Dopamine - Wikipedia, The Free Encyclopedia

Dopamine - Wikipedia, the free encyclopedia
http://en.wikipedia.org/wiki/Dopamine
Dopamine
From Wikipedia, the free encyclopedia
Dopamine is a simple organic chemical in the catecholamine and phenethylamine families that plays a number of important roles in the brains and bodies of animals. Its name derives from its chemical structure: it is an amine that is formed by removing a carboxyl group from a molecule of L-DOPA. In the brain, dopamine functions as a neurotransmittera chemical released by nerve cells to send signals to other nerve cells. The brain includes several distinct dopamine systems, one of which plays a major role in reward-motivated behavior. Every type of reward that has been studied increases the level of dopamine in the brain, and a variety of addictive drugs, including stimulants such as cocaine, amphetamine, and methamphetamine, act by amplifying the effects of dopamine. Other brain dopamine systems are involved in motor control and in controlling the release of several important hormones. Several important diseases of the nervous system are associated with dysfunctions of the dopamine system. Parkinson's disease, a degenerative condition causing tremor and motor impairment, is caused by loss of dopamine-secreting neurons in the midbrain area called the substantia nigra. There is evidence that schizophrenia involves altered levels of dopamine activity, and the antipsychotic drugs that are frequently used to treat it have a primary effect of attenuating dopamine activity. Attention deficit hyperactivity disorder (ADHD) and restless legs syndrome (RLS) are also believed to be associated with decreased dopamine activity. Outside the nervous system, dopamine functions in several parts of the body as a local chemical messenger. In the blood vessels it inhibits norepinephrine release and acts as a vasodilator; in the kidneys
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Dopamine
IUPAC name 4-(2-aminoethyl)benzene-1,2-diol Other names 2-(3,4-dihydroxyphenyl)ethylamine; 3,4-dihydroxyphenethylamine; 3-hydroxytyramine; DA; Intropin; Revivan; Oxytyramine
Identifiers CAS number PubChem 681 51-61-6 , 62-31-7 (hydrochloride)
ChemSpider 661 UNII VTD58H1Z2X
DrugBank DB00988 KEGG ChEBI ChEMBL ATC code Jmol-3D images D07870 CHEBI:18243 CHEMBL59 C01CA04 (http://www.whocc.no/atc_ddd_index /?code=C01CA04) Image 1 (http://chemapps.stolaf.edu /jmol/jmol.php?model=c1cc%28c%28cc1CCN%29O%29O) SMILES InChI Properties Molecular C8H11NO2 formula Molar mass 153.18 g/mol Appearance colorless solid Density 1.26 g/cm3
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it increases sodium excretion and urine output; in the pancreas it reduces insulin production; in the digestive system it reduces gastrointestinal motility and protects intestinal mucosa; and in the immune system it reduces the activity of lymphocytes. With the exception of the blood vessels, dopamine in each of these peripheral systems has a "paracrine" function: it is synthesized locally and exerts its effects on cells that are located near the cells that release it.
Melting point Boiling point Solubility in water
128 C, 401 K, 262 F
decomposes 60.0 g/100 ml (verify) (what is: / ?)
Except where noted otherwise, data are given for materials in their standard state (at 25 C, 100 kPa) Infobox references
A variety of important drugs work by altering the way the body makes or uses dopamine. Dopamine itself is available for intravenous injection: although it cannot reach the brain from the bloodstream, its peripheral effects make it useful in the treatment of heart failure or shock, especially in newborn babies. L-DOPA, the metabolic precursor of dopamine, does reach the brain and is the most widely used treatment for Parkinson's disease. Dopamine-activating stimulants such as cocaine, amphetamine, and Ritalin are addictive in high doses, but are used at lower doses to treat ADHD. Conversely, many antipsychotic drugs act by suppressing the effects of dopamine. Drugs that act against dopamine by a different mechanism are also some of the most effective anti-nausea agents.
Contents
1 Dopaminergic systems of the body 1.1 In the brain 1.2 Outside the nervous system 2 Cellular effects 3 The substantia nigra dopamine system and motor control 3.1 Anatomy and physiology 4 The ventral tegmental area, reward, and cognition 4.1 Reinforcement and reward-seeking behavior 4.1.1 Animal studies 5 Diseases and disorders 5.1 Parkinson's disease 5.2 Attention deficit hyperactivity disorder 5.3 Drug addiction 5.4 Pain 5.5 Nausea 5.6 Psychosis 6 Comparative biology and evolution 6.1 Microorganisms 6.2 Animals 6.3 Plants 6.4 As a precursor for melanin 7 Pharmacology 7.1 Dopamine as an injectable drug 7.2 L-DOPA 7.3 Psychomotor stimulants 7.4 Antipsychotic drugs 7.5 Toxicity 8 Biochemical mechanisms
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8.1 Biosynthesis 8.2 Storage, release, and reuptake 8.3 Degradation 9 Chemistry 9.1 Oxidation 9.2 Polydopamine 10 History 11 See also 12 References 13 External links
Dopaminergic systems of the body

In the brain
Main article: Dopaminergic pathways Inside the brain, dopamine plays important roles in motor control, motivation, arousal, cognition, and reward, as well as a number of lower-level functions including lactation, sexual gratification, and nausea. Dopaminergic neurons (i.e., neurons whose primary neurotransmitter is dopamine) are comparatively few in number a total of around 400,000 in the human brain[1] and their cell bodies are confined to a few relatively small brain areas, but they send projections to many other brain areas and exert powerful effects on their targets. These dopaminergic cell groups were first mapped in 1964 by Annica Dahlstrm and Kjell Fuxe, who assigned them labels starting with the letter "A" (for "aminergic").[2] In their scheme, areas A1 through A7 contain the neurotransmitter norepinephrine, whereas A8 through A14 contain dopamine. Here is a list of the dopaminergic areas they identified:
The substantia nigra, a small midbrain area that forms a component of the basal ganglia. The dopamine neurons are found mainly in a part of this structure called the pars compacta (cell group A8) and nearby (group A9).[3] In rodents, their most important projections go to the striatum, globus pallidus, and subthalamic nucleus, all of which also belong to the basal ganglia, and play important roles in motor control. The name substantia nigra is Latin for "dark substance", and refers to the fact that the dopaminergic neurons there are darkly pigmented. These neurons are especially vulnerable to damage. When a large fraction of them die, the result is a Parkinsonian syndrome.[4] The ventral tegmental area (VTA), another midbrain area. This cell group (A10) is the largest group of dopaminergic cells in the human brain, though still quite small in absolute terms. Projections from these dopaminergic neurons go to the nucleus accumbens and the prefrontal cortex as well as several other areas.[3] These neurons play a central role in reward and other aspects of motivation. The nucleus accumbens is often considered to be the "limbic" part of the striatum. As such, it is the part of the striatum involved in the highest level aspects of motor control, which include motivation and decision-making. Thus, the role of the VTA in motivation and decision-making is structurally
Major dopamine pathways. As part of the reward pathway, dopamine is manufactured in nerve cell bodies located within the ventral tegmental area (VTA) and is released in the nucleus accumbens and the prefrontal cortex. The motor functions of dopamine are linked to a separate pathway, with cell bodies in the substantia nigra that manufacture and release dopamine into the striatum.
