Kelompok Kontrol Nomor Preparat 1 2 3 4 5 6 A B A B A B A B A B A B Ginjal Kanan Sel Nekrosis Piknosis Karyoeksis 3 1 4 1 5 3 2 3 0 2 2 0 4 4 4 2 4 2 4 3 4 2 1 3 Ginjal Kiri Karyolisis 2 2 0 2 3 6 1 0 1 2 1 3 Jumlah 6 7 8 7 5 8 9 6 7 9 7 7 Nomor

Preparat 1 2 3 4 5 6 A B A B A B A B A B A B

Kelompok Perlakuan II Nomor Preparat 1 2 3 4 A B A B A B A B 5 A B 6 A Ginjal Kanan Sel Nekrosis Piknosis Karyoeksis 11 7 13 4 12 6 11 7 10 9 9 7 13 12 13 12 10 13 12 3 9 10 Ginjal Kiri Karyolisis 6 4 8 10 8 8 6 6 13 7 4 Jumlah 24 26 26 28 27 24 31 31 28 26 27 6 5 Nomor Preparat 1 2 3 4 A B A B A B A B A B A

12

26

Kelompok Perlakuan IV Nomor Preparat 1 2 3 A B A B A B Ginjal Kanan Sel Nekrosis Piknosis Karyoeksis 8 4 7 5 5 5 9 4 10 5 8 4 Ginjal Kiri Karyolisis 4 5 3 3 4 3 Jumlah 16 17 13 16 19 15 Nomor Preparat 1 2 3 A B A B A B

4 5 6

A B A B A B

7 8 9 6 7 7

7 3 5 4 5 6

6 5 6 4 4 4

20 16 20 14 16 17

4 5 6

A B A B A B

Group Statistics Status Intervensi Kerusakan Total Kontrol paracetamol N 24 24 Mean 7.00 35.75 Std. Deviation 1,504 3,313 Std. Error Mean .307 .676

Descriptives Std. Deviation 3,313 95% Confidence Interval for Mean Lower Bound 34.35

Mean

Std. Error

paracetamol paracetamol + sambiloto dosis rendah

24

35.75

.676

24

27.21

2,587

.528

26.12

paracetamol + sambiloto dosis Kerusakan sedang Total paracetamol + sambiloto dosis tinggi

24

21.63

2,337

.477

20.64

24

16.04

2,678

.547

14.91

Total

96

25.16

7,803

.796

23.58

trol Ginjal Kiri Sel Nekrosis Piknosis Karyoeksis 3 2 1 3 2 1 5 1 3 4 1 3 1 1 2 3 1 2 1 1 4 0 2 1 Jumlah 9 6 5 7 9 7 5 8 8 5 9 4 Nomor Preparat 1 2 3 4 5 6 A B A B A B A B A B A B Ginjal Kanan Sel Nekrosis Piknosis 14 11 16 15 14 11 12 12 11 14 15 11

Ke

Karyolisis 4 2 2 1 2 3 3 3 5 3 5 1

uan II Ginjal Kiri Sel Nekrosis Piknosis Karyoeksis 13 7 8 6 13 9 15 8 10 7 15 6 11 9 15 10 10 13 9 6 9 12 Jumlah 29 24 30 31 25 28 28 31 25 26 30 6 5 `+ Nomor Preparat 1 2 3 4 A B A B A B A B A B A Ginjal Kanan Sel Nekrosis Piknosis 10 10 10 7 9 10 10 13 8 10 13

Kel

Karyolisis 9 10 8 7 8 7 8 7 9 7 5

22

10

uan IV Ginjal Kiri Sel Nekrosis Piknosis Karyoeksis 7 4 8 5 8 4 5 3 5 3 5 5 Jumlah 14 16 18 11 10 14

Karyolisis 3 3 6 3 2 4

8 8 7 9 7 10

6 6 3 5 3 5

5 6 4 3 4 3

19 20 14 17 15 18

ANOVA Sum of Squares Between Groups Kerusakan Total Within Groups Total 5,087,615 697,042 5,784,656 df 3 92 95

Multiple Comparisons 95% Confidence Interval for Mean Upper Bound 37.15 30 40
(I) Status Intervensi (J) Status Intervensi Mean Difference (IJ) Std. Error

