77

LITERATURE CITED

Abelson, J.L. and Young, E.A., 2003. Hypothalamic-pituitary adrenal response to cholecystokinin-B receptor agonism is resistant to cortisol feedback inhibition. Psychoneuroendocrinology, 28, 169-180. Adlercreutz, H., 1999. Phytoestrogens. State of the art. Environmental Toxicology and Pharmacology, 7, 201-207. Agarwal, M.K. and Mirshahi, M., 1999. General overview of mineralcorticoid hormone action. Pharmacology & Therapeutics, 84, 273-326. Agarwal, Ramesh, Diwanay, Sham, Patki, Pralhad and Patwardhan, Bhushan, 1999. Studies on immunomodulatory activity of Withania somnifera (Ashwagandha) extracts in experimental immune inflammation. Journal of Ethnopharmacology, 67(1), 27-35. Ahmad, Ghufran, Amin, K.M. Yusuf, Khan, Naeem A. and Tajuddin, 1998. The anti-stress activity of a gemcontaining Unani formulation against diverse stressors. Journal of Ethnopharmacology, 59, 187-193. Albrecht, Ester W.J.A., 2003. Protective role of endothelial nitric oxide synthase. Journal of Pathology, 199, 8-17. Al-Qarawi, A.A., Abdel-Rahman, H.A., Ali, B.H. and Mougy, S.A. El, 2002. Liquorice (Glycyrrhiza glabra) and the adrenal-kidney-pituitary axis in rats. Food and Chemical Toxicology, 40, 1525-1527. Alvarenga, S.A.V., Ferreira, M.J.P., Emerenciano, V.P. and Cabrol-Bass, D., 2001. Chemosystematic studies of natural compounds isolated from Asteraceae: characterization of tribes by principle component analysis. Chemometrics and Intelligent Laboratory Systems, 56, 27-37. Ames, Bruce N., 2001. DNA damage from micronutrient deficiencies is likely to be a major cause of cancer. Mutation Research, 475, 7-20. Ames, Bruce N., 2003. The metabolic tune-up: metabolic harmony and disease prevention. Journal of Nutrition, 133, 1544S-1548S. Anonymous, 2002. WHO Traditional Medicine Strategy 2002-2005, World Health Organization, Geneva. Archana, R. and Namasivayam, A., 2000. Effect of Ocimum sanctum on noise induced changes in neutrophil functions. Journal of Ethnopharmacology, 73, 81-85. Archana, R. and Namasivayam, A., 2002. A comparative study of different crude extracts of Ocimum sanctum on noise stress. Phytotherapy Research, 16(6), 579-580. Armbruster, W. Scott, 1997. Exaptations link evolution of plant-herbivore and plant-pollinator interactions: a phylogenetic inquiry. Ecology, 78(6), 1661-1672. Assinewe, Valerie A., Baum, Bernard R., Gagnon, Daniel and Arnason, J. Thor, 2003. Phytochemistry of wild populations of Panax quinquefolius L. (North American ginseng). Journal of Agricultural and Food Chemistry, 51, 4549-4553. Attele, Anoja S., Wu, Ji An and Yuan, Chun-Su, 1999. Commentary: Ginseng pharmacology. Multiple constituents and multiple actions. Biochemical Pharmacology, 58, 1685-1693.

78
Auddy, B., Ferreira, M.J.P., Blasina, F., L., Lafon, Arredondo, F. et al., 2003. Screening of antioxidant activity of three Indian medicinal plants, traditionally used for the management of neurodegenerative diseases. Journal of Ethnopharmacology, 84, 131-138. Babu, T.D., Kuttan, G. and Padikkala, J., 1995. Cytotoxic and anti-tumour properties of certain taxa of Umbelliferae with special reference to Centella asiatica (L.) Urban. Journal of Ethnopharmacology, 48, 53-57. Bai, Hong, Li, Wei, Koike, Kazuo, Dou, Deqiang, Pei, Yuping et al., 2003. A novel biflavonoid from roots of Glycyrrhiza uralensis cultivated in China. Chemical and Pharmacology Bulletin, 51(9), 1095-1097. Baker, M.E., 1992. Evolution of regulation of steroid-mediated intercellular communications in vertebrates: insights from flavonoids, signals that mediate plant-rhizobia symbiosis. Journal of Steroid Biochemistry and Molecular Biology, 41(3-8), 301-308. Baker, M.E., 1995. Endocrine activity of plant-derived compounds: an evolutionary perspective. Proceedings of the Society of Experimental Biology and Medicine, 280(1), 131-138. Baker, M.E., 1998a. Evolution of mammalian 11- and 17-hydroxysteroid dehydrogenases-type 2 and retinal dehydrogenases from ancestors in Caenorhabditis elegans and evidence for horizontal transfer of a eukaryote dehydrogenase to E. coli. Journal of Steroid Biochemistry and Molecular Biology, 66(5-6), 355-363. Baker, M.E., 1998b. Flavonoids as hormones. A perspective from an analysis of molecular fossils. Advances in Experimental Medicine and Biology, 439, 249-276. Baker, M.E., 2001a. Evolution of 17 beta-hydroxysteroid dehydrogenases and their role in androgen, estrogen and retinoid action. Molecular and Cell Endocrinology, 171, 211-215. Baker, Michael E., 2001b. Hydroxysteroid dehydrogenases: ancient and modern regulators of adrenal and sex steroid action. Molecular and Cell Endocrinology, 175, 1-4. Baker, Michael E., 2003. Evolution of adrenal and sex steroid action in vertebrates: a ligand-based mechanism for complexity. BioEssays, 25(4), 396-400. Bale, Tracy L. and Vale, Wylie W., 2003. CRF and CRF receptors: role in stress responsivity and other behaviors. Annual Review of Pharmacology and Toxicology, 44, 525-558. Baranov, A.I., 1982. Medicinal uses of ginseng and related plants in the Soviet Union: recent trends in the Soviet literature. Journal of Ethnopharmacology, 6, 339-353. Barron, Denis and Ibrahim, Ragai K., 1996. Isoprenylated flavonoids - a survey. Phytochemistry, 43(5), 921-982. Barron, Denis, Varin, Luc, Ibrahim, Ragai K., Harborne, Jeffrey B. and Williams, Christine A., 1988. Sulphated flavonoids--an update. Phytochemistry, 27(8), 2375-2395. Bartlova, Milena, Opletal, Lubomir, Chobot, Vladimir and Sovova, Helena, 2002. Liquid chromatographic analysis of supercritical carbon dioxide extracts of Schizandra chinensis. Journal of Chromatography B, 770, 283-289. Bast, Aalt, Chandler, R. Frank, Choy, Patrick C., Delmulle, Luc M., Gruenwald, Joerg et al., 2002. Botanical health products, positioning and requirements for effective and safe use. Environmental Toxicology and Pharmacology, 12, 195-211. Bastien, Joseph W., 1987, Healers of the Andes: Kallawaya Herbalists and Their Medicinal Plants. University of Utah Press, Salt Lake City. Bthori, Mria, 2002. Phytoecdysteroids effects on mammalians, isolation and analysis. Mini Reviews in Medicinal Chemistry, 2, 285-293.

79
Beek, T.A. van, Bombardelli, E., Morazzoni, P. and Peterlongo, F., 1998. Ginkgo biloba L. Fitoterapia, 69(3), 195-244. Belay, Tesfaye, Aviles, Herman, Vance, Monique, Fountain, Kimberly and Sonnefeld, Gerald, 2003. Catecholamines and in vitro growth of pathogenic bacteria: enhancement of growth varies greatly among bacterial species. Life Sciences, 73, 1527-1535. Bensky, Dan and Gamble, Andrew, 1986, Chinese Herbal Medicine. Eastland Press, Seattle. Bernhardt, M., Sturm, C., Shaker, K.H. , Paper, D.H., Franz, G. et al., 2001. Structurally related immunological effects of triterpenoid saponins. Pharmazie, 56(9), 741-743. Bhatia, A.L. and Jain, Manish, 2003. Amaranthus paniculatus (Linn.) improves learning after radiation stress. Journal of Ethnopharmacology, 85(1), 73-79. Bhattacharya, S.K., Bhattacharya, A. and Chakrabarti, A., 2000. Adaptogenic activity of siotone, a polyherbal formulation of Ayurvedic rasayanas. Indian Journal of Experimental Biology, 38(2), 119-128. Bhattacharya, S.K. and Muruganandam, A.V., 2003. Adaptogenic activity of Withania somnifera: an experimental study using a rat model of chronic stress. Pharmacology, Biochemistry and Behavior, 75, 547-555. Blee, Elizabeth, 1998. Phytooxylipins and plant defense reactions. Progress in Lipid Research, 37(1), 33-72. Ble, Elizabeth, 2002. Impact of phyto-oxylipins in plant defense. Trends in Plant Science, 7(7), 315-321. Bnouham, Mohamed, Merhfour, Fatima-Zahra, Ziyyat, Abderrahim, Mekhfi, Hassane, Aziz, Mohammed et al., 2003. Antihyperglycemic activity of the aqueous extract of Urtica dioica. Fitoterapia, 74, 677-681. Bohlmann, Jorg, Meyer-Gauen, Gilbert and Croteau, Rodney, 1998. Plant terpenoid synthases: molecular biology and phylogenetic analysis. Proceedings of the National Academy of Sciences (USA), 95, 4126-4133. Bohm, Bruce A. and Stuessy, Tod F., 2001, Flavonoids of the Sunflower Family (Asteraceae). Springer Wien, New York. Bone, Kerry, 1996, Clinical Applications of Ayurvedic and Chinese Herbs: Monographs for the Herbal Practitioner. Phytotherapy Press. Bone, Kerry, 2002. Modern phytotherapy: integrating scientific data and methodology with traditional herbal practice. Journal of the American Herbalists Guild, 3(1), 34-39. Boon-Niermeijer, E.K., van den Berg, A., Wikman, G. and Wiegant, F.A.C., 2000. Phyto-adaptogens protect against environmental stress-induced death of embryos from the freshwater snail Lymnaea stagnalis. Phytomedicine, 7(5), 389399. Bouic, Patrick J.D., 2001. The role of phytosterols and phytosterolins in immune modulation: a review of the past 10 years. Current Opinion in Clinical Nutrition and Metabolic Care, 4(6), 471-475. Bouic, Patrick J.D., 2002. Sterols and sterolins: new drugs for the immune system? Drug Discovery Today, 7(14), 775778. Bourdy, G., DeWalt, S.J., Chavez de Michel, L.R., Roca, A., Deharo, E. et al., 2000. Medicinal plant uses of the Tacana, an Amazonian Bolivian ethnic group. Journal of Ethnopharmacology, 70, 87-109. Bowey, E., Adlercreutz, H. and Rowland, I., 2003. Metabolism of isoflavones and lignans by the gut microflora: a study in germ-free and human flora associated rats. Food and Chemical Toxicology, 4, 631-636. Breinbauer, Rolf, Vetter, Ingrid R. and Waldmann, Herbert, 2002. From protein domains to drug candidates--natural products as guiding principles in the design and synthesis of compound libraries. Angw. Chem. Int. Ed., 41, 2878-2890.

