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I will praise thee; for I am fearfully [and] wonderfully made: marvellous [are] thy works;
and [that] my soul knoweth right well. Psalms 139:1

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Table of Contents
Table of Contents ii
Encouraging The Study Of A&P 1
Intro to Human Anatomy and Physiology 1
Levels of Organization 2
Two divisions of the body 2
The Eleven Systems of the human body & their functions 2
Life Factors 3
Vital Signs 3
5 Requirements of Organisms 3
Homeostasis 4
Organization of the Body 5
Cells 7
Introduction 7
Composite Cell (three main parts)no cell as all these parts 7
Vesicular Transport 10
Cell Life Cycle 10
Tissue 11
Four major types of tissues 11
Membranes 17
Four major types of membranes 17
The Integumentary System 18
The Skeletal System 22
Parts of the longs bones 22
Parts of flat, irregular, short Bones 22
Functions of the bones 22
Structure of the Compact bone 23
Trabecula 23
Osteogenesis (Ossification) - The beginning of a bone 23
Stage of life 23
Bone remodeling 23
Hormones 25
Muscular System 26
Smooth 26
Skeletal 26
Cardial 27
Muscular 27
Sliding filament theory 27
Nervous System 29
Organs 29
Information 29
Characteristics of neurons 29
Axon 29
The Synapse 31
Parts of a Synapse 31
Plexus 32
The Brain 32
Somatic and Special Senses 35
Somatic (soma body) 35
Special Sense 35
Sensory Receptor 35
Sensory Adaptation 36
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Classification of Sensory Receptors 36
Sense of Pain 36
Classification of Pain 37
Headaches 37
Sense of Smell 37
Olfactory Pathway 37
Sense of Taste 37
Primary taste 38
Taste pathway 38
Sense of hearing 38
Hearing Disorders 38
Sense of Equilibrium 39
Path way of Static Equilibrium 39
Dynamic Equilibrium 39
Sense of Sight 39
Eyes disorders 40
The Lacrimal Apparatus 41
Endocrine System 42
Glands 42
Two types of glands 42
Major Endocrine Glands with one function 42
Major Endocrine Glands with Dual functions 42
Minor Endocrines Tissues 42
Functions of the Endocrine System 43
What are hormones? 43
Control of hormonal secretions 44
Hypothalamus Control 44
Thyroid 44
Parathyroid Glands 44
Abnormal Secretion of PTH 45
Adrenal Glands 45
Corticosteroids 45
Cushings Syndrome 45
Hormones Secreted by the Adrenal Medulla 45
The Pancreas A dual glad 46
Abnormalities of Pancreas 46
Thymus Glad 46
Reproductive Glands 46
Other hormone Producing Structure 47
The Blood System 48
Three functions of the blood 48
Formed Elements 48
Percentage of RBCs 48
Hematopoiesis before Birth 48
Hematopoiesis 49
Primary Nutrients Needs for Erythropoiesis 50
Types of Anemia 51
Sickle Cell Anemia 51
Thalassemia 51
Iron Deficiency Anemia 51
Vegan Sources of Iron 51
Vegan Sources of B12 51
Best Sources of Folate 52
What happens when RBC dies? 52
Leukocytes or White Blood Cells 53
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Diapedesis - Chemotaxis 54
Leukemia 54
Platelets 55
Hemostasis 55
Hemophilia 56
Three Steps to Homeostasis 56
The Cardiovascular System 58
Introduction 58
Anatomy of the Heart 58
Heart chambers and valves 59
Valvular Incompetence 60
The fetal heart 60
Pathway of blood 61
Blood supply to the heart (Coronary Circulation) 62
Coronary Occlusion 62
Congestive Heart Failure 62
Heart Actions 63
Factors that contribute to venous return 64
S-A Node 64
Blood Vessels 65
Arteries 65
Capillaries 66
Venules 66
Veins 67
Blood Pressure 67
Hypertension = persistent high blood pressure. 68
Hypertension can lead to left heart failure. 69
Blood pressure homeostasis 69
Atherosclerosis 69
The Digestive System 70
Definition 70
Digestive Processes 70
Components of the Gastric Juice 71
Structure of the Wall of the GI Tract 71
Six Sphincters of the GI Tract 73
Organs of the Digestive System 73
Salivary glands 74
Pharynx 75
Esophagus 75
Stomach 76
Gastric emptying 78
Pancreas 79
Liver 80
Gallbladder 81
Regulation of bile secretion: 81
Small Intestine 82
Peristaltic 83
Large intestine 83
Normal Flora 84
The Lymphatic System 86
General Functions 86
What is the Lymphatic system? 86
Lymphoid Organs 86
Lymph Nodes 86
Clusters of lymph nodes 86
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Structure of the lymph Node 87
Non-specific defense system 87
Inflammation 88
Fever 88
Specific Defenses 88
Cells of the Immune System 89

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Encouraging The Study Of A&P

1T 486 In order to be fitted for translation, the people of God must know themselves. They
must understand in regard to their own physical frames that they may be able with the psalmist to
exclaim: "I will praise Thee; for I am fearfully and wonderfully made." They should ever have the
appetite in subjection to the moral and intellectual organs. The body should be servant to the mind,
and not the mind to the body.

Ed 201 Let pupils be impressed with the thought that the body is a temple in which God desires to
dwell, that it must be kept pure, the abiding place of high and noble thoughts. As in the study of
physiology they see that they are indeed "fearfully and wonderfully made" (Psalm 139:14),
they will be inspired with reverence. Instead of marring God's handiwork, they will have an ambition
to make all that is possible of themselves, in order to fulfill the Creator's glorious plan. Thus they will
come to regard obedience to the laws of health, not as a matter of sacrifice or self-denial, but as it
really is, an inestimable privilege and blessing.

HL 13 We have special duties resting upon us. We should be acquainted with our physical
structure and the laws controlling natural life. While Greek and Latin, which are seldom of any
advantage, are made a study by many, physiology and hygiene are barely touched upon. The study to
which to give thought is that which concerns natural life, a knowledge of oneself. . . . It is the house in
which we live that we need to preserve, that we may do honor to God who has redeemed us. We need
to know how to preserve the living machinery, that our soul, body, and spirit may be consecrated to
his service. As rational beings we are deplorably ignorant of the body and its requirements. While
the schools we have established have taken up the study of physiology, they have not taken hold with
the decided energy they should. They have not practised intelligently that which they have received
in knowledge, and do not realize that unless it is practised, the body will decay. . . . This living
machinery should be understood. Every part of its wonderful mechanism should be carefully
studied.U. T., May 19, 1897

GCDB, March 18, 1897 par. 21 The ministers in our country should become intelligent on health
reform. They ought to become acquainted with the science of physiology. None can understand the
subject thoroughly unless they understand something about physiology, and this is a subject which
everybody ought to understand. It has not received the attention in our schools that it ought to have
received. The philosopher remarked years ago that the deepest study of mankind is man. How much
we neglect this study.

Advocate, February 1, 1900 par. 12 The Holy Scriptures were the essential study in the schools of
the prophets, and they should hold the first place in every educational system...Used as a textbook in
our schools, the Bible will do for mind and morals what cannot be done by books of science or
philosophy." "While the Bible should hold the first place in the education of children and youth, the
book of nature is next in importance." "It is well that physiology is introduced into the common
schools as a branch of education. All children should study it. It should be regarded as the basis of all
educational effort.
Intro to Human Anatomy and Physiology
Anatomy is the branch of science that deals with the structure of body partstheir forms
and how they are organized.
Physiology is the branch of science that studies the functions of body partswhat they do
and how they do it. Structure and Function are difficult to separate because the body parts
are so closely associated with their functions.

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Levels of Organization
A atom make up molecules make up macromolecules which makes up organelles which makes up
cells which makes up tissue which makes an organ which compose of an organ system and finally
composes of an organism (a human)
Organ system
Two divisions of the body
Axial Portionincludes head, neck and trunk, the ventral and dorsal cavities and the
cavities of the head are found in this portion.
Appendicular PortionIncludes the upper and lower limbs. The only cavities in the
appendicular portion are synovial cavities.
The Eleven Systems of the human body & their functions
Integumentary System
o Covering and protection
Skeletal System
o Support and movement
Muscular System
o Support and movement
Nervous System
o Integration and coordination
Endocrine System
o Integration and coordination
Cardiovascular System
o Transport
Lymphatic System
o Transport
Digestive System
o Absorption and excretion
Respiratory System
o Absorption and excretion
Urinary System
o Absorption and excretion
Reproductive System
o Reproduction

Functions of the living Organism (GR-DREAM-CAR) (Sheet 2)

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Movement (muscular and skeletal system)
Responsiveness (reactions to changes inside or outside the body) (nervous)
Growth (increases in number of cells results in growth (endocrine system)
Reproduction (1) division of cells (2) making a whole new organism (endocrine,
Respiration (obtaining oxygen, removing waste) (respiratory system)
Digestion (the breakdown of foods into particles that can be absorbed into the blood)
(digestive system)
Absorption (passage of substance through membranes (pressure produced by the
cardiovascular system)
Circulation (movement of substance from place to place (cardiovascular, lymphatic
Assimilation (change absorbed substances into chemically different forms)
o Lipids (carries) into lipoproteins, eg. LDL/HDL.
o Amino acids into proteins to make muscular tissue, hormones, enzymes.
Excretion (the removal of waste from the body
o respiratory
o urinary and integumentary
o digestive
Life Factors
Vital Signs
Blood pressure
Breathing rate
5 Requirements of Organisms
o Most abundant chemical in the body
o Required for metabolic processes
o Transportation
o Regulate body temperature
o Provides nutrients
o Nutrients provide energy and raw materials

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o Six types of nutrients are:
o Carbohydrates. Fuel for the body cells
o Proteins. For production of structure material
o Lipids (fat)
o Vitamins, minerals and water
Oxygen (20% of the air)
o Used to release of energy from the nutrients. All the nutrients in the world are
useless if the oxygen is not available to release the energy from them.
o Without oxygen, cells can survive for only a few minutes.
Heat (from a reaction of cell movement)
o A from of energy. Energy is the power required to make something happen. Most of
our energy is used for homeostasis relatively stable system (p5).
o Most body heat is generated by the activity of the muscular system.
o Application of force against something.
o Atmospheric pressure is the force outside of the body due to the weight of the air
around it. Breathing depends on appropriate atmospheric pressure.
o Hydrostatic pressure
The five external environmental factors are able to changes therefore the body must be able to
maintain the internal environmental.

Homeostasis - Maintenance of a retaliative stable internal environment.
There are to two types of homeostatic control mechanisms
o Negative feedback mechanismsregulation of body temperature
o Positive feedback mechanismsthe system response in the same (positive)
direction of the initial change, increasing the deviation from the set point
Examples: Blood clotting & uterine contraction during labor

The three main elements
o Sense changes (eg. temperature, thermal sensor > brain, hypothalamus)
Control center (brain, hypothalamus)
Effectors (always muscles and glands)

Example: Blood pressure

Good range 100 120. The arteries have sensors called baroreceptors for blood pressure. It sends
the message to the control center, the heart. Then in one of the chambers there is a node that will
then either increases or decreases the rate of the cardiac muscle to control the flow rate of the

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LEARN Example: Temperature (p6)

Set point for temperature is 37C 98.6F

If temperature is rising then:

If temperature is falling then:
Sensory input to the hypothalamus
Hypothalamus will analyse
1) effectors blood cells (smooth muscles) restrict, sweet glands restrict
2) effectors muscles (skeletal) active to create heat (shivers)
Organization of the Body
A. Cavities (Two Division of the Bodysee above)
a. Axial Division
i. Dorsal cavity (axial division)
1. Cranial cavity
2. Vertebral canal
ii. Ventral Cavity (axial division)
1. Thoracic cavity (contains the lungs, the heart, esophagus, aorta)
a. Mediastinum
i. Superior Mediastinum
ii. Pericardial cavity (membrane)the parietal
pericardium (lining outside wall) & the visceral
pericardium (clinging to the heart)
b. Pleural cavity (membrane)parietal pleural & visceral
pleural (contains the lungs)
2. Abdominaopelvic cavity (contains the kidneys, liver, etc.)
a. Peritoneal cavitythe visceral peritoneum & the parietal
b. Pelvic cavity (contains the sex organs)
c. Abdominal cavity
b. Other cavities
i. Cavities that do not open to the outside of the body are lined with a serous
membrane that secretes serous fluid
ii. All the cavities that are opened to the outside, which is lined with mucous
membrane (mucus)
iii. Pericardial cavitythe visceral pericardium parietal pericardium which is
the wall
c. Five types of smaller cavities within the head (axial division)
i. Oral cavity
ii. Nasal cavity
1. Sinusesthey are lined with mucous
iii. Orbital cavities
iv. Middle ear cavity
v. Frontal and sphenoidal sinus
1. Joint cavity (called the synovial cavity (a type of joint) which are
covered with synovial fluid or synovial membrane

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B. Body planes
a. Sagittal Planeright and left
b. Transverse Planesuperior and inferior
c. Coronal Planeanterior and posterior
C. The four abdominopelvic quadrants
a. Right upper quadrantliver, gallbladder
b. Right lower quadrantcolon, small intestine
c. Left upper quadrantstomach, part of small intestine,
d. Left lower quadrantpart of small intestine, colon
D. Relative Body Positions
a. Superior (cranial)Toward the head end or upper part of a structure or the body,
above (the head is superior to the abdomen)
b. AnteriorToward or at the front of the body, in front of(the breastbone in
anterior to the spine)
c. Inferiormeans that a body part is below another body part or is toward the feet
(the neck is inferior to the head)
d. Posteriortoward or at the back of the body; behind (the heart is posterior to the
breastbone, sternum)
e. Medialtoward or at the midline of the body; on the inner side of (the heart is
medial to the arm)
f. Lateralaway from the midline of the body; on the outer side of (the arms are
lateral to the chest)
g. Proximalcloser to the origin of the body part or the point of attachment of a limb
to the body trunk (the elbow is proximal to the wrist)
h. Distalfarther from the origin of a body part or the point of attachment of a limb to
the body trunk (the knee is distal to the thigh)
i. Superficialtoward or at the body surface (the skin superficial to the skeletal
j. Deepaway from the body surface; more internal (the lungs are deep to the skin)

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A. Over 75 trillion (some say 100 trillion) cells in the human body
B. The shape and content determine the function and activities of a cell.
Composite Cell (three main parts)no cell as all these parts
Main substances in the cell: Water, electrolytes, proteins, lipids, and carbohydrates
A. Plasma membrane (cell membrane)the boundary, maintains cell integration
a. Parts of Plasma membrane
i. A bi-layer of Phospholipids
ii. A protective envelope
iii. With Selective Permeabilityits flexible, not to hard and not to soft
b. Functions
i. Separates the cell from the external environment
ii. Control the pass of substances, molecules
c. How do does it control entrance & exitingwhat makes the plasma membrane
i. Its hydrophilicThe head (phosphate) likes water (soluble in water),
hydrophobicthe tail (lipid) dislikes water (soluble in fat)
ii. Water goes through water-soluble channels of protein
iii. Oxygen & carbon monoxide goes through the fat-soluble bi-layer
iv. Glucose gets into the cell by the way of protein carriers and receptors
v. Because one is fat soluble and water soluble
d. Selective permeability is lost when plasma membrane is damaged
i. First degreethe first layer is destroyed
ii. Second degree the selective permeability was lost because the cell
membrane was destroyed
iii. Third degree the selective permeability was lost because the cell
membrane was destroyed
e. Characteristics of a bi-layer
i. Ciliamotile extensions that help you move things around the cell and to
remove harmful substances; produced with the centrioles
ii. Microvillito increase the surface area
iii. Flagellum (the sperm cells are the only kind of flagellum)for motility also
made with the centrioles
B. Cytoplasmeverything that is inside the plasma membranes and outside the nucleus
a. Cytosolcell like fluid in the cytoplasm
i. All organelles are suspended on the cytosol
b. Organelleslittle organs
Reminder: the activities of cells are determined and made possible by its sub cellular
structure known as organelles (little organs)
i. Endoplasmic Reticulumproduction and transportation of proteins and
1. Rough ER Cells membrane factory Ribosome specs the ER, its
job is to produce protein and transports, it puts into vesicles and
sends it to the Golgi apparatus (traffic director)which will
modified, repackaged and transport it to where it is needed by

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vesicles, when it reaches the plasma membrane where the proteins
is released by exocytosis (outside of the cell)
2. Smooth ERmanufactures lipids, not in producing the proteins
ii. Golgi apparatus traffic directorwhich will modified, repackaged and
transport it to where it is needed by vesicles
1. Membrane vesiclesproteins for production and repair of the
plasma membrane
2. Secretory vesiclesproteins to the plasma membrane and secrets
it out of the cell
3. Enzymes vesiclesvessels that carry protein that will be taken to
the lysosomes (inside you have lysozymesorganelles that contain
powerful enzymes that destroys things)
iii. Ribosomesones that are floating free, used for the production of protein
for the cell itself. Some are attached to the ER (they receive the coating from
the DNA)
iv. Mitochondria power plantproduction of energy.
1. Energy is separate from food energy to chemical energy (ATP)
2. Major sites of chemical reactions that transform this energy into
adenosine triphosphate (ATP) Mitochondria replicates itself.
3. (Muscle cells contain thousands of mitochondria; red blood cells
dont have a nucleus and dont have mitochondria)
v. Lysosomes garbage disposalsvesicles that contain powerful digestive
enzymes that breakdown or destroy microorganisms or debris that is
invading us.
1. Lysosomes also destroy decaying cellular parts.
2. They are active in the breakdown of tissue and excess of bone tissue
as well (the osteoclast have lots of lysosomes).
vi. PeroxisomesThey are membranous sacks that contain detoxifying
substances, which detoxify alcohol and free radicals (molecules that have
unpaired electrons). They are self replicating
vii. Centrosome & Centriolesare a region where the Centrioles are located.
1. The Centrioles are a pairs of hallow tubules composed of
2. They function in mitosis (the division f cells). In the production of
cilia and flagellum.
viii. Cilia & FlagellaMotile cellular extensions, cilia are hair in structure and
move only in one direction (found in the trachea and bronchia), flagella only
found in sperm cells.
ix. Vesiclesare membranous sacks that are used for transportation in the cell
and out of the cell.
1. Macromolecules transported in vesicles:
a. EndocytosisVesicular transportation into the cell.
i. Phagocytosismeans eating cells
ii. Pinocytosisliquid substances that have to go in
through this process
iii. Receptor mediated endocytosis
b. Exocytosiswhen things are transported out of the cell
(secretion of substances from the cell via membranous

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x. Microfilaments & Microtubulesthey are rods and tubes that are there to
maintain the structure.
1. Mircofilaments are thin, made of protein. They make up the
cytoskeleton Cell skeleton.
2. The tubules are used for transportation within the cellthey are
hallowed. They can have substances between one organelle to the
c. Inclusionsparticles that are not fluid or organelles, not found in very cell
i. Ex: melanin in the cells, glycogen (the storage form of glucose) in liver cells,
lipid granules (mostly fat) in adipose cells)
C. Nucleusthe control center of the cell (contains the genetic coding, DNA) (also can be
classified as an organelle)
a. Nuclear envelope
b. Nucleolus (little nucleus)where RNA is found
c. Nucleoplasm filled with chromatin (loosely coiled fibers of DNA suspended in the
i. Consists of DNA helices coiled around histones (protein molecules)
d. Nuclear poresmore permeable then the plasma membrane

Membrane Transport Processes (Movement of substances through the membrane)

Description Examples
Passive process of
Diffusion (molecules
move down their
concentration gradient
until equilibrium is
Simple diffusion



Passive Process of
Filtration (molecules
move down their
pressure gradient





Movement of lipid soluble particles
through the lipid bi-layer and small
molecules of ions through the
protein pores

Simple diffusion of water through
the plasma membrane. (Does not
require hydrostatic pressure.)

