POSTOPERATIVE MANAGEMENT: After surgery, the eyes received topical antibiotics (levofloxacin [Cravit]; Santen Phar aceutical Co,

!sa"a, #apan$ and %&'( beta ethasone (Sanbetason; Santen$, starting fro five ti es daily, then tapering off over several onths& )he standardi*ed regi en +as used unless steroid,related intraocular pressure rise occurred& -hen pseudocha ber for ation +as observed, extent and location deter ined +hether it should be treated i ediately or "ept under observation& -hen detach ent of the ./ +as extensive and central, it +as treated +ith air or 0%( of sulfurhexafluoride in1ection into the anterior cha ber& !ne percent atropine ophthal ic solution (2itten Phar aceutical Co, 2agoya, #apan$ +as instilled at the end of the procedure to avoid anteroposterior cha ber bloc"age& Patients +ho under+ent air or gas in1ection +ere instructed to re ain supine overnight& 3f the ./ detach ent re ained extensive after a single air or gas in1ection, ultiple in1ections +ere carried out& -hen the pseudocha ber +as shallo+, locali*ed peripherally, or both or the patients did not agree +ith an air or gas in1ection, gas ta ponade +as not perfor ed& EXAMINATIONS: 4raft clarity +as assessed using slitla p bio icroscopy at each patient visit and +as catego, ri*ed into three groups5 '$ clear, 0$ stro al scar +ithout ede a, and 6$ stro al ede a resulting fro endothelial deco pensation& 7isual acuity +as of the ini u easured using the standard Snellen chart and 8SC7A +as recorded at three, six, and '0 8SC7A +as converted to logarith surgery using a noncontact specular statistical analysis& )he corneal endotheliu onths after surgery& )he onths after

angle of resolution visual acuity for

+as photographed at three, six, and '0 ean cell density&

icroscope (2oncontact 9obo SP,:%%%; ;onan, <yogo,

#apan$& Approxi ately =% cells +ere analy*ed to calculate

STATISTICAL ANALYSIS: .ata +ere expressed as

ean > standard deviation& ?or

associations of gender and original diseases bet+een the eyes +ith and +ithout ./ perforation, the Chi,s@uare test and ?isher analysis +ere perfor ed& .ifferences in age, preoperative 8SC7A, and endothelial density bet+een the eyes +ith and +ithout perforation +ere analy*ed using the /ann,-hitney U test& )he differences bet+een these para eters of patient profiles and the perforation si*e +ere analy*ed in a si ilar anner& Association bet+een ./ perforation and either pseudocha ber for ation or graft survival +as analy*ed using the Chi,s@uare test and ?isher analysis& 8oth differences in 8SC7A and endothelial cell loss bet+een eyes +ith and

+ithout perforation +ere analy*ed using the /ann,-hitney U test& )he association bet+een si*e of perforation and incidence of pseudocha ber also +as analy*ed using the Chi,s@uare test and ?isher analysis& P values less than &%= +ere considered significant&