80
Brekhman, I.I., 1980, Man and Biologically Active Substances. Pergamon Press, Kronberg Taunus. Brekhman, I.I. and Dardymov, I.V., 1969. New substances of plant origin which increase nonspecific resistance. Annual Review of Pharmacology, 9, 419-430. Breytenbach, Ulrike, Clark, Anel, Lamprecht, Johan and Bouic, Patrick, 2001. Flow cytometric analysis of the Th1Th2 balance in healthy individuals and patients infected with the human immunodeficiency virus (HIV) receiving a plant sterol/sterolin mixture. Cell Biology International, 25(1), 43-49. Brown, Richard P., Gerbarg, Patricia L. and Ramazanov, Zakir, 2002. Rhodiola rosea: a phytomedical review. HerbalGram, 56, 40-52. Bruneton, Jean, 1995, Pharmacognosy, Phytochemistry, Medicinal Plants. Intercept Limited, New York. Bucci, Luke R., 2000. Selected herbals and human exercise performance. American Journal of Clinical Nutrition, 27(suppl), 624S-636S. Butterfield, D. Allan, Castegna, Alessandra, Pocernich, Chava B., Drake, Jennifer, Scapagnini, Giovanni et al., 2002. Nutritional approaches to combat oxidative stress in Alzheimer's disease. Journal of Nutritional Biochemistry, 13, 444461. Byrnes, Allison, 2003. Black Hills National Forest Preliminary Report on the Medicinal Plants of the Black Hills Area of South Dakota, University of Wyoming. Caddick, Lizabeth R., Wilkin, Paul, Rudall, Paula J., Hedderson, Terry A.J. and Chase, Mark W., 2002. Yams reclassified: a recircumscription of Dioscoreaceae and Dioscoreales. Taxon, 51, 103-114. Cai, D., Shen, S. and Chen, X., 1998. Clinical and experimental research of Epimedium brevicornum in relieving neuroendocrino-immunological effect inhibited by exogenous glucocorticoid. Zhongguo Zhong Xi Yi Jie He Za Zhi, 18(1), 4-7. Cai, Y.J., Dai, J.Q., Fang, J.G., Ma, L.P., Hou, L.F. et al., 2002. Antioxidative and free radical scavenging effects of ecdysteroids from Serratula strangulata. Canadian Journal of Physiology and Pharmacology, 80(12), 1187-1194. Calabrese, Edward J., 2002, Proposing a definition of hormesis, Biological Effects of Low Level Exposures, pp. 25-41. Calabrese, Edward J. and Baldwin, Linda A., 2002a, Defining hormesis, Biological Effects of Low Level Exposures, pp. 25-41. Calabrese, Edward J. and Baldwin, Linda A., 2002b. Hormesis and high-risk groups. Regulatory Toxicology and Pharmacology, 35, 414-428. Calabrese, Edward J. and Baldwin, Linda A., 2003. Hormesis: the dose-response revolution. Annual Review of Pharmacology and Toxicology, 43, 175-197. Calabrese, Edward J., Baldwin, Linda A. and Holland, Charles D., 1999. Hormesis: A highly generalizable and reproducible phenomenon with important implications for risk assessment. Risk Analysis, 19(2), 261-281. Cannon, Walter B., 1911, Mechanical Factors of Digestion. Edward Arnold Publishers, London. Cardellina II, John H., 2002. Challenges and opportunities confronting the botanical dietary supplement industry. Journal of Natural Products, 65, 1073-1084. Carlini, E.A., 2003. Plants and the central nervous system. Pharmacology, Biochemistry and Behavior, 75, 501-512. Carrasco, Gonzalo A. and Van de Kar, Louis D., 2003. Neuroendocrine pharmacology of stress. European Journal of Pharmacology, 463, 235-272.

81
Cech, Richo, 2003, Personal communication, November 27, 2003. Chappell, Joe, 2002. The genetics and molecular genetics of terpene and sterol origami. Current Opinion in Plant Biology, 5, 151-157. Chattopadhyay, Debprasad, Arunachalam, G., Mandal, Subhash C., Bhadra, R. and Mandal, Asit B., 2003. CNS activity of the methanol extract of Mallotus peltatus (Geist) Muell Arg. leaf: an ethnomedicine of Onge. Journal of Ethnopharmacology, 85, 99-105. Chattopadhyay, R.R., 1999. A comparative evaluation of some blood sugar lowering agents of plant origin. Journal of Ethnopharmacology, 67(3), 367-372. Cheeptham, N. and Towers, G.H.N., 2002. Light-mediated activities of some Thai medicinal plant teas. Fitoterapia, 73, 651-662. Chen, W.C., Hau, D.M., Chen, K.T., Wang, M.I. and Lin, I.H., 1996. Protective effects of Gynostemma pentaphyllum in gamma-irradiated mice. American Journal of Chinese Medicine, 24(1), 83-92. Chen, Y., Zhu, Y., Wei, J. and Liang, N., 1995. Chemical components of Codonopsis pilosula (Franch.) Nannf. var. volubilis (Nannf.) L.T. Shen. Zhongguo Zhong Yao Za Zhi, 10, 611-612, 639-640. Chiba, Kenzo, Yamazaki, Matsumi, Umegaki, Emiko, Li, Ming Run, Xu, Zhen Wen et al., 2002. Neuritogenesis of herbal (+)-and (-)-syringaresinols separated by chiral HPLC in PC12h and neuro2a cells. Biological & Pharmaceutical Bulletin, 25(6), 791-793. Chintawar, S.D., Somani, R.S., Kasture, Veena S. and Kasture, S.B., 2002. Nootropic activity of Albizzia lebbeck in mice. Journal of Ethnopharmacology, 81(3), 299-305. Chiu, P.Y., Mak, D.H., Poon, M.K. and Ko, K.M., 2002. In vivo antioxidant action of a lignan-enriched extract of Schisandra fruit and an anthraquinone-containing extract of Polygonum root in comparison with schisandrin B and emodin. Planta Medica, 68(11), 951-956. Chiu, Po Yee, Tang, Man Ho, Mak, Duncan H.F., Poon, Michel K.T. and Ko, Kam Ming, 2003. Hepatoprotective mechanism of schizandrin B: role of mitochondrial glutathione antioxidant status and heat shock proteins. Free Radical Biology & Medicine, 35(4), 368-380. Choi, S., Lee, J.H., Oh, S., Rhim, H., Lee, S.M. et al., 2003. Effects of ginsenoside Rg2 on the 5-HT3A receptormediated ion current in Xenopus oocytes. Mol Cells. Chrousos, G.P. and Gold, P.W., 1992. The concepts of stress and stress system disorders. Journal of the American Medical Association, 267, 1244-1252. Chrousos, George P., 1998, Stressors, stress, and neuroendocrine integration of the adaptive response. In: Peter Csermely (Ed.), Stress of Life: From Molecules to Man. Annals of the New York Academy of Sciences. The New York Academy of Sciences, New York. Chung, Cha-Kwon and Jung, Myung-Eun, 2003. Ethanol fraction of Aralia elata Seemann enhances antioxidant activity and lowers serum lipids in rats when administered with benzo(alpha)pyrene. Biological & Pharmaceutical Bulletin, 26(10), 1502-1504. Chung, Eunah, Lee, Kwang Youl, Lee, YoungJoo, Lee, Yong Hee and Lee, Seung Ki, 1998. Ginsenoside-Rg1 downregulates glucocorticoid receptor and displays synergistic effects with cAMP. Steroids, 63, 421-424. Cicero, A.F.G., Bandieri, E. and Arletti, R., 2001. Lepidium meyenii Walp. Improves sexual behavior in male rats independently from its action on spontaneous locomotor activity. Journal of Ethnopharmacology, 75, 225-229.

82
Cirino, Giuseppe, Fiorucci, Stefano and Sessa, William C., 2003. Endothelial nitric oxide synthase: the Cinderella of inflammation? Trends in Pharmacological Sciences, 24(2), 91-95. Clouse, Steven D., 2002, Brassinosteroids: plant counterparts to animal steroid hormones? In: Gerald Litwack (Ed.), Vitamins and Hormones. Advances in Research and Applications. Academic Press, San Diego, pp. 195-223. Cock, J. Mark, Vanoosthuyse, Vincent and Gaude, Thierry, 2002. Receptor kinase signaling in plants and animals: distinct molecular systems with mechanistic similarities. Current Opinion in Cell Biology, 14, 230-236. Connolly, Joseph D. and Hill, Robert A., 2000. Triterpenoids. Natural Product Reports, 17, 463-482. Connolly, Joseph D. and Hill, Robert A., 2001. Triterpenoids. Natural Product Reports, 18, 131-147. Costa-Neto, Eraldo Medeiros, 2002. The use of insects in folk medicine in the state of Bahia, northeastern Brazil, with notes on insects reported elsewhere in Brazilian folk medicine. Human Ecology, 30(2), 245-263. Cui, Rutao, He, Jinchun, Wang, Baoen, Zhang, Fukui, Chen, Guangyong et al., 2003. Suppressive effect of Astragalus membranaceus Bunge on chemical hepatocarcinogenesis in rats. Cancer Chemotherapy and Pharmacology, 51, 75-80. Culbreth, David M.R., 1927, A Manual of the Materia Medica and Pharmacology. Lea & Febiger, Philadelphia. Cullen, J., 1997, The Identification of Flowering Plant Families. Cambridge University Press, Cambridge. Dai, Yi, Miki, Kenji, Fukuoka, Tetsuo, Tokunaga, Atsushi and Tachibana, Toshiya, 2000. Suppression of neuropeptides' mRNA expression by herbal medicines in a rat model of peripheral inflammation. Life Sciences, 66(1), 19-29. Das, Amitava, Shanker, Girja, Nath, Chandishwar, Pal, Raghwendra, Singh, Satyawan et al., 2002. A comparative study in rodents of standardized extractts of Bacopa monniera and Ginkgo biloba. Anticholinesterase and cognitive enhancing activities. Pharmacology, Biochemistry and Behavior, 73, 893-900. Davydov, Marina and Krikorian, A.D., 2000. Eleuthrococcus senticosus (Rupr. & Maxim.) Maxim. (Araliaceae) as an adaptogen: a closer look. Journal of Ethnopharmacology, 72(3), 345-393. De Feo, Vincenzo, 2003. Ethnomedical field study in northern Peruvian Andes with particular reference to divination practices. Journal of Ethnopharmacology, 85, 243-256. Demmig-Adams, Barbara and Adams, William W. III, 2002. Antioxidants in photosynthesis and human nutrition. Science, 298, 2149-2153. de-Paris, F., Neves, G., Salgueiro, J.B., Quevedo, J., Izquierdo, I. et al., 2000. Psychopharmacological screening of Pfaffia glomerata Spreng. (Amaranthaceae) in rodents. Journal of Ethnopharmacology, 73(1,2), 261-269. Dev, Sukh, 1999. Ancient-modern concordance in Ayurvedic plants: some examples. Environmental Health Perspectives, 107, 783-789. Dewick, Paul M., 2002, Medicinal Natural Products: A Biosynthetic Approach. John Wiley & Sons Ltd., West Sussex. Dhuley, Jayant, 2000. Adaptogenic and cardioprotective action of ashwagandha in rats and frogs. Journal of Ethnopharmacology, 70, 57-63. Dinan, L., Savchenko, T. and Whiting, P., 2002. Chemotaxonomic significance of ecdysteroid agonists and antagonists in the Ranunculaceae: phytoecdysteroids in the genera Helleborus and Hepatica. Biochemical Systematics and Ecology, 30, 171-182. Dinan, Laurence, Savchenko, Tamara and Whiting, Pensri, 2001a. On the distribution of phytoecdysteroids in plants. Cellular and Molecular Life Sciences, 58(8), 1121-1132.