Water-soluble molecules that
cannot pass the lipid bi-layer and
molecules that are too large to pass
through the protein pores attach to
protein carriers.

Movement of water and solvents
from a region of higher hydrostatic
pressure to a region of lower
hydrostatic pressure.

(1) Movement of fats, oxygen,
carbon dioxide, and alcohol
through the lipid bi-layer of
the membrane. (2) Movement
of small ions through protein
pores (sodium).

Movement of water through
the pores of GI tract cells.

Movement of glucose into the
cells. (Glucose combines with
a protein carrier at the
surface of the membrane and
is released into the

Water molecules leaving
blood capillaries or passing
through the kidney tubules.

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Active Transport (Solutes
pumped against
concentration gradient)
Vesicular Transport
transported in vesicles)











Movement of substances
through the plasma
membrane against a
concentration gradient.
Requires a membrane carrier
protein, which is energized by

Secretion or ejection of
substances from cell interior
via a membranous vesicle

Vesicular transportation into
the cell

Cell eating large particles
(bacteria, dead cells debris,
etc.) enclosed in a vesicle and
moved into cell.

Cell drinking. Similar to
phagocytosis but droplets are

High selective. External
substances bind to specific
membrane receptors and the
vesicles is formed.

Sugars in the intestine and
renal tubules, amino acids,
sodium, potassium, and
calcium, ions through the
plasma membrane.

Secretion of hormones,
neurotransmitters, mucus;
ejection of wastes.

Occurs in phagocytic cells
like macrophages and

Occurs in most cells. Very
important in cells that
function in nutrient
absorption like some cells
that line the large intestine.

Cholesterol, iron and other
molecules are transported
into the cell by this process.

Cell Life Cycle

1. Interface Phase (longest phase)
G1 - Growth
S Growth and DNA replication
G2 Growth and finial preparation for division
2. Mitotic Phase
Mitosis division of the nucleus
Cytokinesis division of the cell cytoplasm
3. Cell Differentiation Phase Cells develop different characteristic and functions

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Four major types of tissues
a. Epothelial tissues (known as epithelium)9 sub types;
i. Ephite = means laid on, covering. The epidermis is composed of
epothelial tissues
ii. Forms sheets of cells for a protective coverings
1. Six characteristics
a. Widespread
b. Highly cellularwith little matrix
c. Occurring in two forms
i. Membrane epithelium
ii. Glandular epithelium
d. Has two surfaces
i. Apical surfacea free surface
ii. Basal surfaceanchored to a basement
e. It is Avasular (no blood vessels) but highly innervated
a lot of nerve endings, the tissue gets its nutrition from
the basal surface
f. Has high regeneration capacity
i. Mitosis takes place at the basal surface the
2. Functions of the epithelial tissue
a. Forms boundariesthe mucous membrane (made of
epithelial tissue) that is separating the acidic
environment from the wall of the stomach
b. Protects
c. Absorbswhen they are damaged by drugs, spices,
intemperate habits, you destroy the efficiency of
d. Filtratesfound in the kidney, simple cubiodal and
simple columnar epithelial tissue
e. SecretesET makes up glands
f. Sensory receptionthe ET has lots of nerve endings
3. Cells that make up the Epithelial tissue
a. Squamous cell
b. Cuboidal cell
c. Columnar cell
4. Classification of Epithelial Tissue
a. SimpleOne layer of cells
b. Stratifiedmore than on layer of cells
c. 9 Sub-types
i. Simple Squamous Epothelium
1. One layer

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2. Location
a. Alveoli, glomeruli, endothelium,
Bowmans capsul, and serosa
3. Main function
a. Diffusion and filtration
ii. Simple Cuboidal Epothelium (has a large
1. Location
a. Kidney tubules, ducts of small
2. Secretion and Absorption
iii. Simple Columnar Epithelium
1. Location
a. Non ciliated type
i. Lines the digestive tract
b. Ciliated type
i. Found in the small bronchi
2. Function
a. Secretion and absorption
3. Always has lots of goblet cells (secretory
cells by themselves are one gland)
a. Globlet cellssecretion of mucous
iv. Stratified Squamous Epithelium, (for
1. They are flat-different than the
transitional Epithelium
2. Apical cellssquamous
3. Basal cellsColumnar or cuboidal
4. Keratin is a protein that hardens the cell
a. 2 Types:
i. KeratinizedThe
epidermis is made of
Keratinized Stratified
Squamous Epothelium
ii. NonkeratinizedLining of
the mouth and esophagus is
Nonkeratinized Stratified
Squamous Epothelium
5. FunctionProtection
v. Stratified Cuboidal Epithelium
1. Two three layers
2. Main functionSecretion
3. Location
a. Rare in the bodyduct salivary

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vi. Stratified Columnar Epithelium of sweat
glands and
1. Two layers
2. Main function
a. Secretion and protection
3. Location
a. Rare in the bodysmall amounts
in the male urethra
vii. Pseudostratified Columnar Epithelium
1. False stratification
2. Location
a. Ciliated type lines most of the
respiratory tract
b. Lining the trachea
3. Main function
a. Secretion of mucus
viii. Transitional Epithelium
1. They stretch therefore lining the Urinary
bladder, ureters, and parts of the urethra
2. They are composed of about 6 layers
3. Type of cells
a. Apical surface cells
i. Dome-like when the tissue
is not distended, but
squamous-like when tissue
b. Basal surface cells
i. Cuboidal or columnar
ix. Glandular Epithelium
1. Types of cells
a. Cuboidal cells
b. Columnar cells
2. Main Function
a. Production and secretion of
3. Location
a. In all exocrine glands (have ducts)
and in some endocrine glands
4. Three types
a. Merocine gland
b. Apocrine gland
c. Holocrine gland
b. Connective tissues
i. Functions of the connective tissue
1. Produces blood cells

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2. Transport substances
3. Connect and binds
4. Supportsbones
5. Protectsadipose tissue protecting the kidney
6. Insulatesadipose tissue
7. Fills spacesAveolar tissue
8. Stores fat
ii. Matrix
1. Intercellular material = made of ground substance + Fiber
2. 3 kinds of fibersCollagen, reticular, elastic
iii. Four types of Connective tissue
1. Connective tissue proper
a. Loose connective tissues
i. Areolarmostly for packing, support, and
1. Lots of matrix (lots of fibers and ground
a. Fibroblast is the main cell in
connective tissue
b. Fibrocytesare the ones that old,
2. Stores water and salts
3. Fills spaces
4. Houses macrophages
ii. Adipose(adipocytes)
1. Scant matrix
2. Lots of cells
3. Protects organsAdipose tissue is
abundant in subcutaneous tissue and
around the kidneys and other viscera
4. Fills spaces
5. Insulates
6. Stores fat
a. Composed mostly triglycerides
iii. Reticularin lymph nodes, spleen, bone
marrowlots of ground substances, but more
cellular than areolar, lot of matrix
b. Dense connective tissue
i. Dense regularconsists largely of tightly
packaged collagenous fibers (fibroblast fibers),
going in the same directionideal for tendons
ii. Dense irregularconsists of collagenous fibers
going in different directionsfound in the
dermis of skin
2. Cartilage tissue

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a. Cell types
i. Chondroblastactive tissue (in a fetus being
ii. Chondrocytemature resting cell in the Lacona
(cavity)a pocket in the ground substance
(found on your nose)
b. Types of cartilage
i. Hyaline cartilage
1. Protects articulating areas of long bones
ii. Elastic cartilage
1. A dense network of elastic fibers and this
is more flexible than hyaline cartilage
2. Found in the external part of the ears and
parts of the larynx
iii. Fibrocartilage
1. Has the most collagen fibersits a
stronger cartilage
2. Found between the vertebrae
3. Ossesous tissue
a. Made up of:
i. Osteoblast and osteocytes (makes up bones)
ii. Haversian systems
1. Central Canal
a. Haversian canal (opening in each
b. Two types of bones
i. Spongy bonethe inside part (looks rough)
ii. Compact bonethe outside partlooks smooth
4. Blood tissue
a. Made of soluble fiber called fibrinogen when it
coagulates and forms fibrin-solid
fibersHemocytoblastmaking bloodwhen active in
the bone marrow and goes to the
b. Cell types:
i. Erythrocyte (red blood cells)they are matured,
for transportation of gases, oxygen
ii. Leukocytes (white blood cells)
iii. Thrombocytes (platelets)make clots
c. Muscle tissue
i. Types of tissue
1. Skeletal muscle
a. This forms the muscles attached to bones, which
produce movement of the skeleton.
b. Cell: Striated skeletal muscle fiber
c. Multinucleated (many nuclei)

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i. Provide protein because they are the most
d. Striated
i. Lines that appear across the muscle rods (fibers)
2. Smooth muscle
a. This is found in the wall of moving viscera
i. Any organ that is hallow and needs to move
1. Example: Intestine, blood vessel, and the
b. Cell: smooth muscle fiber
c. Nonstriated and mononucleated
3. Cardiac muscle tissue
a. Striated
b. Intercalatedthe part where fibers meet together and
unite together, usually short fibers that have striations
c. Monoucleated or binucleated
d. Cell: striated cardiac muscle fiber
e. This one is found in the wall of the heart (myocardium)
B. Nervous tissue
a. Made of neurons and neuroglial cells
b. They are one type of tissue
c. The nervous tissue is mostly found in the
i. Brain
ii. Spinal cord
iii. Nervescollection of neurons

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Any sheet like cover usually with epithelium and connective tissue
Four major types of membranes
a. Serous membranestwo layers, in cavities that dont open to the outside
i. Function
1. Secretes serous fluid
ii. Examples: Parietal and ventral cavities/parietal and visceral pleura
b. Mucous membranesone layer, in cavities that do open
i. They secrete mucous from the goblet cells
ii. Examples
1. Mucosa of the GI Tract
a. Mucosa of the large intestine
b. Mucosa of the stomach, etc.
2. Mucosa of the Respiratory Tract
iii. Lining of the Urinary Bladder
c. Cutaneous membrane (the skin)two layers, a protective covering
i. Secretes the acid mantle
ii. Dense Irregular Connective Tissue
d. Synovial membranesforms a capsule
i. Secretes synovial fluid
ii. Lining synovial joints

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The Integumentary System

A. Facts
a. Has more than organ, integument means covering
b. The integument is the largest organ in the body
c. 1.5 square meters
d. 9-11 pounds, which is about to 7 to 10% of total body weight.
B. Organs of the Integumentary System
a. Skin
i. Two Layers
a. The EpidermisFour to five strata (layers)
i. Cells of the Epidermis
1. Keratinocytessecretes keratin (for
protection), life span is 25-45 days
2. Melanocytessecrete melanin (protection
for the DNA, from the ultraviolet light)
3. Langerhans cellsmacrophages (big cells),
for protection
4. Merkel cellstouch receptor (Messiener
corpuscle also a touch receptor)
ii. The stratum lucidium is an extra shield against ultra
violet light preventing sunburns of the palms and
b. Layers of the Epidermis
i. Stratum corneum
ii. Stratum lucidium (found only in thick skin)
iii. Stratum granulosum
1. Contains granules of lipid that waterproofs
the skin
iv. Stratum spinosum
v. Stratum basale (another name Germinativum)
c. Types of layers
i. Thick skinfive layers of skin
ii. Thin skinhas four layers, they have no lucidium
2. The Dermis
a. Cells of the Dermis
i. Fibroblastscells of the connective tissue proper
ii. MacrophagesPhagocytosis
iii. White blood cellsprovide immunity
iv. Mast cellscells in the connective tissue containing
histamine and heparin
1. Histamine causes dilation of capillaries and
increases permeability of tissues
2. Heparininhibits coagulation of the blood,
blood clotting
b. Dermis contains a rich supply of tissues
i. Dense irregular connective tissuethe bulk of the
ii. Nervous tissuenerve ending and receptors

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iii. Epithelial tissueglands, lining of blood vessels,
lining lymphatic vessels, hair
iv. Smooth musclewalls of blood vessels and
lymphatic vessels, arrecto pili
v. Blood tissuewithin the blood vessels
ii. Skin Color
1. Melaninsecreted by melanocytes, different colors
2. Hemoglobinprotein molecule that carries oxygen
3. Bilirubinis a product of erythrocytes, people that have jaundice
have a problem eliminating bilirubin
4. Carotenedetermines the color of the skin
iii. Skin diseases
1. Albinismlack of melanin
2. Freckleslack of melanin
3. Nevusa congenital pigmented area of the skin, may become
4. Vitiligolack of melanin production in small areas, it might be an
autoimmune disease
5. Cyanosiswhen you have low hemoglobin, it will show bluish
purple, can be found on the bed of the nail
iv. Accessory organ of the skin
1. Hair and hair follicles
2. Nailsthe nail matrix is an area of growth, towards the proximal of
the bed of the nail
3. Sebaceous glands
4. Sweat glands
v. Classifications of burns
1. 1
degreeInvolves only the epidermis
2. 2
degreeinvolves the epidermis and upper region of the dermis
3. 3
degreeinvolves the entire thickness of the skin or more.
vi. Types of Cancer
1. Carcinoma (epithelial cells) 90%
2. Melanoma (Melanocytes)
3. Lymphoma (Lymphatic system cells)
4. Sarcoma (muscles and connective tissue cells)
5. Leukemia (blood cells)
vii. Two general types of skin cancer
1. Cutaneous Carcinoma
a. Basal cell carcinoma (stratum basale)
i. Slow metastasisstays in the tissue, doesnt travel,
slow spreading. Has full cure if removed on time.
b. Squamous cell carcinoma (stratum spinosum)
i. Slow growth, a little faster than Basal. Full cure if
treated before.
2. Cutaneous Melanoma (malignant melanoma)
a. Most dangerous, rapid metastisis. 50% survival rate. Begins
with a mole.
b. ABCD rule for recognizing melanoma
i. AsymmetryThe 2 sides of the pigmented spot or
mole do not match

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ii. Border irregularityThe borders of the lesion is not
smooth but exhibit indentations.
iii. ColorSpot contains several colors) blacks, browns,
tans, blues, etc.)
Diameter: the spot is larger than a pencil eraser.
b. Hair follicles
c. Nails
d. Sebaceous Glands
i. Secrete sebum. Not found in thick skin. Starts at puberty. (Oily face)
ii. AcneAn inflammation of the sebaceous gland. Accumulation of hormones,
keratin, sebum, and bacteria
iii. Styand inflammation of the sebaceous gland of an eyelash (hordeloum)
e. Sweat Glands
i. Eccrine glandsmore abundant in palms, soles and forehead (99% water)
ii. Apocrine glandmore abundant in auxiliary and genital areas. The
secretion has fatty substances and proteins.
1. The ceruminous glands are apocrine glands in the lining of the
externl ear canal.
C. Functions of the Integumentary System
a. Temperature control
i. Dermal vasoconstriction and vasodilatation
ii. Sweat glands are inhibited or stimulated into hyper secretion
b. Protection
i. Chemical protection
1. Acid mantlethe sum of the skin secretions (has low pH and
bactericidal chemicals)
2. Antibiotics (defensins) secreted by the skin cells (punch holes in
3. Melanina dark pigment that is secreted by the melanocytes, it
shields nuclei from UV light
ii. Physical protection
1. Hard keratinocytes protect from abrasion
2. Lipid granules in the granulosum and corneum protect from water-
soluble substances
iii. Biological protection
1. Macrophages
2. White blood cells
c. Sensory perception
i. The skin is richly supplied with sensory receptors that help us respond to
heat, cold, pressure, and pain
d. Metabolic functions
i. Vitamin D is being synthesized, Melanocytes produce melanin
1. 7 dehydrocholestrolthe cholesterol that is found in the skin and
when the rays of the sun hit the skin it turns this cholesterol to a
precursor of Vitamin D (which turn to Vitamin D later)
ii. Synthesis of enzymes that can destroy carcinogens that penetrate the skin
iii. Production of interferons (proteins that block viral infections)
e. Excretions
i. Small amounts of nitrogenous wastes are eliminated from the body in the
sweat (urea, ammonia, uric acid)

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f. Blood reservoir
i. Extensive supply of dermal blood vessels holds large volumes of blood
ii. When other body organs demand a greater blood supply, vasoconstriction of
dermal blood vessels provides it
g. Water retention
i. If too much fluid is lost, the brain signals the sweat glands to remain inactive
in an effort to minimize fluid loss.
ii. What happens if the weather is hot and humid while the person is exercising
vigorously and not drinking water?
1. Your body temperature will increase but the sweat can not
evaporate (to help cool the body down) and therefore it may lead to
heat stroke

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The Skeletal System

1. Bone - 206
2. Cartilage - Connective tissue, Hyaline, Elastic, Fibrocartilage
3. Ligaments - Connects bones to bones, Dense regular connective tissue
4. Joints - the junctions between bones, Fibrous, cartilaginous, synovial
Parts of the longs bones
1. Epiphysis - coated hyaline cartilage
2. Diaphysis - the shaft
3. Epiphyseal line - a line which marks what use to be the epiphyseal plate, in active
4. Periosteum - tissue around the bone, dense irregular, osteoblast - cell building, osteoclasts -
macrophages (cell eating)
5. Endosteum - lining the inside of the bone,
6. Articular cartilage - hyaline cartilage on the articulating end of the epiphyses
Parts of flat, irregular, short Bones
Two thin plates of compact bones surrounding spongy bone. Diploe - is the spongy part inside of
the two compact bones. Red bone marrow is only found in the epiphysis of some long bones and in
the flat, shot and irregular bones.