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analogous to the role of the substantia nigra in low-level motor control.[5] In primates (i.e. monkeys and humans), the dopamine neurons from the regions of the substantia nigra and VTA project throughout most of the cortical mantle, with particularly dense innervation of the motor and premotor cortices. Thus, there are major species differences in cortical dopamine projections.[6] The posterior hypothalamus. These dopaminergic cells (group A11) project to the spinal cord, and their function is not well established. There is some evidence that pathology in this area plays a role in restless legs syndrome, a condition in which people have difficulty sleeping due to an overwhelming compulsion to constantly move parts of the body, especially the legs.[7] The arcuate nucleus (cell group A12) and periventricular nucleus (cell group A14) of the hypothalamus. An important projection from these dopaminergic neurons goes to the pituitary gland, where it influences the section of the hormone prolactin. Dopamine is the primary neuroendocrine inhibitor of the secretion of prolactin from the anterior pituitary gland. Dopamine produced by neurons in the arcuate nucleus is secreted into the hypothalamo-hypophysial blood vessels of the median eminence, which supply the pituitary gland. The lactotrope cells that produce prolactin, in the absence of dopamine, secrete prolactin continuously; dopamine inhibits this secretion. Thus, in the context of regulating prolactin secretion, dopamine is occasionally called prolactin-inhibiting factor (PIF), prolactin-inhibiting hormone (PIH), or prolactostatin.[8] The zona incerta. These cells (group A13) project to several areas of the hypothalamus, and participate in the control of gonadotropin-releasing hormone, which is necessary to activate the development of reproductive systems that occurs following puberty, both in males and females.[8] An additional group of dopamine-secreting neurons are located in the retina of the eye. These neurons are amacrine cells, meaning that they have no axons. They release dopamine into the extracellular medium, and are specifically active during daylight hours, becoming silent at night. This retinal dopamine acts to enhance the activity of cone cells in the retina while suppressing rod cells the result is to increase sensitivity to color and contrast during bright light conditions, at the cost of reduced sensitivity when the light is dim.[9]
Outside the nervous system

Dopamine does not cross the bloodbrain barrier, so its synthesis and functions in peripheral areas are to a large degree independent of its synthesis and functions in the brain. A substantial amount of dopamine circulates in the bloodstream, but its functions there are not entirely clear. Dopamine is found in blood plasma at levels comparable to those of epinephrine, but in humans, over 95% of the dopamine in the plasma is in the form of dopamine sulphate, a conjugate produced by the enzyme Sulfotransferase 1A3/1A4 acting on free dopamine. The bulk of this dopamine sulphate is produced in the mesentric organs that surround parts of the digestive system. The production of dopamine sulphate is thought to be a mechanism for detoxifying dopamine that is ingested as food or produced by the digestive process plasma levels typically rise more than fifty-fold after a meal. Dopamine sulphate has no known biological functions and is excreted in urine.[10] The relatively small quantity of unconjugated dopamine in the bloodstream may be produced by the sympathetic nervous system, the digestive system, or possibly other organs. It may act on dopamine receptors in peripheral tissues, or be metabolized, or be converted to norepinephrine by the enzyme dopamine beta hydroxylase, which is released into the bloodstream by the adrenal medulla.[10] Some dopamine receptors are located in the walls of arteries, where they act as a vasodilator and an inhibitor of norepinephrine release.[11] These responses might be activated by dopamine released from the carotid body under conditions of low oxygen, but whether arterial dopamine receptors perform other biologically useful functions is not known. Beyond its role in modulating blood flow, there are several peripheral systems in which dopamine circulates
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within a limited area and performs an exocrine or paracrine function.[10] The peripheral systems in which dopamine plays an important role include: The immune system. Dopamine acts upon receptors present on immune cells, especially lymphocytes.[12] Dopamine can also affect immune cells in the spleen, bone marrow, and circulatory system.[13] In addition, dopamine can be synthesized and released by immune cells themselves.[12] The main effect of dopamine on lymphocytes is to reduce their activation level. The functional significance of this system is unclear, but it afford a possible route for interactions between the nervous system and immune system, and may be relevant to some autoimmune disorders.[14] The kidneys. Multiple types of dopamine receptors are present in cells of the kidneys. Dopamine is also synthesized there, by tubule cells, and discharged into the tubular fluid. Its actions include increasing the blood supply to the kidneys, increasing filtration by the glomeruli, and increasing excretion of sodium in the urine. Defects in renal dopamine function can be produced by high blood pressure or by genetic problems, and can lead to reduced sodium excretion as well as hypertension.[15] The pancreas. The role of dopamine here is somewhat complex. The pancreas consists of two parts, known as exocrine and endocrine. The exocrine part synthesizes enzymes and other substances, and secretes them into the small intestine, where food is digested. One of the substances synthesized and secreted by the exocrine pancreas is dopamine. The function of this secreted dopamine after it enters the small intestine is not clearly established the possibilities include protecting the intestinal mucosa from damage and reducing gastrointestinal mobility (the rate at which food moves through the intestines).[16] The endocrine part of the pancreas, also known as the islets of Langerhans, synthesizes a number of hormones, including insulin, and secretes them into the bloodstream. There is evidence that the beta cells that synthesize insulin contain dopamine receptors, and that dopamine acts to reduce the amount of insulin they release. The source of their dopamine input is not clearly established it may come from dopamine that circulates in the bloodstream and derives from the sympathetic nervous system, or it may be synthesized locally by other types of pancreatic cells.[16]
Cellular effects
Main article: Dopamine receptor Dopamine receptors in the mammal brain Gene Type DRD1 (http://www.genenames.org /data/hgnc_data.php?match=DRD1) DRD5 (http://www.genenames.org /data/hgnc_data.php?match=DRD5) DRD2 (http://www.genenames.org /data/hgnc_data.php?match=DRD2) DRD3 (http://www.genenames.org /data/hgnc_data.php?match=DRD3) DRD4 (http://www.genenames.org /data/hgnc_data.php?match=DRD4) Gi/Gocoupled.
