ORES 520-01 3 credit hours Introduction to Statistics for the Biomedical Sciences Summer2012 Syllabus TuesdayandThursday 2:30pm5pm June4throughJuly27th

7th Caroline204 Coursemasters:

PaulaBuchanan,PhD,MPH
AssistantProfessor Salus409B Phone:9779446 Fax:9771101 pbuchan1@slu.edu OfficeHours: Byappointmentonly

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CourseOverview Introduction, Purpose, and Goals: The purpose of this course is to introduce the basic principles and methods of statistics, providing students with a sound methodological foundation. This course will cover fundamental concepts and techniques of descriptive and inferential statistics with applications in the biomedical sciences. Basic statistics, including probability, descriptive statistics, inferences for means and proportions, regression methods, andnonparametricstatisticsarepresented. LearningObjectives: Uponcompletionofthecoursestudentswill: 1. Appropriatelyperformandinterpretdescriptiveandinferentialstatisticaltechniques includingtheconstructionoftablesandgraphs,andtheuseofttests,Chisquare tests,ANOVA,andregressionanalysis 2. Communicatewithstatisticiansandotherprofessionalsabouttheplanning, implementation,andinterpretationofanalyticstudies 3. Useappropriatesoftwarepackagestosolveanalyticproblems 4. Criticallyread,critique,andinterpretpublishedresearchaswellasstatistical reportinginthenewsmedia Thiscoursewillprovide: 1. Anintroductoryknowledgeofprobabilityanddistributiontheory 2. Anunderstandingofbasicdescriptiveandinferentialstatisticsincludingthe conceptsandprinciplesofresearchdesignandstatisticalinference Prerequisites:EnrolledinCoreGraduateProgramsintheBiomedicalSciences CourseDescription CourseFormat:Coursecontentwillbecoveredthroughreadings,lectures,computerexercises, andpracticalproblems. RequiredTextbooks: Zar,J.(1999).BiostatisticalAnalysis,4thed.PrenticeHall. CourseElementsandRequirements: HomeworkAssignments:Therewillbe10problemsetsassignedoverthecourseofthe semester.Youmaydropyour1lowestscoringassignments. Quizzes:Therewillbe10quizzesoverthecourseofthesemester(Expectoneeveryclass periodafteralectureday).Youmaydropyour1lowestscoringquiz.

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Labs13:Wewillhave3inclasscomputerlabs.Analysesforthelabmaybedoneinpairs; howeverlabwriteupsshouldbedoneindividually.Thelabassignmentsareachanceforyouto analyzedatausingstatisticalsoftwareaswellasanexerciseinpresentingresultsina professionalmanner.Beforesubmitting,eachlabMUSTBEREVIEWED/EDITEDforcontentand formatting.Pointswillbedeductedforimproperformatting(Includingtablesandfigures)as wellasegregiousgrammaticalandtypographicalerrors.Pleaseseethelastpageofthe syllabusforlabformatting.Thegradewillbereducedby20pointsforeachdaypastdue. Participation&Teamwork:Theparticipationandteamworkgradewillbeevaluatedfromyour attendance,inclassexercises,labparticipation. Final:Thefinalwillconsistoftwoparts,aSPSSlabandawrittenfinal.Bothesectionswillbe takehomehoweverallworkmustbedoneindividually.Thegradewillbereducedby10points foreachdaypastdue. GradingDeterminationandPolicy: Assignment %Grade Homework assignments 20% Quizzes 20% Labs 1 3 30% Final lab 20% Participation & Teamwork 10% FinalGrades Finalgradeswillbeassignedasfollows: A 92100 C+ 77<80 A 90<92 C 72<77 B+ 87<90 C 70<72 B 82<87 D 60<70 B 80<82 F <60 AcademicIntegrityPolicy AllstudentsenrolledinSLUCORcoursesarealsoexpectedtoabidebyandupholdtheSaint LouisUniversityGraduateSchoolsPolicyonAcademicIntegrityandEthics.The2004editionof thispolicyisreprintedbelowandcanbeaccessedat http://www.slu.edu/provost/Adobe%20Pages/Academic%20Integrity%20Policy.pdf. TheUniversityisacommunityoflearning;itseffectivenessrequiresanenvironmentofmutual trustandintegrity.Asmembersofthiscommunity,studentssharewithFacultyand Administratorstheresponsibilitytomaintainthisenvironment.Academicintegrityisviolatedby

