Robert A.

Weinberg

The Biology of Cancer

First Edition

Chapter 12: Maintenance of Genomic Integrity and the Development of Cancer

Copyright Garland Science 2007

Figure 12.1 The Biology of Cancer ( Garland Science 2007)

Figure 12.2a The Biology of Cancer ( Garland Science 2007)

Figure 12.2b The Biology of Cancer ( Garland Science 2007)

Figure 12.2c The Biology of Cancer ( Garland Science 2007)

Figure 12.3a The Biology of Cancer ( Garland Science 2007)

Figure 12.3b The Biology of Cancer ( Garland Science 2007)

Figure 12.3c The Biology of Cancer ( Garland Science 2007)

Figure 12.4 The Biology of Cancer ( Garland Science 2007)

Figure 12.5a The Biology of Cancer ( Garland Science 2007)

Figure 12.5b The Biology of Cancer ( Garland Science 2007)

Figure 12.5c The Biology of Cancer ( Garland Science 2007)

Figure 12.5d The Biology of Cancer ( Garland Science 2007)

Figure 12.5e The Biology of Cancer ( Garland Science 2007)

Figure 12.5f The Biology of Cancer ( Garland Science 2007)

Figure 12.6 The Biology of Cancer ( Garland Science 2007)

Figure 12.6 (part 1 of 2) The Biology of Cancer ( Garland Science 2007)

Figure 12.6 (part 2 of 2) The Biology of Cancer ( Garland Science 2007)

Figure 12.7 The Biology of Cancer ( Garland Science 2007)

Figure 12.8a The Biology of Cancer ( Garland Science 2007)

Figure 12.8b The Biology of Cancer ( Garland Science 2007)

Figure 12.8c The Biology of Cancer ( Garland Science 2007)

Figure 12.8d The Biology of Cancer ( Garland Science 2007)

Figure 12.9 The Biology of Cancer ( Garland Science 2007)

Figure 12.10 The Biology of Cancer ( Garland Science 2007)

Figure 12.11a The Biology of Cancer ( Garland Science 2007)

Figure 12.11b The Biology of Cancer ( Garland Science 2007)

Figure 12.12a The Biology of Cancer ( Garland Science 2007)

Figure 12.12b The Biology of Cancer ( Garland Science 2007)

Figure 12.13 The Biology of Cancer ( Garland Science 2007)

Figure 12.14a The Biology of Cancer ( Garland Science 2007)

Figure 12.14b The Biology of Cancer ( Garland Science 2007)

Figure 12.14c The Biology of Cancer ( Garland Science 2007)

Figure 12.15a The Biology of Cancer ( Garland Science 2007)

Figure 12.15b The Biology of Cancer ( Garland Science 2007)

Figure 12.16 The Biology of Cancer ( Garland Science 2007)

Figure 12.17 The Biology of Cancer ( Garland Science 2007)

Figure 12.18a The Biology of Cancer ( Garland Science 2007)

Figure 12.18b The Biology of Cancer ( Garland Science 2007)

Figure 12.19a The Biology of Cancer ( Garland Science 2007)

Figure 12.19b The Biology of Cancer ( Garland Science 2007)

Figure 12.20 The Biology of Cancer ( Garland Science 2007)

Figure 12.21a The Biology of Cancer ( Garland Science 2007)

Figure 12.21b The Biology of Cancer ( Garland Science 2007)

Figure 12.21c The Biology of Cancer ( Garland Science 2007)

Figure 12.22a The Biology of Cancer ( Garland Science 2007)

Figure 12.22b The Biology of Cancer ( Garland Science 2007)

Figure 12.22c The Biology of Cancer ( Garland Science 2007)

Figure 12.22d The Biology of Cancer ( Garland Science 2007)

Figure 12.23a The Biology of Cancer ( Garland Science 2007)

Figure 12.23b The Biology of Cancer ( Garland Science 2007)

Figure 12.24 The Biology of Cancer ( Garland Science 2007)

Figure 12.25 The Biology of Cancer ( Garland Science 2007)

Figure 12.26 The Biology of Cancer ( Garland Science 2007)

Figure 12.27 The Biology of Cancer ( Garland Science 2007)

Table 12.1 The Biology of Cancer ( Garland Science 2007)

Figure 12.28 The Biology of Cancer ( Garland Science 2007)

Table 12.2 The Biology of Cancer ( Garland Science 2007)

Figure 12.29 The Biology of Cancer ( Garland Science 2007)

Figure 12.30 The Biology of Cancer ( Garland Science 2007)

Figure 12.31a The Biology of Cancer ( Garland Science 2007)

Figure 12.31b The Biology of Cancer ( Garland Science 2007)

Figure 12.32 The Biology of Cancer ( Garland Science 2007)

Figure 12.32 part 1 of 2 The Biology of Cancer ( Garland Science 2007)

Figure 12.32 part 2 of 2 The Biology of Cancer ( Garland Science 2007)

Figure 12.33 The Biology of Cancer ( Garland Science 2007)

Figure 12.34a The Biology of Cancer ( Garland Science 2007)

Figure 12.34b The Biology of Cancer ( Garland Science 2007)

Figure 12.35 The Biology of Cancer ( Garland Science 2007)

Figure 12.36a The Biology of Cancer ( Garland Science 2007)

Figure 12.36b The Biology of Cancer ( Garland Science 2007)

Figure 12.37a, b The Biology of Cancer ( Garland Science 2007)

Figure 12.37c The Biology of Cancer ( Garland Science 2007)

Figure 12.38a The Biology of Cancer ( Garland Science 2007)

Figure 12.38b The Biology of Cancer ( Garland Science 2007)

Figure 12.38c The Biology of Cancer ( Garland Science 2007)

Table 12.3 The Biology of Cancer ( Garland Science 2007)

Figure 12.39 The Biology of Cancer ( Garland Science 2007)

Figure 12.40 The Biology of Cancer ( Garland Science 2007)

Figure 12.41 The Biology of Cancer ( Garland Science 2007)

Key Concepts

Structural integrity, mutability two barriers to cancer occurrence Stem cell, transit-amplifying cell, differentiated cell DNA replication, error-correction, MMR, HNPCC Mutagenesis mechanisms- internal and exogenous, oxidative phosphorylation, ROS, detoxifying enzymes, xenobiotics Base excision repair, nucleotide excision repair Double strand break, chromosomal scrambling, chromosomal number change

Cancer Genome Analysis

Copy number change CGH Gene expression pattern Microarray, qPCR DNA sequence alteration NGS

Figure 11.20 The Biology of Cancer ( Garland Science 2007)

Figure 11.21 The Biology of Cancer ( Garland Science 2007)