Red morrow - Hematopoiesis - blood cell formation
Functions of the bones
1. Support
2. Protection
3. Movement
4. Hematopoiesis - hemocytoblast are the blood cells stem cells
5. Mineral storage - calcium, phosphate
6. Point of attachment to muscles

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Structure of the Compact bone
Osteon = Haversian system > Lamella - made of collagen fibre, between them is the lucan are
connected by Canaliculus > osteochydes, Haversian canal

Longitudinal growth (length)- in the epiphyseal plate
Appositional growth (width) - osteoblast found under the periosteum (Bone formation,
bone deposit)
Osteoclast - bone absorption, bone brake down
Osteoclast + osteoblast = homeostasis
Lamellar bone = spongy bone
Bone marrow - yellow, red
Yellow marrow is fatty tissue
The epiphysis - is where the red blood marrow comes from (in a adult)
The Diaphysis - is red as a unborn but yellow in adult
Osteogenesis (Ossification) - The beginning of a bone
Embryo stage the bone is not bone but cartilage
1. (8 week) Formation of the bone collar around hyaline cartilage model
2. (around 8 week) Primary ossification center
3. Periostea bud appears (blood vessels, 1 lymphatic vessel, never fibres, osteoclasts,
4. Osteoblast > produces osteoid
5. Osteoclast > break it down
6. Medullary cavity is formed, by the osteoclast breaking down the osteoblast
7. When the baby is born the bone is ossified but the epiphysis is still cartilage
8. After the baby is born, you have secondary ossification centers in the epiphysis
Stage of life
1. Embryo - Fatal Stages - Bony skeleton formation
2. Birth - Early adulthood - bone growth (females end around 18, male around 21, by 25 bone
growth is ended)
3. Adult - No more bone growth - Bone remodeling / Repair
Bone remodeling
1. Bone deposit - by osteoblast > osteoid (controlled by a hormone call calcitonin - secreted by
thyroid gland) This is determined by good nutrition, protein, vitamin C, A, D, B12, calcium,
2. Takes place in bone injury or required strength
3. Bone resorption - Osteoclast > Lysozyme, Controlled by the Parathyroid hormone
4. Ensures the bone is not to thick/heavy

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5. When a person has fracture site if the do electrical stimulation then it heals faster

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Calcitonin (thyroid gland) Secreted when:
1. Blood calcium level increased
2. Brain sends message to thyroid gland to secrete calcitonin
3. Osteoblast activity increases
4. Blood calcium level drops

Parathormone (PR gland) secreted when:
1. Blood ca level decreases
2. Brain sends message to PT gland
3. PT hormone secreted
4. Stimulates osteoclasts activity
5. Blood calcium level increases

Growth hormone
1. stimulates epiphyseal plate activity
2. Pituitary gland
3. Hypersecretion growth hormone = gigantism - during childhood
4. = acromegaly - after growth has ended
5. Hyposecretion growth hormone = pituitary dwarfism

Examples of those who have stronger bones

Osteoclast is more active then Osteoblast = Osteoporosis

Factor that increase the risk
1. Age - bone resorption dominates
2. Decrease in blood oestrogen / testosterone hormones (inhibit osteoclast activity)
3. Insufficient exercise (mechanical stress)
4. Speed walking
5. Weight lifting
6. Too much sodium - increases the excretion of calcium in the urine
7. Too much protein - increases the excretion of calcium in the urine
8. Too much phosphorus - increases the excretion of calcium in the urine
9. Deficient intake of protein, calcium, magnesium, Vit C, D, A, B12
10. Smoking - decrease estrogens levels
11. Alcohol
12. Certain drugs (corticosteroids)

READ THIS ONE Joint pg 158 - Synovial Joints

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Muscular System
Three types: smooth, skeletal, and cardial.
Controlled by the Autonomic division of the nervous system
Visceral muscular
Found in the walls of hollow organs, iris of the eye
Involuntary control
Controlled by Somatic division of the nervous system
Of voluntary control
Transportation and movement
o Allow for body movement, and expression
o Maintain body posture
o Produce heat
o Skeletal
o Nervous
o Blood
o Connective
Each muscle fibres are surrounded by Endomysium, all these form a fascicle
which are surrounded by Perimysium. On top of all the fascicles is the
Epimysium and on top of that there is the Fascia (separates one muscle from
Tendon - fascia in a cordlike fashion
Aponeurosis - Flat/broad fashion
Tendon - muscle to bones
Aponeurosis - muscles to muscles
Sarcolemma - (Plasma membrane)
Sarcoplasm - (Cytoplasm)
Inclusions - Myoglobin - red pigment that carries oxygen
Inclusions - Glycogen - storage of glucose
Organelles - Sarcoplasmic reticulum - smooth (regulate the calcium)
Organelles - Cisternae of sarcoplasmic reticulum - Play major role in muscle
Organelles -Myofibrils - Play major role in muscle constriction
Muscles are connected to neurons
Motor neuron connect from the CNS to the muscle
Motor neuron > motor terminals > motor units
Neuro muscular junction is where the terminal meets the muscle

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Motor endplate
Found in the walls of the heart
Involuntary control
Controlled by the Autonomic division of the nervous system

Fibres in a single unit are not clustered in one place but are spread through out the muscle, there
for a single weak contraction will effect the entire muscle.

Myosin = thick, two tail and heads intertwined
Cross bridge = the head of a myosin molecule
The red dot is the myosin binding site
Sliding filament theory
1. Electoral impulse is sent down the axon
2. Reaches the synaptic
3. Reaches the axonal terminal
4. Action potential is generated - ACh
5. It then travels along the sarcnima
6. When it reaches the tube to travels down the tubule
7. It then hits the cisternae and the Ca2 in it moves out as the higher conistration is inside the
8. Which then moves the troppnin So it will leave the binding site on the actin filament
9. Now the cross bridge on the myosin attaches to the binding site on the actin

Cramp - p180

Rigor mortis - sets in within 72 hours of death

Two kinds of muscle fibres

Hypertrophy - development of a muscle that is forceful exercised

1. Slow fibre (endurance)
Walking, swimming
Mitochondria is increased, ATP
Blood capillaries increased
Gives the muscle the ability to resist fatigue
2. Fast fibre
Weight lifting
Production of new filaments (actin, alyosin, titin)

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Atrophy - decrees in muscle mass
Loss blood capillaries
Loss of mitochondria
Loss of filaments

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Nervous System
Function - Integrations and coordination (makes the body act as one system)
1. Brain
2. Spinal Cord
3. Nervous
The system works using electrical signals and produce immediate responses.

Two main divisions
Central Nervous System
Spinal Cord
Perferial Nervous System
Cranial + Spinal Nerves

Nerves are bundles of Axons
Spinal Nerves
Cranial Tissue
Characteristics of neurons
- Extreme Longevity over 100 years
- Amitotic - can not me replaced is destroyed
- Cannot survive with our oxygen and glucose.

p220 - structure of nervous
- Around axon you have Endoneurium
- A bundle of Axons is a Fascicle
- Surrounded by Perineurium
- All the fascicle surrounded by Epineurium

Three main functions of the nervous system

Two type of neurons

p210 part of a neuron

Parts of a Neuron
Cell Body = Soma
Cell membrane

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Nissl Bodies = chromophilic substance
Dendrites - receiving component (neuron process) (grey matter)
Axon - sending component (only one per neuron)
Tenodynia - axonal terminals (can have 1000s)
Synaptic knob
On the axon there are the Myelin sheets (a cell called Schwann cell, covered with white, is
called white matter, wraps around the long axons. Because it wraps so tight the cytoplasm
moves to the outside of the cell. Neurilemmal)
Oligodendrocytes - make the myelin in the CNS (short axons) No Neurilemmal sheath
Schwann cells - make the myelin in the PNS (long axons) Neurilemmal sheath
Any tissue that is made from myelin sheath is called white matter.
Grey matter is un-myelinated axons.

Functions of the Myelin sheath
1. Protections - physical barrier
2. Electrical insulation - made of fatty substance
3. Increases the speed of transmission of nerve impulse

Speed difference
- 25 cm / second - un-myelin
- 150 m / second - myelin

The gap is called NODE of RANVIER - allows for conductions
Saltatory conduction - leaping from one node to another

Different types on Neurons - Classification by Structure
Bipolar - two process
Unipolar - one process
Multipolar - (most common) - more then two process

Different types on Neurons - Classification by functions
Sensory neurons- PNS
Motor neurons - PNS
Inter neurons - usually in the spinal cord (CNS)

Classification of neuroglia cells which are the support cells, Six types
4 in the CNS
1. Astrocytes most abundant
2. Microglial macrophage of the CNS
3. Ependymal cell forms membrane called choroid plexuses (secretes the cerebrospinal
fluid) (a membrane that lines the ventricles of the brain
4. Oligodendrocytes makes myelin
2 in the PNS
1. Schwann cells
2. Satellite cell

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The Synapse
The junction between to communicating neurones
Axosomatic synapse axon to soma
Axodendritic synapse axon to dendrites
Axoaxonic synapse axon to axon
Dendrodenditric synapse dendrites to dendrites
Parts of a Synapse
- Synaptic knob - pre
- Synaptic Vesicles - pre
- Synaptic cleft microscopic gap 1 millionth of an inch
- Presynaptic and Postsynaptic from and to
- Neuron transmitter receptors on the postsynaptic

What is action potential?
- Depolarization
- Repolarization

Nerve impulse = is a wave of action potential of moving down the axon to the end of it.

Na+ = Sodium
K + = Potassium
Inside has more (-) negative then outside

Resting potential = when the inside is (-) outside (+) (The membrane is polarised)

There are two factors that maintain the resting potential
1. The membrane of the resting neuron is slightly more permeable to potassium.
2. Sodium / potassium pump. Two molecules of potassium are brought into the cell, and three
of sodium is taken out side. Per pump.

Neurons are highly excitable -

MS Multiple sclerous of the myelin sheath = demyelination of the white matter causing
neurological disorders

Read p216 Table 9.1

All-or-none response
This is a law that states that whenever a stimulus of threshold potential is applied to a nerve fibre
(axon) nerve impulses is conducted.

Protection of the CNS
Meninges membranes of connective tissues deep to the bone.
o Skin
o Bone
o Dura mater

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o Arachnoid mater looks like a spider
Subarachnoid - CSF
o Pia mater (gentle matter) connective tissue connects to the bran itself (p223)
Cerobrospinal fluid
o Found in and around the brain and spinal fluid
o Made in the ventricles
o Occupies the brain ventricles
o Produced by the epidianly cells
o Liquid cushion, floating, reduces the weight of the brain 97%
o CSF protects from trauma
o CSF nourishes the brain
What is a plexus? A Plexus is a network or nerves or capillaries

Hydrocephalus occurs when there is blocking of the CSF

Spinal Cord
- Begins at the magman foraman
- Consist of grey and white matter
- Functions:
o Conducts nerve impulses up and down the descending and ascending tracts (nerves
in the CNS)
o Its divide into 31 segments each segment has two sets nerves.
o Grey matter in the spinal cord is within the white matter

Ten Nerves that come out of the brain
1. Olfactory = sense of smell
2. Optic = vision
3. Oculomotor = movement of eye
4. Troclear = eye movement
5. Trigeminal = sensory / motor, lips, tongue, teeth
6. Abducens = eye movement
7. Facial = facial expression
8. Vestibulocochlear = ear
9. Glossopharyngeal = movement of tongue
10. Vagus = heart, lung, digestive system etc.
11. Accessory = movement of the sternocleidomastoid
12. Hypoglossal = movement of the tongue

Neural stem cells
Approx 100 billion neural cells in the brain, multi-polar type
The Brain
The brain has four major regions
1. Cerebrum
2. Diencephalon
3. Cerebellum

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4. Brain stem

Connected by the corpus callosum are axons of neurons that are the right and left hemispheres.
Cerebrum cortex the grey matter

The gyri = convolutions of the cerebrum
Sulci = Shallow grooves
Fissura = deep grooves

Areas of the Cerebrum
association = from memory makes decision based on sensory

The follow effect he frontal lobe
Rock and roll music

The Diencephalon
Consist of mainly grey matter
It is sub divided
o Thalamus has the Pineal gland melatonin=sleep/mood, and serotonin=Neuro
Deals more with sensory functions
Called the relay centre
o Hypothalamus from this hangs the pituitary gland, it makes 9 hormones.
Control centre for temp
Water balance
Sleep cycle
Pleasure, anger, pain, sexual arousal, fear
It controls more motor functions
o Epithalamus

Cerebellum small brain
Deals with movement
Provides precise movement
Equilibrium is controlled
Two hemispheres

Brain Steam
Divides into three parts
Medulla oblongata
o Cardiac centre - controls the heart rate
o Vasomotor control blood pressure
o Respiratory centre
o Contains tracks boundless of axons

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Frontal Lobe prefrontal lobotomy 1930-1940 this made things worse then better.

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Somatic and Special Senses
This is apart of the nervous system. There are two types of sense.
Somatic (soma body)
1. Touch
2. Pressure
3. Vibration
4. Stretch
5. Temperature

Types of receptors
Free dendritic nerves ending receive (Pain and temperature)
Encapsulated dendritic nerve endings ()
Receptors are found in the skin and deep tissues like muscles, joints, and viscera.

Meissners corpuscle
Pacinian corpuscle
The merkel disc light pressure
Root hair plexus
Special Sense
1. Taste
2. Smell
3. Sight
4. Hearing
5. Equilibrium

This are involved with complex receptors
Olfactory organ
Taste bud
Organ of corti
Organs of eubilibrium (crista ampullaris and maculae)
All of these are all found in the head.
Sensory Receptor
Sensory Receptor - A structure that responds to stimuli
A cell
A Collection of cells
The nerve ending o a sensory neuron

Stimuli - are chang4es in the internal or external environment.
A feeling that occurs when the cerebral cortex interprets a sensory input this happens in
with in the gray matter on the outside of the brain.
The result of the simulation of a sensory receptor

NOTE: Damage to the cerebral cortex (gray matter) can result in lost of sensation.

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Sensory Adaptation
When a receptors stops sending signals because it adjusts to a continual, unchanging
An adapted receptor can respond only if the threshold of the stimulus is increased.
Sensory Adaptation Receptor of pressure, touch, and smell adapt rapidly. That is why we
adapt of the feel of our clothing against our skin.
Classification of Sensory Receptors
1. Location
o Exteroreceptors (near bodys surface)
o Interoreceptors (on smooth muscles or the viscera)
o Propioceptors (our own movement skeletal muscles)

(Cartridge is devoid of nerve fibers)

2. Type of stimulus
o Mechanoreceptors (mechanical)
o Thermoreceptors (Heat)
o Photoreceptors (Light)
o Chemoreceptors (Chemical)
o Pain receptors or nociceptors

Noxious stimuli harmful stimuli

3. Structural complexity
o Simple receptor one cell or few cells together
o Complex receptors eye, ear organs
Sense of Pain
Free Nerve Endings

Pain Receptors are widely distributed except in the nervous tissue of the brain.
Pain is a response to noxious stimuli
Pain protects from tissue damage
Pain receptors adapt poorly

Pain can be the result of
Chemical stimulation - bradykinis
o Released when tissue is damaged
Lack of blood/oxygen ischemia

Pain suppressors
Enkephalins secreted by neurons in the spinal cord (secretion increased during labor)
The second win.
Endorphins secreted by the pituitary gland. (Secretion increased duing exercise)

Pain Threshold Pain Tolerance
Pain threshold point at which perception begins.
We all have the same pain threshold

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Pain tolerance our reaction to paint
Pain tolerance vary wildly influenced by cultural and psychological factors.

Example: Heat (77F 113F) above 113F stimulates pain receptors
Classification of Pain
1. Somatic Skin, skeletal, muscles, or joints
2. Visceral organs
3. Referred pain visceral pain that is perceived as somatic pain
a. Visceral pain impulses travel along the same pathway as the somatic pain impulses.
Example is heart attack
We have headaches because meninges, blood vessels, and muscles are highly innervated.
Sense of Smell
Special sense olfactory organ, it is located on the Ethmoid
bone. Sniffing is needed to enhance the concentration of
smell by bringing up the molecules to the bulb.
Olfactory Pathway
1. Olfactory cilia
2. Olfactory cell
3. Olfactory nerve fiber bundle
4. Olfactory bulb
5. Olfactory tact
6. Thalamus
7. Olfactory cortex (frontal and temporal lobe)

There are only 7 primary odors. A combination of these make up all other odors.
1. Floral
2. Musky
3. Camphorus
4. Pepperminty
5. Etheral
6. Pungent
7. Putrid

Anosmia lack of the sense of smell
Sense of Taste
Taste bud is the organ for the sense of taste
About 10000 taste buds
Each as 40 to 100 cells (taste cells
and supporting cells)
Fast sensory adaptations
Chewing and moving food in the
mouth prevents adaptation

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In order to have good taste we need to chew well and to move the food around in the mouth
otherwise there is very little taste
Primary taste
Sweet - Front
Sour - Side
Salt - Tip
Biter - Back
Taste pathway
1. Taste hairs
2. Taste cell (gystatory cell)
3. Facial nerve and glossopharyngeal nerve
4. Medulla oblongata
5. Thalamus
6. Gustatory cortex (parietal lobe)
Sense of hearing
Organ of Corti is the organ for hearing

1. The external ear
a. (auricle)
b. External auditory meatus
i. Sebaceous glands
ii. Ceruminous glands
iii. Sticky traps for foreign
iv. Repels insects
v. Ceruminous
impactation (impairs
2. The middle ear
a. The tympanic membrane (Ear drum)
i. A barrier to protect the inner and middle ear
b. The tympanic cavity
c. Auditory ossicles
3. The inner ear (labyrinth)
a. Osseous labyrinth
b. Membranous labyrinth

The Labyrinth of made up of two parts Osseous which is filled with Perilymph which comes from
the CSF. The membranous contains Endolymph which also comes from the CSF which is produced
by the choroids plexus.
Hearing Disorders
1. Conduction Deafness (Person tends to speak softly)
a. Ostosclerosis or damage to ossicles
b. A perforated or hardned eardrum
c. Impacted cerumen (or plugged meatus) (Wax)

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2. Sensorineural Deafness (Talk loud)
a. Damaged to neural structure (hair cells, nervers, cochlea)
3. Menieres Syndrome
a. People cant stand still, this deals with pressure
4. Tinnitus
a. Loud noise always ringing in the ears
Sense of Equilibrium
The Labyrinth The inner ear is apart of the sense of equilibrium this is located in the
temporal bone of the head
Ampulla houses the crista ampullaries, which respond to rotation
Utricle Two chambers for the maculae use for movement of the head except for rotation
Path way of Static Equilibrium
Perilymph moves
Endolymph moves
Hairs of hair cells
Hair cells
Vestibular nerve
Vestibulocochlear nerve
Brain Stem or Cerebellum
Auditory cortex in the temporal lobe

This is when we are not moving but we are moving eg. Being on a boat.

