Escolar Documentos
Profissional Documentos
Cultura Documentos
New AdenoPlus aids in the rapid differential diagnosis of acute conjunctivitis, allowing for appropriate management based on diagnostic evidence
Viral, bacterial, or allergicthe signs and symptoms of acute conjunctivitis can be indistinguishable
It has been estimated that at least 6 million cases of acute conjunctivitis are diagnosed in the U.S. each year1 Viral, bacterial, and allergic are the most common types and present similarly2-4 Differential diagnosis using only signs and symptoms can be challenging5-8
Purulent discharge
Mucoid discharge
Studies indicate that eye care professionals make an accurate differential diagnosis for acute conjunctivitis approximately 50% of the time2-4
47% 42%
The majority of acute conjunctivitis cases result in a prescription for antibiotics, even when they are unnecessary19 Unnecessary antibiotic use may increase adverse effects and promote resistance11
While some cases of acute conjunctivitis are more obviously associated with one etiology or another, the majority of cases have similar presentation, making the differential diagnosis challenging.
Kelly Nichols, OD, MPH, PhD, FAAO
Treatment of conjunctivitis is ideally directed at the root cause. Indiscriminate use of topical antibiotics or corticosteroids should be avoided, because antibiotics can induce toxicity and corticosteroids can potentially prolong adenoviral infections18
American Academy of Ophthalmology (AAO), Preferred Practice Pattern, 2011
Introducing AdenoPlusthe first in-office immunoassay that aids in the rapid differential diagnosis of acute conjunctivitis
Fast
2 minutes to complete test; results in just 10 minutes
Accurate
Identifies adenovirus (which accounts for 90% of all viral conjunctivitis2,20,21) with 90% sensitivity and 96% specificity
Easy
Completed in the office in 4 simple steps
More effectively and efficiently manage their patients with red eye2,11,22
AdenoPlus features proprietary technology utilizing direct sample microfiltration with a lateral flow assay strip, enabling a small sample of ocular fluid to aid in a rapid differential diagnosis in the office.
1. Use a dab and drag motion in 6 to 8 locations on the palpebral conjunctiva (lower eyelid) to collect a tear sample.
2. Snap the sample collector into the test cassette and press firmly where indicated.
3. Dip the test cassette into the provided buffer vial for 20 seconds. Replace the cap.
4. Read the results: 2 lines (1 red, 1 blue) = positive, 1 line (blue) = negative
With AdenoPlus, practices benefit from a laboratory-quality diagnosis at the point of care.
Paul Karpecki, OD, FAAO
[AdenoPlus] helps reduce the number of misdiagnoses and leads to better patient management and treatment.2
Terrence P. OBrien, MD
ECP interprets test results and determines appropriate treatment based on diagnostic evidence
Positive
Consider nonantibiotic therapy Patient counseling: isolation (7 to 10 days); hand washing; no towel sharing or close contact Supportive care: artificial tears, antihistamines, cold compresses, or topical corticosteroids with close patient monitoring Implementation of CDC guidelines for decontamination of exposed surfaces and equipment in the ECP office
Negative
C ontinue the differential diagnosis (with adenovirus ruled out) to determine likelihood of bacterial or allergic C onsider topical antibiotic or antihistamine therapy, or a combination F ollow up or refer if decreased vision or pain, or lack of improvement over 7 days
CDC=Centers for Disease Control *The Red Eye Protocol was developed based on published literature of best practices in managing the acute red eye.
The most important reason for early detection of conjunctivitis is that prompt, appropriate treatmentspeeds resolution of the disease, minimizing both the sequelae of untreated conjunctivitis and time away from work or school.18
American Academy of Ophthalmology (AAO), Preferred Practice Pattern , 2011
Implementation of an in-office red eye protocol and point-of-care diagnostic tools, such as AdenoPlus, can greatly improve the treatment and management of conjunctivitis patients.
Mile Brujic, OD
For more information or to order AdenoPlus, contact your local Ophthalmic Account Manager or call 1.855.MY.NICOX (1.855.696.4269).