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anydishonestyinsubmittingforevaluationassignment's,tests,research,reports,etc.,required tovalidatethestudentslearning.Inacaseofclearindicationofsuchdishonesty,theFaculty memberorAdministratorhastheresponsibilitytoapplysanctionstoprotecttheenvironmentof integritynecessaryforlearning. Althoughnotallformsofacademicdishonestycanherebelisted,theinstanceslistedbelow shouldbeseenasactionsthatnotonlyviolatethemutualtrustnecessarybetweenFacultyand students,buttheyalsounderminethevalidityoftheUniversity'sevaluationofstudentsand takeunfairadvantageoffellowstudents.Soliciting,receiving,orprovidinganyunauthorized assistanceinthecompletionofanyworksubmittedtowardacademiccreditisdishonest. Examplesofacademicdishonestywouldbecopyingfromanotherstudent,copyingfromabook orclassnotesduringaclosedbookexam,submittingmaterialsauthoredbyoreditorially revisedbyanotherpersonbutpresentedasthestudentsownwork,copyingapassageortext directlyformapublishedsourcewithoutappropriatelyciting/recognizingthatsource,takinga testordoinganassignmentorotheracademicworkforanotherstudent,orsecuringor supplyinginadvanceacopyofanexaminationwithouttheknowledgeorconsentofthe Instructor. Anyclearviolationofacademicintegritywillbemetwithsanctions.Inacaseofdishonesty withinacourse,theInstructormayassignanappropriategradeand/orrecommendfurther sanctionstotheDean.TheDeanmay,inaclearlyseriousinstanceofapparentoralleged academicdishonest,appointandadhoccommitteestohear,judge,renderanopinion,and,if warranted,recommendsanctions.TheDeanisresponsibleforthefinaldecisionand notificationsofallassociatedparties. DisabilityStatement Studentswithdisabilitieswhobelievethattheymayneedaccommodationsinthisclassare encouragedtocontacttheOfficeofDisabilitiesServicesat3149772930assoonaspossibleto betterensurethatsuchaccommodationsareimplementedinatimelyfashion. AbouttheCourseInstructor PaulaBuchananisanassistantprofessoratSt.LouisUniversityCenterforOutcomesResearch. InadditiontoteachinganddoingresearchsheistheOperationsManagerforSLUCORs ConsultingPractice.Herresearchareasincludethecostofsolidorgantransplantationand qualityofcareforpatientswithliverdisease.

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CourtesyExpectations: StudentExpectationsandRequirements Studentsareexpectedtoattendallclassesontime.Thiscoursecoversanimmense amountofmaterialinashorttimeanditisimportanttobepresentforalllectures, discussions,andactivities.Irecognizethattheremaybeextenuatingcircumstances thatpreventclassattendance.Ifyouaregoingtomissclasspleaseletmeknowassoon aspossible. Studentsareexpectedtocompleteallassignedreadingsbeforeclassandcome preparedtoparticipateinclassdiscussions,groupexercises,andcomputerwork. Studentsareexpectedtocompleteallassignmentsontime. Studentsareexpectedtoseekclarificationregardingcourseexpectationsorconcepts thatareunclear.Rememberthathelpisalwaysavailabletothosewhoaskforit. InstructorExpectationsandRequirements Willcometoclassprepared,organized,andenthusiastic. Willbeavailabletostudentsafterclassandbyappointment Willprovidetimelyfeedbackonassignments.

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CourseCalendar Topic Class Date 1 65 Lookingatyourdata TypesofData Tables&Graphs Centraltendency& dispersion 2 67 Lab1 3 612 Probability BayesTheorem Sensitivity&Specificity OddsRatio&RelativeRisk 4 614 Distributions Binomialdistribution Poissondistribution Normaldistribution CentralLimitTheorem Standardscores/zscores 5 619 Statisticalinference: Samplesandpopulations Power Confidenceintervals pvalues TypeI&IIerror 6 621 Oneandtwogroups (continuousoutcomes): Onesamplepopulation mean Pairedsamplettest Independentsamplest test Wilcoxonsignedranktest MannWhitneytest Wilcoxonpairedsample 7 626 Lab2 8 628 Comparingmorethantwo groups(continuous outcomes): OnewayANOVA KruskalWallistest

Readings 1.13.4 4.14.7

Due

5.15.7

HW1 Lab1

6.16.3,6.5, 24.124.2,25.1

HW2

6.4 Handout

HW3

7.17.4,7.9, 8.18.2,8.98.10, 9.19.2,9.59.6

HW4

10.110.2, 10.410.5

HW5

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Class Date Topic 73 NOClassHappy4thofJuly! 9 75 Comparingmorethantwo groups(continuous outcomes): Contrasts TwowayANOVA 10 710 Comparingtwogroups (categoricaloutcomes): Chisquaretest McNemarstest Oddsratio 11 712 Correlation LinearRegression Rankcorrelation 12 13 14 717 Lab3 719 LogisticRegression WrapupandReview 724 PowerAnalysis Finalhandedout 726 FinalLabworksession 727 FinalLabDue5pm

Readings 11.111.9, 12.112.6, 12.812.11

Due LAB2 HW6

22.122.9 9.7

HW7

17.117.7,17.10, 19.119.3,19.5, 19.719.9,20.1 20.6,20.11 Handout 7.57.6,8.38.4, 9.3,10.3,12.7,17.8, 19.4,22.10

HW8

HW9 Lab3 HW10

16

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Labs - handout All Labs must be conducted and formatted in the manner stated within this handout in order to receive full credit. Analysis for labs (except for the final lab) may be done with a partner. However each student is responsible for turning in their own lab write-up. All labs are required to include annotated SPSS syntax attached to the end of the write-up. We will cover what annotated syntax is during the first lab. The write up must be typed, single space in 12 point font with 1 inch margins. Answers must be numbered and written in complete sentences. Whether implicitly stated or not, all statistical tests must include your null hypothesis, alternative hypothesis, results, and conclusions. In your results please give the exact p-values calculated. DO NOT include SPSS output directly. Rather create your own tables with the necessary results if needed. Your table must meet the definition of a good table as described on day 1. This means title at the top and minimizing lines within the table. Figures may be copied and pasted directly from SPSS. Please bear in mind that they will be printed in black and white for grading. They must also include an appropriate title.