The macula sense the position of the head and maintain equilibrium and posture when the head
and body are still.
Dynamic Equilibrium
Detects movement of the head and aid in equilibrium when the body is in movement.

Other sensory structures for equilibrium
1. Shift of visual images sends information to equilibrium centers in the cortex
2. Propioceptors in the neck and other parts of the body also communicate with the
equilibrium centers in the cortex. (Detect own movement)
Sense of Sight
The organ for sight is the eye
1. Fibrous tunic
a. Sclera and cornea (Wind to the eye)
b. Choroid posterior
c. Ciliary body
2. Vascular tunic
a. Choroids, ciliary body and iris (open
or close)
b. iris anterior and annular opens
when light is dim, close when light is
c. has the color

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d. there are tow kinds of smooth muscle
e. inner muscle around the pupil - circular muscle when they contract it closes the
f. outer are called the radial muscle
when they contract it opens the
3. Sensory tunic = retina The innermost
a. Pigmented layer epithelial cells
1. Epithelial cells act as
b. Neural layer Rods and Cones
1. has about 250 million
rods and cones
2. There are more rods
then cones
c. This as all the blood cells, also the neurons
d. Rods and Cones are the Receptor cells
e. Stores vitamin A for the Rods if you are lacking in this you will have night
f. Rods are for night vision Cannot see color
g. Cones are for day vision For color, for detail
h. Macula Iutea a yellow spot with a depression know as the fovea centralis. Contains
only cones which is the area for the sharpest color vision.
Eyes disorders
Cataracts lens becomes cloudy {page 270}
o Smoking, diabetes, intense sunlight
Glaucoma Increased pressure in the eye
(page 271}
o The large space in the eye filled with
liquid has too much pressure from a
build up
Night Blindness vitamin A deficiency {page
Retina Detachment Pigmented and
nervous layers separate and vitreous humor
seeps between them
Myopia (nearsightedness) distant objects
are blurred, Eye is too long or lens is too
Hyperopia (farsightedness) close objects
are blurred. Eyes is too short and lens is
Macular Degeneration Tissue of the macula
lutea deteriorates. Loss of central vision, not
peripheral vision.
Floaters Clumps of gels in the vitreous humor that cast a shadow in the retina producing
moving specks in the field of vision

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Conjunctivitis inflammation of the conjunctiva, a membrane that lines the eyelid.
o Pinkeye, may be caused by allergic reactions or bacteria last about two weeks
o Epidemic or viral conjunctivitis highly contagious. Last 2 to 3 weeks.
The Lacrimal Apparatus
Keeps the conjunctive moist
Carry away small particles
Contains lypozones

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Endocrine System
A system made of glands, all the organs are glands that secret hormones. The two regulatory
systems Endocrine and nervous.

The nervous system provides rapid, brief control by fast traveling nerve impulses through
The endocrine system provides slower but longer lasting control by hormones secreted into
the blood by glandular epithelium.
Two types of glands
1. Exocrine glands ducts
a. Salivary glands
2. Endocrines glands hormones, are ductless
The pancreas has both glands it has dual function
Major Endocrine Glands with one function
Pineal gland
Pituitary gland (hypophysis)
Thyroid gland
o Three hormones
o Four little glands {page 291}
o Has one hormone this is needed for
calcium homeostasis
Thymus gland
o This is in the stimim (chest)
o This is for the production of WBC
o Works with the lymphatic system
Adrenals gland
o Two of these glands
Major Endocrine Glands with Dual functions
o Seven hormones
o Controls rest of the glands, this is called
the master gland
o Exocrine and endocrine functions
o Insulin
o Glucose
o Ovaries or Testes
o Reproduction and endocrine functions
Minor Endocrines Tissues

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o Has tissues that secretes
Gastrin - increases the HCl acid
Serotonin increases the contractions of stomach muscle
o The first section of the intestine
Cholecystokinin increase the production of bile
Made in the lever
Stored in the gall blattor
Secretine increase the release of pancreatic juice and bile
Intestinal gastrin decrease HCl secretion
o Erythropoietin production of erythropoiesis (RBC)
o Estrogen and progesterone influence the course of pregnancy
o Atrial natruretic peptide (ANP) decrease blood volume and BP
Functions of the Endocrine System
1. Controls rates of chemical reactions (T3 & T4 hormones)
a. Controls the metabolic rate
2. Aids in transport of substances across cell membranes (insulin)
3. Helps regulate water and electrolytes (ADH & aldosterone, calcitonin)
4. Controls reproduction, growth and development (sex hormones & growth hormones)
What are hormones?
Chemical messengers secreted by cells into the extracellular fluids to regulate the metabolic
function of target cells or target organs.

Two types of hormones
Amio-acid based (non-steroid hormones) {page
282, 283}
o Are made with amio acid derivatives
o Not soluble in the phospholipd bilayer of
the plasma membrane
o Needs to combine with a receptor
Steroid hormones
o Steroids are made with cholesterol
o Coluble in the lipids of the plasma membrane
o Once in the target cell they combine with a receptor and are allowed to enter the
o Like hormones, they act as chemical
o Synthesized in virtually every cell of the body
o Known as local hormones
o Affect only the cells of the tissue where they are
o Made from arachidonic acid comes from meat
o Enhance inflammation, pain, allergic reactions,

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and blood clotting
o These are needed but too much of it is bad and can lead to heart problems
Control of hormonal secretions
There are three turn on mechanisms all employ negative feedback
1. Hypothalamus control (hormonal stimuli)
a. Hormone controls secretion of other hormones
2. Nervous system control (neural stimuli)
a. Impulse Controls secretion of other hormones
3. Humoral stimuli
a. Homeostasis control of secretion of other hormones
Hypothalamus Control
Anterior pituitary gland
Hypothalamus stimulates the pituitary gland. Pituitary gland releases hormones that
stimulate other endocrine glands.
Hypothyroidism in Adults Myxedea
Sensitive to cold

Hyperthyroidism Graves disease

Certinism in children

Calcitonin Another hormone of the
Thyroid gland
is secretion is stimulated by
increased calcium levels in the
Calcitonin stimulates osteoblast
Inhibits osteoclasts activity
Parathyroid Glands
Parathormone is stimulated by low
levels of calcium
Thyroid glands
Parathyroid glands
It affects three things
o Bones PTH Calcium
o Kidneys PTH Vit D increase
absorption of calcium
o Small intestine PTH calcium
absorption, vit D is needed for

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All of this to increases the level of calcium level in the blood. When this happens the negative
feedback system will stop the release of this hormone.
Abnormal Secretion of PTH
- Hyperparathyroidism
o Results in increased osteoclast activity (bones resorption) soften, deform and
fracture spontaneously.
o Excess calcium in the blood can be deposit in the kidneys and the endothelium
causing kidney stones or
- Hypoprathyroidism
o Reduced osteoclast activity
o Bones remain strong, but blood
calcium concentration
decreases, which affects
transmission of electrical
impulses and muscular

Osteoporosis when osteoclasts activity
outpaces osteoblasts activity. Normal, Thinning,
Adrenal Glands
Hormones Secreted by the Adrenal Cortex.
Stimulated by hormones.
- Mineralocorticoids
o Aldosterone it regulates the
metabolism, potassium
- Glucocorticoids
o Regulates glucose
o Cortisol increased during
- Gonadocorticoids
o Sex hormone control
o Androgens
Cushings Syndrome
- Excess glucose production caused by hypersecretion of cortisol, and glucocorticoid.

Gluconeogenesis the body is making glucose from protein, from the muscles and collagen.
Hormones Secreted by the Adrenal Medulla
- Stimulated by neural transmitters

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- Ephinephrine
- Norepinephrine

Addisons Disease Hyposecretion of adrenal cortex hormones, especially cortisole. The
pigmentation of the skin and oral mucosa due to over stimulation of the melanocytes by ACTH,
which has melanostimulating properties.
The Pancreas A dual glad
Islet of Langerhans
- Is apart of the endocrine gland
- Alpha cells Secrete glucagons When it goes down
- Beta cells secrete insulin When it goes up
Abnormalities of Pancreas
Hypersecretion of insulin, results in hypoglycemia
o Need whole fiber
Hypersecretion of glucagons results in hyperglycemia.
o Diabeties Type 1 or 2 (normally type 2)
Hyposecretion of insulin results in hyperglycemia
o Diabetes mellitus

Diabetes Type 1 person does not produce insulin or enough of it.
Diabetes Type 2 starts with reception insufficient (insulin resistance)

What to do: Exercise improves diabetes by increasing the number of insulin receptors
and by increasing receptors and by increasing utilization of glucose by the skeletal

Pineal Gland
Production of the melanoma
Thymus Glad
Secretes thymosins this is used for the production of anti-bodies
Reproductive Glands
- Ovaries estrogen and progesterone
- Placenta estrogen, progesterone and gonadoropin
- Testes - testosterone

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Other hormone Producing Structure
{Refer to week one}

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The Blood System
A liquid connective Tissue

1. Systemic Circulation
a. Oxygenated
b. Whole body but the lungs
2. Pulmonary Circulation
a. Deoxygenated
b. This is for the lungs
Three functions of the blood
1. Distribution
a. Oxygen
b. Waste products
c. hormones
2. Regulation
a. Temperature
c. pH
d. fluid volume
3. Protection
a. From infection
b. From blood loss

The average sized adult has 5 liters of blood
Formed Elements
1. Erythroctes (RBC) (45%)
a. 1 kind
2. Leukocytes (WBC) (<1%)
a. 5 kinds
3. Thrombocytes (Clotting cells or platelets)

- Liquid part is plasma (55%)
o The fiber of this connective tissue becomes visible
during blood clotting.
Percentage of RBCs
1. Normal blood
2. Anemia
a. Less RBC more Plasma
3. Polycythemia
a. Too many RBC
Hematopoiesis before Birth
1. Liver
2. Thymus gland

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3. Spleen
4. Lymph nodes
5. Read bond marrow (all bones)

After Birth: Read bone marrow of bones in the axial skeleton, in the girdles, and in the
epiphyses of the humerus and femur.

All formed elements are derived from a stem cell: the hemocytoblasts. These are in the red bone
marrow of adults.
- Erythrocytes (RBC)
o Anuclated
o 120 days of life
o Biconcave disk
o Confined blood stream
o RBC count
1. Women 4.3-5.2 million / mm3
2. Men 5.1 5.8 /mm3
o Content: 97% hemoglobin oxygen carrying protein
o Erythropoises creation of red cell production
o Erythropoietin (kidneys, liver)
o Production of more then 2 million cells per second
o Kidney failure low RBC count which leads to Anemia = lack of blood
o Hypoxia - lack of oxygen at the cellular level this is the result of lack of RBC
o Hypoxia triggers secretion of erythropoietin
1. Target cell is bone marrow
2. Starts the production of RBC
3. When there is more the negative feedback will stop the release of
- Erythropoieses
o This process takes from 3-5 days
o They start in the bone marrow until the loss
the nucleus
- Hypoxia the result of..
o Loss of RBCs
1. Hemorrhage / destruction)
o Decrease of Oxygen
1. High altitude, low temperature,
vasoconstriction, etc)
o High demand for Oxygen

Polycythemia (too many
RBCs) can result as the body
tries to compensate for the
lack of Oxygen

o Children with Tetralogy turn blue and are

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sometimes called blue baby
Primary Nutrients Needs for Erythropoiesis
B12 Bacterial digestion, made in the gut of many animals. We produce it in the upper part
of the GI track.
o Deficiency can result;
Low HCl acid
Lack of Intrinsic factor
Folate deficiency cant activate B12
- We get this from legumes like lentils, beans, and also from greens.
Raw vegetables.
Folate Acid
Iron is part of the hemoglobin
B12 deficiency = pernicious anemia. Macrocyticanemia RBCs are too large.
Folate deficiency = macrocytic anermia
Iron deficiency = microcytic anemia (iron deficiency anemia) looks small and pale.
o Red pigment in RBCs
o Transports oxygen
o Oxyhemoglobin = hemoglobin combined with oxygen.
Has 4 molecules of protein
Has 4 molecules of Heme
In each Heme there is one oxygen
One atom can carry 4 oxygen atoms
o Deoxyhemoglobin = hemoglobin without oxygen (deoxygenated blood)

The number of RBC does not indicates the content of oxygen in the
blood. Because some cells may contain more hemoglobin then others.

NOTE: Whole grains, greens, legumes this is what to do for Anemia

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Globin > Heme > Iron > Oxygen

Each molecule of hemoglobin transports four molecules of oxygen

NOTE: 1 RBC contains about 250 million hemoglobin molecules

250 x 4 = 1 billion oxygen molecules per RBC

Types of Anemia
Sickle Cell Anemia
In sickle cell anemia, the patients has an abnormally shaped
hemoglobin known as sickle hemoglobin (hgbS). Sickle hemoglobin
creates misshapen RBCs which from blockages in the vessels.
Thalassemia is an inherited recessive hemoglobinopathy. It results
from a failure to produce sufficient globin molecules. Cant carry
enough oxygen.
Iron Deficiency Anemia
A normal RBC count but a low hemoglobin level. This situation occurs with iron-deficiency anemia,
in which red blood cells have less hemoglobin than Norman. Iron deficiency anemia is also referred
to hypochromic anemia. Hypochromic is a term that means less then normal color.
Vegan Sources of Iron
Nonhem iron comes from plans. Where do we find these?
- Legumes
o Peas, beans
- Whole grains
o Refined lacks iron
- Dried fruits
o During the drying process they are contaminated with iron from the machines
- Blackstrao molasses
- Greens leafy vegetables

Signs of Problems
- Fatigue
- Lack of energy
Vegan Sources of B12
- Fortified nutritional yeast flakes
o When they are grown they have bacteria
- Other fortified foods like soy products, cereals, meat substitutes
- Plant food does not have activated B12 which is not good for us

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Signs of Problems
- Numbness of the fingers tingling
- Bad coordination
- Bad memory
Best Sources of Folate
- Legumes
- Green leafy vegetables
What happens when RBC dies?

After about 120 days, a macrophage will eat the RBC keep the hemoglobin and then a few days after
it will through it out destroyed into two groups, Heme and Globin.

Globin > broken down into amino acids which are recycled.
Heme > decomposes into Iron and bilirubin (green part)

Iron > sent to the liver and stored
Biliverdin > sent to liver to be broken down into bilirubin
Bilirubin > sent to the intestine this is what gives the stool the brown color.

New Born Jaundiec
The child looks yellow because their liver is not getting rid of the bilirubin. They need
to be placed in the sun daily. Protect their eyes, feed them with breast milk to help them
to get rid of the bilirubin. Also charcoal water is good for them.

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Leukocytes or White Blood Cells
1. Leukocytes are the only formed elements that are true cells, with nuclei and the usual
2. They account for 1% of total blood volume. The average person has 5,000 to 10,000 WBCs
per cubic millimeter of blood. (RBC are 4-5 millions per cubic millimeter (mm
3. They protect us from bacteria, viruses, parasites, toxins, and tumor cells. The defend us from
4. The main reason WBCs are in the blood is simply to be transported from the bone marrow
or lymphoid tissue to the areas of the body where they are needed to engage in immune
system responses.
5. The leukocytes squeeze in and out of the blood vessels through the pores by the process of
diapedesis (a small portion of the cell slides through the pore at a time, and the portion
sliding through is constricted to the size of the pore).
6. Once outside the bloodstream, leukocytes move through the tissues by amoeboid motion,
self-propelled by cytoplasmic extensions. Leukocytes follow a chemical trail left by damaged
cells. That is known as chemotaxis.
7. The production of leukocytes - Leukopoiesis
a. Hormonally stimulated (several hormones known as cytokines).
b. Leukopoiesis takes place in the marrow, the thymus, the lymph nodes and other lymph
c. If needed for action, the body can speed up the WBCs production and twice the normal
amount may appear in the blood within a few hours.
d. A WBC count of over 10,000 per cubic millimeter is called leukocytosis - a normal
homeostatic response to bacterial or viral invasion of the body.
(1) Leukemia - A cancerous condition of the WBC that results in too many WBC but
they are nonfunctional (unspecialized and mitotic) and cannot defend the body from
(2) Mononucleosis - A viral disease that results in too many leukocytes. Symptoms:
tired, achy, sore throat, low fever. TX: rest.
e. A WBC count lower than 5,000 is called leukopenia (penia = lack), which can occur
after chemotherapy, in mumps, chicken pox, AIDS, and other diseases of the immune

8. There are 5 leukocytes grouped into two major
categories, granulocytes and agranulocytes. (See

- Granulocytes
o Neutrophils (very phagocitics)
(Most abundant)
o Eosinophils (kills parasites and
o Basophils (release heparin and
histamines reduces blood clotting)
- Agranulocytes
o Monocytes (very phagocytic)
o Lymphocytes (B cell and T cell,
produce antibodies) (Second

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9. Granulocytes, which are larger than erythrocytes include neutrophils, eosinophils and
basophils. Their nuclei are lobes shaped in many ways (polymorphonuclear). They have a
short life span (hours to a few days). All granulocytes can do phagocytosis. Why? The
granules are strong digestive enzymes. Remember: lysosomes are known as the garbage
disposals of the cells.
a. Neutrophils more abundant of all the leukocytes (62%), engulf bacteria and fungi
b. Eosinophils 2.3% of all the leukocytes, destroy parasitic worms by releasing
digestive enzymes on the worm surface.
c. Basophils rarest leukocytes, 0.5% of all the leukocyte population, release
(1) Histamine - an inflammatory chemical that acts as a vasodilator, increases
blood flow and makes blood vessels leaky
(2) Heparin - inhibits blood clotting

10. Agranulocytes include monocytes and lymphocytes. They lack cytoplasmic granules, and
their nuclei are spherical. Live longer than granulocytes (months to years).
a. Lymphocytes about 30% of all the leukocytes, but a small amount is found in the
bloodstream, found mostly in the lymphoid tissues (lymph nodes, spleen, tonsils,
etc.), produce antibodies (antibodies destroy foreign particles), may live 100 to 300
days of even years.
(1) T lymphocytes (T cells) attack virus infected cells and tumor cells. Differentiate in
the thymus.
(2) B lymphocytes (B cells) secrete antibodies that destroy foreign substances.
Differentiate in the bone marrow.
b. Monocytes 5% of all the leukocytes, may live from weeks to months or even years,
very phagocytic. When monocytes enter the site of attack, they begin to grow in size
(5X) and develop into macrophages, which can engulf very large objects.
c. We have macrophages in all routes by which invading organisms frequently enter the
1) The skin (broken skin)
2) The alveolar walls
3) In the liver (for the portal blood circulation). They are
known as the Kupffer cells.
4) The lymph nodes (For the lymph, because it does not
enter the liver.)
- The skin (langerhans cells)
- The alveoli (Alveolar macroghpages)
- The liver (Kupffer cells)
- The lymph nodes (lymph nodes macrophages)
11. To remember the leukocytes in order from most abundant to
least abundant: Never let monkeys eat bananas.