Family Receptor D1 D1-like D5 D2 D2-like D3 D4
Mechanism
Increase intracellular levels of cAMP Gs-coupled. by activating adenylate cyclase.
Decrease intracellular levels of cAMP by inhibiting adenylate cyclase.
Like many other biologically active substances, dopamine exerts its effects by binding to and activating receptors located on the surface of cells. In mammals, five subtypes of dopamine receptors have been
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identified, labeled D1 through D5. All of them function as G protein-coupled receptors, meaning that they exert their effects via a complex second messenger system. Glossing over the details, dopamine receptors in mammals can be divided into two families, known as D1-like and D2-like. The ultimate effect of D1-like receptors (D1 and D5) can be excitation (via opening of sodium channels) or inhibition (via opening of potassium channels); the ultimate effect of D2-like receptors (D2, D3, and D4) is usually inhibition of the target neuron. Consequently, it is incorrect to describe dopamine itself as either excitatory or inhibitory. Its effect on a target neuron depends on which types of receptors are present on the membrane of that neuron and on the internal responses of that neuron to cyclic AMP. D1 receptors are the most numerous dopamine receptors in the central nervous system; D2 receptors are next; D3, D4, and D5 receptors are present at significantly lower levels. The level of extracellular dopamine is modulated by two mechanisms: tonic and phasic dopamine transmission. Tonic dopamine transmission occurs when small amounts of dopamine are released independently of neuronal activity, and is regulated by the activity of other neurons and neurotransmitter reuptake.[17] Phasic dopamine release results from the activity of the dopamine-containing cells themselves. This activity is characterized by irregular pacemaking activity of single spikes, and rapid bursts of typically 2-6 spikes in quick succession.[18][19]
The substantia nigra dopamine system and motor control

The substantia nigra is a component of the basal ganglia, a group of interconnected structures in the forebrain and midbrain that play a central role in motor control. The precise nature of that role has been difficult to work out, but one popular line of thought describes it as "response selection". The response selection theory proposes that when a person or animal is in a situation where several behaviors are possible, activity in the basal ganglia determines which of them is executed, by releasing that response from inhibition. Thus the basal ganglia are responsible for initiating behaviors but not for determining the details of how they are carried out. Dopamine is thought to modulate the response selection process in at least two important ways. First, dopamine sets the "effort threshold" for initiating behaviors. The higher the level of dopamine activity, the lower the impetus required to evoke a given behavior. As a consequence, high levels of dopamine lead to high levels of motor activity and "impulsive" behavior; low levels of dopamine lead to torpor and slowed reactions. Parkinson's disease, in which dopamine levels in the substantia nigra circuit are greatly reduced, is characterized by stiffness and greatly reduced movement Main circuits of the basal ganglia. The dopaminergic however, when people with the disease are confronted pathway from the substantia nigra pars compacta to with strong stimuli such as a serious threat, their the striatum is shown in light blue. reactions can be as vigorous as those of a healthy person. In the opposite direction, drugs that increase the effects of dopamine, such as cocaine or amphetamine, produce heightened levels of activity, including at the highest levels psychomotor agitation and stereotyped movements. The second important effect of dopamine is as a "teaching" signal. When a motor response is followed by an increase in dopamine activity, the basal ganglia circuit is altered in a way that makes the same response
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easier to evoke when similar situations arise in the future. This is a form of operant conditioning, in which dopamine plays the role of a reward signal.
Anatomy and physiology

The anatomy of the basal ganglia is extraordinarily complex, and the role of dopamine there is correspondingly complex. On a macroscopic scale there is only one major dopamine projection, from the substantia nigra pars compacta to the striatum, but the dopamine inputs contact multiple types of neurons and have several distinct effects on their targets, activating some via D1 receptors while inhibiting others via D2 receptors. A substantial number of dopamine inputs are delivered to the necks of dendritic spines, where they are well-placed to exert a gating effect on specific synaptic connections, often arising from the cerebral cortex. There are two distinct pathways of signal flow arising from the striatum, known as the direct pathway and indirect pathway. Dopamine is thought to promote action by upregulating the direct pathway while suppressing the indirect pathway. Many theoreticians believe that the mechanism underlying motor learning in the basal ganglia involves a form of long-term potentiation that occurs in the striatum and is strongly modulated by dopaminein other words, a mechanism by which dopamine activity induces strengthening or weakening of synaptic connections inside the striatum.[20]
The ventral tegmental area, reward, and cognition

The ventral tegmental area (VTA) contains the largest group of dopamine neurons in the human brain. They project to numerous brain areas, but the two largest projections are the mesolimbic pathway, which targets the nucleus accumbens and other limbic structures, and the mesocortical pathway, which targets the prefrontal and insular parts of the cerebral cortex. There is a strong functional analogy between the VTA dopamine system and the substantia nigra dopamine system. The basal ganglia consist of a set of parallel circuits, which all have similar architecture but control different aspects of behavior. Most of these circuits run through the striatum, which receives dopamine from the substantia nigra. The striatal circuits control low-level forms of response selection, that is, behaviors that use particular muscle groups or specific action patterns. The "limbic" circuit, however, runs through the nucleus accumbens (also known as the "limbic striatum"), which receives dopamine from the VTA. The limbic circuit controls the highest-level aspects of response selection, such as planning and decision-making. The low-level striatal circuits are connected to the primary motor and premotor parts of the cerebral cortex; the limbic circuit is connected to the prefrontal cortex. Thus, the effect of VTA dopamine on high-level decision-making is functionally analogous to the effect of substantia nigra dopamine on the execution of simple movements.
