Code No: 07A81204

R07

Set No. 2

IV B.Tech II Semester Examinations,APRIL 2011 BIO-INFORMATICS Information Technology Time: 3 hours Max Marks: 80 Answer any FIVE Questions All Questions carry equal marks

1. Describe the le format in EMBL and describe its parameters? 2. Overview of methods of sequence alignment. 3. Explain the applications of multiple sequence alignments with examples. 4. Explain about the methods employed for sequencing an entire Genome.

[16] [16] [16] [16]

5. Explain how secondary databases in bioinformatics are dierent in organization and management from primary databases. [16] 6. Describe in brief about the biochemical databases and applications. 7. Explain about the functions of Telnet and ftp on servers? [16] [16]

8. How does the theory of Charles Darwin can be related to homology modelling. [16]

Code No: 07A81204

R07

Set No. 4

IV B.Tech II Semester Examinations,APRIL 2011 BIO-INFORMATICS Information Technology Time: 3 hours Max Marks: 80 Answer any FIVE Questions All Questions carry equal marks

1. Write short notes on: (a) Russel Wallace (b) Charles Darwin. 2. Describe the following: (a) Uniform Resource Locator (URL) (b) Role of Internet in Bioinformatics. 3. Describe in brief about the tools available in BRENDA. [8+8] [16] [8+8]

4. Discuss about the molecular modeling databases that are available on internet and state their importance? [16] 5. Explain about DNA Hybridization-Melting curves. [16]

6. What do you understand k-tuple method? Explain its use in similarity searching? [16] 7. Explain briey about CLUSTALX & CLUSTALW programs in construction of protein proles and motifs. [16] 8. Discuss the bioinformatics analysis tools available in KEGG. [16]

Code No: 07A81204

R07

Set No. 1

IV B.Tech II Semester Examinations,APRIL 2011 BIO-INFORMATICS Information Technology Time: 3 hours Max Marks: 80 Answer any FIVE Questions All Questions carry equal marks

1. Describe in brief about the tools available in EXPASY. 2. What is multiple sequence alignment. Briey Explain. 3. Discuss the applications of bioinformatics tools available in Swissprot. 4. Explain about Darwins evolutionary thoery.

[16] [16] [16] [16]

5. Compare the NCBI, EMBL formats with any one example you have studied? [16] 6. Write short notes on: (a) Shot gun approach. (b) Clone contig approach. [8+8]

7. By choosing two sequences when do you say that both sequences are signicantly similar. Explain with neat ow chart. [16] 8. What is Telnet? Explain its functioning system? [16]

Code No: 07A81204

R07

Set No. 3

IV B.Tech II Semester Examinations,APRIL 2011 BIO-INFORMATICS Information Technology Time: 3 hours Max Marks: 80 Answer any FIVE Questions All Questions carry equal marks

1. Discuss about the concept of Homology searches.

[16]

2. What are biological databases? What are the parameters used in management of these biological databases? [16] 3. Describe the following:

(a) Physical mapping of DNA

(b) Genetic mapping of DNA. [8+8]

4. Discuss the relative merits of Pair-wise and Multiple sequence alignment methods? [16] 5. Describe in brief about EXPASY and state usefulness in research. 6. Explain the applications of Phylogenetic analysis in biosciences. [16] [16]

7. Discuss briey the search and analysis tools available in PIR and state their applications. [16] 8. Why should Biologists use computers? Explain the importance and scope of bioinformatics in biotechnology. [16]