References: 1. Data on file, Nicox Ophthalmic Diagnostics. 2. OBrien TP, Jeng BH, McDonald M, et al. Acute conjunctivitis: truth and misconceptions. Curr Med Res Opin. 2009;25(8):1953-1961. 3. Leibowitz HM, Pratt MV, Flagstad IJ, et al. Human conjunctivitis. Arch Ophthalmol. 1976;94:1747-1749. 4. Stenson S, Newman R, Fedukowicz H. Laboratory studies in acute conjunctivitis. Arch Ophthalmol. 1982;100:1275-1277. 5. Fitch CP, Rapoza PA, Owens S, et al. Epidemiology and diagnosis of acute conjunctivitis at an inner-city hospital. Ophthalmology. 1989;96:1215-1220. 6. Rietveld RP, ter Riet G, Bindels PJE, et al. Predicting bacterial cause in infectious conjunctivitis: cohort study on informativeness of combinations of signs and symptoms. BMJ. 2004;329:206. 7. Rietveld RP, vanWeert CPM, ter Riet G, et al. Diagnostic impact of signs and symptoms in acute infectious conjunctivitis: systematic literature search. BMJ. 2003;327:789. 8. Gigliotti F, Williams WT, Hayden FG, et al. Etiology of acute conjunctivitis in children. J Pediatrics. 1981;98(4):531-536. 9. Solomon AS. Symptoms of allergic conjunctivitis. Arch Ophthalmol. 1985;103(7):891. 10. Kosrirukvongs P, Visitsunthorn N, Vichyanond P, et al. Allergic conjunctivitis. Asian Pac J Allergy. 2001;19:237-244. 11. Sambursky R, Tauber S, Schirra F, et al. The RPS Adeno Detector for diagnosing adenoviral conjunctivitis. Ophthalmology. 2006;113:1758-1764. 12. Udeh BL, Schneider JE, Ohsfeldt RL. Cost effectiveness of a point-of-care test for adenoviral conjunctivitis. Am J Med Sci. 2008;336(3):254-264. 13. Butt AL, Chodosh J. Adenoviral keratoconjunctivitis in a tertiary care eye clinic. Cornea. 2006;25(2):199-202. 14. Hyde KJ, Berger ST. Epidemic keratoconjunctivitis and lacrimal excretory system obstruction. Ophthalmology. 1988;95(10):1447-1449. 15. Hammer LH, Perry HD, Donnenfeld ED, et al. Symblepharon formation in epidemic keratoconjunctivitis. Cornea. 1990;9(4):338-340. 16. Kaufman HE. Adenovirus advances: new diagnostic and therapeutic options. Curr Opin Ophthalmol. 2011;22:290-293. 17. Gordon YJ, Gordon RY, Romanowski E, et al. Prolonged recovery of desiccated adenoviral serotypes 5, 8, and 19 from plastic and metal surfaces in vitro. Ophthalmology. 1993;100(12):1835-1840. 18. American Academy of Ophthalmology Cornea/External Disease Panel. Preferred Practice Pattern Guidelines. ConjunctivitisLimited Revision. San Francisco, CA: American Academy of Ophthalmology; 2011. Available at: www.aao.org/ppp. 19. Everitt H, Little P. How do GPs diagnose and manage acute infective conjunctivitis? A GP survey. Fam Pract. 2002;19(6):658-660. 20. Matsui K, Shimizu H, Yoshida A, et al. Monitoring of adenovirus from conjunctival scrapings in Japan during 20052006. J Med Virol. 2008;80:997-1003. 21. Woodland RM, Darougar S, Thaker U, et al. Causes of conjunctivitis and keratoconjunctivitis in Karachi, Pakistan. Royal Soc Tropical Medicine Hygiene. 1992;86(3):317-320. 22. Sambursky RP, Fram N, Cohen EJ. The prevalence of adenoviral conjunctivitis at the Wills Eye Hospital emergency room. Optometry. 2007;78:236-239.
AdenoPlus is a trademark of Rapid Pathogen Screening, Inc. 2012 Nicox, Inc. All rights reserved. www.Nicox.com