Reinforcement and reward-seeking behavior

Dopamine is strongly associated with the reward system of the brain. Dopamine is released in areas such as the nucleus accumbens and prefrontal cortex as a result of rewarding experiences such as food, sex, and neutral stimuli that become associated with them.[21] The source of this dopamine is primarily the VTA, although the substantia nigra may also contribute. Electrical stimulation of the VTA or its output pathways can itself serve as a potent reward: animals will quickly learn to press a lever if it results in stimulation of dopamine release, and often will continue pressing the lever for a long time, at steadily increasing rates.[22] A variety of drugs that increase dopamine levels are intrinsically rewarding and increase the effects of other types of reward.[22] In spite of the overwhelming evidence showing a strong association between dopamine and reward, there has been a great deal of dispute about whether the function of dopamine should be described as reward per
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se, or as some more complex construct that relates strongly to reward. The difficulty arises mainly from two observations: (1) in addition to being rewarding, dopamine is also arousing it produces a general increase in movement of all sorts; (2) dopamine release can be caused by events that do not seem to have anything to do with reward, most notably pain. One of the most popular alternatives to the reward theory is the "incentive salience" theory, which argues that the function of dopamine is to increase the effects of motivators of all sorts, both positive and negative.[23] A substantial body of evidence suggests that dopamine encodes not reward itself, but rather reward prediction error , that is, the degree to which reward is surprising. According to this hypothesis, which derives initially from recordings made by Wolfram Schultz, rewards that are expected do not produce any activation of dopamine cells, but rewards that are greater than expected produce a short-lasting increase in dopamine, whereas the omission of an expected reward actually causes dopamine release to drop below its ordinary background level. The "prediction error" hypothesis has drawn particular interest from computational neuroscientists, because an influential computational-learning method known as temporal difference learning makes heavy use of a signal that encodes prediction error. This confluence of theory and data has led to a fertile interaction between theoretical and empirical neuroscientists.[23] Recent research finds that while some dopaminergic neurons react in the way expected of reward neurons, others do not and seem to respond in regard to salience, including aversive stimuli.[24] This research finds the reward neurons predominate in the ventromedial region in the substantia nigra pars compacta as well as the ventral tegmental area. Neurons in these areas project mainly to the ventral striatum and thus might transmit value-related information in regard to reward values.[24] The salience neurons are predominate in the dorsolateral area of the substantia nigra pars compacta which projects to the dorsal striatum and may relate to orienting behaviour.[24] It has been suggested that the difference between these two types of dopaminergic neurons arises from their input: reward-linked ones have input from the basal forebrain, while the salience-related ones from the lateral habenula.[24] In primates, neurons from the regions of both the substantia nigra and VTA project to the prefrontal cortex;[25] the origins of the dopamine innervation of other cortical areas in primate have not been studied. It has been appreciated for many years that exposure to even mild, uncontrollable stress increases dopamine release in the rodent prefrontal cortex, e.g. reviewed in,[26] suggesting that dopamine salience cells have a large influence on this cortical region. Animal studies Clues to dopamine's role in motivation, desire, and pleasure, as well as in higher cognition, have come from studies performed on animals. In one such study, rats were depleted of dopamine by up to 99 percent in the nucleus accumbens and neostriatum using 6-hydroxydopamine.[21] With this large reduction in dopamine, the rats would no longer eat of their own volition. The researchers then force-fed the rats food and noted whether they had the proper facial expressions indicating whether they liked or disliked it. The researchers of this study concluded that the reduction in dopamine did not reduce the rat's consummatory pleasure, only the desire to eat. In another study, mutant hyperdopaminergic (increased dopamine) mice show higher "wanting" but not "liking" of sweet rewards.[27] Mice who cannot synthesize dopamine are unable to feed sufficiently to survive more than a few weeks after birth, but will feed normally and survive if administered L-DOPA.[28] Dopamine modulates foraging behavior in animals, by activating brain systems registering reward when food sources are found.[29] When monkeys are given a highly palatable food, dopamine levels rise, but levels then decline when the palatable food is available for prolonged periods of time and is no longer novel.[30] Dopamine's effects on higher cognitive function have been studied in monkeys and rodents. This work began with the landmark study of Brozoski et al., 1979 showing that depletion of catecholamines from the dorsolateral prefrontal cortex in monkeys impaired spatial working memory to the same degree as removing
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the cortex itself.[31] It is now known that both dopamine and norepinephrine have essential actions on prefrontal cortical function, and help coordinate cognitive state with arousal state.[32] Dopamine has an "inverted U" influence on prefrontal function through its actions on D1 receptors, where either too little or too much impairs working memory function.[33] In the primate prefrontal cortex, dopamine D1 receptor stimulation selectively influences the firing of "Delay" cells (also called "Memory" cells), while dopamine D2 receptors selectively alter the firing of "Response cells".[34] The role of dopamine in primate cortex beyond the frontal lobe has not been
Diseases and disorders

The dopamine system plays a central role in a number of important medical conditions, including Parkinson's disease, attention deficit hyperactivity disorder, schizophrenia, and drug addiction.