83
Dinan, Laurence, Whiting, Pensri, Girault, J.P., Lafont, R., Dhadialla, T.S. et al., 1997. Cucurbitacins are insect steroid hormone antagonists acting at the ecdysteroid receptor. Biochemical Journal, 327(3), 643-650. Dinan, Laurence, Whiting, Pensri and Savchenko, Tamara, 2001b. Phytoecdysteroids in seeds of Lloydia serotina (Liliaceae). Biochemical Systematics and Ecology, 29(9), 923-928. Dinan, Laurence, Whiting, Pensri and Scott, Andrew J., 1998. Taxonomic distribution of phytoecdysteroids in seeds of members of the Chenopodiaceae. Biochemical Systematics and Ecology, 26(5), 553-576. Dixon, Richard A. and Ferreira, Daneel, 2002. Genistein. Phytochemistry, 60, 205-211. Dong, Tina T.X., Cui, Xiu M., Song, Zong H., Zhao, Kui J., Ji, Zhao N. et al., 2003. Chemical assessment of roots of Panax notoginseng in China: regional and seasonal variations in its active constituents. Journal of Agricultural and Food Chemistry, 51, 4617-4623. Downie, S.R., Plunkett, G.M., Watson, M.F., Spalik, K., Katz-Downie, D.S. et al., 2001. Tribes and clades within Apiaceae subfamily Apioideae: the contribution of molecular data. Edinburgh Journal of Botany, 58, 301-330. Drewes, Siegfried E., George, Jacob and Khan, Fatima, 2003. Recent findings on natural products with erectiledysfunction activity. Phytochemistry, 62, 1019-1025. Dubowchik, Gene M., Michne, Jodi A., Zuev, Dmitry, Schwarts, Wendy, Scola, Paul M. et al., 2003. 2arylaminothiazoles as high-affinity corticotropin-releasing factor 1 receptor (CRF1R) antagonists: synthesis, binding studies and behavioral efficacy. Bioorganic & Medicinal Chemistry, 13, 3997-4000. Duffy, Rosanna, Wiseman, Helen and File, Sandra E., 2003. Improved cognitive function in postmenopausal women after 12 weeks of consumption of a soya extract containing isoflavones. Pharmacology, Biochemistry and Behavior, 75, 721-729. Eisenberg, David M., Davis, Roger B., Ettner, Susan L., Appel, Scott, Wilkey, Sonja et al., 1998. Trends in alternative medicine use in the United States, 1990-1997. Journal of the American Medical Association, 280(18), 1569-1575. Elenkov, Ilia J. and Chrousos, George P., 1999. Stress hormones, Th1/Th2 patterns, pro/anti-inflammatory cytokines and susceptibility to disease. Trends in Endocrinology and Metabolism, 10(9), 359-368. Elsevier Science Ireland, Ltd., 1997-2003, Journal of Ethnopharmacology. ISSN 0378-8741. Etkin, Nina, 2001. Perspectives in ethnopharmacology: forging a closer link between bioscience and traditional empirical knowledge. Journal of Ethnopharmacology, 76, 177-182. Evans, D.A., Subramoniam, A., Rajasekharan, S. and Pushpangadan, P., 2002. Effect of Trichopus zeylanicus leaf extract on the energy metabolism in mice during exercise and at rest. Indian Journal of Pharmacology, 34, 32-37. Fahey, Jed W., Zalcmann, Amy T. and Talalay, Paul, 2001. The chemical diversity and distribution of glucosinolates and isothiocyanates among plants. Phytochemistry, 56, 5-51. Fan, Cheng-Qi and Yue, Jian-Min, 2003. Biologically active phenols from Saussurea medusa. Bioorganic & Medicinal Chemistry, 11, 703-708. Farzad, Maryam, Griesbach, Robert, Hammond, John, Weiss, Martha R. and Elmendorf, Heidi G., 2003. Differential expression of three key anthocyanin biosynthetic genes in a color-changing flower, Viola cornuta cv. Yesterday, today and tomorrow. Plant Science, 165, 1333-1342. Felter, H.W., 1922, The Eclectic Materia Medica, Pharmacology and Therapeutics. Eclectic Medical Publications, Sandy,OR.

84
Fenech, M., 2002. Micronutrients and genomic stability: a new paradigm for recommended dietary allowances (RDAs). Food and Chemical Toxicology, 40, 1113-1117. Ferguson, Lynnette R., 2001. Role of plant polyphenols in genomic stability. Mutation Research, 475, 89-111. Fernandez-Alonso, Jose Luis, Vega, Nohora, Filgueira, Juan Jose and Perez, Gerardo, 2003. Lectin prospecting in Colombian Labiatae. A systematic-ecological approach. Biochemical Systematics and Ecology, 31, 617-633. Ferrari, C.K.B. and Torres, E.A.F.S., 2003. Biochemical pharmacology of functional foods and prevention of chronic diseases of aging. Biomedicine & Pharmacotherapy, 57, 251-260. Ferreira, M.J.P., Alvarenga, S.A.V., Macari, P.A.T., Rodrigues, G.V. and Emerenciano, V.P., 2003. A program for terpenoid skeleton prediction based on botanical information. Biochemical Systematics and Ecology, 31, 25-43. Flannery, Tim, 2001, The Eternal Frontier: An Ecological History of North America and Its Peoples. Grove Press, New York. Fournel, S. and Muller, S., 2002. Peptides as DNA mimics: cross-reactivity and mimicry in systemic autoimmune diseases. Cellular and Molecular Life Sciences, 59, 1280-1284. Fremont-Smith, Kenneth, 1998. Adverse Drug Reactions in Hospitalized Patients. Journal of the American Medical Association, 280, 1741-1743. Galichet, Arnaud and Gruissem, Wilhelm, 2003. Protein farnesylation in plants -- conserved mechanisms but different targets. Current Opinion in Plant Biology, 6, 530-535. Galvo, S.M.P., Marques, L.C., Oliveira, M.G.M. and Carlini, E.A., 2002. Heteropterys aphrodisiaca (extract BST0298): a Brazilian plant that improves memory in aged rats. Journal of Ethnopharmacology, 79, 305-311. Ganasoundari, A., Devi, P.U. and Rao, M.N.A., 1997. Protection against radiation-induced chromosome damage in mouse bone marrow by Ocimum sanctum. Mutation Research, 373(2), 271-276. Ganju, Lilly, Karan, Dev, Chanda, Sudipta, Srivastava, K.K., Sawhney, R.C. et al., 2003. Immunomodulatory effects of agents of plant origin. Biomedicine & Pharmacotherapy, 57, 296-300. Gao, X.Y., Wang, D.W. and Li, F.M., 2000. Determination of ecdysterone in Achyranthes bidentata Bl. and its activity promoting proliferation of osteoblast-like cells. Yao Xue Xue Bao, 35(11), 868-870. Geissler, P. Wenzel, Harris, Stephen A., Prince, Ruth J., Olsen, Anja, Odhiambo, R. Achieng' et al., 2002. Medicinal plants used by Luo mothers and children in Bondo district, Kenya. Journal of Ethnopharmacology, 83, 39-54. Genton, Laurence and Kudsk, Kenneth A., 2003. Interactions between the enteric nervous system and the immune system: role of neuropeptides and nutrition. The American Journal of Surgery, 186, 253-258. Gillis, C. Norman, 1997. Commentary: Panax ginseng pharmacology: a nitric oxide link? Biochemical Pharmacology, 54, 1-8. Gleason, Henry A. and Cronquist, Arthur, 1991, Manual of the Vascular Plants of Northeastern United States and Adjacent Canada. The New York Botanical Garden, Bronx. Gohil, Kishorchandra, 2002. Genomic responses to herbal extracts: lessons from in vitro and in vivo studies with an extract of Gingko biloba. Biochemical Pharmacology, 64, 913-917. Gorovoi, P.G., Ponomarchuk, G.I. and Stringina, L.I., 1971. A chemotaxonomic study on Russian far-eastern Campanulaceae. Phytochemistry, 10, 2419-2423.

85
Gottlieb, Otto R., Borin, Maria Renata De M.B. and de Brito, Nei Regis S., 2002. Integration of ethnobotany and phytochemistry: dream or reality? Phytochemistry, 60, 145-152. Grammatopoulos, Dimitris K. and Chrousos, George P., 2002. Functional characteristics of CRH receptors and potential clinical applications of CRH-receptor antagonists. Trends in Endocrinology & Metabolism, 13(10), 436-444. Grassman, Johanna, Hippeli, Susanne and Elstner, Erich F., 2002. Plant's defence and its benefits for animals and medicine: role of phenolics and terpenoids in avoiding oxygen stress. Plant Physiology and Biochemistry, 40, 471-478. Grayer, Rene J., Chase, Mark W. and Simmonds, Monique S. J., 1999. A comparison between chemical and molecular characters for the determination of phylogenetic relationships among plant families: An appreciation of Hegnauer's "Chemotaxonomie der Pflanzen." Biochemical Systematics and Ecology, 27(4), 369-393. Grayer, Rene J., Eckert, Maria R., Veitch, Nigel C., Kite, Geoffrey C., Marin, Petar D. et al., 2003. The chemotaxonomic significance of two bioactive caffeic acid esters, nepetoidins A and B, in the Lamiaceae. Phytochemistry, 64, 519-528. Grayer, Rene J., Kite, Geoffrey C., Veitch, Nigel C., Eckert, Maria R., Marin, Petar D. et al., 2002. Leaf flavonoid glycosides as chemosystematic characters in Ocimum. Biochemical Systematics and Ecology, 30, 327-342. Grieve, Maude, 1931, A Modern Herbal. Dover Publications, Inc., New York. Guo, Fang-Qing, Okamoto, Mamoru and Crawford, Nigel M., 2003. Identification of a plant nitric oxide synthase gene involved in hormonal signaling. Science, 302(3 October), 100-103. Gupta, Y.K., Veerendra Kumar, M.H. and Srivastava, A.K., 2003. Effect of Centella asiatica on pentylenetetrazoleinduced kindling, cognition and oxidative stress in rats. Pharmacology, Biochemistry and Behavior, 74, 579-585. Habib, Kamal E., Gold, Philip W. and Chrousos, George P., 2001. Neuroendocrinology of stress. Neuroendocrinology, 30(3), 695-728. Haller, John S., 1994, Medical Protestants: The Eclectics in American Medicine, 1825-1939. Southern Illinois University Press, Carbondale. Haller, John S., 2000, The People's Doctor: Samuel Thomson and the American Botanical Movement, 1790-1860. Southern Illinois University Press, Carbondale. Han, C., Li, L., Piao, K., Shen, Y. and Piao, Y., 1999. Experimental study on anti-oxygen and promoting intelligence development of Codonopsis lanceolata in old mice. Zhong Yao Cai, 22(3), 136-138. Haridas, Va sala, Arntzen, Charles J. and Gutterman, Jordan U., 2001. Avicins, a family of triterpenoid saponins from Acacia victoriae (Bentham), inhibit activation of nuclear factor-KB by inhibiting both its nuclear localization and ability to bind DNA. Proceedings of the National Academy of Sciences (USA), 98(20), 11557-11562. Harrewijn, Paul, van Oosten, Adriaan M. and Piron, Paul G.M., 2001, Natural Terpenoids as Messengers: a multidisciplinary study of their production, biological functions and practical applications. Kluwer Academic Publishers, Boston. Hartmann, Marie-Andree, 1998. Plant sterols and the membrane environment. Trends in Plant Science, 3(5), 170-175. Havsteen, Bent H., 2002. The biochemistry and medical significance of the flavonoids. Pharmacology & Therapeutics, 96, 67-202. Hayashi, Hiroaki, Hattori, Sayaka, Inoue, Kenichiro, Khodzhimatov, Olimjon, Ashurmetov, Ozodbek et al., 2003. Field survey of Glycyrrhiza plants in central Asia (3). Chemical characterization of G. glabra collected in Uzbekistan. Chemical and Pharmacology Bulletin, 51(11), 1338-1340.

86
Hegnauer, Robert, 1966-1989, Chemotaxonomie der Pflanzen ein Ubersicht uber die Verbreitung und die systematische Bedeutung der Pflanzenstoff. Birkhauser Verlag, Basel. Heinrich, Michael, 2003. Ethnobotany and natural products: the search for new molecules, new treatments of old diseases or a better understanding of indigenous cultures? Current Topics in Medicinal Chemistry, 3(2), 141-154. Hellion-Ibarrola, M.C., Ibarrola, D.A., Montalbetti, Y., Villalba, D., Heinichen, O. et al., 1999. Acute toxicity and general pharmacological effect on central nervous system of the crude rhizome extract of Kyllinga brevifolia Rottb. Journal of Ethnopharmacology, 66, 271-276. Helm, Katherine A., Rada, Pedro and Hoebel, Bartley G., 2003. Cholecystokinin combined with serotonin in the hypothalamus limits accumbens dopamine release while increasing acetylcholine: a possible satiation mechanism. Brain Research, 963, 290-297. Hippeli, Susanne, Heiser, Ingrid and Elstner, Erich F., 1999. Activated oxygen and free oxygen radicals in pathology: new insights and analogies between animals and plants. Plant Physiology and Biochemistry, 37(3), 167-178. Hobbs, Christopher, 1995, Medicinal Mushrooms: An Exploration of Tradition, Healing, and Culture. Botanica Press, Santa Cruz. Holmes, Peter, 1996, Jade Remedies: A Chinese Herbal Reference for the West, vol. 1. Snow Lotus Press, Boulder. Hou, Chia-Chung, Lin, Shwu-Jiuan, Cheng, Juei-Tang and Hsu, Feng-Lin, 2002. Bacopaside III, bacopasaponin G, and bacopasides A, B, and C from Bacopa monniera. Journal of Natural Products, 65, 1759-1763. Houghton, Peter J., 2003. Plants and the central nervous system: editorial. Pharmacology, Biochemistry and Behavior, 75, 497-499. Houghton, Peter J., Mensah, Abraham Y., Iessa, Noha and Hong, Liao Yong, 2003. Terpenoids in Buddleja: relevance to chemosystematics, chemical ecology and biological activity. Phytochemistry, 64, 385-393. Howe, Gregg A. and Schilmiller, Anthony L., 2002. Oxylipin metabolism in response to stress. Current Opinion in Plant Biology, 5, 230-236. Howes, Melanie-Jayne R. and Houghton, P.J., 2003. Plants used in Chinese and Indian traditional medicine for improvement of memory and cognitive function. Pharmacology, Biochemistry and Behavior, 75, 513-527. Hsu, Hong-yen, Chen, Yuh-pan, Hsu, Chau-shin, Shen, Shuenn-jyi, Chen, Chien-chih et al., 1986, Oriental Materia Medica: a Concise Guide. Keats Publishing, Inc., New Canaan. Huan, Zhang Yu and Rose, Ken, 2001, A brief history of qi. Paradigm Publications, Brookline. Ingolfsdottir, K., 2002. Usnic acid. Phytochemistry, 61, 729-736. Iuvone, Teresa, Esposito, Giuseppe, Capasso, Francesco and Izzo, Angelo A., 2003. Induction of nitric oxide synthase expression by Withania somnifera in macrophages. Life Sciences, 72, 1617-1625. Jacobs, Helen, 2003. Comparative phytochemistry of Picramnia and Alvaradoa, genera of the newly established family Picramniaceae. Biochemical Systematics and Ecology, 31, 773-783. Janas, Teresa, Walinska, Krystyna, Chojnacki, Tadeusz, Swiezewska, Ewa and Janas, Tadeusz, 2000. Modulation of properties of phospholipid membranes by the long-chain polyprenol (C160). Chemistry and Physics of Lipids, 106, 3140. Janero, David R., 2001. Nutritional aspects of nitric oxide: human health implications and therapeutic opportunities. Nutrition, 17, 896-903.