Of the blood cells 98% is RBC and 2% is WBC
Diapedesis - Chemotaxis
- WBCs follow chemical trails left by damaged cells or by other leukocytes.
A cancerous growth of nonfunctional leukocytes that overcrowds the RBSs and causes anemia.

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1. Sometimes called thrombocytes (thrombo = clot). Contain chemicals that act in the clotting
process. (Basophils are the antagonist to the platelets. Basophils are anticlotting agents.
They secrete heparin.)
2. Not a real cell, but cytoplasmic fragments of the disintegrating megakaryocytes.
3. Half the size of an erythrocyte.
4. Capable of amoeboid movement.
5. Life span is about 10 days.
6. Thrombocytopenia - A condition in which the number of circulating platelets is deficient,
causes spontaneous bleeding from small blood vessels all over the body.
7. Platelets count per cubic millimeter is 130,000 to 360,000.

8. Play a key role in hemostasis (stoppage of bleeding) of a ruptured vessel. (See Overhead.)
Three steps of hemostasis:
a. Vascular spasm (vasoconstriction) vessel contracts and blood flow is reduced.
Vasocontraction is also caused by serotonin, which is secreted by the platelets to
contract the smooth muscles of the walls. The spasm lasts long enough (20-30
minutes) to allow for the formation of
a platelet plug.
b. Platelet plug (by platelets
aggregation) Platelets contact the
exposed collagen fibers of the ruptured
blood vessel and begin to release the
platelet factor (makes them sticky and
attract other platelets. They swell,
become sticky and adhere to each other
and to the exposed collagen fiber to
form a platelet plug. Platelet plugs
control the blood loss from small
breaks. Larger ones may need a blood
c. Blood clot formation. (See overhead
and handout with illustration. p320)

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Platelet factors and collagen factors released, combine with calcium in the plasma and
form an enzyme known as prothrombin activator. The prothombin activator plus the
calcium in the blood combine to stimulate the conversion of prothombin (an inactive
coagulating factor present in the blood) into thrombin (an active enzyme). Thrombin
converts fibrinogen (a soluble protein in the blood) into fibrin threads within 10 to 15
seconds. These threads form a mesh that traps RBCs and plasma to form a clot. It must
be in the presence of calcium.
d. Vitamin K is required by the liver for production of clotting factors. Vitamin K is fat
soluble. Vitamin K deficiency can occur if fat absorption is impaired and also if dietary
fat is severely restricted.
- Sources of vitamin K: green leafy vegetables, broccoli, cabbage, etc. Vitamin K is also
the product of bacterial digestion in the colon.
e. Vitamin E is a potent anticoagulant. A vitamin K antagonist.
- Sources of vitamin E: nuts, seeds especially sunflower seeds, whole grains, avocados,
olives, vegetable oils, wheat germ, green leafy vegetables, unrefined vegetable oils, etc.
- Heparin is secreted by Basophils
f. Fibrinolysis - When vessel is repaired, clot is digested within two days.
g. Undesirable blood clots Abnormal blood clot formation can occur due to changes in
the lining of vessels (Simple Squamous Epithelium). For example: atherosclerosis,
smoking, high blood pressure, are factors that may damage the lining of vessels. Those
changes initiate undesirable blood clots. Can lead to complete occlusion.
1) Thrombus is a nonmoving clot.
2) Embolus is a clot that broke loose and is circulating in the blood. Emboli can reach
narrow places in the vessels and interfere with blood flow. This is very dangerous.
h. Hemophilia a bleeding disorder due to a deficiency of coagulating factors.
1) Hemophilia affects mostly men.
2) Symptoms: Severe bleeding episodes throughout lifetime. First episode before the
age of 18 months. IV injections can cause large hematomas (masses of blood
confined to an organ, tissue or space due to tissue hemorrhage). Even a light blow to
the head may cause intracranial bleeding.
3) Dental extractions or surgeries can precipitate severe bleeding episodes that could
be fatal.
4) No cure.
5) Life expectancy of a hemophilic depends on the deficiency level of the coagulating
(a) Severe deficiencies with severe bleeding episodes = early death.
(b) Mild deficiencies with mild bleeding episodes = possible normal life span if
properly managed.
6) Treatment: Replacement therapy (blood or plasma transfusion, which contain the
lacking factor) and oral administration of coagulating factors. These therapies
provide relief for several days only.
7) Recommendations: Avoid trauma and the use of aspirin, which has an anticoagulant
effect. Carry identification as a hemophiliac in case of an accident.
Three Steps to Homeostasis
The arrest of bleeding or circulation of the blood
1. Vascular Spasm injured smooth muscles

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2. Platelet Plug
3. Blood Clot Formation

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The Cardiovascular System
1. Ancient cultures believed that the heart was the seat of intelligence and the source of
emotions. Although those theories have proven false, we do know that emotions affect
heart rate. Hormones of the endocrine system (norepinephrine and epinephrine) and nerve
fibers from the sympathetic system can increase the heart rate dramatically.

2. The heart does not work alone. It is part of a system, the cardiovascular system, which
consists of:
a. The heart - A powerful pump connected to
b. Hollow blood vessels - An extensive system of pipes that run throughout the body
c. Blood (a connective tissue) as the transport medium to propel oxygen, nutrients,
hormones, wastes, and other substances to and from the cells.
Anatomy of the Heart
1. Size and location.
a. About the size of a fist. Weighs less than a pound. Its about 5 inches long and 3 inches
b. Has two pumps
c. Hollow, cone shaped organ.
d. Enclosed in the pericardial cavity of the mediastinum, intermediate between the
right and left lungs, posterior to the sternum, and anterior to the vertebral column.
e. The base, the flat posterior surface beneath the second rib, attaches to large blood
vessels, is about 3 inches wide, and it points toward the right shoulder.
f. The apex, a pointed end found between the 5
and the 6
ribs, points inferiorly toward
the left hip.

2. Coverings of the heart (See Overhead.)
a. Pericardium A double layered sac that protects the heart.
1) The outer layer is called the fibrous pericardium (dense connective tissue that
protects the heart and anchors it to the diaphragm, vessels, sternum, and vertebral
2) The inner layer is called the serous pericardium, and has 2 layers:
(a) The parietal layer of the serous pericardium, lines the fibrous pericardium.
(b) The visceral layer of the serous pericardium, also known as the epicardium.
(c) Between the parietal and visceral layers a space, called the pericardial cavity
contains a serous fluid that reduces the friction between the pericardial serous
membranes as the heart moves.
b. Pericarditis inflammation of the pericardium that hinders the production of serous
fluid and the heart rubs against the pericardium causing a sound known as pericardial friction.
Pericardia may stick together, which interferes with the activity of the heart. In severe
pericarditis excess inflammation fluid can seep between layers of the pericardium limiting the
hearts pumping ability. This is known as cardiac tamponade.

PEME Pericardium, Epicardium, Myocardium, Endocardium

3. Three layers of the heart wall (very vascular layers)

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4. Epicardium (corresponds to the visceral pericardium) a serous membrane of epithelial
tissue that reduces friction.
a. Myocardium a thick layer of cardiac muscle that forms the bulk of the heart. It is the
layer that contracts and forces the blood out of the heart chambers. Supplied with blood
capillaries, lymph capillaries, and nerve fibers (axons of neurons).
(1) The myocardium around the left ventricle is 3X thicker than the myocardium
around the right ventricle.
(2) The left ventricle must force the blood to all parts of the body (the systemic
circuit). Right ventricle pumps blood a short distance (the pulmonary circuit);
b. Endocardium squamous epithelium that lines the heart chambers.

- Inflammation of the Wall
1. Percarditis - inflammation of the paricardium
2. Endocarditis - inflammation of the endocardium and also the valves
3. Myocarditis inflammation of the myocardium
Heart chambers and valves
a. 4 chambers 2 superior atria
(singular, atrium), and 2 inferior
ventricles. The four of them constitute
two side-by-side pumps (two hearts).
b. The atria receive blood returning to
the heart.
1) Right atrium receives blood
from the systemic circuit
through 3 veins: (See
(a) Superior vena cava
drains blood from body
parts superior to the
diaphragm, except blood
returning from the
pulmonary circuit and the coronary ci rcuit.
(b) Inferior vena cava drains blood from body parts below the diaphragm.
(c) Coronary sinus (large, flat vein in the
coronary sulcus) drains blood from the
2) Left atrium receives blood from the lungs
through the pulmonary veins.
3) The atria are small and have thin walls because
they do not need to contract too much to push
blood into the ventricles.
4) Auricles -Small appendages called (little ears),
which increase the atrial volume.
c. The ventricles
(1) Receive blood from the atria through the
atrioventricular valves. The atrioventricular
valves prevent backflow to the atria when the ventricles contract.
(a) Tricuspid valve on the right. (Three)
Heart valves
open and close
in response to
difference in
blood pressure
on either side.

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(b) Bicuspid or mitral <mc' tral> valve on the left) (Two)
- The papillary muscles and the chordae tendineae play a role in the
atrioventricular valve function. (They keep the atrioventricular valves from
being pushed to far into the atria.)
(2) Ventricles contract to force blood out into the arteries through the semilunar
(a) The pulmonary semilunar valve prevents backflow to the heart during
ventricular relaxation. The pulmonary trunk, exiting the right ventricle, divides
into right and left pulmonary arteries transporting deoxygenated blood to the
lungs for gas exchange (pulmonary circuit).
(b) The aortic semilunar valve prevents backflow during ventricular relaxation.
The aorta, exiting the left ventricle, transports oxygenated blood to the systemic
(c) Systole Pressure (Top), Dyastole (Bottom) Relaxed to the Atria contract and
the ventricle relax, then vice versa.
(3) There are no valves guarding the entrances of the venae cavae and pulmonary veins
into the right and left atria, respectively. Small amounts of blood do spurt back onto
these vessels during atrial contraction, but blood backflow is largely prevented
because the atrial myocardium compresses these venous entry points as it
d. Interatrial or interventricular septum a partition that divides the heart longitudinally
and does not allow blood from one side to go into the other side.
Valvular Incompetence
1. A condition in which blood leaks in the wrong direction because the valves is closing
improperly. Also known as valvular regurgitation.
2. Leaky Valve does not close completely
3. Valvular Stenosis Vales does not open completely.
a. The flaps become stiff (Stenosis) the restrict the opening. That increases the load of
the heart. If in the left it will create congestion in the Lungs which is known as
Congestive Heart Failure. If in the right side of the heart it creates congestion in
the legs.
b. This is more common in the mitra valve. And the artic valve.
4. Murmur The sound of regulation, the sound produced by the vibration of the thin
myocardium in the old or infants.
The fetal heart
a. The foramen ovale - The adult
interatrial septum bears a shallow
depression known as fossa ovale, which
marks the spot where an opening, the
foramen ovale, existed in the fetal heart.
The foramen ovale is a bypass of the
pulmonary circuit. Closure of the
foramen ovale begins immediately after
birth and is completed within a year.
b. The ductus arteriosum This is another
bypass of the pulmonary circuit found
between the aorta and the pulmonary

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trunk. Its closure also begins immediately after birth. Only a remnant is left, which is
known as the ligamentum arteriosum.
c. 70% of the fetal blood goes through these bypasses. The other 30% may go through the
pulmonary trunk but will not be for gas exchange (fetal lungs are collapsed), only for
tissue nourishment.
d. The umbilical arteries and umbilical vein of the umbilical cord provide gas exchange for
the fetus.
e. Congenital heart failure If any of these bypasses fail to close, it results in a congenital
heart failure.

5. Heart Skeleton Rings of fibrous connective tissue surround the semilunar and AV valves
to provide attachment for the valves and to prevent AV valves dilation during contraction of
the myocardium. Dense fibrous connective tissue is present also in the septum.

Pathway of blood
a. Ventricles and atria are sometimes referred to as the right heart and the left heart.
b. They are two pumps, each serving a separate circuit:
1) The pulmonary circuit is served by the right heart.
- Pathway: Oxygen-poor/carbon dioxide rich blood goes from the right ventricle
through pulmonary semilunar valve pulmonary trunk right and left
pulmonary arteries lungs pulmonary veins left atrium through
atrioventricular bicuspid valve left ventricle.)
2) The systemic circuit is served by the left heart.
- Pathway: Oxygen-rich blood goes from the left ventricle through the aortic
semilunar valve aorta smaller arteries systemic capillaries small veins
venae cavae to the right atrium through the tricuspid atrioventricular valve
right ventricle.

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Note: It takes around 60 seconds for one drop of blood to go around the whole system.
Blood supply to the heart (Coronary Circulation)
a. It is part of the systemic circulation.
b. The heart is beating constantly to supply blood to all the body tissues, so the cells of the
cardiac muscle (the myocardium) require a constant supply of oxygen.
c. The first two branches of the aorta supply blood to the heart.
1) The right coronary artery and the left coronary artery, which subdivide into
anterior and posterior interventricular arteries and the marginal artery, etc.
2) The openings to the right and left coronary arteries are just beyond the semilunar
aortic valve.
d. After passing through capillary beds of the myocardium, venous blood is collected by
the cardiac veins to be returned to the heart.
e. In the posterior side of the heart all the cardiac veins join to form a very large vessel
known as the coronary sinus or great cardiac vein, which drains the blood into the
right atrium.
f. IMPORTANT: Any blockage to the coronary arteries can be very serious or even
1) Partial obstruction results in reduced oxygen supply to myocardial cells (ischemia
= lack of blood), which in turn results in angina pectoris (thoracic pain). Cells are
weakened, but they do not die.
2) However, in complete obstruction
(coronary thrombosis or blot clot
obstruction) cells die and it results
in a myocardial infarction (heart
attack). Whether a person survives a
myocardial infarction depends on the
extent and location of the damage.
3) Contraction of the myocardium
shortly blocks the coronary arteries.
The myocardium receives blood only
during diastole. If the heart rate is
high, plus there is atherosclerosis in
the coronary arteries, the blood supply to the myocardium is seriously decreased,
which results in damage to the cardiac muscle.
Coronary Occlusion
- CHD Coronary heart disease
- Partial or complete blocking of coronary artery.
Angina pectoris.
- Complete obstruction of coronary arteries - heart
- Atherosclerosis -
Congestive Heart Failure
- CHF the heart is not pumping efficiently. It is the
result of other cardiac conditions.
- Because there is less blood being pumped the heart has to work more, this enlarges the

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- It is going to congest in the lungs.
Heart Actions
1. Cardiac cycle
a. Cardiac cycle is all the events associated
with the flow of blood through the heart
during one complete heartbeat. In other
words, a cardiac cycle is atrial systole and
diastole followed by ventricle systole and
b. The term systole and diastole refer to the
contraction and relaxation period of heart
c. Each chamber goes through a systole and diastole period.
1) When the atria relax (diastole), blood flows into them from the large venae cavae,
the coronary sinus, and the pulmonary veins. As pressure increases in those
chambers, the A-V valves open and allow 70% of the blood to flow passively into the
ventricles. As blood is flowing into the ventricles the atria contract (systole) and
force the rest of the
(1) .
(2) Begins the chemical digestion of carbohydrates with amylase (a digestive
2) Dissolves food blood (30%) into the ventricles.
3) Due to increased pressure in the ventricles, the A-V valves close, the ventricles
contract (systole) and the semilunar valves are forced open. Blood is ejected into
the large arteries (pulmonary trunk and aorta). Pressure in the ventricles drop and
they relax (diastole). Blood in the arteries begin to back flow, which causes the
semilunar valves to close.
4) The cardiac cycle includes all the events associated with the flow of blood through
the heart during one complete heartbeat - that is, atrial systole and diastole
followed by ventricular systole and diastole.
5) One heartbeat equals a cardiac cycle.
6) Heart rate is the total heartbeats in a minute. The average heart rate is 70 to 80
heartbeats per minute.
7) Sinoatrial (SA) node, AV node, atrioventricular bundle The SA node is also
known as the heart pacemaker. It is a mass of conducting cells located in the right
atrium (below the superior vena cava). It generates impulses that cause contraction
of cardiac muscle (70 to 80 per minute). Impulses from SA node travel to the AV
node (near the tricuspid valve) and down the septum on the atrioventricular
8) Tachycardia heart rate >100.
9) Bradycardia heart rate <60
10) LUBB-DUPP is the sound of the opening and closing of the valves. This is one heart

2. Cardiac Output is the quantity of blood pumped into the aorta each minute by the heart. a.
Cardiac output = Stroke Volume (SV) x Heart Rate (HR)
c. Stroke volume = the volume of blood pumped by a ventricle with each heartbeat.
d. CO = SV X HR

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e. CO = Is the quantity of blood pumped into the aorta in a minute.
f. SV = is the volume of blood pumped by a ventricle with each heart beat.
g. HR = is total heart beats in a minute.
h. Tachycardia = HR > 100
i. Bracdycardia = HR < 60
j. Ventricular Diastole = as preasure increases in the atria, the AV valves open and allow
about 70% of the blood to flow passively into the ventricles. Then atria contacts to force
the rest of the blood in the ventricles.