Parkinson's disease
Parkinson's disease is a disorder characterized by stiffness of the body, slowing of movement, and trembling of limbs when they are not in use. In advanced stages it progresses to dementia and eventually death. The main symptoms are caused by massive loss of dopamine-secreting cells in the substantia nigra. These dopamine cells are especially vulnerable to damage, and a variety of insults, including encephalitis (as depicted in the book and movie "Awakenings"), repeated sports-related concussions, and some forms of chemical poisoning, can lead to substantial cell loss, producing a Parkinsonian syndrome that is similar in its main features to Parkinson's disease. Most cases of Parkinson's disease, however, are "idiopathic", meaning that the cause of cell death cannot be identified. The most widely used treatment for Parkinsonism is administration of L-DOPA, the metabolic precursor for dopamine. This treatment cannot restore the dopamine cells that have been lost, but it causes the remaining cells to produce more dopamine, thereby compensating for the loss to at least some degree. In advanced stages the treatment begins to fail because the cell loss is so severe that the remaining ones cannot produce enough dopamine regardless of L-DOPA levels. As this stage is approached, the metabolic regulatory mechanisms in the dopamine cells, operating far above their normal level, become erratic, producing dopamine dysregulation syndrome, in which patients fluctuate unpredictably between states of hyperactivity and paralysis.[35]
Attention deficit hyperactivity disorder

Altered dopamine neurotransmission is implicated in attention deficit hyperactivity disorder (ADHD), a condition associated with impaired ability to regulate attention, behavior, and/or impulses. There are some genetic links between dopamine receptors, the dopamine transporter and ADHD,[36], in addition to links to other neurotransmitter receptors and transporters. The most important relationship between dopamine and ADHD involves the drugs that are used to treat ADHD. Some of the most effective therapeutic agents for ADHD are psychostimulants such as Ritalin and amphetamine, drugs that increase both dopamine and norepinephrine levels in brain.[37]
Drug addiction
A variety of addictive drugs produce an increase in reward-related dopamine activity. For some addictive drugs such as alcohol or heroin, activation of the reward system may play only a minor role in addiction, with suppression of suffering being the dominant mechanism, but for other drugs, including nicotine and psychomotor stimulants such as cocaine and methamphetamine, enhancement of dopamine activity appears to be the primary factor. When people addicted to stimulants go through withdrawal, they do not experience the physical suffering associated with withdrawal from alcohol or opiates; instead they experience apathy,
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boredom, restlessness, and most importantly an overwhelming urge to consume more of the drug. When dopamine levels are increased for a period of time, the sensitivity of the receptors is down-regulated the consequence is that steadily increasing doses of a drug are required to produce the same effect, and that the brain's reward system becomes less active than usual in the absence of the drug. This mechanism causes people who abuse stimulants to feel an urge to steadily escalate their consumption. If consumption levels become very high, the ability of the body to regulate dopamine may be compromised, producing erratic behavior as well as cardiac side-effects that in some cases can be fatal. The addiction potential for stimulants is strongly dependent on the level of dopamine increase they produce, and particularly on the speed with which they act. The most addictive drugs, such as cocaine in the form of "crack", raise dopamine levels in the brain within seconds of consumption. For drugs such as these, even a few exposures can be enough to produce symptoms of addiction in some people. Treatment of stimulant addiction is very difficult, because even if consumption ceases, the urge to consume takes a long time to decrease, and even when apparently gone can reappear unexpectedly if a person is placed in a situation that is mentally associated with drug use. The brain mechanisms underlying these cravings have been a topic of extensive research. There is evidence that they are associated with long-lasting changes in the density of dopamine receptors in parts of the brain.
Pain
Dopamine has been demonstrated to play a role in pain processing in multiple levels of the central nervous system including the spinal cord, periaqueductal gray (PAG), thalamus, basal ganglia, and cingulate cortex. Accordingly, decreased levels of dopamine have been associated with painful symptoms that frequently occur in Parkinson's disease. Abnormalities in dopaminergic neurotransmission have also been demonstrated in painful clinical conditions, including burning mouth syndrome,[38] fibromyalgia, and restless legs syndrome. In general, the analgesic capacity of dopamine occurs as a result of dopamine D2 receptor activation; however, exceptions to this exist in the PAG, in which dopamine D1 receptor activation attenuates pain presumably via activation of neurons involved in descending inhibition.[39] In addition, D1 receptor activation in the insular cortex appears to attenuate subsequent pain-related behavior.
Nausea
Nausea and vomiting are largely determined by activity in a brainstem area known as the chemoreceptor trigger zone. This area contains a large population of type D2 dopamine receptors. Consequently, drugs that activate D2 receptors have a high potential to cause nausea. This group includes some medications that are administered for Parkinson's disease, as well as other dopamine agonists such as apomorphine. In many cases, D2-receptor antagonists such as metoclopramide are useful as anti-nausea drugs.
Psychosis
Main article: Dopamine hypothesis of schizophrenia Abnormally high dopaminergic transmission has been linked to psychosis and schizophrenia.[40] However, clinical studies relating schizophrenia to brain dopamine metabolism have ranged from controversial to negative, with HVA levels in the CSF the same for schizophrenics and controls.[41] Increased dopaminergic functional activity, specifically in the mesolimbic pathway, is found in schizophrenic individuals. However, decreased activity in another dopaminergic pathway, the mesocortical pathway, may also be involved. The two pathways are thought to be responsible for differing sets of symptoms seen in schizophrenia.
[citation needed]
Antipsychotic medications act largely as dopamine antagonists, inhibiting dopamine at the receptor level, and thereby blocking the effects of the neurochemical in a dose-dependent manner. The older, so-called
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typical antipsychotics most commonly act on D2 receptors,[42] while the atypical drugs also act on D1, D3 and D4 receptors, though they have a lower affinity for dopamine receptors in general.[43][44] The finding that drugs such as amphetamines, methamphetamine and cocaine, which can increase dopamine levels by more than tenfold,[45] can temporarily cause psychosis, provides further evidence for this link.[46] However, many non-dopaminergic drugs can induce acute and chronic psychosis.[47] The NMDA antagonists Ketamine and PCP both are used in research to reproduce the positive and negative symptoms commonly associated with schizophrenia.[48][49] Dopaminergic dysregulation has also been linked to depressive disorders.[50] Early research in humans used various methods of analyzing dopamine levels and function in depressed patients. Studies have reported that there is decreased concentration of tyrosine, a precursor to dopamine, in the blood plasma, ventricular spinal fluid, and lumbar spinal fluid of depressed patients compared to control subjects.[51][52] One study measured the amount of homovanillic acid, the major metabolite of dopamine in the CSF, as a marker for the dopamine pathway turnover rate, and found decreased concentrations of homovanillic acid in the CSF of depressed patients.[53] Postmordem real time reverse transcriptase-polymerase chain reaction (RT-PCR) has also been used to find that gene expression of a specific subtype of dopamine receptor was elevated in the amygdale of people suffering from depression as compared to control subjects.[54] The action of commonly used antidepressant drugs also has yielded information about possible alterations of the dopaminergic pathway in treating depression. It has been reported that many antidepressant drugs increase extracellular dopamine concentrations in the rat prefrontal cortex,[55] but vary greatly in their affects on the striatum and nucleus accumbens.[56][57] This can be compared to electro convulsive shock treatment (ECT), which has been shown to have a multiple fold increase in striatal dopamine levels in rats.[58] More recent research studies with rodents have found that depression-related behaviors are associated with dopaminergic system dysregulation.[59] In rodents exposed to chronic mild stress, decreased escape behavior and decreased forced swimming is reversed with activation of the dopaminergic mesolimbic pathway.[59] Also, rodents that are susceptible to depression-related behavior after social defeat can have their behavior reversed with dopamine pathway activation.[60] Depletion of dopamine in the caudate nucleus and nucleus accumbens has also been reported in cases of learned helplessness in animals. These symptoms can be reversed with dopamine agonists and antidepressant administration prior to the learned helplessness protocol.[61]
