Name of the drug

Action

Indications

Dosage

Side / Adverse Effects . Blurred vision; constipation; dizziness; drowsiness; dry mouth; light sensitivity; nasal congestion. Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest or throat; swelling of the mouth, face, lips, or tongue); changes in breasts; changes in menstrual period; changes in vision; chest pain; chills; confusion; difficulty swallowing;

Contraindication and Precaution

Nursing Responsibilities

GENERIC NAME: Chlorpromazine BRAND NAME: Thorazine

Classification

antipsychotics antiemetics

Chlorpromazine is a neuroleptic that acts by blocking the postsynaptic dopamine receptor in themesolimbic dopaminergic system and inhibits the release of hypothalamic and hypophysealhor mones. It has antiemetic, serotoninblocking, and weak antihistaminic properties and slightganglionblocking activity

Chlorpromazine is used virtually in all types of psychoses. It can be combined with other antipsychotics. Chlorpromazine is also used to control anxiety or agitation in certain patients,to relieve a wide range of drug or disease induced vomiting, and in severe hiccups. Chlorpromazine is also used in the treatment of tetanus in combination with other drugs. Acute and chronic psychoses, particularly when accompanied by increased psychomotor activity.Nausea and vomiting. Also used in the treatment of intractable hiccups.

Adult: 25 mg tid; may be given as a single 75 mg dose at night. Maintenance: 25-100 mg tid increased to 1 g daily as required in psychotic patients. Elderly: Initially, 1/3 to the normal adult dose

Hypersensitivity. Cross-sensitivity may exist among phenothiazines. Should not be used in narrowangleglaucoma. Should not be used in patients who have CNS depression. Coma bone-marrow suppression phaeochromocyto ma

1. Assess mental status prior to and periodically during therapy 2. Monitor BP and pulse prior to and frequently during the period of dosage adjustment. 3. The drug may be taken with or without food. 4. Observe patient carefully when administering medication. 5. Monitor I&O ratios and daily weight. . Monitor for development of neuroleptic malignant syndrome (fever, respiratorydistress, tachycardia, seizures, diaphoresis, hypertension

difficulty urinating; drooling; extreme tiredness; fever; inability to move eyes; involuntary movements of the face, mouth, tongue, or jaw; jitteriness; lip smack ingor puckering; mask-like face; muscle spasms of the face, neck, or back; prolonged or painful erection; puffing of cheeks; rigid muscles; seizures; shuffling walk; skin CNS: neuroleptic malignant syndrome, sedation,

or hypotension, pallor, tiredness,severe muscle stiffness, loss of bladder control. Report symptoms immediately 7. Advise patient to take medication as directed. Take missed doses as soon asremembered, with remaining doses evenly spaced through out the day. 8. Do not increase dose or discontinue medication without consulting health care 9. Monitor cardiovascular status of the patient. 10. Watch out for somnolence, coma, hypotension and extrapyramidal symptoms,agitation and restlessness, convulsions, fever, autonomic reactions such as dry mouth andileus, EKG changes

extrapyramidal reactions, tardivedyskines ia CV: hypotension (increased with IM, IV) EENT: blurred vision, dry eyes, lens opacities GI: constipation, dry mouth, anorexia, hepatitis, ileus GU: urinary retention Hematologic: agranulocytosis , leucopenia Skin: photosensitivit y, pigment changes, rashes

and cardiac arrhythmias.