3. Venous return is the quantity of blood flowing from the veins into the right atrium each
a. The venous return and the cardiac output are most of the time equal to each other.
b. Blood in the veins is under low pressure. The venous return is aided by four factors
known as the muscular pump, the venous valve
c. Comes from the venae cavae and the coronary sinus into the right atrium each minute.
Factors that contribute to venous return
- Respiratory Pump
o Main organ is the diaphragm
- Muscular Pump
- Venous Valves one way valves that help the blood
to move one way up back to the heart.
- Large Lumen the hollow space inside the vain
- Venous Constriction nervous impulse to vain to
S-A Node
- The nature pace maker for the heart
- Sometimes controlled by the medulla oblongata.
- A-V Node controls the rate of the heart.
- A-V bundles this is the fibers that send the impulses.

4. Heart sounds
a. A heartbeat sounds like lub-dub.
b. It is due to vibration in the heart
tissues during the opening and closing
of the valves.
c. The lub occurs when the A-V valves
close, during ventricular contraction
d. The dub occurs when the semilunar
valves snap shut, during ventricular
relaxation (diastole).
e. Heart murmurs are abnormal or
unusual heart sounds that often
indicate valve problems (leaking or
incompetent valves that allow blood
backflow). Such backflow is known as
regurgitation. Regurgitation

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produces the sounds known as murmurs. However, the thin heart walls in old people or
young children may vibrate with the rushing blood and produce heart murmurs also.

5. Cardiac muscle fibers (See Overhead.).
a. Cardiac muscle fibers, like skeletal muscle fibers, are striated.
b. Contraction is accomplished by the sliding filament mechanism.
c. Cardiac muscle fibers are short, branched, and interconnected by the intercalated discs,
whereas skeletal muscle fibers are independent of one another.
d. Because of this interconnection of the cardiac fibers, the entire myocardium functions as
a single unit

6. Electrocardiogram - This is the recording of the electrical changes in the myocardium
during a cardiac cycle.
Blood Vessels

1. The blood vessels of the body form a closed delivery system that begins and ends at the
heart. Function: blood transport

2. There are three major types of blood vessels: arteries, capillaries, and veins.

3. The walls of blood vessels, except for the very small capillaries, are composed of three
layers or tunics that surround the central opening known as lumen.
a. Tunica interna or intima (in intimate contact with the blood) contains the
endothelium (very smooth simple squamous epithelium) and a subendothelial layer of
loose connective tissue that supports the endothelium. Very thin in both arteries and
b. Tunica media a layer of smooth muscle cells that contract (vasoconstriction) and
relax (vasodilation) depending on the needs of the body. Vasoconstriction and
vasodilation are actions regulated by the autonomic nervous system to control blood
pressure. This layer is thicker in arteries. It contains elastic fibers and elastin sheets.
c. Tunica externa or adventitia (coming from outside) Composed mainly of collagen
fibers that protects the blood vessels. Has nerve fibers and very tiny blood vessels
(nourish the external tissues of the blood vessel walls).
(BP =120 to 70 mm Hg)
a. Carry oxygenated blood (except for the pulmonary arteries) away from the heart
under high pressure.
b. There are three groups of arteries that branch down. (Not in the book.)
1) Elastic arteries (aorta and major branches)
(a) Thick arteries near the heart that conduct the blood from the heart to medium-
sized arteries. Know as conductive arteries.
(b) Largest in diameter and the most elastic.
(c) Have a large lumen.
(a) Are very distensible (capacity to stretch) because they contain elastin in all
three tunics, which allows arteries to expand and recoil adjusting to changes
in blood volume. The tunica media of the elastic arteries contains most of the
elastin (elastic membrane. (See Overhead)
is hardening of
the blood vessel.
results in increased
peripheral resistance,
which leads to HBP.
Blood pressure in
vessels decreases as
distance from the left
ventricle increases.

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(b) If blood pressure is constantly high, arteries weaken and may balloon out
(aneurysm) and even burst. It is the same as a hernia.
2) Muscular (distributing) arteries
(a) Deliver blood to organs (kidneys, heart, liver, etc.) Known as distributing arteries
(b) Contain less elastin than elastic arteries.
(c) Their tunica media is thicker (more smooth muscle fiber) because these arteries
are more active in vasoconstriction.
3) Arterioles -
(a) The smallest of the arteries.
(b) Contain very little elastin.
(c) Larger arterioles have the three tunics (each very thin).
(d) The smaller arterioles have no tunica externa. They are merely a very thin
layer of smooth muscle cells (tunica media) around the endothelial lining
(BP = 40 to 20 mm Hg. 40 in the beginning and 20 at the end of the capillary bed)
a. Microscopic blood vessels.
b. Consist of tunica interna only (very thin endothelium). So thin that RBCs have to flow
through in single file.
c. Semipermeable vessels, through which substances are exchanged between blood and
tissue fluids (interstitial fluid).
d. Function: allow for exchange of material (gases, nutrients, hormones, ions, etc.)
between blood and interstitial fluid. The exchange is done by diffusion (from higher
concentration to lower concentration- oxygen and nutrients), filtration (molecules are
forced through the membrane by pressure) and osmosis (diffusion of water).
e. Capillaries do not function independently. They form a network called capillary beds.
f. Smooth muscle fibers (precapillary sphincters) encircle capillary entrances and
regulate blood distribution in the capillaries. If cells are low in oxygen or nutrients,
sphincters relax and blood flows in.
g. Vasoconstriction and vasodilation of arterioles and the precapillary sphincters
determine the route of blood flow. Example: during exercise blood flow is
increased to capillary beds of the skeletal muscles, while blood flow to capillary
network of the digestive tract is reduced.
h. Most tissue have a rich capillary supply (tendons and ligaments are poorly
vascularized). Tissues that require large quantities of oxygen and nutrients (muscle and
nerve) have more capillaries than tissues that require less oxygen and nutrients.
Cartilage and epidermis lack capillaries.
i. The blood that flows from arterioles to venules through capillary beds is called
(drain blood from capillaries) (BP in all veins = aprox. 20 mm Hg)
a. Blood is carried from the capillaries to the heart by veins that merge.
b. Capillaries join/merge to form venules.
c. Smaller venules = only endothelium (tunica interna).
d. Larger venules = may have the three tunics (interna, media and externa) but each is
very thin.

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a. Venules join/merge to form veins.
b. Veins have three tunics; but they are thinner. As a result veins have thinner walls than
arteries, and they collapse.
c. Large lumen.
d. Carry blood under low pressure (about 20 mm Hg).
e. Low pressure condition demands some special adaptation to help return blood to the
heart. There are five factors aiding venous return:
(1) Respiratory pump abdominal pressure increases, which forces blood to the
thoracic cavity
(2) Muscular pump Skeletal muscles around deep veins contract and squeeze or milk
the blood.
- Skeletal muscle inactivity during prolonged period of standing may result in
swollen ankles because blood poolins in the feet.
(3) Large lumen The larger the lumen the lower the peripheral resistance.
(4) Venous valves (formed from folds of the tunica intima) Only open upward,
preventing backflow of blood.
(5) Venous Constriction - low venous pressure stimulates SNS, which stimulates
smooth muscle in the walls of veins to contract.
f. Venous valves are abundant in veins of the limbs. They are absent in veins of the ventral
g. Varicose veins are veins that have become tortuous and dilated because of
incompetent venous valves. Causes: prolong standing, obesity, pregnancy and
constipation. The belly of an obese person or a pregnant lady exerts pressure on vessels
of the groin. This restricts return of blood to the heart. Blood pools in the legs and, with
time, the valves weaken and the venous walls stretch and become floppy.
h. Venous sinuses are large flattened veins with extremely thin walls that are supported
by the tissues around them. Example: coronary sinus supported by the pericardium,
the dural sinus in the dural space.
Blood Pressure
1. Blood pressure is the force the blood exerts against the inner walls of blood vessels.
2. The direct cause of blood pressure is the volume of blood in the vessels. The larger the
blood volume, the more pressure the blood exerts on the walls of the arteries.
3. Prolonged hypertension causes the myocardium to thicken and the heart enlarges. If
coronary heart vessels cannot supply all myocardium, heart muscle fibers die and heart
4. Blood pressure changes with age. In a newborn baby BP is 90/55. This tends to increase
with age, due to arteriosclerosis (hardening of the vessels). Elastin in blood vessels
deteriorates and walls are not so distensible.
5. This force occurs throughout the whole vascular system, but it is highest in the arteries and
lowest in the veins. The term blood pressure usually refers to pressure in the larger
arteries (elastic arteries) near the heart.
6. Ventricular systole forces blood into the pulmonary trunk and aorta, which increases the
pressure in these arteries. Since the pumping of the heart is intermittent, the arterial
pressure fluctuates between a systolic pressure of 120 and a diastolic pressure of 80. The
maximum pressure during ventricular systole is called systolic pressure. During
ventricular diastole the arterial pressure drops, and the lowest pressure before the
next ventricular systole is diastolic pressure.

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7. Blood pressure is expressed in terms of millimeters of mercury (mm Hg). 120 mm Hg is
equal to the pressure exerted by a column of mercury 120 mm high.
8. As the blood flows through the systemic circulation, the blood pressure drops until it gets to
near zero in the large venae cavae.
9. Factors that influence arterial blood pressure are:
a. Cardiac output = the blood volume discharged from the left ventricle per minute.
(Higher cardiac output = higher pressure because it increases blood volume in the
(1) Cardiac output depends on heart rate. Heart rate is controlled by sympathetic and
parasympathetic division of nervous system and by the hormones of the adrenal
(2) Often, when the heart rate increases, each contraction of the left ventricle takes
place so rapidly that it has little time to fill, and it squeezes out much less blood than
usual into the aorta. Lower stroke volume results in lower pressure.

b. Blood volume = the amount of blood in the vascular system. (Average is 5 liters.)
Hemorrhage reduces blood volume. High sodium or glucose increases blood volume
because of an increase in osmotic pressure.
c. Peripheral resistance = Resistance is opposition to flow produced by friction between
the blood and the walls of blood vessels. (Higher resistance = higher pressure.) There
are three factors that increase resistance:
1) Blood viscosity
2) Length of vessels
3) Diameter of vessels - Vasoconstriction and vasodilation affect the peripheral
(a) A hot footbath induces vasodilation and decreases the peripheral resistance.
(b) Atherosclerosis can increase the resistance by decreasing the diameter of the
vessel. (The smaller the vessel the greater the peripheral resistance.)
(c) Arteriosclerosis can increase the resistance by decreasing the distensibility of
the vessel.
d. Blood viscosity = thickness of the blood. (The greater the viscosity, the greater the
force required to move the blood through the vascular system.) Polycythemia (too many
erythrocytes) increases the viscosity of the blood.
e. Total blood vessel length increases peripheral resistance = higher blood pressure.
Example: an extra pound or two of fat requires that miles of small vessels be added to
service the new tissue.
f. Fear, anger, exercise, and rise in body temperature.
Hypertension = persistent high blood pressure.
a. Possible causes:
1) Kidney tumor or diseases (increases blood volume)
2) High sodium intake (increases blood volume)
3) Obesity (increases total blood vessel length, which increases peripheral resistance)
4) Stress (sympathetic nervous system response increased heart rate, etc.) If
sustained high blood pressure, the baroreceptors tend to reset to monitor
pressure changes at a higher set point. This is why exercise is an important factor in
the prevention and control of hypertension. Stress is eliminated and baroreceptors
will not reset the set point.
5) Arteriosclerosis (loss of elasticity of the vessels) increases peripheral resistance
6) Atherosclerosis (accumulation of fatty plaque or lipid containing material reduces

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diameter of the blood vessel, which also increases peripheral resistance)
7) Hormonal imbalance
(a) Aldosterone hypersecretion (mineralocorticoid of the adrenal cortex) -
Aldosterone reduces excretion of sodium from the body by stimulating sodium
reabsorption into bloodstream, and where sodium goes water follows, which
leads to increase blood volume and HBP.
(b) Epinephrine and norepinephrine (adrenal medulla) Constrict blood vessels,
which increases peripheral resistance. Also increase heart rate, which may
increase cardiac output.
(c) Antidiuretic hormone (neurohypophysis) Increases retention of water,
which increases blood volume.
Hypertension can lead to left heart failure.
Left heart weakens because of work overload.
Ventricle cannot pump out all of its blood.
Blood dams back to the left atrium and into the pulmonary veins.
Pulmonary circuit becomes congested, which increases blood pressure in the pulmonary
Fluid in the pulmonary capillaries filtrate into the interstitial spaces and into the alveoli
(pulmonary edema)
This impairs gas exchange, which can be life threatening.
Blood pressure homeostasis
By baroreceptors and hormonal control
a. Baroreceptors are located in the carotid, aorta and nearly all elastic arteries of neck
and thorax. When blood pressure increases baroreceptors are stretched, which sends
impulses to vasomotor center of the medulla oblongata. (Vasomotor center in the
medulla oblongata contains clusters of nerve fibers that stimulate vasoconstriction.)
The vasomotor center is inhibited when impulses from the baroreceptors are received.
That results in vasodilation, which decreases the BP.
b. Baroreceptors also send impulses to other medulla centers (1) the cardio inhibitory
center (parasympathetic fibers) and (2) the cardio acceleratory center (sympathetic
fibers). Impulses from these centers are send to the SA node and the heart rate either
increases or decreases.
is the cause of ischemic heart disease (insufficient coronary blood flow).
a. A common site for development of atherosclerotic plaque is the first few centimeters of
the major coronary arteries.
b. Atherosclerosis causes a rough endothelium.
c. That leads to platelet aggregation and fibrin production.
d. A thrombus (a non-moving blood clot, attached blood clot) is formed.
e. Thrombus continues to grow until it occludes the artery
f. Or the clot breaks away (an embolus) and blocks a more distal coronary artery.
g. After the coronary occlusion, blood flow ceases beyond the occlusion, which results in
necrosis (death of the tissue) known as myocardial infarction.

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The Digestive System

1. Digestion The mechanical and chemical
breakdown of foods into nutrients that cell
membranes can absorb.

2. Accomplished by the alimentary canal also
known as the gastrointestinal (GI) tract, which
is a continuous, muscular digestive tube from
the mouth to the rectum.

3. The GI tract digests (dissolves) food, and
absorbs the digested fragments through its
lining into the blood.
Digestive Processes
The processing of food by the digestive system involves
six essential activities: ingestion, propulsion,
mechanical digestion, chemical digestion, absorption, and defecation.

1. Ingestion taking of food into the GI tract via the mouth. (Only the mouth ingests.)
2. Propulsion moving food through the GI tract. Includes:
a. Swallowing (initiated voluntarily by the tongue)
b. Peristalsis (peri = around; stalsis = constriction) Involuntary process of alternate waves
of contraction and relaxation of muscles in the organ walls. Squeezes food from one
organ to the next. Peristaltic waves are so powerful that food and fluids will reach your
stomach even if you stand on your head.
3. Mechanical digestion physical preparation of food for chemical digestion. Only the
appearance of the food changes. Mechanical processes include:
a. Mixing of food with saliva by the tongue
b. Churning food in the stomach (very powerful contractions, three layers of muscle
c. Segmentation a rhythmic local constrictions of the small intestine that mixes food
with digestive juices and increases absorption by moving the chyme closer to the
intestinal wall.
4. Chemical digestion a series of catabolic steps in which complex food molecules are
broken down to their chemical building blocks or monomers. (Carbohydrates into
monosaccharides, fats into fatty acids, proteins into amino acids, and nucleic acids into
a. Chemical digestion is accomplished by enzymes secreted by various glands into the
lumen of the GI tract.
(1) Salivary amylase Salivary Glands
(2) Gastric enzymes - Pepsinogen (chief cells), HCl, and Intrinsic factor (Not enzymes,
but part of the gastric juice.) (parietal cells)
(3) Bile Liver cells (Not an enzyme but needed for the emulsification of fats.)
(4) Pancreatic enzymes pancreatic amylase, lipase and protease (Secreted by the
acinar cells of the pancreas)

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(5) Intestinal enzymes - maltase, sucrase, lactase, lipases, proteases Secreted by the
brush border (secretory cells of the small intestine)
b. Enzymatic breakdown or chemical digestion of food begins in the mouth and is
completed in the small intestine.
5. Absorption the passage of digested end products (monosaccharides, amino acids, fatty
acids) plus vitamins, minerals, water, etc., from the lumen of the GI tract into the blood or
lymph. Most of the absorption takes place in the small intestine.
6. Defecation Elimination of indigestible substances from the body via the anus in the form
of feces. (Only the large intestine defecates.)
Components of the Gastric Juice
- Pepsin formed by the activation of pepsinogen in the presence of HCl. Pespsinogen is
secreted by the chief cells of the gastric glands.
- HCl activates pepsinogen, lowers the pH in the stomach. Secreted by the parietal cells.
- Intrinsic Factor Binds to B12 and protects it from the low pH. Necessary for B12
absorption in the ileum. Secreted by the parietal cells.
- Mucus Lubricaton and compacting of the chime. Secreated by surface mucus cells, mucus
neck cells and goblet cells.