87
Jensen, Soren Rosendal, Franzyk, Henrik and Wallander, Eva, 2002. Chemotaxonomy of the Oleaceae: iridoids as taxonomic markers. Phytochemistry, 60, 213-231. Jian-Wen, Tan, Ze-Jun, Dong, Zhi-Hui, Ding and Ji-Kai, Liu, 2002. Lepidolide, a novel seco-ring-A cucurbitane triterpenoid from Russula lepida (Basidiomycetes). Zeitschrift fur Naturforschung, 57c, 963-965. Judd, Walter S., Campbell, Christopher S., Kellogg, Elizabeth A., Stevens, Peter F. and Donoghue, Michael J., 2002, Plant Systematics: A Phylogenetic Approach. Sinauer Associates, Inc., Sunderland. Kala, Chandra Prakash, 2003, Personal communication, October 27, 2003. Kazuma, Kohei, Noda, Naonobu and Suzuki, Masahiko, 2003. Flavonoid composition related to petal color in different lines of Clitoria ternatea. Phytochemistry, 64, 1133-1139. Kelly, Gregory S., 1999. Nutritional and botanical interventions to assist with the adaptation to stress. Alternative Medicine Review, 4(4), 249-265. Kelly, Gregory S., 2001. Rhodiola rosea : a possible plant adaptogen. Alternative Medicine Review, 6(3), 293-302. Keplinger, Klaus, Laus, Gerhard, Wurm, Martin, Dierich, Manfred P. and Teppner, Herwig, 1999. Uncaria tomentosa (Willd.) DC.--ethnomedical use and new pharmacological, toxicological and botanical results. Journal of Ethnopharmacology, 64, 23-34. Kern, J.R. and Cardellina II, John H., 1983. Native American medicinal plants. Anemonin from the horse stimulant Clematis hirsutissima. Journal of Ethnopharmacology, 8(1), 121-123. Keyu, Gu, 2002. Lipopolysaccharide, a potential inducer of plant defense response. Trends in Plant Science, 7(5), 196. Khalifa, Amani E., 2001. Hypericum perforatum as a nootropic drug: enhancement of retrieval memory of a passive avoidance conditioning paradigm in mice. Journal of Ethnopharmacology, 76, 49-57. Khan, Seher A. and Vanden Heuvel, John P., 2003. Role of nuclear receptors in the regulation of gene expression by dietary fatty acids. Journal of Nutritional Biochemistry, 14, 554-567. Khanna, N. and Bhatia, Jagriti, 2003. Antinociceptive action of Ocimum sanctum (Tulsi) in mice: possible mechanisms involved. Journal of Ethnopharmacology, 88, 293-296. Kholodova, Y., 2001. Phytoecdysteroids: biological effects, application in agriculture and complementary medicine. Ukr Biokhim Zh, 73(3), 21-29. Kilkkinen, Annamarie, Valsta, Liisa M., Virtamo, Jarmo, Stumpf, Katariina, Adlercreutz, Herman et al., 2003. Intake of lignans is associated with serum enterolactone concentration in Finnish men and women. Journal of Nutrition, 133, 1830-1833. Kim, C., Ha, H., Kim, J.S., Kim, Y.T., Kwon, S.C. et al., 2003a. Induction of growth hormone by the roots of Astragalus membranaceus in pituitary cell culture. Archives of Pharmaceutical Research, 26(1), 34-39. Kim, Do-Hoon, Moon, Yoo-Sun, Jung, Jun-Sub, Min, Sung-Kil, Son, Bong-Ki et al., 2003b. Effects of ginseng saponin administered intraperitoneally on the hypothalamo-pituitary-adrenal axis in mice. Neuroscience Letters, 343, 62-66. Kim, Hyung-Min, Moon, Eu-Jeong, Li, En, Kim, Kun-Min, Nam, Sang-Yun et al., 1999a. The nitric oxide-producing activities of Scutellaria baicalensis. Toxicology, 135, 109-115. Kim, Joung-Hoon, Mun, Yeun-Ja, Im, Sook-Jung, Han, Jong-Hyun, Lee, Ho-Sub et al., 2001. Effects of the aqueous extract of Epimedii Herba on the antibody responses of mice. International Immunopharmacology, 1, 935-944.

88
Kim, Young-Dong and Jansen, Robert K., 1998. Chloroplast DNA restriction site variation and phylogeny of the Berberidaceae. American Journal of Botany, 85(12), 1766-1778. Kim, Young-Ran, Lee, Shee-Yong, Shin, Boo-Ahn and Kim, Kyeong-Man, 1999b. Panax ginseng blocks morphineinduced thymic apoptosis by lowering plasma corticosterone level. General Pharmacology, 32, 647-652. Kindscher, Kelly, 1992, Medicinal Wild Plants of the Prairie: An Ethnobotanical Guide. University Press of Kansas, Lawrence. Kirtikar, K.R. and Basu, B.D., 1918, Indian Medicinal Plants. Sudhindra Nath Basu Paaninai, Bahadurgani. Koh, Jong-Ho, Kim, Kyung-Mi, Kim, Jin-Man, Song, Jae-Chul and Suh, Hyung-Joo, 2003. Antifatigue and antistress effect of the hot-water fraction from mycelia of Cordyceps sinensis. Biological & Pharmaceutical Bulletin, 26(5), 691694. Komarov, V.L., 1937, Flora of the U.S.S.R. In: V.L. Komarov (Ed.), Flora of the U.S.S.R. Moskva, Leningrad. Koonin, Eugene V., Makarova, Kira S., Rogozin, Igor B., Davidovic, Laetitia, Letellier, Marie-Claude et al., 2003. The rhomboids: a nearly ubiquitous family of intramembrane serine proteases that probably evolved by multiple ancient horizontal gene transfers. Genome Biology, 4, 1-12. Koudela, Karel, Tenora, Jan, Bajer, Jiri, Mathova, Anna and Slama, Karel, 1995. Stimulation of growth and development in Japanese quails after oral administration of ecdysteroid-containing diet. European Journal of Entomology, 92, 349-354. Krishnakumar, Asha and Katakam, Anupama, 2002, Credit for conservation, Frontline. Kshirsagar, N.A., 2000. Clinical pharmacology. Indian Journal of Pharmacology, 32, S43-S53. Kumar, M.H. Veerendra and Gupta, Y.K., 2002. Effect of different extracts of Centella asiatica on cognition and markers of oxidative stress in rats. Journal of Ethnopharmacology, 79, 253-260. Kuroda, M., Mimaki, Y., Y., Sashida, Umegaki, E., Yamazaki, M. et al., 2000. Flavonol glycosides from Epimedium sagittatum and their neurite outgrowth activity on PC12h cells. Planta Medica, 66(6), 575-577. Kutepova, T.A., Syrov, V.N., Kushbaktova, Z.A. and Saatov, Z., 2001. Hypoglycemic activity of the total ecdysteroid extract from Ajuga turkestanica. Pharmaceutical Chemistry Journal, 35(11), 608-609. Lafont, R. and Wilson, I., 1992, The Ecdysone Handbook. Chromatographic Society, Nottingham. Lafont, Rene, 1997. Ecdysteroids and related molecules in animals and plants. Archives of Insect Biochemistry and Physiology, 35, 3-20. Lavin, Matt and Marriott, Hollis, 1997. Astragalus molybdenus s.l. (Leguminosae): Higher taxonomic relationships and identity of constituent species. Systematic Botany, 22(2), 199-217. Lazarev, N.V., 1946, Experimental data for the evaluation of the Far East Schisandra as a stimulant, Transactions of the Scientific and Medical Board of the Administration of the Medical-Sanitary Department of the USSR Navy, Leningrad, pp. 62-69. Lazarev, N.V., 1962, Actual problems in studies of the action of adaptogens, particularly preparations of Eleutherococcus, Symposium on Ginseng and Eleutherococcus. Twentieth Meeting on Investigations of Ginseng and Other Medicinal Plants of the Far East. Dalne Vostochnoiy Filial Sibirskogo Otdeleniya Academii Nauk SSSR, Vladivostok, pp. 7-14. Lazarou, J., Pomeranz, B.H. and Corey, P.N., 1998. Incidence of adverse drug reactions in hospitalized patients. A meta-analysis of prospective studies. Journal of the American Medical Association, 279, 1200-1205.

89
Leaf, Alexander, Xiao, Yong-Fu, Kang, Jing X. and Billman, George E., 2003. Prevention of sudden cardiac death by n-3 polyunsaturated fatty acids. Pharmacology & Therapeutics, 98, 355-377. Lee, Jeong-Chae, Jung, Ha-Na, Kim, Jung-Soo, Woo, Won-Hong, Jeong, Woo-Yeal et al., 2003. Selective priming of Th1-mediated antigen-specific immune responses following oral administration of mixed prescriptions of traditional Korean medicines. Clinica Chimica Acta, 329, 133-142. Lee, K.T., Choi, J., Jung, W.T., Nam, J.H., Jung, H.J. et al., 2002. Structure of a new echinocystic acid bisdesmoside isolated from Codonopsis lanceolata roots and the cytotoxic activity of prosapogenins. Journal of Agricultural and Food Chemistry, 50(15), 4190-4193. Lemaire, Irma, Assinewe, Valerie, Cano, Pablo, Awang, Dennis V.C. and Arnason, J. Thor, 1999. Stimulation of interleukin-1 and -6 production in alveolar macrophages by the neotropical liana, Uncaria tomentosa (Una de Gato). Journal of Ethnopharmacology, 64, 109-115. Lephart, Edwin D., West, Timothy W., Weber, K. Scott, Rhees, Reuben W., Setchell, Kenneth D.R. et al., 2002. Neurobehavioral effects of dietary soy phytoestrogens. Neurotoxicology and Teratology, 24, 5-16. Leshem, Ya'acov Y., 2000, Nitric Oxide in Plants: Occurrence, Function and Use. Kluwer Academic Publishers, Boston. Leung, A.Y. and Foster, S., 1996, Encyclopedia of Common Natural Ingredients Used in Food, Drugs, and Cosmetics. John Wiley & Sons, Inc., New York. Lev, E. and Amar, Z., 2000. Ethnopharmacological survey of traditional drugs sold in Israel at the end of the 20th century. Journal of Ethnopharmacology, 72(1-2), 191-205. Li, Hua-Bin and Chen, Feng, 2001. Preparative isolation and purification of salidroside from the Chinese medicinal plant Rhodiola sachalinensis from high-speed counter-current chromatography. Journal of Chromatography A, 932, 9195. Li, Rachel W., Myers, Stephen P., Leach, David N., Lin, G. David and Leach, Greg, 2003a. A cross-cultural study: anti-inflammatory activity of Australian and Chinese plants. Journal of Ethnopharmacology, 85, 25-32. Li, Wenkui, Gu, Chungang, Zhang, Hongjie, Awang, Dennis V.C., Fitzloff, John F. et al., 2000. Use of highperformance liquid chromatography-tandem mass spectrometry to distinguish Panax ginseng C.A. Meyer (Asian ginseng) and Panax quinquefolius L. (North American ginseng). Analytical Chemistry, 72, 5417-5422. Li, Yushan, Ishibashi, Masami, Satake, Masayuki, Chen, Xigui, Oshima, Yasukatsu et al., 2003b. Sterol and triterpenoid constituents of Verbena littoralis with NGF-potentiating activity. Journal of Natural Products, 66, 696-698. Li, Z.K. and Li, Z.Z., 1997. The immunomodulatory effect of Achyranthes bidentata polysaccarides. Yao Xue Xue Bao, 32(12), 881-887. Liang, Po-Huang, Ko, Tzu-Ping and Wang, Andrew H.-J., 2002. Structure, mechanism and function of prenyltransferases. European Journal of Biochemistry, 269, 3339-3354. Lin, C.C., Huang, P.C. and Lin, J.M., 2000. Antioxidant and hepatoprotective effects of Anoectochilus formosanus and Gynostemma pentaphyllum . American Journal of Chinese Medicine, 28(1), 87-96. Lindsey, Keith, Pullen, Margaret L. and Topping, Jennifer F., 2003. Importance of plant sterols in pattern formation and hormone signalling. Trends in Plant Science, 8(11), 521-525. Liu, J., 1995. Pharmacology of oleanolic and ursolic acid. Journal of Ethnopharmacology, 49, 57-68.

