Escolar Documentos
Profissional Documentos
Cultura Documentos
2. HAZARDS IDENTIFICATION
Appearance: Signal Word: Statement of Hazard: White crystalline powder WARNING Suspected of damaging the unborn child. May cause harm to breastfed babies.
Adverse effects most commonly reported in clinical use include sedation, dizziness, weakness, clumsy motion of limbs/trunk (ataxia), incoordination, fatigue, drowsiness, amnesia, confusion, state of intense good feeling (euphoria), suicidal behavior. Benzodiazepines may cause fetal damage when administered during pregnancy. Secreted in human breast milk. Toxic to Reproduction: Category 2
EU Risk Phrases: R61 - May cause harm to the unborn child. R64 - May cause harm to breastfed babies. Hazardous Substance. Non-Dangerous Goods.
This document has been prepared in accordance with standards for workplace safety, which require the inclusion of all known hazards of the active substance or its intermediates regardless of the potential risk. The precautionary statements and warnings included may not apply in all cases. Your needs may vary depending upon the potential for exposure in your workplace.
_______________________________________________________________________________________________________ WP00037
2. HAZARDS IDENTIFICATION
3. COMPOSITION/INFORMATION ON INGREDIENTS
Hazardous Ingredient Lorazepam CAS Number 846-49-1 EU EINECS/ELINCS List EU Classification 212-687-6 R64 Repr. Cat.2;R61 232-674-9 209-150-3 Not Listed Not Listed % 1-2
9004-34-6 557-04-0
* *
EU EINECS/ELINCS List EU Classification Not Listed Not Listed Not Listed Not Listed
% * *
Ingredient(s) indicated as hazardous have been assessed under standards for workplace safety.
For the full text of the R phrases mentioned in this Section, see Section 16
Symptoms and Effects of Exposure: For information on potential signs and symptoms of exposure, See Section 2 - Hazards Identification and/or Section 11 - Toxicological Information.
_______________________________________________________________________________________________________ WP00037
Storage Conditions:
10 mg/m3 TWA 10 mg/m3 Listed Listed Listed Listed Listed 15 mg/m3 total 5 mg/m3 Listed Listed Listed
_______________________________________________________________________________________________________ WP00037
Acute Toxicity: (Species, Route, End Point, Dose) Lorazepam Mouse Oral
Magnesium stearate Rat Oral LD50 > 2000 mg/kg Rat Inhalation LC50 > 2000 mg/m3 _______________________________________________________________________________________________________ WP00037
Rabbit
Intravenous 40 mg/kg/day
LOAEL
Fetotoxicity
Carcinogenicity: (Duration, Species, Route, Dose, End Point, Effect(s)) Lorazepam 18 Month(s) 18 Month(s)
Rat Oral Not carcinogenic Mouse Oral Not carcinogenic None of the components of this formulation are listed as a carcinogen by IARC, NTP or OSHA.
Carcinogen Status:
_______________________________________________________________________________________________________ WP00037
OSHA Label: WARNING Suspected of damaging the unborn child. May cause harm to breastfed babies.
Canada - WHMIS: Classifications WHMIS hazard class: D2a very toxic materials
Lorazepam California Proposition 65 U.S. Drug Enforcement Administration: Australia (AICS): EU EINECS/ELINCS List Microcrystalline cellulose Inventory - United States TSCA - Sect. 8(b) Australia (AICS): EU EINECS/ELINCS List Lactose hydrous Australia (AICS): Magnesium stearate Inventory - United States TSCA - Sect. 8(b) Australia (AICS): EU EINECS/ELINCS List Additional Information:
developmental toxicity, initial date 7/1/90 Schedule IV Controlled Substance Listed 212-687-6
Listed
_______________________________________________________________________________________________________ WP00037
Pfizer Inc believes that the information contained in this Material Safety Data Sheet is accurate, and while it is provided in good faith, it is without warranty of any kind, expressed or implied. If data for a hazard are not included in this document there is no known information at this time. End of Safety Data Sheet
_______________________________________________________________________________________________________ WP00037