Comparative biology and evolution

Microorganisms
There are no reports of dopamine in archaea, but it has been detected in some types of bacteria and in a type of protozoan called Tetrahymena.[62] Perhaps more importantly, there are types of bacteria that contain homologs of all the enzymes that animals use to synthesize dopamine. It has even been proposed that animals derived their dopamine-synthesizing machinery from horizontal gene transfer that may have occurred relatively late in evolutionary time, perhaps as a result of the symbiotic incorporation of bacteria into eukaryotic cells that gave rise to mitochondria.[63]
Animals
Dopamine is used as an intercellular messenger in virtually all multicellular animals. In sponges only a single report exists of the presence of dopamine, with no indication of its function;[64] however, dopamine has
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been reported in the nervous systems of numerous radially symmetric species, including cnidaria (jellyfish, hydra, corals, etc.).[65] This dates the emergence of dopamine as a neurotransmitter back to the earliest appearance of the nervous system, over 500 million years ago in the Cambrian era. Among existing species, dopamine functions as a neurotransmitter in vertebrates, echinoderms, arthropods, molluscs, and several types of worms.[66][67] In every type of animal that has been examined, dopamine acts to modify motor behavior.[68] In the much-studied nematode worm Caenorhabditis elegans, it reduces locomotion and increases food-exploratory movements; in planarian worms it produces "screw-like" movements; in leeches it inhibits swimming and promotes crawling; etc. Across a wide range of vertebrates, dopamine has an "activating" effect on behavior-switching and response selection, comparable to its effect in mammals.[68] Dopamine also consistently plays a role in reward learning, in all animal groups that have been examined except arthropods. In nematodes, planarians, molluscs, and vertebrates, animals can be trained to repeat an action if it is consistently followed by an increase in dopamine levels.[68] Arthropods are an exception, though. In these species insects, crustaceans, etc. dopamine has an aversive effect, and reward is instead mediated by octopamine, a neurotransmitter that is not found in vertebrates but is thought to be closely related to norepinephrine. In insects, dopamine increases aversion learning for olfactory stimuli as well as visual stimuli, and reduces approach learning for stimuli that are followed by rewards. It also improves recall for aversive memories and reduces recall for positive memories.[68] The origin of the striking reversal between dopamine's effects in arthropods versus all other types of animals has not been explained.
Plants
Many plants synthesize dopamine to varying degrees, including a variety of food plants. The highest concentrations have been observed in bananas the fruit pulp of red and yellow bananas contains dopamine at levels of 40 to 50 parts per million by weight. Potatoes, avocados, broccoli, and Brussels sprouts may also contain dopamine at levels of 1 part per million or more; oranges, tomatoes, spinach, beans, and other plants contain measurable concentrations less than 1 part per million.[69] The dopamine in plants is synthesized from the amino acid tyrosine, by biochemical mechanisms similar to Dopamine can be found in the peel and those that animals use. It can be metabolized in a number of ways, fruit pulp of bananas producing melanin and a variety of alkaloids as byproducts.[69] The functions of plant catecholamines have not been clearly established, but there is evidence that they play a role in the response to stressors such as bacterial infection, act as growth-promoting factors in some situations, and modify the way that sugars are metabolized. The receptors that mediate these actions have not yet been identified, nor have the intracellular mechanisms that they activate.[69] Dopamine consumed in food cannot act on the brain, because it cannot cross the bloodbrain barrier. However, there are also a variety of plants that contain L-DOPA, the metabolic precursor of dopamine.[70] The highest concentrations are found in the leaves and bean pods of plants of the genus Mucuna, especially in Mucuna pruriens (velvet beans), which have been used as a source for L-DOPA as a drug.[71] Another plant containing substantial amounts of L-DOPA is Vicia faba, the plant that produces fava beans (also known as "broad beans"). The level of L-DOPA in the beans, however, is much lower than in the pod shells and other parts of the plant.[72] The seeds of Cassia and Bauhinia trees also contain substantial amounts of L-DOPA.[70] In the marine green alga Ulvaria obscura, which is a major component of some algal blooms, dopamine is
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present in very high concentrations, estimated at 4.4% of dry weight. There is evidence that this dopamine functions as an anti-herbivore defense, reducing consumption by snails and isopods.[73]
As a precursor for melanin

Melanins are a family of dark-pigmented substances that are found in a wide range of organisms. Their physical properties make them difficult to work with experimentally, and consequently a number of aspects of their biochemistry are not well understood. Chemically they are closely related to dopamine, and there is a type of melanin, known as "dopamine-melanin", that can be synthesized by oxidation of dopamine via the enzyme tyrosinase.[74] The melanin that darkens human skin is not of this type: it is synthesized by a pathway that uses L-DOPA as a precursor but not dopamine. However, there is substantial evidence that the "neuromelanin" that gives a dark color to the brain's substantia nigra is at least in part dopamine-melanin.[75] Dopamine-derived melanin probably appears in at least some other biological systems as well. Some of the dopamine in plants is likely to be used as a precursor for dopamine-melanin.[76] The complex patterns that appear on butterfly wings, as well as black-and-white stripes on the bodies of insect larvae, are also thought to be caused by spatially structured accumulations of dopamine-melanin.[77]
Pharmacology
Dopamine as an injectable drug
Under the trade names Intropin, Dopastat, Revimine, or other names, dopamine can be used as a drug in injectable form. It is most commonly used in the treatment of severe hypotension, bradycardia (slow heart rate), circulatory shock, or cardiac arrest, especially in newborn infants. Its effects, depending on dosage, include an increase in sodium excretion by the kidneys, an increase in urine output, an increase in heart rate, and an increase in blood pressure. At a "cardiac dose" of 5 to 10 g/kg/min, dopamine acts through the sympathetic nervous system to increase heart muscle contraction force and heart rate, thereby increasing cardiac output and blood pressure. At a "pressor dose" of 10 to 20 g/kg/min, dopamine also causes vasoconstriction that further increases blood pressure, but can produce negative side effects such as an impairment of kidney function.[78] Older literature also describes a so-called "renal dose" of 2 to 5 g/kg/min thought to improve kidney function without other consequences, but recent reviews have concluded that doses at this low level are not clinically effective and may sometimes be harmful.[79]
L-DOPA
Levodopa is a dopamine precursor used in various forms to treat Parkinson's disease and dopa-responsive dystonia. It is typically co-administered with an inhibitor of peripheral decarboxylation (DDC, dopa decarboxylase), such as carbidopa or benserazide. Inhibitors of alternative metabolic route for dopamine by catechol-O-methyl transferase are also used. These include entacapone and tolcapone.