All these cells are found in the gastric glad.
Structure of the Wall of the GI Tract
1. The GI tract in a cadaver is
approximately 9 meters long
(about 30 feet). Shorter in a
living person because of muscle
2. Food material within this tube
is technically outside the body
because the canal is open to
external environment at both
3. Most of the alimentary tract
resides in the abdominopelvic
cavity (esophagus is in the
thoracic cavity). Remember
that the ventral body cavities
contain a slippery serous
membrane. In the
abdominopelvic cavity this
membrane is call the
peritoneum the visceral
peritoneum and the parietal
peritoneum. Between the two
peritoneum is the peritoneal
cavity filled with serous fluid that protects the organs as they carry out their digestive
4. From the esophagus to the anal canal, the walls of every organ of the alimentary canal are
made up of the same four basic layers:

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a. The mucosa
1) Most inner layer around the lumen.
2) An endothelium made mostly of simple columnar epithelium (from the stomach
and down) rich in mucus-secreting goblet cells. Mouth, pharynx, and esophagus are
nonkeratinized stratified squamous epithelium.
3) May have folds (like rugae in the stomach), projections (like vili in the large
intestine), or circular folds (like folds in the small intestine).
4) Functions of the mucosa are:
(a) Secretion the mucosa is a serous membrane that secretes a serous fluid. It also
secretes hormones and enzymes.
(b) Protection Protects against infectious diseases with bactericidal secretions,
and mucus secreted by goblet cells protects some organs from being digested by
the strong digestive enzymes.
(c) Absorption Vitamins, minerals, and water are absorbed into the blood.
b. The Submucosa
c. - Loose (areolar) connective tissue containing blood vessels, lymphatic vessels,
lymph nodes, and nerve fibers. The vessels nourish surrounding tissues and carry
away absorbed material.
d. The muscular layer
1) Consists of two layers of smooth
muscle tissue and nerve plexus (a
network of nerve fibers). The
muscular layer of the stomach has
three layers of muscle fibers -
circular, longitudinal, and the
2) Responsible for peristalsis,
churning, and segmentation.
When circular fibers contract, the
diameter of the tube decreases.
When the longitudinal fibers
contracts, the length of the tube
3) In several places along the GI tract
the circular layer thickens to form
sphincters that act as valves to
prevent backflow and control food
passage from one organ to the next.
(a) upper esophageal sphincter
(b) lower esophageal sphincter
(c) pyloric sphincter
(d) ileocecal valve
(e) external anal sphincter (of voluntary control)
(f) internal anal sphincter
4) A peristalsis wave occurs when a ring of smooth muscle fibers contracts at the
same time that the muscular wall just ahead of the ring relaxes.
e. The Serosa
1) Also known as the visceral peritoneum.
2) Made of loose areolar connective tissue and simple squamous epithelium.
3) It is a moist outer covering that protects the GI tract. Secretes serous fluid which

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moistens and lubricates the tube so that organs of abdominal cavity slide freely
against one another.
Six Sphincters of the GI Tract
1. Upper esophageal sphincter
2. Lower esophageal sphincter ( Cardiac sphincter)
3. Pyloric sphincter
4. Ileocecal valve
5. Internal anal sphincters
6. External anal sphincters
Organs of the Digestive System
(organs of the GI tract: oral cavity, pharynx, esophagus, stomach, small intestine, and large
intestine; accessory organs: teeth, tongue, salivary gland, liver, gallbladder, pancreas)

1. Mouth or oral cavity (See Overhead)
a. Digestive function
1) Ingestion
2) Mechanical digestion (chewing and mixing food)
3) Chemical digestion of starches (a complex carbohydrate)
4) Propulsion (initiated by the tongue)
b. A chamber known as the oral cavity, and a space known as the vestibule between the
teeth, cheeks and lips.
c. Boundaries are the lips anteriorly, the cheeks laterally, the palate superiorly, and the
tongue inferiorly. Lips are made of skeletal muscles and sensory receptors helpful in
judging the temperature and texture of food.
d. Openings are: oral orifice anteriorly, and the fauces posteriorly.

e. Functions:
f. Begins ingestion and
g. mechanical digestion by reducing the size of solid particles and
h. mixing them with saliva (beginning of chemical digestion). Only of the complex
i. Tongue mixes the food with enzymes and mucuse, forms a bolus (propulsion)

j. Cheeks lining consists of moist (non-keratinized) stratified squamous epithelium.
Cheeks help maintain food out of the vestibule.
k. The tongue (an accessory organ of the digestive system)
(1) Consists largely of skeletal muscles
(2) Mixes food particles with saliva during chewing,
(3) Compacts the food into a bolus
(4) Pushes food toward the pharynx when swallowing
(5) Has papillae and taste buds (sensory receptors of taste)
(6) Posterior part of the tongue is anchored to the hyoid bone
(7) Contains the lingual tonsil in the posterior aspect (Lingual tonsil is a lymphatic
organ that helps protect the body against infections.)
l. Hard palate, soft palate and uvula. The palate is the roof of the mouth cavity. During
swallowing, the soft palate and the uvula move upward, preventing food from entering
the nasal cavity. If we try to talk or inhale while swallowing, the various protective

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mechanisms may be interrupted and food may enter the respiratory tract. This triggers
the cough reflex in an attempt to expel the food.
m. Palatine tonsils are located on either side of the fauces (back opening of the mouth).
These lymphatic organs are common sites of infections (tonsillitis) (tonsillectomy =
surgical extraction).
n. Pharyngeal tonsils another lymphatic organ on the posterior wall of the pharynx.
Also known as adenoids. They may become infected and enlarged blocking the
o. Lingual tonsils (posterior surface of the tongue)

p. Tubal tonsils (around the opening of the auditory tube)
q. Pharangeal tonsils
r. Lingual tonsils
s. Palatine tonsils

t. Teeth (accessory organs of the digestive system) (See Overheads)
1) Primary teeth There are ten in each jaw. Their roots are resorbed and pressure
from the secondary teeth pushes them out of their socket.
2) Secondary teeth Sixteen in each jaw.
3) Teeth break food into smaller pieces, which enables digestive enzymes to mingle
more effectively with food molecules. There are four types:
(a) Incisors (Vv-oc,vo) - bite pieces off large pieces of food.
(b) Cuspids (one cusp or pointed projection) grasp and tear food.
(c) Bicuspids (two cusps) and (d) molars (four cusps) grind food.
4) Parts: crown (part above the gingiva or gum), root (anchors the teeth to the
jawbone), neck (where the crown and the root meet), enamel (covers the crown),
dentin (part under the enamel, harder than bone), pulp cavity-within the crown,
root canal-within the root (contain blood vessels and nerves), cementum (encloses
the root and attaches the tooth to the jaw)
u. Mastication muscles masseter and temporalis
Salivary glands
(See Overhead (accessory organs of the digestive system)
a. Functions of saliva:
(3) Cleanses the mouth.
(4) Protects against microorganisms with
(a) antibodies - immunoglobulin A (Ig A)
(b) bactericidal lysozyme (enzyme that inhibits bacterial growth in the mouth and
protects against tooth decay)
(c) antibiotics - defensins, which function as cytokines to call defensive cell
(lymphocytes and phagocytes) into the mouth for battle
(5) Aids in propulsion (mucin) - Moistens and binds food particles, making a bolus
that is easy to swallowmolecules so they can be sensed by the gustatory cells in the
taste buds (97% water)
b. Extrinsic salivary glands - found outside the oral cavity and empty their secretions
into the mouth through ducts.
c. Intrinsic salivary glands - known as buccal glands that are found throughout the
mucosa of the oral cavity. These secrete saliva continuously.
d. There are 3 pairs of extrinsic salivary glands, which are major exocrine glands that
secrete saliva (not hormones) through ducts when food enters the mouth.
Salivation is
controlled by the
division of the
nervous system.
Salivary centers
are in the pons
and medulla

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e. Salivary glands are composed of serous (watery secretion containing enzymes) cells,
and mucous (sticky secretion) cells. These cells are present in varying proportions
within different glands.
(1) Parotid glands Largest of the salivary glands. Secrete a serous fluid that contains
amylase, which begins the digestion of carbohydrates. Mumps is an inflammation
of the parotid gland caused by a virus that spreads from person to person in the
(2) Submandibular glands Secrete serous fluid and mucus, which bind food
particles to make a bolus and to lubricate during swallowing.
(3) Sublingual glands Smallest of the major salivary glands. More mucus than serous
f. Major components of saliva:
(1) Water 97%
(2) Digestive enzymes - Most significant is amylase
(3) Mucus - Mucin
(4) Bactericidals - Ex: lysozyme
(5) Antibodies - Ex: Immunoglobulin A
(6) Antibiotics - Ex: defensins
g. Smelling, tasting, or thinking of food stimulates parasympathetic nerve impulses to
elicit secretion of large volumes of saliva.
h. Halitosis may be the result of a dried mouth because decomposing food particles are
allowed to accumulate in the mouth and bacteria can grow. Drinking water increases
secretion of saliva.
(Connects the nasal and oral cavity with the larynx and the esophagus.)
a. A passageway for food from the mouth to the esophagus (oropharynx and
b. Digestive function: food propulsion The muscular wall of the pharynx propels food
into the esophagus.
c. Mucosa membrane consists of non-keratinized stratified squamous epithelium.
d. Muscular layer is skeletal muscle. (Remember that first part of swallowing is a
voluntary action.)
e. Pharingitis Inflammation of the pharynx.
a. A food passage, approximately 10 inches long, from the pharynx to the stomach.
b. Mucosa is non-keratinized stratified squamous epithelium.
c. Muscular layer is
(1) First third = skeletal muscle fibers
(2) Second third = a mixture of skeletal muscle fibers and smooth muscle fibers
(3) Inferior third = only smooth muscle fibers
d. Glands in the mucosa secrete lubricating mucus that aids in food propulsion.
e. Begins at the base of the pharynx and descends behind the trachea, passing through
the mediastinum and penetrating the diaphragm through an opening called the
esophageal hiatus where it enters the abdomen to join the stomach. The esophageal
hiatus surrounds the cardiac sphincter of the stomach and helps keep it closed when
food is not being swallowed.

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f. Has two sphincters (upper esophageal and lower esophageal sphincters)
g. Hiatal hernia: A portion of the superior part of the stomach protrudes slightly above
the diaphragm. Since the diaphragm no longer reinforces the cardiac sphincter, gastric
juices may flow back into the esophagus (gastroesophageal reflux) causing heartburn.
If this reflux is prolonged, an esophageal ulcer may result.
h. Heartburn: (gastroesophageal reflux disease) Burning pain that occurs when gastric
juice regurgitates into the esophagus. Symptoms are similar to those of a heart attack.
Heartburn is most likely to occur when one has eaten or drunk to excess or in
conditions such as extreme obesity, pregnancy, and running.
i. Caffeine
j. Tobacco
k. Stress
l. Running
m. Spicy or fatty foods, citrus, onion, coffee, or alcohol
n. Shortage of saliva
o. Side effects of certain drugs

p. Natural Treatment for heartburn: (1)Aloe vera one hour after meals or any time
heartburn occurs helps reduce burning pain by coating the walls of the esophagus. (2)
One tsp. slippery elm powder with cup aloe vera before meals. (3) No overeating. (4)
Avoiding strong stimulants of acid secretion like coffee and alcohol. (5) Avoiding
smoking and certain foods like fats and chocolate, which reduces esophageal sphincter
competence. (6) No tight clothing around the waist. (7) Elevating the head of the bed 6
a. General characteristics:
(1) J-shaped organ with 1 liter or more
capacity. (Maximum capacity: about 1 gallon
of food extending all the way to the pelvis.) 4
(2) Mucosa is made of simple columnar
epithelium with lots of mucus producing
goblet cells. This mucus protects the wall
from being digested by the pepsin. The
epithelium is completely renewed every three
to six days.
(3) Thick folds of the lining called rugae allow
the stomach walls to distend when food is
b. Digestive functions of the stomach
(1) Continues mechanical digestion (churning)
to produce a chyme (a creamy mixture).
(2) Chemical digestion
(a) Begins digestion of proteins with pepsin.
(b) The digestion of carbohydrates continues in the stomach for a short period of
time until the stomach content is mixed with the gastric juice. The gastric juice
blocks the activity of amylase. Carbohydrates' digestion is resume later in the
duodenum, because the pancreatic secretion contains large amounts of amylase.
(3) Absorption The stomach absorbs only small amounts of water, some salts, alcohol

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and some drugs, like aspirin. (alcohol and aspiring absorption cause gastric
(4) Propulsion Food moves from the body region to the pyloric region aided by
stomach contractions (peristaltic waves), and as the pyloric region fills up, the
pyloric sphincter relaxes, allowing small
portions of the chyme to move to the
duodenum of the small intestine for further
(5) Stomach emptying takes approximately 4
hours (depending on the quantity and quality of
(6) Another function of the stomach: A holding
tank. Holds chyme until duodenum is ready to
receive it.
c. Anatomy of the stomach: (See Overhead)
(1) Cardiac region small regions that surrounds
the cardiac orifice.
(2) Fundus the dome-shaped part of the
(3) Body the main part of the stomach where most of the chemical digestion occurs.
(4) Pyloric region a funnel shaped region that continues to narrow and become the
(5) Pylorus This is the opening to the duodenum.
(6) Pyloric sphincter - where the muscular wall of the stomach thickens to form a
valve, which controls gastric emptying.
d. Gastric secretions
(1) The lining of the stomach mucosa is a simple columnar epithelium composed
entirely of goblet cells (tiny glands), which produce a protective coat of mucus
(protects the mucosa from being digested by its own highly acidic enzymes).
(2) Gastric glands Found in the gastric
pits of the stomach wall. Made of three
types of secretory cells that collectively
produce the gastric juice.
(a) Mucous neck cells mucus (not the
same as the goblet cells mucus) Its
about 1mm thick.
(b) Chief cells - pepsinogen (the
inactive form of pepsin) Pepsinogen
is activated by hydrochloric acid.
(c) Parietal cells - hydrochloric acid
(HCl) and intrinsic factor (necessary
for B12 absorption in the small
intestine). HCl is very acid (pH 1.5-
3.5), harsh enough to kill many of
the bacteria ingested with foods.
(d) The mixture of the mucus, the
hydrochloric acid and the digestive
enzymes is called gastric juice
(3) Pyloric Glands - Found in the pyloric region
(a) Similar to the gastric glands but less parietal and chief cells.
(b) Mostly mucous cells that secrete a thin mucus that lubricate chyme movement

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and protect the stomach wall from digestion
(c) Also secrete the hormone gastrin which controls gastric secretion its in
inhibitor of the gastric juices.
(4) Surface mucous cells - A different type of mucous cells found on the entire surface
of the stomach mucosa
(a) Secrete large quantities of a very viscous, sticky mucus.
(b) Provides a shell of protection for the stomach wall (>1 mm thick).
(c) It is alkaline.
(d) So a normal stomach wall is never exposed to the highly acidic gastric juice.
(5) In the presence of hydrochloric acid, pepsinogen becomes pepsin, an enzyme
that digests proteins. Pepsin can digest the stomach itself, but the secretion of the
goblet cells (mucus) creates a barrier between the pepsin and the stomach walls.
(6) Gastric ulcers - Hypersecretion of hydrochloric acid or hyposecretion of mucus can
offset the mucosal barrier and lead to ulcer. (A perforated ulcer can lead to
peritonitis or severe hemorrhage when blood vessels are perforated also.)
(7) Factors that favor high HCl or low mucus production are:
(a) Aspirin
(b) Smoking
(c) Alcohol
(d) Coffee
(e) Stress
(8) Helicobacter pylori is a bacterium that buries itself under the mucosa, destroys the
mucosa and leaves unprotected wall areas. Treatment: 2 antibiotics, a coating agent
(bismuth) like Pepto-Bismol, and a drug that inhibits hydrochloric acid secretion
like Zantac or Tagamet. Natural Treatment: Goldenseal tea + another antibiotic
(garlic, burdock root, mullein or yellow dock root), aloe vera gel, slippery elm tea or
(9) Regulation of gastric secretions
(a) The sight, smell, and taste of food initiate parasympathetic impulses that
stimulate gastric glands to secrete more.
(b) Parasympathetic impulses also stimulate the production of the gastric
hormone gastrin, which increases the secretory activity of the gastric glands.
(More gastrin = more HCl acid and more pepsinogen.)
(c) Protein molecules in the stomach stimulate the production of gastrin. (high
protein diet)
(d) Distention of the stomach stimulates the production of gastrin. (overeating)
(e) Caffeine in coffee, colas, and tea stimulate the production of gastrin. (addiction)
(f) Emotional upsets, fear, anxiety, or anything that triggers the fight-or-flight
response inhibits gastric secretion, because the sympathetic division overrides
the parasympathetic control of digestion.
Gastric emptying
1. The stomach usually empties completely
within four hours 4-6 after a meal.
2. Liquid meals pass quickly through the stomach.
3. Carbohydrates usually pass through rapidly.
4. Proteins take longer than carbohydrates. It is
digested in the stomach.
5. However, the rate of gastric emptying depends

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also on what is happening in the duodenum. When the chyme entering the duodenum is
fatty, food may remain in the stomach six hours or more. (high fat diet = longer digestion,
high carbohydrates diet = shorter digestion)
6. Fatty foods may remain in the stomach from 5-6 hours. That is because portions of a fatty
chyme are digested slowly by the enzymes in the small intestine, and that causes the rest of
the chyme to stay longer in the stomach. If food is too long in the stomach, fermentation
f. Gastritis An inflammation of the underlying
layers of the stomach wall due to a breach in the
mucosal barrier. Persistent gastritis can lead to a
stomach ulcer (erosion of the stomach wall).
(an accessory organ of the digestive system)
a. The pancreas has two functions
endocrine and exocrine functions.
b. Structure of the pancreas
(1) It joins the C-shaped curve of the
(2) Exocrine cells are the pancreatic
acinar cells. They make the bulk
of the pancreas. (Endocrine cells <alpha and beta cells> are found only in the islets
of Langerhans. Alpha cells secrete glucagon and beta cells secrete insulin.)
(3) Acinar cells release their secretion into tiny tubes that join the pancreatic duct.
(4) The pancreatic duct extends the length of the pancreas and fuses with the bile
duct just before it enters the duodenum. (The bile duct transport bile from the liver
and gallbladder.)
(5) The secretion of the acinar cells is called the pancreatic juice, which contains
different enzymes: pH8 alkaline (The stomach is pH2 acid)
(a) Pancreatic amylase breaks down carbohydrate molecules (starch and
(b) Pancreatic lipase breaks down fat molecules into fatty acids.
(c) Pancreatic protease breaks down protein molecules into amino acids. This
enzyme is secreted in an inactive form and is activated in the duodenum. This is
to prevent the pancreas from self-digestion.
(d) Pancreatic nuclease breaks down nucleic acids into nucleotides.
(e) Bicarbonate makes the juice alkaline.

Cholecystokinin is a hormone which is released to the gallbladder and the pancreas
which helps the releasing of Bicarbonate

c. Pancreatitis: Inflammation of the pancreas that could be the cause of a gallstone within
the sphincter of Oddi (hepatopancreatic sphincter) blocking the pancreatic juice
resulting in a build up that could digest part of the pancreas. Alcohol intake, traumatic
injuries, certain drugs can also cause pancreatitis.

