WHAT IS DRUG REPURPOSING: Identification of alternative indications for known drugs or compounds WHY DRUG REPURPOSING?

Significant cost advantage as clinically tested and safer drugs are classically employed for repurposing Shorter path to regulatory approval due to preexisting PK, safety and toxicology data Efficacy for proposed therapeutic indication is the only criterion to be fulfilled Smart way to reduce risks for drug discovery and development organizations KEY FEATURES: Identification of novel therapeutic indications for a given drug or compound Repurposing recommendations for the candidate drug could be extended to in-house preclinical discovery service Proven expertise in conventional drug centric repurposing studies extended to target centric or disease centric studies Combination of strategies includes structural similarity, gene expression, interactome, metabolic pathways, off target effects etc. Multi domain expertise in handling database and biology aspects of drug repurposing Comprehensive Drug Repurposing Report Generation with evidence supported recommendations Customized repurposing solutions to suit multiple/changing priorities of drug discovery and development setups Ability to develop an online query based repurposing tool suitable to the clients needs

DRUG REPURPOSING AT GVKBIO: Repurposing of the candidate drug or chemical compound using number of different strategies Repurposing strategies include but not limited to Structural similarity, Genomic, GWAS, Literature, Interactome, Adverse events and Pathways. Repurposing work flow explores virtually all aspects of Drug-Target-Pathway-Disease associations through comprehensive analysis of public and proprietary databases Robust in silico platform to recommend novel drugtarget-disease associations based on integrated information from all the different approaches Flexibility to initiate repurposing activity centered around the Drug, Target or Disease to discover novel alternative indications

DRUG REPURPOSING

SERVICE OFFERINGS: FFS Model: Fee for service to identify novel therapeutic indications for a given candidate drug FTE Model: FTE based drug repurposing analysis to identify possible repurposing candidates using GVKBIO proprietary tools and databases Pre-clinical Package: Option to include preclinical discovery package for the novel recommendations Collaborative Research: Collaborative research effort to generate candidate drug molecule pipeline for clinical studies

GVKBIO EXPERTISE: GVKBIO has large collection of proprietary data in multiple areas such as Structure Activity Relationship, Pharmacology, Biology, Biomarker and Clinical Pharmacology to support the drug repurposing pipeline and offer best- in-class recommendations GVKBIO has more than 10 years experience in data mining, curation and analysis aspects comprising the prime components in identification of novel therapeutics for existing drugs GVKBIO is distinguished as one of the largest CRO in Southeast Asia providing a complete range of drug discovery contract services under one roof. Provides complete drug repurposing package services which includes in-silico, in-vitro and invivo experimental capabilities.

GVK Biosciences 5457 Twin Knolls Road,Suite 101 Columbia, MD 21045 Tel : 001 443 542 5805 Fax: 001 703 940 4088 Email: sreeni.devidas@gvkbio.com Web: www.gvkbio.com

Corporate Address GVK Biosciences Private Limited Plot No. 28 A, IDA Nacharam Hyderabad 500076, INDIA Tel : +91 40 66929999 Fax : +91 40 66929900 Web: www.gvkbio.com