90
Liu, Jianquan, Chen, Zhiduan and Lu, Anming, 2002. Molecular evidence for the sister relationship of the eastern AsiaNorth American intercontinental species pair in the Podophyllum group (Berberidaceae). Botanical Bulletin of the Academia Sinica, 43, 147-154. Liu, Z.Y., Yang, Y.G. and Zheng, B., 1993. Effect of improving memory and inhibiting acetylcholinesterase activity by invigorating-qi and warming-yang recipe. Zhongguo Zhong Yao Za Zhi, 13(11), 675-666, 646. Liu, Zai-Qun, Luo, Xu-Yang, Liu, Guo-Zong, Chen, Yan-Ping, Wang, Zhi-Cai et al., 2003. In vitro study of the relationship between the structure of ginsenoside and its antioxidative or prooxidative activity in free radical induced hemolysis of human erythrocytes. Journal of Agricultural and Food Chemistry, 51, 2555-2558. Losel, Ralf, Feuring, Martin and Wehling, Martin, 2003. Non-genomic aldosterone action: from the cell membrane to human physiology. Journal of Steroid Biochemistry & Molecular Biology, 83, 167-171. Lowry, C.A., 2002. Functional subsets of serotonergic neurones: implications for control of the hypothalamic-pituitaryadrenal axis. Journal of Neuroendocrinology, 14, 911-923. Luconi, Michaela, Forti, Gianni and Baldi, Elisabetta, 2002. Genomic and nongenomic effects of estrogens: molecular mechanisms of action and clinical implications for male reproduction. Journal of Steroid Biochemistry & Molecular Biology, 80, 369-381. Ma, A. and Guo, H., 1998. Effect of radix Achyranthis bidentatae on memory and endurance. Zhong Yao Cai, 21(12), 624-626. Ma, Lifu and Dolphin, David, 1999. The metabolites of dietary chlorophylls. Phytochemistry, 50, 195-202. Ma, Xia Q., Shi, Q., Duan, J.A., Dong, Tina T.X. and Tsim, Karl W.K., 2002. Chemical analysis of radix Astragali (huang qi) in China: a comparison with its adulterants and seasonal variations. Journal of Agricultural and Food Chemistry, 50, 4861-4866. MacRae, W. Donald and Towers, G.H. Neil, 1984. Biological activities of lignans. Phytochemistry, 23(6), 1207-1220. Mann, Douglas L., 2003. Stress-activated cytokines and the heart: from adaptation to maladaptation. Annual Review in Physiology, 65, 81-101. Manthey, John A., Buslig, Bela S. and Baker, Michael E., 2002. Flavonoids in cell function. Advances in Experimental Medicine and Biology, 505, 1-7. Marcus, Donald M., 2002. Botanical medicines - the need for new regulations. New England Journal of Medicine, 347(25), 2073-2074. Marles, Robin J., Clavelle, Christina, Monteleone, Leslie, Tays, Natalie and Burns, Donna, 2000, Aboriginal Plant Use in Canada's Northwest Boreal Forest. UBC Press, Vancouver. Masood, Anbrin, Banerjee, Basudeb, Vijayan, V.K. and Ray, Arunabha, 2003. Modulation of stress-induced neurobehavioral changes by nitric oxide in rats. European Journal of Pharmacology, 458, 135-139. Matsuda, Hisashi, Toguchida, Iwao, Ninomiya, Kiyofumi, Kageura, Tadashi, Morikawa, Toshio et al., 2003. Effects of sesquiterpenes and amino acid-sesquiterpene conjugates from the roots of Saussurea lappa on inducible nitric oxide synthase and heat shock protein in lipopolysaccharide-activated macrophages. Bioorganic & Medicinal Chemistry, 11, 709-715. McEwen, Bruce S., 1998. Protective and damaging effects of stress mediators. New England Journal of Medicine, 338(3), 171-179. McEwen, Bruce S., 1999. Stress and the aging hippocampus. Frontiers in Neuroendocrinology, 20, 49-70.

91
McEwen, Bruce S., 2003. Mood disorders and allostatic load. Biological Psychiatry, 54, 200-207. McEwen, Bruce S. and Wingfield, John C., 2003a. The concept of allostasis in biology and biomedicine. Hormones and Behavior, 43, 2-15. McEwen, Bruce S. and Wingfield, John C., 2003b. Response to commentaries on the concept of allostasis. Hormones and Behavior, 43, 28-30. Mediratta, P.K., Sharma, K.K. and Singh, Surender, 2002. Evaluation of immunomodulatory potential of Ocimum sanctum seed oil and its possible mechanism of action. Journal of Ethnopharmacology, 80, 15-20. Melzig, Matthias F., Bader, Gerd and Loose, Renate, 2001. Investigations of the mechanism of membrane activity of selected triterpenoid saponins. Planta Medica, 67, 43-48. Menezes, Hercules and Jared, Carlos, 2002. Immunity in plants and animals: common ends through different means using similar tools. Comparative Biochemistry and Physiology Part C, 132, 1-7. Miettinen, Tatu A., 2001. Phytosterols - what plant breeders should focus on. Journal of the Science of Food and Agriculture, 81, 895-903. Mills, Simon and Bone, Kerry, 2000, Principles and Practice of Phytotherapy: Modern Herbal Medicine. Churchill Livingstone, New York. Mills, Simon Y., 1991, Out of the Earth: The Essential Book of Herbal Medicine. Viking Arcana, New York. Miraldi, E., Ferri, S. and Mostaghimi, V., 2001. Botanical drugs and preparations in the traditional medicine of West Azerbaijan (Iran). Journal of Ethnopharmacology, 75, 77-87. Misra, Renuka, 1998. Modern drug development from traditional medicinal plants using radioligand receptor-binding assays. Medical Research Review, 18(6), 383-402. Mitaine-Offer, Anne-Claire, Marouf, Abderrazak, Hanquet, Bernard, Birlirakis, Nicolas and Lacaille-Dubois, MarieAleth, 2001. Two triterpene saponins from Achyranthes bidentata . Chemical and Pharmacology Bulletin, 49(11), 14921494. Mizuno, Mizuo, Kanie, Yoko, Iinuma, Munekazu, Tanaka, Toshiyuki and Lang, Frank A., 1991. Two flavonol glycosides, hexandrasides C and D, from the underground parts of Vancouveria hexandra. Phytochemistry, 30(8), 2765-2768. Mizushina, Yoshiyuki, Ikuta, Akira, Endoh, Kenji, Oshige, Masahiko, Kasai, Nobuyuki et al., 2003. Inhibition of DNA polymerases and DNA topoisomerase II by triterpenes produced by plant callus. Biochemical and Biophysical Research Communications, 305, 365-373. Moerman, Daniel E., 1998, Native American Ethnobotany. Timber Press, Portland. Mook-Jung, Inhee, Kim, Hee, Fan, Wenzhe, Tezuka, Yasuhiro, Kadota, Shigetoshi et al., 2002. Neuroprotective effects of constituents of the Oriental crude drugs, Rhodiola sacra, R. sachalinensis and Takaku-joki-to, against beta-amyloid toxicity, oxidative stress and apoptosis. Biological & Pharmaceutical Bulletin, 25(8), 1101-1104. Moore, Michael, 1979, Medicinal Plants of the Mountains West. Museum of New Mexico Press, Santa Fe. Moreau, Robert A., Whitaker, Bruce D. and Hicks, Kevin B., 2002. Phytosterols, phytostanols, and their conjugates in foods: structural diversity, quantitative analysis, and health-promoting uses. Progress in Lipid Research, 41, 457-500. Morfin, Robert, 2002. Involvement of steroids and cytochromes P450 species in the triggering of immune defenses. Journal of Steroid Biochemistry & Molecular Biology, 80, 273-290.

92
Mors, Walter B., do Nascimento, Maria Celia, Pereira, Bettina M. Ruppelt and Pereira, Nuno Alvares, 2000. Plant natural products active against snake bite - the molecular approach. Phytochemistry, 55, 627-642. Moundipa, F.P., Kamtchouing, P., Koueta, N., Tantchou, Justine, Foyang, N.P.R. et al., 1999. Effects of aqueous extracts of Hibiscus macranthus and Basella alba in mature rat testis function. Journal of Ethnopharmacology, 65, 133139. Muller, Christa E., Schumacher, Britta, Brattstrom, Axel, Abourashed, Ehab A. and Koetter, Uwe, 2002. Interactions of valerian extracts and a fixed valerian-hop extract combination with adenosine receptors. Life Sciences, 71, 1939-1949. Mummenhoff, Klaus, Bruggemann, Holger and Bowman, John L., 2001. Chloroplast DNA phylogeny and biogeography of Lepidium (Brassicaceae). American Journal of Botany, 88(11), 2051-2063. Mungantiwar, A.A., Nair, A.M., Shinde, U.A., Dikshit, V.J., Saraf, M.N. et al., 1999. Studies on the immunomodulatory effects of Boerhavia diffusa alkaloidal fraction. Journal of Ethnopharmacology, 65, 125-131. Murota, Kaeko and Terao, Junji, 2003. Antioxidative flavonoid quercetin: implication of its intestinal absorption and metabolism. Archives of Biochemistry and Biophysics, 417, 12-17. Nalini, K., Karanth, K.S., Rao, A. and Arror, A.R., 1995. Effect of Celastrus paniculatus on passive avoidance performance and biogenic amine turnover in albino rats. Journal of Ethnopharmacology, 47, 101-108. Nathan, P.J., Clarke, J., Lloyd, J., Hutchison, C.W., Downey, L. et al., 2001. The acute effects of an extract of Bacopa monniera (brahmi) on cognitive function in healthy normal subjects. Human Psychopharmacology, 16, 345-351. Nersesyan, A.K. and Collins, A.R., 2002. Possible genotoxic activity of extracts of Bryonia alba roots on human lymphocytes and transformed cells. Neoplasma, 49(2), 114-116. Newman, David J., Cragg, Gordon M. and Snader, Kenneth M., 2003. Natural products as sources of new drugs over the period 1981-2002. Journal of Natural Products, 66, 1022-1037. Ngadjui, Bonaventure T., Dongo, Etienne, Abegaz, Berhanu M., Fotso, Serge and Tamboue, Helene, 2002. Dinklagins A, B and C: three prenylated flavonoids and other constituents from the twigs of Dorstenia dinklagei. Phytochemistry, 61, 99-104. Nocerino, Emilia, Amato, Marianna and Izzo, Angelo A., 2000. The aphrodisiac and adaptogenic properties of ginseng. Fitoterapia, 71, S1-S5. Novy, Julia W., 1997. Medicinal plants of the eastern region of Madagascar. Journal of Ethnopharmacology, 55, 119126. Nurnberger, Thorsten and Brunner, Frederic, 2002. Innate immunity in plants and animals: emerging parallels between the recognition of general elicitors and pathogen-associated molecular patterns. Current Opinion in Plant Biology, 5(4), 318-324. Oberdorster, Eva, Clay, Mark A., Cottam, D.M., Wilmot, Felicity A., McLachlan, John A. et al., 2001. Common phytochemicals are ecdysteroid agonists and antagonists: a possible evolutionary link between vertebrate and invertebrate steroid hormones. Journal of Steroid Biochemistry & Molecular Biology, 77(4-5), 229-238. Ohara, Seiji and Ohira, Tatsuro, 2003. Plant growth regulation effects of triterpenoid saponins. Japan Wood Science, 49, 59-64. Ohno, Shuji, Shinoda, Satoshi, Toyoshima, Satoshi, Nakazawa, Hiroyuki, Makino, Tsunehisa et al., 2002. Effects of flavonoid phytochemicals on cortisol production and on activities of steroidogenic enzymes in human adrenocortical H295R cells. Journal of Steroid Biochemistry & Molecular Biology, 80, 355-363.