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Hepatopancreatic Sphincter - the one out let for the Liver, Gallbladder and Pancreas


(accessory organ of the digestive system)
a. Hepatocytes = 150 days of average lifespan.
b. Veins draining the digestive viscera empty their blood into a common vessel, the
hepatic portal vein, which transports the blood into the liver before it is allowed to
enter the major systemic circulation via the hepatic veins.
c. Blood drained from digestive organs carry nutrients into the liver to nourish the hepatic
d. Over 500 functions
e. Lymphatic function: Macrophages (Kupffer <koopfer> cells) in the lymphatic tissue of
the liver remove pathogens that were absorbed through the intestinal wall and remove
worn-out blood cells from the blood. (Blood Purification)
f. Metabolic function: Metabolism of carbohydrates, lipids, and proteins.
(1) Changes glucose to glycogen when glucose level is high (glycogenesis).
(2) Breaks down glycogen to glucose when glucose level is low (glycogenolysis).
(3) Makes new glucose from noncarbohydrate molecules (gluconeogenesis).
e. Storage function: Stores glycogen, iron, and vitamins A, D, and B12.
f. Makes clotting factors with vitamin K
g. Detoxification of blood: Removes toxic substances such as alcohol.
h. Digestive function: to produce bile for export to the duodenum through the hepatic
duct. Bile breaks fat globules (large round pieces) into tiny particles that are more
accessible to the digestive enzyme lipase. This is known as emulsification of fats.
(1) Bile is a yellowish green liquid that hepatic cells secrete continuously.
(2) Bile contains water, bile salts, bile pigments (bilirubin and biliverdin, waste
products of hemoglobin breakdown), cholesterol, and electrolytes.
(3) Bile salts are the most abundant substances of bile. Bile salts are the only bile

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substances with a digestive function.
i. Hepatitis: Inflammation of the liver due to viral infection, alcohol or drug toxicity,
characterized by necrosis (death of tissue).
(1) Today there are 6 known forms of hepatitis: A F.
(2) Hepatitis A is the most benign. (32% of the cases in the USA)
(3) Hepatitis B can lead to cancer of the liver. (40% of the cases in the USA)
(4) Hepatitis C is also dangerous, but responds to treatment of interferon.
(5) Hepatitis D is a mutated virus that needs B to be infectious.
(6) Hepatitis E is similar to A.
(7) Types A and E are transmitted by contact with food, water or objects that are
contaminated with feces. Ex: unwashed hands.
(8) Types B, C, and D are the most chronic cases that are transmitted by blood or other
body fluids like saliva, semen, and lymph.
(9) Little is known so far about the newly discovered hepatitis F.
(an accessory organ of the digestive system)
a. A small, green muscular sac with a duct (the cystic
duct) that is seen in the inferior part of the liver.
b. Function of the gallbladder: Stores bile that is not
immediately needed for digestion and concentrates it
by absorbing some of its water.
c. Function of the bile: Emulsification of fat molecules
(large fat globules are broken down into millions of
small droplets so that the fat splitting enzymes can
digest fat more effectively).
d. When its muscular wall contracts, bile is expelled into
the cystic duct. Bile then flows into the common bile
duct to be released into the duodenum through the
hepatopancreatic sphincter.

Regulation of bile secretion:
a. When fatty chyme enters the duodenum, minor endocrine glands in the intestine release
cholecystokinin, a hormone that
stimulates the gallbladder contractions.
(Bile is not release unless gallbladder
b. Cholecystokinin also stimulates secretion
of the pancreatic juice, which contains
c. Gallstones - Bile salts keep the
cholesterol dissolved within the bile. Too
much cholesterol or too few bile salts can
lead to crystallization of cholesterol,
forming gallstones. When the gallbladder
or its duct contract, the sharp crystals
cause agonizing pain. Treatment: drugs
that dissolve the crystals, ultrasound vibration to pulverize the crystals, vaporizing with

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lasers, or surgical removal of the gallbladder. When the gallbladder is surgically
removed, the cystic duct enlarges to assume the bile-storing role. Natural Treatment:
Prevention (low saturated fat and cholesterol diet, high fiber diet, exercise, and water)
Drinking plenty of water reduces risk of gallstones because bile is kept diluted. Healing
Treatment: Apple juice and apple diet for the whole day. The pectin will dissolve the
crystals. Olive oil & lemon juice at night.
Small Intestine
General characteristics
(1) Extends from the pyloric sphincter to the ileocecal valve.
(2) Occupies most of the abdominal cavity.
(3) Longest part of the GI tract (about 20 feet long).
(4) Receives secretions from pancreas and liver. (Chemical digestion)
(5) Completes digestion of nutrients in chyme (3-6 hours journey). (Chemical digestion)
(6) Segmentation movements ringlike contractions that divide chyme into segments and
move it back and forth. (Mechanical digestion)
(7) Absorbs the end products of digestion. (Absorption)
(8) Transports the residues to the large intestine with peristalsis. (Propulsion) (After most
nutrients have been absorbed peristalsis gets stronger and segmenting movements
8) Diarrhea - The chyme in the small intestine moves slowly. If the intestinal wall
becomes irritated by toxins and bacteria the chyme is rushed (peristaltic rush) into
the large intestine so quickly that water, nutrients, and electrolytes are not
absorbed through the wall of the small intestine. This causes a watery stool
(diarrhea) and a lost of electrolytes (vitamin and mineral deficiencies) and water

a. Anatomy of the small intestine
(1) Three portions: duodenum, jejunum, and ileum
(a) Duodenum a short C-shape section about 10 inches long, from the pyloric
sphincter to the jejunum.
(b) Jejunum (8 feet) - about 8 feet long
(c) Ileum about 12 feet long, joins the large intestine at the ileocecal valve. This
is where B12 is digested.

(2) Microscopic anatomy
(a) Mucosa consists of simple columnar epithelium.
(b) Circular folds of the mucosa and submucosa allow for distention and
(c) Villi fingerlike projections of the mucosa that increase the surface area of the
mucosa. (This allows for more absorption.) Inside each villus is a blood
capillary bed and a lymphatic capillary (lacteal absorbs fatty acids). End
products of digestion are absorbed by these capillaries.
(d) Microvilli (Brush Border) tiny projections of the plasma membrane of the
cells of the mucosa that increase surface area even more and release more
digestive enzymes like sucrase (sucrose), maltase (maltose) and lactase
(lactose), which split sugars into monosaccharides. Another intestinal enzyme
is protease, which breaks down short peptides into amino acids, and more
lipase for the final digestion of fat.
(e) Peyers patches (lymphoid nodules) are found in the submucosa to prevent
Absorption Object Lesson:

We can eat the bread of life, but if the
heart does not absorb it, we will
experience spiritual deficiencies. We
need to be doers, not only hearers.
Treatment for
Carob powder,
Slurry water for
1-2 Tbsp charcoal
in one large glass
H2O for adults.

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the entrance of bacteria into the blood.
(3) Absorption in the small intestine
(a) Monosaccharides (Simple Sugar)- Digestion of carbohydrates begins in the
mouth and is finished in the small intestine (monosaccharides).
Monosaccharides are then absorbed by the blood capillaries in the villi of the
intestinal mucosa.
(b) Amino acids Digestion of proteins begins in the stomach and is completed
(Pepsin) in the small intestine (amino acids). Amino acids are then absorbed by
the blood capillaries of the villi of the intestinal mucosa.
(c) Fatty acids Digestion of fats begins in the duodenum and is finished there
(fatty acids). Fatty acids are then absorbed mainly by the lymphatic capillary
(lacteal) in the villi. A D E K Are Fat soluble vitamins.
(d) Electrolytes (mineral salts) - are absorbed by the blood capillaries in the villi.
(e) Water most of the water ingested is absorbed by the blood capillaries in the
microvilli. Some water absorption occurs in the stomach and in the large
(f) Vitamins: After separation from fiber, fat soluble vitamins are absorbed by the
lacteals, water soluble vitamins are absorbed into the blood, these are all the B
and C.
- Diarrhea
- Intestinal wall becomes irritated by toxins and bacteria
- Chyme is rushed into the large intestine
- Poor absorption of water, nutrients, and electrolyte (watery stool)
- Electrolytes imbalance and dehydration.
Large intestine
a. Shorter than the small
intestine, but larger in
b. Major functions are to absorb
water from indigestible food
residues, which are delivered
in a fluid state, and eliminate
them from the body as
semisolid feces. (Absorption
and defecation)
c. Parts of the large intestine:
(1) Cecum First part of the
large intestine. It lies below
the ileocecal valve. The
vermiform appendix,
which contains masses of lymphoid tissue, is attached to cecum and plays an important
role in the immunity system. Appendicitis: an inflammation of the appendix. If the
appendix ruptures, bacteria can spread over the abdominal cavity causing a serious
infection of the peritoneum called peritonitis.
(2) Colon It is subdivided into four regions: Ascending colon, transverse colon,
descending colon, and the sigmoid colon.

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(3) Rectum begins at the end of the sigmoid colon. Hemorrhoids: dilated veins of the
anorectal area. Internal and external. Major causes: straining to have a bowel
movement (constipation) and childbirth.
(4) Anal canal Last segment of the large intestine. It has two sphincters, the internal anal
sphincter of smooth muscle, and the external anal sphincter of skeletal muscle.
d. The mucosa is made of simple columnar epithelium except in the anal canal, which is
non-keratinized stratified squamous epithelium.
e. The mucosa contains lots of mucus producing goblet cells. The mucus eases the passage of
feces and protects the intestinal wall.
f. Content of the large intestine has 12 to 24 hours more to spend there.
g. Digestive processes occurring in the large intestine:
(1) No chemical digestion occurs in the large intestine (just bacterial digestion)
(2) Some water absorption takes place in the large intestine, but it is not a major
function of this organ.
(3) Propulsion and defecation are the primary functions of the large intestine.
(4) Propulsion is accomplished by mass peristalsis or mass movement (powerful
but slow contraction waves that force the contents toward the rectum). Mass
peristalsis only occurs three or four times a day (during or after eating).
(5) Constipation: When food remains in the colon for extended periods too much
water is absorbed and the stool becomes dry, hard, and difficult to pass.
Constipation may result from a lack of fiber in the diet, improper bowel habits
(failing to heed the call), lack of exercise, emotional upset (anxiety, fear, and
stress), laxative abuse, or lack of water.
h. Inflammatory bowel diseases (Ulcerative Colitis, Chrons Disease)
Normal Flora
- At birth the entire intestinal tract is sterile, but bacteria enters the first feed
- Some bacteria that enter the cecum are still alive.
- These bacteria ferment some of the indigestible carbohydrates
- Bacterial digestion produces gases, vit K, and come vit B
- If you dont have good Flora then you while have a lot of gas (this can come from lost of

Normal flora is found mostly;
On the skin
In the eyes
In the nose
In the mouth
In the upper throat
In the lower urethra
In the small intestine
In the larger intestine

Benefits of normal flora
Prevent colonization of pathogens
Protects against infection
Synthesize vit K, folate
Prevent cancer by lowing pH, which lowers the risk of colon cancer.
Mutualism E.Coli this lives in the intestines, it produces vit K, which the human body

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requires for the process of blood clotting.

Factors that destroy normal flora
High sugar diet refined foods
Drinking alcohol
Use of enemas
Use of colonics
Use if laxatives

Factors that bost the normal flora
Easting many servings of fruits and vegetables a day
High fiber / low fat diet
Go easy on sugar
Avoid or limit consumptions of refined foods
Avoid alcohol

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The Lymphatic System
Definition of infection: The multiplication of pathogens. Pathogens are disease-causing agents
like viruses, bacteria, fungi and protozoans. The body can prevent the entry of pathogens or
destroy them once they gained entrance. It employs different mechanisms to protect itself against
pathogens: (1) nonspecific surface and chemical defense and (2) specific defense: immunity.)
General Functions
Returns fluid to the blood
Transports digested fats and some protein molecules
to the bloodstream
Protects the body from pathogens
What is the Lymphatic system?
Organs and glands that produce cells and
A network of vessels that transport lymph fluid.
Lymphoid Organs
Lymph nodes
Bone marrow
Patches of lymphoid tissues
Lymph Nodes
These are the filters;
Contains masses of lymphocytes (B and T cells)
o Filters lymph (macrophages)
o Destroy antigens (T cells)
o Secrete antibodies (B cells)
o Lymphocyte production
Clusters of lymph nodes
Submandibular nodes
Cervical nodes
Axillary nodes
Lumber nodes
Inguinal nodes
Pelvic nodes
Mesenteric nodes
Popliteal nodes

Only lymph nodes filter lymph

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Structure of the lymph Node
There is more vessels coming in, and few coming out which is building up of pressure
Non-specific defense system
1. Non-specific defense system is always ready and responds immediately against all types
(not a specific type) of pathogens.
a. Species resistance - Tissues of some species do not provide the environment for the
development of a particular pathogen.
b. Surface or mechanical barriers - The skin and the mucous membranes. (First line of
(1) The dermis and the epidermis (keratinized cells) along with the connective tissues
underneath form a very thick barrier. Cannot be penetrated very easily unless it is
cut, scratched, perforated or burnt.
(2) The linings (mucous membrane) of the respiratory, digestive, urinary, and
reproductive systems create a protection (mechanical) barrier.
c. Chemical barriers The secretions of the skin and mucous membranes. (Second line of
(1) The acid mantle consists of skin secretions -sweat (perspiration) and sebum.
(a) It has a low pH making the epidermal surface acid.
(b) The sebum also contains chemicals that are toxic to bacteria.
(c) Skin cells also secrete a natural antibiotic called human defensin, which punches
wholes in bacteria.
(2) The linings are mucous membranes that secrete protecting chemicals (chemical
(a) The stomach mucosa secretes a concentrated hydrochloric acid and pepsin
(which digests proteins) that kill pathogens.
(b) The saliva and the lacrimal fluid contain lysozyme, an enzyme that destroys
(c) Sticky mucus (secreted by goblet cells) traps many microorganisms that enter
the digestive and respiratory passageways.
(d) Mucus coated hairs inside the nose trap inhaled particles. The cilia of the
respiratory tract sweep dust and bacteria upward towards the pharynx.
(e) Interferons produced by lymphocytes and other cells inhibit the replication of
(3) Melanin, secreted by the melanocytes in the stratum basale of the epidermis,
prevents ultraviolet light damage.
(4) All these surface and chemical barriers are quite effective, but small nicks and cuts
resulting from brushing your teeth, shaving, burns, etc. allow pathogens to invade
deeper tissues. It is here that phagocytes come into action...
d. Phagocytes (a non-specific cellular defense)
(1) They engulf pathogens and digest them with chemicals like lysozyme.
(2) Macrophages
(a) Derived from the WBC known as monocytes.
(b) Leave the bloodstream by squeezing between cells of the endothelium (di-pd-
(c) Differentiate into macrophages, and search for foreign invaders
(d) Are the chief phagocytes. Some macrophages are:
- Kupffer cells in the liver
- Langerhans cells in the skin

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- Alveolar macrophages in the alveoli (air sags in the lungs)
- Macrophages of the Peyers patches in the small intestine
(3) Neutrophils, the most abundant type of leukocytes. They also leave the bloodstream
and become very phagocytic.
(4) Eosinophils are weak phagocytes; however, they destroy parasitic worms by
discharging their destructive chemical (enzymes) all over the invaders.
Natural killer cells (another non-specific cellular defense)
(1) A special type of lymphocyte that police the blood and lymph.
(2) Can kill cancer cells and virus-infected cells.
(3) Destroy the target cell's membrane, causing the nucleus to disintegrate.
1. It is a tissue response to injury or infection.
2. It inhibits the spread of pathogens and toxic substances by enclosing the injured or infected
area in a sac of fibrous connective tissue. Produces:
(a) Redness caused by increased blood volume to the area as a result of blood vessel
dilation caused by prostaglandins (tissue hormones that induce vasodilation).
(b) Swelling Increased capillary permeability as a result of histamine (a strong
vasodilator secreted by the basophils), which increases fluid leakage, resulting in
edema (swelling). The increased amount of blood to the area adds to the swelling.
(c) Heat Produced by the warmer blood that comes from deeper body parts.
(d) Pain the edema (increased volume of interstitial fluid) presses on the nearby nerve
endings (pain receptors or nociceptors) causing pain and limiting movement, which in
turn aids in the healing process. Pain also results from bacterial toxins, lack of nutrition
to cells in the area, etc.
(e) Leukocytosis - Leukocytes are attracted to the area to clear it of debris and pathogens.
(f) Fribrin and other fibers - form a capsule that prevents the spread of toxins and
pathogens to other areas.
(g) Four cardinal signs of inflammation are redness, heat, swelling, and pain
1. Bacteria require large amounts of iron and zinc. High body temperature causes iron and
zinc to go to liver and spleen, which stops the replication of fungi and bacteria.
2. Phagocytes become more active in higher temperature.
3. Fever also increases the metabolic rate of the tissue cells, speeding up defensive actions.
Specific Defenses
The third line of defense
Known as immunity
Provides resistance to specific antigens that resisted the first and second line defense
(surface and chemical barrier)
Provided by lymphocytes
Lymphocytes attack nonself molecules, known as antigens (proteins)
Substances that can mobilize the immune system and provoke an immune response.
A contraction of antibody generating anti-gens
If the immune system fails, devastating diseases like cancer, lupus, AIDS develop.

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Cells of the Immune System
T lymphocytes (T Cells)
B lymphocytes (B cells)
Origin of Lymphocytes
o Bone marrow (irregular, and flat bones)
o The then go to the Thymus glad
o They then become a T Cell
o Some lymphocytes come from Bone marrow (B Cells)
o Travel in the Blood
o Then go to the Lymph node
T Cells
o Provide cell-mediated immunity (direct attack, by cell to cell to contact)
o Secrete chemicals to attract other T cells to the area and cause B cells proliferation
o Secrete toxins (cytokines) that are lethal to antigens
Growth inhibiting factors prevent target cell growth
Interferon interfere with the production of antigens
o Types of T Cells
Killer T Cells Destroy antigens directly
Helper T Cells Release cytokines to stimulate B Cells, T Cells, and
macrophages to destroy antigens.
Suppressor T Cells Inhibit or suppress the immune response.
Memory T Cells Do not respond to antigens on first exposure, but are
ready to become active immediately upon subsequent exposure to the same
antigen. This is immunity.
B Cells
o Provide antibody-mediated immunity
o Differentiates into plasma cells and memory cells
o The plasma cells produce antibodies also known as immunoglobulin (lg)
o The antibodies destroy antigens
o The long-lived memory cells can immediately differentiated into plasma cells when
Two Main Categories of immunity
o Inborn Immunity
Genetical differences that makes
us immune to diseases that affect
other species.
o Acquired Immunity
Immunity developed as the
person encounters specific
antigens in life.
Nature acquired immunity there
are Two Type;
- Natural
o Active
Exposure to an
antigen producing an immune response. (like chicken pox,
we develop an immunity)
o Passive Antibodies are passed from mother to fetus via
placenta and milk. No immune response.

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- Artificial
o Active Vaccination with antigen to stimulate an immune
o Passive Injection pf antibody-rich plasma from a donor. No
immune response.

Be able to explain what the course of informational is