Psychomotor stimulants
Cocaine and amphetamines inhibit the re-uptake of dopamine; however, they influence separate mechanisms of action. Cocaine is a dopamine transporter and norepinephrine transporter blocker that competitively inhibits dopamine uptake to increase the lifetime of dopamine and augments an overabundance of dopamine (an increase of up to 150 percent) within the parameters of the dopamine neurotransmitters. Like cocaine, amphetamines increase the concentration of dopamine in the synaptic gap, but by a different mechanism. Amphetamines and methamphetamine are similar in structure to dopamine, and so can enter the terminal bouton of the presynaptic neuron via its dopamine transporters as well as by diffusing through the neural membrane directly.[citation needed] By entering the presynaptic neuron, amphetamines force dopamine
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molecules out of their storage vesicles and expel them into the synaptic gap by making the dopamine transporters work in reverse.
Antipsychotic drugs
A range of drugs that reduce dopamine activity have been found useful in the treatment of schizophrenia and other disorders that produce psychosis. These antipsychotic drugs are also sometimes known as neuroleptics or "major tranquilizers", in contrast to "minor tranquilizers" such as Valium that are used to treat anxiety or sleep disorders. These drugs have a broadly suppressive effect on most types of active behavior, and particularly reduce the delusional and agitated behavior characteristic of overt psychosis. The introduction of the first widely used antipsychotic drug, chlorpromazine (Thorazine), in the 1950s, led to the release of many schizophrenia patients from institutions in the years that followed. Even so, the widespread use of antipsychotic drugs has long been controversial. There are several reasons for this. First, these drugs are perceived as very aversive by people who have to take them, because they produce a general dullness of thought and suppress the ability to experience pleasure.[80] Second, it is difficult to show that they act specifically against psychotic behaviors rather than merely suppressing all types of active behavior. Third, they can produce a range of serious side effects, including weight gain, diabetes, fatigue, sexual dysfunction, hormonal changes, and a type of movement disorder known as tardive dyskinesia. Some of these side effects may continue long after the cessation of drug use, or even permanently. The first drugs introduced specifically for the treatment of psychosis all had strong direct effects on multiple aspects of dopamine function. Drugs of this type are known as "typical antipsychotics". Because of the problems they cause, there has been wide interest in newer types of drugs known as "atypical antipsychotics" or "second-generation antipsychotics", which aim to target the specific types of dopamine receptors involved in psychosis, and thereby reduce psychotic symptoms without producing as many undesirable side effects. There remains substantial dispute, however, about how much of an improvement in the patient experience these drugs produce.
Toxicity
The LD50, or dose which is expected to be lethal in 50% of the population, has been found to be: 59 mg/kg (mouse; administered i.v.); 950 mg/kg (mouse; administered i.p.); 163 mg/kg (rat; administered i.p.); 79 mg/kg (dog; administered i.v.)[81]
Biochemical mechanisms
Structurally, dopamine belongs to the catecholamine and phenethylamine classes. In biological systems, dopamine is synthesized in brain cells and adrenal cells from the precursor L-DOPA. In brain cells, it is transported to synaptic sites and packaged into vesicles for release, which occurs during synaptic transmission. After release, free dopamine is either reabsorbed into the presynaptic terminal for reuse, or broken down by the enzymes monoamine oxidase or COMT, producing a variety of degradation metabolites.
Biosynthesis
Dopamine is synthesized in a restricted set of cell types, mainly neurons and cells in the medulla of the adrenal glands. This is the metabolic pathway:
L-Phenylalanine
L-Tyrosine L-DOPA Dopamine
Thus the direct precursor of dopamine is L-DOPA, but this itself can be synthesized from the essential amino
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acid phenylalanine or the non-essential amino acid tyrosine. These amino acids are found in nearly every protein and as such are provided from ingestion of protein-containing food, with tyrosine being the most common. Although dopamine itself is also found in many types of food, it is incapable of crossing the bloodbrain barrier that surrounds and protects the brain. It must therefore be synthesized inside the brain in order to perform its neural actions. is converted into L-tyrosine by the enzyme phenylalanine hydroxylase (PAH), with molecular oxygen (O2) and tetrahydrobiopterin (THB) as cofactors. L-Tyrosine is converted into L-DOPA by the enzyme tyrosine hydroxylase (TH), with tetrahydrobiopterin (THB), O2, and ferrous iron (Fe2+) as cofactors. L-DOPA is converted into dopamine by the enzyme aromatic L-amino acid decarboxylase (AAAD; also known as DOPA decarboxylase (DDC)), with pyridoxal phosphate (PLP) as the cofactor. Dopamine itself is also used as precursor in the synthesis of the neurotransmitters norepinephrine and epinephrine. Dopamine is converted into norepinephrine by the enzyme dopamine -hydroxylase (DBH), with O2 and L-ascorbic acid as cofactors. Norepinephrine is converted into epinephrine by the enzyme phenylethanolamine N-methyltransferase (PNMT) with S-adenosyl-L-methionine (SAMe) as the cofactor. It should be noted that some of the cofactors also require their own synthesis. Deficiency in any required amino acid or cofactor will result in subsequent dopamine, norepinephrine, and epinephrine biosynthesis impairment and deficiency.
Catecholamine biosynthesis
L-Phenylalanine
Storage, release, and reuptake

Inside the brain dopamine functions as a neurotransmitter, and is controlled by a set of mechanisms that are common to all neurotransmitters. After synthesis, dopamine is transported from the cytosol into synaptic vesicles by the vesicular monoamine transporter 2 (VMAT2). Dopamine is stored in and remains in these vesicles until an action potential occurs and causes the contents of the vesicles to be ejected into the synaptic cleft. Once in the synapse, dopamine binds to and activates dopamine receptors, which can be located either on postsynaptic target cells or on the membrane of the dopamine-releasing cell itself (i.e., autoreceptors). After an action potential, the dopamine molecules quickly become unbound from their receptors. They are then absorbed back into the presynaptic cell, via reuptake mediated either by the high-affinity dopamine transporter (DAT) or by the low-affinity plasma membrane monoamine transporter (PMAT). Once back in the cytosol, dopamine is subsequently repackaged into vesicles by VMAT2, making it available for future release.