93
Ohsugi, Mizue, Fan, Wenzhe, Hase, Koji, Xiong, Quanbo, Tezuka, Yasuhiro et al., 1999. Active-oxygen scavenging activity of traditional nourishing-tonic herbal medicines and active constituents of Rhodiola sacra. Journal of Ethnopharmacology, 67, 111-119. Ohyama, Masayoshi, Tanaka, Toshiyuki, Yokoyama, Junji and Iinuma, Munekazu, 1995. Occurrence of prenylated flavonoids and oligostilbenes and its significance for chemotaxonomy of genus Sophora. Biochemical Systematics and Ecology, 23(6), 669-677. Orzechowski, Arkadiusz, Ostaszewski, Piotr, Jank, Michal and Berwid, Sybilla Jacqueline, 2002. Bioactive substances of plant origin in food--impact on genomics. Reproduction, Nutrition, Development, 42(5), 461-477. Otto, Angelika and Wilde, Volker, 2001. Sesqui-, di-, and triterpenoids as chemosystematic markers in extant conifers-a review. The Botanical Review, 67(2), 141-238. Owuor, Edward D. and Kong, Ah-Ng Tony, 2002. Antioxidants and oxidants regulated signal transduction pathways. Biochemical Pharmacology, 64, 765-770. Pahadiya, S. and Sharma, J., 2003. Alteration of lethal effects of gamma rays in Swiss albino mice by Tinospora cordifolia. Phytotherapy Research, 17(5), 552-554. Panossian, A., Avetissian, G.M., Mnatsakanian, V.A., Batrakov, S.G., Vartanian, S.A. et al., 1983. Unsaturated polyhydroxyl acids having prostaglandin-like activity from Bryonia alba II. Major compounds. Hippokrates Verlag GmbH, 47, 17-25. Panossian, A., Gabrielian, E. and Wagner, H., 1997. Plant adaptogens. II. Bryonia as an adaptogen. Phytomedicine, 4(1), 85-99. Panossian, A., Gabrielian, E. and Wagner, H., 1999a. On the mechanism of action of plant adaptogens with particular reference to cucurbitacin R diglucoside. Phytomedicine, 6(3), 147-155. Panossian, A., Wikman, G. and Wagner, H., 1999b. Plant adaptogens III. Earlier and more recent aspects and concepts on their mode of action. Phytomedicine, 6(4), 287-300. Panossian, A.G., Oganessian, A.S., Ambartsumian, M., Gabrielian, E.S., Wagner, H. et al., 1999c. Effects of heavy physical exercise and adaptogens on nitric oxide content in human saliva. Phytomedicine, 6(1), 17-26. Panossian, A.G., Pashinian, S.A. and Gasparian, G.V., 1981. Cucurbitacine glucosides and trihydroxyoctadecadienoic acids - new tonic compounds from Bryonia alba L. roots. Russian. Panossian, Alexander G., 2003. Adaptogens: a historical overview and perspective. Natural Pharmacy, 7(4), 1, 19-20. Parihar, M.S. and Hemnani, T., 2003. Phenolic antioxidants attenuate hippocampal neuronal cell damage against kainic acid induced excitotoxicity. Journal of Bioscience, 28(1), 121-128. Park, Kyeong Mee, Kim, Young Sook, Jeong, Tae Cheon, Joe, C.O., Shin, Han Jae et al., 2001. Nitric oxide is involved in the immunomodulating acivities of acidic polysaccharide from Panax ginseng. Planta Medica, 67(2), 122-126. Patterson, Glenn W., Xu, Sihua and Salt, Thomas A., 1991. Sterols of Caryophyllales with emphasis on Amaranthaceae. Phytochemistry, 30(2), 523-526. Paul, Bernard, Masih, Isaac, Deopujari, Jayant and Charpentier, Claudine, 1999. Occurrence of resveratrol and pterostilbene in age-old darakchasava, an ayurvedic medicine from India. Journal of Ethnopharmacology, 68, 71-76. Paulo, A. and Houghton, P.J., 2003. Chemotaxonomic analysis of the genus Cryptolepis. Biochemical Systematics and Ecology, 31, 155-166.

94
Pavlova, S.I., Uteshev, B.S. and Sergeev, A.V., 2003. Licorice root: possible mechanisms of antitoxicant, anticarcinogen, and antitumor properties (a review). Pharmaceutical Chemistry Journal, 37(6), 314-317. Pearce, Virginia, Nawaz, Zafar, Xiao, Wu, Weidenfeld, David, Boyle, Nick et al., 2003. 4-Ethoxymethylphenol: a novel phytoestrogen that acts as an agonist for human estrogen receptors. Journal of Steroid Biochemistry & Molecular Biology, 84, 431-439. Peres, Valdir, Nagem, Tanus Jorge and de Oliveira, Fernando Faustino, 2000. Tetraoxygenated naturally occurring xanthones. Phytochemistry, 55, 683-710. Piironen, Vieno, Lindsay, David G., Miettinen, Tatu A., Toivo, Jari and Lampi, Anna-Maija, 2000. Plant sterols: biosynthesis, biological function and their importance to human nutrition. Journal of the Science of Food and Agriculture, 80, 939-966. Plunkett, Gregory M. and Lowry, Porter P., 2001. Relationships among "ancient Araliads" and their significance for the systematics of Apiales. Molecular Phylogenetics and Evolution, 19(2), 259-276. Priyadarsini, K. Indira, Maity, Dilip K., Naik, G.H., Kumar, M. Sudheer, Unnikrishnan, M.K. et al., 2003. Role of phenolic O-H and methylene hydrogen on the free radical reactions and antioxidant activity of cucurmin. Free Radical Biology & Medicine, 35(5), 475-484. Provalova, N.V., Skurikhin, E.G., Pershina, O.V., Suslov, N.I., Minakova, M.Yu. et al., 2002. Mechanisms underling the effects of adaptogens on erythropoiesis during paradoxical sleep deprivation. Bulletin of Experimental Biology & Medicine, 133(5), 428-432. Puri, A., Sahai, R., Singh, K.L., Saxena, R.P., Tandon, J.S. et al., 2000. Immunostimulant activity of dry fruits and plant materials used in Indian traditional medical system for mothers after childbirth and invalids. Journal of Ethnopharmacology, 71, 89-92. Puri, H.S., 2003, Rasayana: Ayurvedic Herbs for Longevity and Rejuvenation. Taylor & Francis, New York. Rahman, K.M. Wahidur and Sarkar, Fazlul H., 2002. Steroid hormone mimics: molecular mechanisms of cell growth and apoptosis in normal and malignant mammary epithelial cells. Journal of Steroid Biochemistry & Molecular Biology, 80, 191-201. Ramsewak, Russel S., Nair, Muraleedharan G., Murugesan, Sorimuthu, Mattson, William J. and Zasada, John, 2001. Insecticidal fatty acids and triglycerides from Dirca palustris. Journal of Agricultural and Food Chemistry, 49, 58525856. Raskin, Ilya, Ribnicky, David M., Komamytsky, Slavko, Ilic, Nebojsa, Poulev, Alexander et al., 2002. Plants and human health in the twenty-first century. Trends in Biotechnology, 20(12), 522-531. Rege, Nirmala N., Thatte, Urmila M. and Dahanukar, Sharadini A., 1999. Adaptogenic properties of six rasayana herbs used in Ayurvedic medicine. Phytotherapy Research, 13, 275-291. Robbers, James E., Speedie, Marilyn K. and Tyler, Varro E., 1996, Pharmacognosy and Pharmacobiotechnology. Williams & Wilkins, Baltimore. Ronsted, Nina, Gobel, Edith, Franzyk, Henrik, Jensen, Soren Rosendal and Olsen, Carl Erik, 2000. Chemotaxonomy of Plantago. Iridoid glycosides and caffeoyl phenylethanoid glycosides. Phytochemistry, 55, 337-348. Rosati, Fabiana, Danza, Giovanna, Guarna, Antonio, Cini, Nicoletta, Racchi, Milvia Luisa et al., 2003. New evidence of similarity between human and plant steroid metabolism: 5a-reductase activity in Solanum malacoxylon. Endocrinology, 144(1), 220-229. Roth, I and Lindorf, H., 2002, South American Medicinal Plants. Springer-Verlag Berlin and Heidelberg GmbH & Co. KG, Berlin.

95
Rupprecht, R., 2003. Neuroactive steroids: mechanisms of action and neuropsychopharmacological properties. Psychoneuroendocrinology, 28, 139-168. Ryu, G., Ju, J.H., Park, Y.J., Ryu, S.Y., Choi, B.W. et al., 2002. The radical scavenging effects of stilbene glucosides from Polygonum multiflorum. Archives of Pharmaceutical Research, 25(5), 636-639. Sabban, Esther L. and Kvetnansky, Richard, 2001. Stress-triggered activation of gene expression in catecholaminergic systems: dynamics of transcriptional events. Trends in Neurosciences, 24(2), 91-98. Saeb-Parsy, Kourosh, Assomull, Ravi G., Khan, Fakhar X., Saeb-Parsy, Kasra and Kelly, Eamonn, 1999, Instant Pharmacology. John Wiley & Sons, New York. Said, O., Khalil, K., Fulder, S. and Azaizeh, H., 2002. Ethnopharmacological survey of medicinal herbs in Israel, the Golan Heights and the West Bank region. Journal of Ethnopharmacology, 83, 251-265. Sakina, M.R., Dandiya, P.C., Hamdard, M.E. and Hameed, A., 1990. Preliminary psychopharmacological evaluation of Ocimum sanctum leaf extract. Journal of Ethnopharmacology, 28(2), 143-150. Sapolsky, Robert M., 2003. Stress and plasticity in the limbic system. Neurochemical Research, 28(11), 1735-1742. Sapolsky, Robert M., Krey, Lewis C. and McEwen, Bruce S., 1986. The neuroendocrinology of stress and aging: the glucocorticoid cascade hypothesis. Endocrine Reviews, 7(3), 284-301. Sarker, Satyajit D., Savchenko, Tamara, Whiting, Pensri, Sik, Vladimir, Lafont, Rene et al., 1997. Occurrence of ecdysteroids in the genus Centaurea (Compositae): 20-hydroxyecdysone from Centaurea moschata. Biochemical Systematics and Ecology, 25(4), 367-368. Saso, L., Valentini, G., Casini, M.L., Mattei, E., Braghiroli, L. et al., 1999. Inhibition of protein denaturation by fatty acids, bile salts and other natural substances: a new hypothesis for the mechanism of action of fish oil in rheumatic diseases. Japan Journal of Pharmacology, 79(1), 89-99. Saunders, Richard M.K., 1998, Monograph of Kadsura (Schisandraceae). American Society of Plant Taxonomists, Ann Arbor. Sautebin, Lidia, 2000. Prostaglandins and nitric oxide as molecular targets for anti-inflammatory therapy. Fitoterapia, 71(Suppl. 1), S48-S57. Savchenko, Tamara, Blackford, Michaela, Sarker, Satyajit D. and Dinan, Laurence, 2001. Phytoecdysteroids from Lamium spp: identification and distribution within plants. Biochemical Systematics and Ecology, 29, 891-900. Savchenko, Tamara, Whiting, Pensri, Sarker, Satyajit D. and Dinan, Laurence, 1998. Distribution and identity of phytoecdysteroids in Gomphrena spp. (Amaranthaceae). Biochemical Systematics and Ecology, 26, 337-346. Schepetkin, Igor A., Khlebnikov, Andrei I., Ah, Shin Young, Woo, Sang B., Jeong, Choon-Soo et al., 2003. Characterization and biological activities of humic substances from mumie. Journal of Agricultural and Food Chemistry, 51, 5245-5254. Schliebs, Reinhard, Liebmann, Andre, Bhattacharya, Salil K., Kumar, Ashok, Ghosal, Shibnath et al., 1997. Systemic administration of defined extracts from Withania somnifera (Indian ginseng) and shilajit differentially affects cholinergic but not glutamatergic and gabaergic markers in rat brain. Neurochemistry International, 30(2), 181-190. Schulkin, Jay, 2003, Rethinking Homeostasis: Allostatic Regulation in Physiology and Pathophysiology. The MIT Press, Cambridge. Schwab, Wilfred, 2003. Metabolome diversity: too few genes, too many metabolites? Phytochemistry, 62, 837-849. Selye, Hans, 1936. A syndrome produced by diverse noxious agents. Nature, 138, 32-36.