Kerusakan Total Minimum Maximum Dunnett T3

28.30

22

31

22.61

18

26

paracetamol

-28.750*

.743

17.17

10

20

Kontrol

paracetamol + sambiloto dosis rendah

-20.208*

.611

26.74

10

40

paracetamol + sambiloto dosis sedang paracetamol + sambiloto

-14.625*

.567

-9.042*

.627

Kontrol

28.750*

.743

paracetamol

paracetamol

paracetamol + sambiloto dosis rendah

8.542*

.858

paracetamol + sambiloto dosis sedang paracetamol + sambiloto dosis tinggi Kontrol

14.125*

.828

19.708* 20.208*

.870 .611

paracetamol

-8.542*

.858

paracetamol + sambiloto dosis rendah

paracetamol + sambiloto dosis sedang

5.583*

.712

paracetamol + sambiloto dosis tinggi Kontrol paracetamol

11.167*

.760

14.625* -14.125
*

.567 .828

paracetamol + sambiloto dosis sedang

paracetamol + sambiloto dosis rendah

-5.583*

.712

paracetamol + sambiloto dosis tinggi Kontrol paracetamol

5.583*

.726

9.042* -19.708*

.627 .870

paracetamol + sambiloto dosis tinggi

paracetamol + sambiloto dosis rendah

-11.167*

.760

paracetamol + sambiloto dosis sedang

-5.583*

.726

*. The mean difference is significant at the 0.05 level.

Kelompok Perlakuan I Ginjal Kanan Sel Nekrosis Karyoeksis Karyolisis 11 13 15 11 14 9 8 10 10 15 15 14 10 10 11 10 10 16 12 14 9 13 15 12 Jumlah 38 36 39 33 39 40 32 33 37 40 37 38 Nomor Preparat 1 2 3 4 5 6 A B A B A B A B A B A B Ginjal Kiri Sel Nekrosis Piknosis Karyoeksis Karyolisis 14 10 6 8 15 8 8 10 14 13 12 15 13 10 12 15 14 10 10 12 15 14 7 10 13 15 8 14 13 13 11 10 10 12 15 7 Jumlah 30 31 33 39 35 39 37 31 36 40 31 34

Kelompok Perlakuan III Ginjal Kanan Sel Nekrosis Karyoeksis Karyolisis 5 6 5 5 9 7 7 5 8 6 5 5 4 5 12 9 5 4 6 5 8 4 Jumlah 21 20 26 19 23 20 19 21 22 23 21 6 5 Nomor Preparat 1 2 3 4 A B A B A B A B A B A Ginjal Kiri Sel Nekrosis Piknosis Karyoeksis Karyolisis 9 5 6 8 6 10 14 8 4 9 6 4 9 7 4 10 8 4 10 8 5 9 10 10 11 7 5 4 5 5 3 6 5 Jumlah 20 26 26 19 20 22 23 21 18 20 21

23

12

25

ANOVA Mean Square 1,695,872 7,577 F 223,832 Sig. .000

Multiple Comparisons

95% Confidence Interval

Sig. Lower Bound Upper Bound

.000

-30.97

-26.53

.000

-22.02

-18.40

.000

-16.30

-12.95

.000

-10.90

-7.18

.000

26.53

30.97

.000

6.02

11.06

.000

11.69

16.56

.000 .000

17.15 18.40

22.26 22.02

.000

-11.06

-6.02

.000

3.50

7.67

.000

8.94

13.40

.000 .000

12.95 -16.56

16.30 -11.69

.000

-7.67

-3.50

.000

3.45

7.71

.000 .000

7.18 -22.26

10.90 -17.15

.000

-13.40

-8.94

.000

-7.71

-3.45

Independent Samples Test Levene's Test for Equality of Variances t-test for Equality of Means

Sig.

df

Sig. (2tailed)

Mean Difference

Kerusakan Total

Equal variances assumed Equal variances not assumed

21,930

.000

-38,709

46

.000

-28,750

-38,709

32,088

.000

-28,750

Test t-test for Equality of Means 95% Confidence Interval of the Difference Lower .743 -30,245 Upper -27,255

Std. Error Difference

.743

-30,263

-27,237