Degradation
Dopamine is broken down into inactive metabolites by a set of enzymes, monoamine oxidase (MAO), aldehyde dehydrogenase (ALDH), and catechol-O-methyl transferase (COMT), acting in sequence. Both isoforms of MAO, MAO-A and MAO-B, are equally effective. The metabolites produced by these processes are:
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DOPAL
Dopamine degradation
(3,4-Dihydroxyphenylacetaldehyde) DOPAC (3,4-Dihydroxyphenylacetic acid) DOPET (3,4-dihydroxyphenylethanol, also known as Hydroxytyrosol) MOPET (3-methoxy-4-hydroxyphenylethanol, also known as Homovanillyl alcohol) 3-MT (3-Methoxytyramine) HVA (Homovanillic acid) All of these are intermediate metabolites except MOPET and HVA, which are filtered from the bloodstream by the kidneys and then excreted in the urine. The specific reactions that make up these pathways are: Dopamine DOPAL, mediated by MAO DOPAL DOPAC, mediated by ALDH DOPAL DOPET, mediated by aldose reductase (minor pathway) DOPAC HVA, mediated by COMT DOPET MOPET, mediated by COMT Dopamine 3-MT, mediated by COMT 3-MT HVA, mediated by MAO In most areas of the brain, including the striatum and basal ganglia, dopamine is inactivated by reuptake via the DAT, then enzymatic breakdown by MAO into DOPAC. In the prefrontal cortex, however, there are very few DAT proteins, and dopamine is inactivated instead by reuptake via the norepinephrine transporter (NET), presumably on neighboring norepinephrine neurons, then enzymatic breakdown by COMT into 3-MT.[82] The DAT pathway is roughly an order of magnitude faster than the NET pathway: in mice, dopamine concentrations decay with a half-life of 200 milliseconds in the caudate nucleus (which uses the DAT pathway) versus 2,000 milliseconds in the prefrontal cortex.[83] Dopamine that is not broken down by enzymes is repackaged into vesicles for future release.
Chemistry
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Dopamine
Catechol structure
Phenethylamine structure
Chemically, a dopamine molecule consists of a catechol structure (a benzene ring with two hydroxyl side groups) with one amine group attached. As such, dopamine is the simplest possible catecholamine, a family that also includes the neurotransmitters norepinephrine and epinephrine. The presence of a benzene ring with an attached amine group makes it a phenethylamine, a family that includes numerous psychoactive drugs. Dopamine, like most amines, is an organic base. At neutral or acidic pH levels it is generally protonated. The protonated form is highly water-soluble and relatively stable, though it is capable of oxidizing if exposed to oxygen or other oxidants. At basic pH levels, dopamine becomes deprotonated. In this free base form it is less soluble and also highly reactive and easily oxidized. Because of this pH-dependence, dopamine is supplied for chemical or pharmaceutical use in the form of dopamine hydochloride, that is, the hydrochloride salt that is created when dopamine is combined with hydrochloric acid. In dry form, dopamine hydrochloride is a fine colorless powder. When dissolved in distilled water it gives a solution that is mildly acidic and therefore relatively stable. It cannot, however, be combined with alkaline solutions such as a bicarbonate buffer without being rendered inactive.
Oxidation
Dopamine in the body is normally broken down by oxidation catalyzed by the enzyme monoamine oxidase. However, dopamine is also capable of autoxidation, that is, direct reaction with oxygen, yielding quinones plus various free radicals as products.[84] The rate of autoxidation can be increased by the presence of ferrous iron or other factors. The ability of dopamine autoxidation to produce quinones and free radicals makes it a potent cell toxin, and there is evidence that this mechanism may contribute to cell loss that occurs in Parkinson's disease or other conditions.[85]
Polydopamine
Research motivated by mussel adhesive proteins led to the discovery in 2007 that a wide variety of materials, if placed in a solution of dopamine at slightly basic pH, will become coated with a layer of polymerized dopamine, often referred to as "polydopamine". This polymerized dopamine forms by a spontaneous oxidation reaction, and is formally a type of melanin.[86] Polydopamine coatings can form on objects ranging in size from nanoparticles to large surfaces. Polydopamine layers have chemical properties that have the potential to be extremely useful, and numerous studies have examined their possible applications. At the simplest level, they can be used for protection against damage by light, or to form capsules for drug delivery. At a more sophisticated level, their adhesive properties may make them useful as substrates for biosensors or other biologically active macromolecules.[86]
History
Main article: History of catecholamine research Dopamine was first synthesized in 1910 by George Barger and James Ewens at Wellcome Laboratories in
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London, England.[87] It was named dopamine because it is a monoamine whose precursor in the Barger-Ewens synthesis is 3,4-dihydroxyphenylalanine (levodopamine or L-DOPA). Dopamine's function as a neurotransmitter was first recognized in 1958 by Arvid Carlsson and Nils-ke Hillarp at the Laboratory for Chemical Pharmacology of the National Heart Institute of Sweden.[88] Carlsson was awarded the 2000 Nobel Prize in Physiology or Medicine for showing that dopamine is not only a precursor of norepinephrine (noradrenaline) and epinephrine (adrenaline), but also a neurotransmitter.
See also
Addiction Amphetamine Antipsychotic Catecholamine Catechol-O-methyl transferase Classical conditioning Cocaine Depression Dopamine hypothesis of schizophrenia Dopamine reuptake inhibitor Epinine (N-methyldopamine) Limbic system Methylphenidate N,N-Dimethyldopamine Neurotransmitter Operant conditioning Parkinson's disease Prolactinoma Schizophrenia Selegiline Serotonin
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External links
DrugBank APRD00085 (http://www.drugbank.ca/drugs/APRD00085) U.S. National Library of Medicine: Drug Information Portal - Dopamine (http://druginfo.nlm.nih.gov /drugportal/dpdirect.jsp?name=Dopamine) Retrieved from "http://en.wikipedia.org/w/index.php?title=Dopamine&oldid=560177713" Categories: Catecholamines Hormones of the hypothalamus Inotropic agents Motivation
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Identifiers CAS number PubChem 681 51-61-6 , 62-31-7 (hydrochloride)

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