96
Seo, W.G., Pae, H.O., Oh, G.S., Kim, N.Y., Kwon, T.O. et al., 2001. The aquaeous extract of Rhodiola sachalinensis root enhances the expression of inducible nitric oxide synthase gene in RAW264.7 macrophages. Journal of Ethnopharmacology, 76, 119-123. Shan, B.E., Yoshida, Y., Sugiura, T. and Yamashita, U., 1999. Stimulating activity of Chinese medicinal herbs on human lymphocytes in vitro. International Immunopharmacology, 21, 149-159. Sharma, M.K., Kumar, M. and Kumar, A., 2002. Ocimum sanctum aqueous leaf extract provides protection against mercury induced toxicity in Swiss albino mice. Indian Journal of Experimental Biology, 40(9), 1079-1082. Sheng, Y., Li, L., Holmgren, K. and Pero, R.W., 2001. DNA repair enhancement of aqueous extracts of Uncaria tomentosa in a human volunteer study. Phytomedicine, 8(4), 275-282. Shiao, M.S., 2003. Natural products of the medicinal fungus Ganoderma lucidum: occurrence, biological activities, and pharmacological functions. Chem. Rec., 3(3), 172-180. Shinwari, Muhammad Ibrar and Khan, Mir Ajab, 2000. Folk use of medicinal herbs of Margalla Hills National Park, Islamabad. Journal of Ethnopharmacology, 69, 45-56. Shobi, V. and Goel, H.C., 2001. Protection against radiation-induced conditioned taste aversion by Centella asiatica. Physiology & Behavior, 73, 19-23. Shuya, Cui, Xingguo, Chen and Zhide, Hu, 2003. Identification and determination of ecdysone and phenylpropanoid glucoside and flavonoids in Lamium maculatum by capillary zone electrophoresis. Biomedical Chromatography, 17, 477-482. Singh, A.K., Raghubanshi, A.S. and Singh, J.S., 2002. Medical ethnobotany of the tribals of Sonaghati of Sonbhadra district, Uttar Pradesh, India. Journal of Ethnobotany, 81, 31-41. Singh, Anubha, Saxena, Ekta and Bhutani, K.K., 2000. Adrenocorticosterone alterations in male, albino mice treated with Trichopus zeylanicus, Withania somnifera and Panax ginseng preparations. Phytotherapy Research, 14(2), 122125. Singh, B., Gupta, D.K. and Chandan, B.K., 2001a. Adaptogenic activity of a glyco-peptido-lipid fraction from the alcoholic extract of Trichopus zeylanicus Gaertn. Phytomedicine, 8(4), 283-291. Singh, B., Saxena, A.K., Chandan, B.K., Gupta, D.K., Bhutani, K.K. et al., 2001b. Adaptogenic activity of a novel, withanolide-free aqueous fraction from the roots of Withania somnifera Dun. Phytotherapy Research, 15, 311-318. Singh, H.K. and Dhawan, B.N., 1997. Neuropsychopharmacological effects of the Ayurvedic nootropic Bacopa monniera Linn. (brahmi). Indian Journal of Experimental Biology, 29, S359-S365. Slama, K., Koudela, K., Tenora, J. and Mathova, A., 1996. Insect hormones in vertebrates: anabolic effects of 20hydroxyecdysone in Japanese quail. Experientia, 52, 702-706. Slama, Karel, 1993. Ecdysteroids: insect hormones, plant defensive factors, or human medicine? Phytoparasitica, 21(1), 3-8. Song, E.K., Kim, J.H., Kim, J.S., Cho, H., Nan, J.X. et al., 2003. Hepatoprotective phenolic constituents of Rhodiola sachalinensis on tacrine-induced cytotoxicity in Hep G2 cells. Phytotherapy Research, 17(5), 563-565. Steinkellner, Hans, Rabot, Sylvie, Freywald, Christian, Nobis, Eva, Scharf, Gerlinde et al., 2001. Effects of cruciferous vegetables and their constituents on drug metabolizing enzymes involved in the bioactivation of DNA-reactive dietary carcinogens. Mutation Research, 480-481, 285-297. Sterling, P. and Eyer, J., 1988, Allostasis: A new paradigm to explain arousal pathology. In: S. Fisher and J. Reason (Eds.), Handbook of Life Stress, Cognition and Health. John Wiley & Sons, New York.

97
Stough, C., Lloyd, J., Clarke, J., Downey, L.A., Hutchison, C.W. et al., 2001. The chronic effects of an extract of Bacopa monniera (brahmi) on cognitive function in healthy human subjects. Psychopharmacology, 156, 481-484. Straus, Stephen E., 2002. Herbal medicines--what's in the bottle? New England Journal of Medicine, 347(25), 19971998. Struwe, L., Kadereit, J.W., Klackenberg, J., Nilsson, S., Thiv, M. et al., 2002, Gentianaceae Systematics and Natural History. Cambridge University Press, Cambridge. Subramoniam, A., Evans, D.A., Valsaraj, R., Rajasekharan, S. and Pushpangadan, P., 1999. Inhibition of antigeninduced degranulation of sensitized mast cells by Trichopus zeylandicus in mice and rats. Journal of Ethnopharmacology, 68, 137-143. Suk, Kyoungho, Lee, Heasuk, Kang, Sang Soo, Cho, Gyeong Jae and Choi, Wan Sung, 2003. Flavonoid baicalein attenuates activation -induced cell death of brain microglia. The Journal of Pharmacology and Experimental Therapeutics, 305(2), 638-645. Sumathi, Thangarajan, Nayeem, Mohemed, Balakrishna, Kedike, Veluchamy, Gopalsamy and Devaraj, Sivasithamparam Niranjali, 2002. Alcoholic extract of 'Bacopa monniera' reduces the in vitro effects of morphine withdrawal in guinea-pig ileum. Journal of Ethnopharmacology, 82, 75-81. Sumner, Lloyd W., Mendes, Pedro and Dixon, Richard A., 2003. Plant metabolomics: large-scale phytochemistry in the functional genomics era. Phytochemistry, 62, 817-836. Sun, P., Wen, Y., Y., Xu, Pei, Y., Chen, Y. et al., 1998. The chemical constituents of Epimedium koreanum Nakai. Yao Xue Xue Bao, 33(12), 919-922. Swofford, D.L., 2001. PAUP*: Phylogenetic Analysis Using Parsimony Version 4.0b8; Sinauer Press. Syrov, V.N., 1984. Mechanism of the anabolic action of phytoecdisteroids in mammals. Nauchnye Doki Vyss Shkoly Biol Nauki, 11, 16-20. Syrov, V.N. and Khushbaktova, Z.A., 2001. Experimental study of pharmacotherapeutic effect of phytoecdisteroids and nerobol in toxic liver damage. Eksp Klin Farmakol, 64(4), 56-58. Syrov, V.N. and Kurmukov, A.G., 1976. Anabolic activity of phytoecdysone-ecdysterone isolated from Rhaponticum carthamoides (Willd.) Iljin. Farmakol Toksikol, 39(6), 690-693. Syrov, V.N., Kurmukov, A.G. and Sakhibov, A.D., 1978. Effect of turkesterone and nerobol on the activity of the protein synthesizing system of mouse liver. Vopr Med Khim, 24(4), 456-460. Syrov, V.N., Nasyrova, S.S. and Khushbaktova, Z.A., 1997. The results of experimental study of phytoecdysteroids as erythropoiesis stimulators in laboratory animals. Eksp Klin Farmakol, 60(3). Syrov, V.N., Saatov, Z., Sagdullaev, Sh. Sh. and Mamatkhanov, A.U., 2001. Study of the structure-anabolic activity relationship for phytoecdysteroids extracted from some plants of Central Asia. Pharmaceutical Chemistry Journal, 35(12), 667-671. Syrov, V.N., Tashmukhamedov, M.S., Khushbaktova, Z.A., Mirtalipov, D.T. and Mamatkhanov, A.U., 1992. Effect of phytoecdysteroids and nerobol on parameters of carbohydrate and lipid metabolism and phospholipid spectrum of liver mitochondrial membrane in experimental diabetes mellitus of rats. Ukr Biokhim Zh, 64(4), 61-67. Szabo, Sandor, 1998, Hans Seyle and the development of the stress concept. In: Peter Csermely (Ed.). Annals of the New York Academy of Sciences. The New York Academy of Sciences, New York. Tahiliani, Pankaj and Kar, Anand, 2000. Achyranthes aspera elevates thyroid hormone levels and decreases hepatic lipid peroxidation in male rats. Journal of Ethnopharmacology, 71, 527-532.

98
Takeda, Hiroshi, Tsuji, Minoru, Miyamoto, Junichi and Matsumiya, Teruhiko, 2002. Romarinic acid and caffeic acid reduce the defensive freezing behavior of mice exposed to conditioned fear stress. Psychopharmacology, 164, 233-235. Tamir, Snait, Eizenberg, Mark, Somjen, Dalia, Izrael, Sarit and Vaya, Jacob, 2001. Estrogen-like activity of glabrene and other constituents isolated from licorice root. Journal of Steroid Biochemistry & Molecular Biology, 78, 291-298. Tanahashi, Tetsuy, Mune, Tomoatsu, Morita, Hiroyuki, Tanahashi, Hiromichi, Isomura, Yukinori et al., 2002. Glycyrrhizic acid suppresses type 2 11beta-hydroxysteroid dehydrogenase expression in vivo. Journal of Steroid Biochemistry & Molecular Biology, 80, 441-447. Tanner, Miles A., Bu, Xin, Steimle, J. Alan and Myers, Paul R., 1999. The direct release of nitric oxide by gypenosides derived from the herb Gynostemma pentaphyllum. Nitric Oxide: Biology and Chemistry, 3(5), 359-365. Thie, Krista K., 1999, Medicinal Plants of the Pacific Northwest: A Digest of Anthropological Writings about Native American Uses. Longevity Herb Press, White Salmon. Thomma, B.P., Cammue, B.P. and Thevissen, K., 2003. Mode of action of plant defensins suggest therapeutic principle. Current Drug Targets in Infectious Disorders, 3(1), 1-8. Toda, Noboru, Ayajiki, Kazuhide, Fujioka, Hideyuki and Okamura, Tomio, 2001. Ginsenoside potentiates NOmediated neurogenic vasodilation of monkey cerebral arteries. Journal of Ethnopharmacology, 76, 109-113. Toda, Shizuo and Shirataki, Yoshiaki, 1999. Inhibitory effects of Astragali Radix, a crude drug in Oriental medicines, on lipid peroxidation and protein oxidative modification by copper. Journal of Ethnopharmacology, 68, 331-333. Tolonen, Ari, Pakonen, Minna, Hohtola, Anja and Jalonen, Jorma, 2003. Phenylpropanoid glycosides from Rhodiola rosea. Chemical and Pharmacology Bulletin, 51(4), 467-470. Tomaschko, Karl-Heinz, 1999. Nongenomic effects of ecdysteroids. Archives of Insect Biochemistry and Physiology, 41, 89-98. Trewavas, Anthony and Stewart, Derek, 2003. Paradoxical effects of chemicals in the diet on health. Current Opinion in Plant Biology, 6, 185-190. Trivedi, Neha and Rawal, U.M., 2000. Hepatoprotective and toxicological evaluation of Andrographis paniculata severe liver damage. Indian Journal of Pharmacology, 32, 288-293. Tsarong, Tsewang J., 1994, Tibetan Medicinal Plants. Tibetan Medical Publications, Kalimpong, India. Turner, Nancy J., Thompson, Laurence C., Thompson, M. Terry and York, Annie Z., 1990, Thompson Ethnobotany: Knowledge and Usage of Plants by the Thompson Indians of British Columbia. Royal British Columbia Museum, Victoria. U.S. Congress. 103rd Congress, 2nd Session, Senate, 1994. Dietary Supplement Health and Education Act of 1994, pp. 1-39. Public Law 103-417-October 25, 1994. 103 Congress, pp. 4325-4335. Vega, Andrea S., Castro, Maria A. and Anderson, William R., 2002. Occurrence and phylogenetic significance of latex in the Malpighiaceae. American Journal of Botany, 89(11), 1725-1729. Verpoorte, Robert, 1998. Exploration of nature's chemodiversity: the role of secondary metabolites as leads in drug development. Drug Discovery Today, 3(5), 232-238. Vgontzas, Alexandros N., Tsigos, Constantine, Bixler, Edward O., Stratakis, Constantine A., Zachman, Keith et al., 1998. Chronic insomnia and activity of the stress system: a preliminary study. Journal of Psychosomatic Research, 45(1), 21-31.

