistonS,etal.EpidemiologyandPreventionof VaccinePreventableDiseases.6ed.Atlanta,GA:TrainingandEducationBranch, NationalImmunizationProgram,CDC2000.