Drug Data Generic Name trihexypheni dyl Trade Name Artane, Trihexane, Trihexy Patients Dose

Classification Therapeutic Antiparkinson agents Pharmacologic anitcholinergics Pregnanc" Categor" C

Minimum Dose PO 1mg/day Ma!imum Dose PO 15mg/day Contents trihexyphenidyl Availabilit " and color Tablets: 2mg, 5mg Elixir: 2mg/5ml Routes of administr ation PO

Mechanism of Action Trihexyphenidyl is a tertiary amine antim scarinic, !hich competiti"ely inhibits the e##ects o# acetylcholine at the m scarinic receptors o# a tonomic e##ector sites inner"ated by parasympathetic ner"es$ %t also brings abo t direct and indirect antispasmodic action on smooth m scle$ Pharmaco#ineti cs A Trihexyphenidyl is absorbed !ell #rom the &% tract a#ter oral admin !ith e##ects "isible a#ter 1 hr$ D 'nkno!n M$% (ainly excreted in the rine$ Onset 1hr$ Pea# 2)*hrs$ Duration +)12hrs$ Drug &alf 'ife *$*),$1hrs$

Indication General Indications Ad- nct in the management o# parkinsonian syndrome o# many ca ses, incl ding dr g) ind ced parkinsonism$ Patients Actual Indication

Contraindications .ypersensiti"ity/ Angleclos re gla coma/ Ac te hemorrhage / Tachycardia secondary to cardiac ins ##iciency/ Thyrotoxicosis/ 0no!n alcohol intolerance 1elixir only2$ Precaution &eriatric and "ery yo ng patients 1increased risk o# ad"erse reactions2/ %ntestinal obstr ction or in#ection/ Prostatic hyperplasia/ 3hronic renal, hepatic, p lmonary, or cardiac disease/ Pregnancy, lactation, or children 1sa#ety not established2 $Drug interaction (drug to drug Other anticholinergic dr gs: side e##ects o# trihexyphenidyl may be increased$ 4 inidine: increase anticholinergic action 1 partic lar on A5 cond ction2 Antipsychotics: long term se o# trihexyphenidyl may mask or increase risk o# tardi"e dyskinesia$ (etoclopromide: action o# metoclopramide is decreased$ Alcohol: risk o# serio s intoxication

Adverse Reaction CN) di66iness, ner"o sness , con# sion, dro!siness, headache, psychoses, !eakness$ %%NT bl rred "ision, mydriasis$ C* orthostatic hypotension , tachycardia$ GI dry mo th, na sea, constipation , "omiting$ G+ rinary hesitancy, rinary retention$ Derm decreased s!eating$

Nursing Responsibilities ,efore 1$ Asses patient7s diagnosis$ 2$ Assess patient7s mental stat s$ *$ Take 5/8 o# patient$ ,$ 3on#irm medication #rom doctor7s orders$ 5$ Obtain prescribed dose$ During 1$ 3on#irm patient7s identity$ 2$ Administer medication at the right prescribed ro te$ *$ 9o not go o"er the recommended dose$ ,$ Practice aseptic techni: e$ 5$ Administer medication !ith #ood$ After 1$ Obser"e proper doc mentation o# administered medication$ 2$ Ens re that patient has # lly s!allo!ed oral #orm o# medication$ *$ Obser"e patient7s beha"ior closely #or atleast 15)*; min tes a#ter administration$ ,$ (onitor patient7s 5/8 thro gho t the therapy$ 5$ %nstr ct patient to rest to decrease risk o# #alls$

)ource 9eglin, <$ et$ Al$ 2;;=$ 9a"is7s 9r g & ide #or > rses$ 12 th ed$ ?$A$ 9a"is$ pp 1**@