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Drug Name atenolol (a ten' o lole) Apo-Atenolol (CAN), GenAtenolol (CAN), Novo-Atenol (CAN), Tenormin Pregnancy Category D Drug

classes Beta1selective adrenergic blocker Antianginal Antihyperten sive

Dosages Available forms: Tablets25, 50, 100 mg; injection5 mg/10 mL ADULTS Hypertension: Initially, 50 mg PO once a day; after 1 2 wk, dose may be increased to 100 mg/day. Angina pectoris: Initially, 50 mg PO daily. If optimal response is not achieved in 1 wk, increase to 100 mg daily; up to 200 mg/day may be needed. Acute MI: Initially, 5 mg IV given over 5 min as soon as possible after diagnosis; follow with IV injection of 5 mg 10 min later. Switch to 50 mg PO 10 min after the last IV dose; follow with 50 mg PO 12 hr later. Thereafter, administer 100 mg PO daily or 50 mg PO bid for 69 days or until discharge from the hospital. PEDIATRIC PATIENTS Safety and efficacy

Therapeutic Actions Blocks betaadrenergic receptors of the sympathetic nervous system in the heart and juxtaglomerular apparatus (kidney), thus decreasing the excitability of the heart, decreasing cardiac output and oxygen consumption, decreasing the release of renin from the kidney, and lowering BP.

Indications Treatment of angina pectoris due to coronary atherosclerosi s Hypertension, as a step 1 agent, alone or with other drugs, especially diuretics Treatment of MI Unlabeled uses: Prevention of migraine headaches; alcohol withdrawal syndrome, treatment of ventricular and supraventricul ar arrhythmias

Adverse effects Allergic reactions: Pharyngitis, erythematous rash, fever, sore throat, laryngospasm, respiratory distress CNS: Dizziness, vertigo, tinnitus, fatigue, emotional depression, paresthesias, sleep disturbances, hallucinations, disorientation, memory loss, slurred speech CV: Bradycardia, CHF, cardiac arrhythmias, sinoatrial or AV nodal block, tachycardia, peripheral vascular insufficiency, claudication, CVA, pulmonary edema, hypotension Dermatologic: Rash, pruritus, sweating, dry skin EENT: Eye irritation, dry eyes, conjunctivitis, blurred vision GI: Gastric pain, flatulence, constipation, diarrhea, nausea, vomiting, anorexia,

Contraindicatio ns Contraindicate d with sinus bradycardia, second- or third-degree heart block, cardiogenic shock, CHF, pregnancy. Use cautiously with renal failure, diabetes or thyrotoxicosis (atenolol can mask the usual cardiac signs of hypoglycemia and thyrotoxicosis) , lactation, respiratory disease.

Nursing considerations Assessment History: Sinus bradycardia, second- or third-degree heart block, cardiogenic shock, CHF, renal failure, diabetes or thyrotoxicosis, lactation, pregnancy Physical: Baseline weight, skin condition, neurologic status, P, BP, ECG, respiratory status, renal and thyroid function tests, blood and urine glucose, cholesterol, triglycerides Interventions WARNING: Do not discontinue drug abruptly after long-term therapy (hypersensitivity to catecholamines may have developed, causing exacerbation of angina, MI, and ventricular arrhythmias). Taper drug gradually over 2 wk with monitoring. Consult physician about withdrawing drug if patient is to undergo surgery (withdrawal is controversial). Teaching points Take drug with meals if GI upset occurs. Do not stop taking this drug unless told to do so by a health care

not established.

ischemic colitis, renal and mesenteric arterial thrombosis, retroperitoneal fibrosis, hepatomegaly, acute pancreatitis GU: Impotence, decreased libido, Peyronie's disease, dysuria, nocturia, frequent urination Musculoskeletal: Joint pain, arthralgia, muscle cramps Respiratory: Bronchospasm, dyspnea, cough, bronchial obstruction, nasal stuffiness, rhinitis, pharyngitis (less likely than with propranolol) Other: Decreased exercise tolerance, development of antinuclear antibodies, hyperglycemia or hypoglycemia, elevated serum transaminase, alkaline phosphatase, and LDH

provider. Avoid driving or dangerous activities if dizziness or weakness occurs. You may experience these side effects: Dizziness, lightheadedness, loss of appetite, nightmares, depression, sexual impotence. Report difficulty breathing, night cough, swelling of extremities, slow pulse, confusion, depression, rash, fever, sore throat.