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T T [ S ] = S [ S Ca ] ; [ Ca ] = Ca [ S Ca ]
d[ S Ca] = k1[ S][Ca] k1[S Ca] dt = k1 (S T [ S Ca])(CaT [S Ca]) k1[ S Ca] = k1S T CaT ( k1( S T + CaT ) + k1 )[ S Ca] + k1[ S Ca]2
OOPS
correct
Assume:
Assume: Under this assumption this is a linear equation for the vector S=(S, S1, S2)T where
Where: These types of results are often used to make the following claim: If the relationship has power greater than 1, the reaction is assumed to be cooperative.
=0
Pseudo steady state hypothesis (an approximation, not always a good one)
Lets create now a very simple, toy model for calcium dependent bidirectional synaptic plasticity. Assume synaptic weight is proportional to Ap.
Assume:
dA p = (Ca)((Ca) A p ) dt
Obtain:
Optional Homework ( I will drop the worst homework grade, can submit after final) a. Program the full Michaelis-Menten kinetics.
and show the dynamics at different values of the coefficients (ki), as well as initial [E] and [S] values. b. Show the dynamics of the reduced system, in the QSSA case. Compare to the full dynamics above, and look at the derivative, of the complex for different parameters. Are these dynamics consistent with the QSSA? Do the values of the coefficients influence if the assumptions are reasonable or not.
It is your job to make assumptions about K(Ca) and P(Ca). Find K(Ca) and P(Ca) that will generate and LTD/LTP model such that for Ca<0.3 we get no change, 0.3<Ca<0.8 we obtain LTD and for Ca>0.8 we get LTP. d. Compare the rate at which you converge to maximal LTD at Ca=0.5 and to maximal LTP at Ca=1.2. Is there a difference, if there is explain why.
Summary