99
Viau, V., 2002. Functional cross-talk between the hypothalamic-pituitary-gonadal and -adrenal axis. Journal of Neuroendocrinology, 14, 506-513. Vieira, Roberto F., Grayer, Rene J. and Paton, Alan J., 2003. Chemical profiling of Ocimum americanum using external flavonoids. Phytochemistry, 63, 555-567. Villasenor, I.M., Angelada, J., Canlas, A.P. and Echegoyen, D., 2002. Bioactivity studies on beta-sitosterol and its glucoside. Phytotherapy Research, 16(5), 417-421. Vohora, Divya, Pal, S.N. and Pillai, K.K., 2000. Protection from phenytoin-induced cognitive deficit by Bacopa monniera, a reputed Indian nootropic plant. Journal of Ethnopharmacology, 71, 383-390. Wagner, H., Norr, H. and Winterhoff, H., 1994. Plant adaptogens. Phytomedicine, 1, 63-76. Wagner, Hildebert K.M., 1995, Immunostimulants and adaptogens from plants. In: John T. Arnason, et al. (Ed.), Phytochemistry of Medicinal Plants. Plenum Press, New York. Wahle, Klaus W.J., Rotondo, Dino and Heys, Steven D., 2003. Polyunsaturated fatty acids and gene expression in mammalian systems. Proceedings of the Nutrition Society, 62, 349-360. Walter, Michael H., Fester, Thomas and Strack, Dieter, 2000. Arbuscular mycorrhizal fungi induce the non-mevalonate methylerythritol phosphate pathway of isoprenoid biosynthesis correlated with accumulation of the 'yellow pigment' and other apocarotenoids. The Plant Journal, 21(6), 571-578. Wang, Ching-Chiung, Lai, Jing-Erh, Chen, Lih-Geeng, Yen, Kun-Ying and Yang, Ling-Ling, 2000. Inducible nitric oxide synthase inhibitors of Chinese herbs. Part 2: Naturally occurring furanocoumarins. Bioorganic & Medicinal Chemistry, 8, 2701-2707. Wang, Shufang, Dai, Jingqiu, Chen, Xingguo and Hu, Zhide, 2002. Identification and determination of ecdysones and flavonoids in Serratula strangulata by micellar electrokinetic capillary chromatography. Planta Medica, 68, 1029-1033. Wang, Zheng-Tao, Ma, Gi-Yuan, Tu, Peng-Fei, Xu, Guo-Jun and Ng, Tzi-Bun, 1995. Chemotaxonomic study of Codonopsis (Family Campanulaceae) and its related genera. Biochemical Systematics and Ecology, 23(7/8), 809-812. Watanabe, Hiroshi, 1997. Candidates for cognitive enhancer extracted from medicinal plants: paeoniflorin and tetramethylpyrazine. Behavioural Brain Research, 83, 135-141. Weiss, Rudolf Fritz, 1988, Herbal Medicine. Beaconsfield Publishers Ltd, Beaconsfield. Welshons, W.V., Thayer, K.A., Judy, B.M., Taylor, J.A., Curran, E.M. et al., 2003. Large effects from small exposures. I. Mechanisms for endocrine disrupting chemicals with estrogenic activity. Environmental Health Perspectives, 5494(February), ? Wen, Jun, 1999. Evolution of Eastern Asian and Eastern North American disjunct distributions in flowering plants. Annual Review in Ecology and Systematics, 30, 421-455. Whiting, Pensri, Savchenko, Tamara, Sarker, Satyajit D., Rees, Huw H. and Dinan, Laurence, 1998. Phytoecdysteroids in the genus Limonium (Plumbaginaceae). Biochemical Systematics and Ecology, 26, 695-698. Wilder, Richard, 2001. Protection of Traditional Medicine. Paper No. WG 4: 4, Commission on Macroeconomics and Health, Washington. Williams, Christine A., Harborne, Jeffrey B. and Colasante, Maretta, 1997. Flavonoid and xanthone patterns in bearded Iris species and the pathway of chemical evolution in the genus. Biochemical Systematics and Ecology, 25(4), 309-325. Wink, Michael, 1999, Biochemistry of Plant Secondary Metabolism, vol. 2. Sheffield Academic Press, Ltd, Sheffield.

100
Winkel-Shirley, Brenda, 2002. Biosynthesis of flavonoids and effects of stress. Current Opinion in Plant Biology, 5, 218-223. Winston, David, 1999, Saw Palmetto for Men & Women. Storey Books, Pownal. Winston, David, 2002, Differentiation of herbal immune therapies, Medicines from the Earth 2002. Gaia Herbal Research Institute, Black Mountain, North Carolina, pp. 138-145. Witkowski, A. and Konopa, J., 1981. Binding of the cytotoxic and antitumor triterpenes, cucurbitacins, to glucocorticoid receptors of HeLa cells. Biochimica et Biophysica Acta, 674(2), 246-255. Witkowski, A., Woynarowska, B. and Konopa, J., 1984. Inhibition of the biosynthesis of deoxyribonucleic acid, ribonucleic acid and protein in HeLa S3 cells by cucurbitacins, glucocorticoid-like cytotoxic triterpenes. Biochemical Pharmacology, 33(7), 995-1004. Wojciechowski, M.F., Sanderson, M.J., Steele, K.P. and Liston, A., 2000, Molecular phylogeny of the "temperate herbaceous tribes" of papilionoid legumes: a supertree approach. In: P. Herendeen and A. Brueneau (Eds.), Advances in Legume Systematics. Royal Botanic Gardens, London, pp. 277-298. Wu, Hao, Lien, Eric J. and Lien, Linda L., 2003a, Chemical and pharmacological investigations of Epimedium species: a survey. In: Ernst Jucker (Ed.), Progress in Drug Research. Birkhauser Verlag, Boston. Wu, Jiu-Wong, Morris-Natschke, Susan L. and Lee, Kuo-Hsiung, 2003b. Progress in the recent discovery and developent of promising anticancer and anti-HIV agents from natural products in the United States. Journal of the Chinese Chemical Society, 50, 11-22. Wu, T., Cui, L., Zhang, Z., Chen, Z., Li, Q. et al., 1996. Experimental study on antagonizing action of herba Epimedii on side effects induced by glucocorticoids. Zhongguo Zhong Yao Za Zhi, 21(12), 748-751. Yamashita, Koichi, Lu, Huangwei, Lu, Jincai, Chen, Guang, Yokoyama, Takeshi et al., 2002. Effect of three triterpenoids, lupeol, betulin, and betulinic acid on the stimulus-induced superoxide generation and tyrosyl phosphorylation of proteins in human neutrophils. Clinica Chimica Acta, 325, 91-96. Yoshikawa, Masayuki, Xu, Fengming, Morikawa, Toshio, Ninomiya, Kiyofumi and Matsuda, Hisashi, 2003. Anastatins a and b, new skeletal flavonoids with hepatoprotective activities from the desert plant Anastatica hierochuntica. Bioorganic & Medicinal Chemistry Letters, 13, 1045-1049. Yu, C.Y., Kim, S.H., Lim, J.D., Kim, M.J. and Chung, I.M., 2003. Intraspecific relationship analysis by DNA markers and in vitro cytotoxic and antioxidant activity in Eleutherococcus senticosus. Toxicology in Vitro, 17, 229-236. Yu, R., Wang, D.S. and Zhou, H., 1996. Clinical and experimental study of effects of yinchen wuling powder in preventing and treating hyperlipoproteinemia. Zhongguo Zhong Yao Za Zhi, 16(8), 470-473. Yuan, C.S., Attele, A.S., Wu, J.A. and Liu, D., 1998. Modulation of American ginseng on brainstem GABAergic effects in the rat. Journal of Ethnopharmacology, 63, 215-222. Yuda, Masamichi, Ohtani, Kazuhiro, Mizutani, Kenji, Kasai, Ryoji, Tanaka, Osamu et al., 1990. Neolignan glycosides from roots of Codonopsis tangshen. Phytochemistry, 29(6), 1989-1992. Zainol, M.K., Abd-Hamid, A., Yusof, S. and Muse, R., 2003. Antioxidative activity and total phenolic compounds of leaf, root and petiole of four accessions of Centella asiatica (L.) Urban. Food Chemistry, 81, 575-581. Zerhouni, Elias, 2003. The NIH roadmap. Science, 302(3 October), 63-64, 72. Zhang, Hai Yan and Tang, Xi Can, 2003. Huperzine A attenuates the neurotoxic effect of staurosporine in primary rat cortical neurons. Neuroscience Letters, 340, 91-94.

101
Zhang, J.T., 2002. New drugs derived from medicinal plants. Therapie, 57(2), 137-150. Zhang, Yong-Hong, Cheng, Jie-Kai, Yang, Li and Cheng, Dong-Liang, 2002a. Triterpenoids from Rhaponticum uniflorum. Journal of the Chinese Chemical Society, 49, 117-124. Zhang, You-Wei, Dou, De-Qiang, Zhang, Lei, Chen, Yin-Jie and Yao, Xin-Sheng, 2001. Effects of ginsenosides from Panax ginseng on cell-to-cell communication function mediated by gap junctions. Planta Medica, 67, 417-422. Zhang, Zhong-Qi, Yuan, Li, Yang, Ming, Luo, Zhi-Pu and Zhao, Yi-Min, 2002b. The effect of Morinda officinalis How, a Chinese traditional medicinal plant, on the DRL 72-s schedule in rats and the forced swimming test in mice. Pharmacology, Biochemistry and Behavior, 72, 39-43. Zhou, Jin, Zhang, Hai Yan and Tang, Xi Can, 2001. Huperzine A attenuates cognitive deficits and hippocampal neuronal damage after transient global ischemia in gerbils. Neuroscience Letters, 313, 137-140. Zhu, Min and Li, Ronald C., 1999. Receptor binding activities of Schefflera triterpenoids and oligosaccharides. Planta Medica, 65, 99-103. Zhuravlev, IuN, Artiukova, E.V., Kozyrenko, M.M. and Reunova, G.D., 2003. Genetic relationships among far eastern species of the family Araliaceae inferred by RAPD analysis. Genetika, 39(1), 57-63. Zibareva, L.N., Girault, J.P., Dinan, L. and Lafont, R., 2002, Chemotaxonomic value of phytoecdysteroid profiles in the genus Silene (Caryophyllaceae), XV International Ecdysone Workshop, pp. 25. Zibareva, L.N., Volodin, Vladimir, Saatov, Zyadilla, Savchenko, Tamara, Whiting, Pensri et al., 2003. Distribution of phytoecdysteroids in the Caryophyllaceae. Phytochemistry, 64, 499-517. Zierau, Oliver, Bodinet, Claudia, Kolba, Susanne, Wulf, Marina and Vollmer, Gunter, 2002. Antiestrogenic activities of Cimicifuga racemosa extracts. Journal of Steroid Biochemistry & Molecular Biology, 80, 125-130. Zorrilla, Eric P., Valdez, Glenn R., Nozulak, Joachim, Koob, George F. and Markou, Athina, 2002. Effects of antalarmin, a CRF type I receptor antagonist, on anxiety-like behavior and motor activation in the rat. Brain Research, 952, 188-199.

Robyn Klein 2006 www.rrreading.com Phylogenetic and phytochemical characteristics of plant species with adaptogenic properties MS Thesis, 2004, Montana State University Citations