dwdwwsssMcDonald TJ, Nathanielsz PW: Bilatewqwqewral 5. Friedman E: The graphic analysis of labor. Am J Obstet Gynecol 1954; 68:1568. 6.

1991; 165:764. 5. Friedman E: The graphic analywwwsis of labor. Am Jdsa Obstet Gynecol 1954; 68:1568. 6. Friedman EA 199132324323321ewqewq2132111 col 1954; 68:1568. sds 6. Friedman EA 1991 labor. Am J Obstet Gynecwwqewq 1954; 68:1568. labor. Am J Obstet Gynecol 1954; 68:1568. 6. Friedman EA 1991 labor. Am J Obstet Gynecol 1954; 68:1568. 6. Friedman EA 83. Jansson T, Wennergren M, Illsley NP: retardation. J Clin Endocrinol Metab 1993; 77: 2825. 85. Wright EM, Loo DD,. 86. Heilig CW, Brosius III FC, Henry DN: Glucose transporters of the glomerulus and the implications for diabetic nephropathy. Kidney Int Suppl 1997; 60:S91. 87. Ciaraldi TP, Kolterman OE, Siegel JA, Olefsky JM: Insulin-stimulated glucose transport in human adipocytes. Am J Physiol 1979; 236:E621. 88. Charron MJ, Katz EB, Olson AL: GLUT4 gene regulation and manipulation. J Biol Chem 1999; 274:3253. 89. Livingstone C, Thomson FJ, Arbuckle MI, et al: Hormonal regulation of the insulinresponsive glucose transporter, GLUT4: some recent advances. Proc Nutr Soc 1996; 55:179. 90. Johnson LW, Smith CH: Monosaccharide transport across microvillous membrane of human placenta. Am J Physiol 1980; 236:E621. 91. Bissonnette JM, Ingermann RL, Th, Silverman M.: Sugar uptake into brush border vesicles from normal human kidney. Pro Natl Acad Sci U S A 1977; 74:2825. 85. Wright EM, Loo DD, Panayotova-Heiermann M, et al: Active sugar transport in eukaryotes. J Exp Biol 1994; 196:197. 86. Heilig CW, Brosius III FC, Henry DN: Glucose transporters of the glomerulus and the implications for diabetic nephropathy. Kidney Int Suppl 1997; 60:S91.

87. Ciaraldi TP, Kolterman OE, Siegel JA, Olefsky JM: Insulin-stimulated glucose transport in human adipocytes. Am J Physiol 1979; 236:E621. 88. Charron MJ, Katz EB, Olson AL: GLUT4 gene regulation and manipulation. J Biol Chem 1999; 274:3253. 89. Livingstone C, Thomson FJ, Arbuckle MI, et al: Hormonal regulation of the insulinresponsive glucose transporter, GLUT4: some recent advances. Proc Nutr Soc 1996ronburg KL: Placental sugar transport. In: Yudilevich DL, Mann GE, ed. Carrier-mediated transport of solutes from blood to tissue, London: Longman; 1985:65. 92. Cordero Jr L, Yeh SY, Grunt JA, Anderson GG: Hypertonic glucose infusion during labor. Am J Obstet Gynecol 1970; 407:295. 93. Baumann MU, Deborde S, Illsley NP: Placental glucose transfer and fetal growth. Endocrine 2002; 19:13. 94. Jansson T, 94. Jansson T, Ekstrand Y, Bjorn C, et al: Alterations in the activity of placental amino acid transporters in preg 94. Jansson T, Ekstrand Y, Bjorn C, et al: Alterations in the activity of placental amino acid transporters in preg 94. Jansson T, Ekstrand Y, Bjorn C, et al: Alterations in the activity of placental amino acid transporters in preg nancies complicated by diabetes. Diabetes 2002; 51:2214. 95. Jansson T, Ylven K, Wennergren M, Powell TL: Glucose transport and system A activity in syncytiotrophoblast microvillous and basal plasma membranes in intrauterine growth restriction. Placenta 2002; 23:392. 96. Hahn T, Barth S, Graf R, et al: Placental glucose transporter expression is regulated by glucocorticoids. J Clin Endocrinol Metab 1999; 84:1445. 97. Hauguel-de MS, Challier JC, Kacemi A, et al: The GLUT3 glucose transporter isoform is differentially expressed within human placental cell types. J Clin Endocrinol Metab 1997; 82:2689. 98. Lesage J, Hahn D, Leonhardt M, et al: Maternal undernutrition during late gestation-induced intrauterine growth restriction in the rat is associated with impaired placental GLUT3 expression, but does not correlate with endogenous corticosterone levels. J Endocrinol 2002; 174:37. 99. Regnault TR, de VB, Battaglia FC: Transport and metabolism of amino acids in placenta. Endocrine 2002; 19:23.

100. Ruzycki SM, Kelly LK, Smith CH: Placental amino acid uptake. IV. Transport by microvillous membrane vesicles. Am J Physiol 1978; 234:C27. 101. Boyd CAR, Lund EK: L-Proline transport by brush border membrane vesicles prepared from human placenta. J Physiol 1981; 315:9. 102. Whitsett JA, Wallick ET: [3H] Oubain binding and Na+-K-ATPase activity in human placenta. Am J Physiol 1980; 238:E38. 103. Zerangue N, Kavanaugh MP: ASCT-1 is a neutral amino acid exchanger with chloride channel activity. J Biol Chem 1996; 271:27991. 104. Chillaron J, Estevez R, Mora C, et al: Obligatory amino acid exchange via systems bo,+like and y+L-like. A tertiary active transport mechanism for renal reabsorption of cystine and dibasic amino acids. J Biol Chem 1996; 271:17761. 105. Torres-Zamorano V, Leibach FH, Ganapathy V.: Amino acid transporter ATB degree. Biochem Biophys Res Commun 1998; 245:824. 106. Hoeltzli SD, Smith CH: Alanine transport systems in isolated basal plasma membrane of human placenta. Am J Physiol 1989; 256:C630. 107. Johnson LW, Smith CH: Neutral amino acid transport systems of microvillous membrane of human placenta. Am J Physiol 1988; 254:C773. 108. Karl PI, Fisher SE: Taurine transport by microvillous membrane vesicles and the perfused cotyledon of the human placenta. Am J Physiol 1990; 258:C443. 109. Liu W, Leibach FH, Ganapathy V.: Characterization of the glycine transport system GLYT 1 in human placental choriocarcinoma cells (JAR). Biochim Biophys Acta 1994; 1194:176. 110. Malandro MS, Beveridge MJ, Kilberg MS, Novak DA: Ontogeny of cationic amino acid transport systems in rat placenta. Am J Physiol 1994; 267:C804. 111. Novak DA, Beveridge MJ: Glutamine transport in human and rat placenta. Placenta 1997; 18:379. 112. Kamath SG, Furesz TC, Way BA, Smith CH: Identification of three cationic amino acid transporters in placental trophoblast: cloning, expression, and characterization of hCAT-1. J Membr Biol 1999; 171:55. 113. Furesz TC, Moe AJ, Smith CH: Lysine uptake by human placental microvillous membrane: comparison of system y+ with basal membrane. Am J Physiol 1995; 268:C755. 114. Hoeltzli SD, Kelley LK, Moe AJ, Smith CH: Anionic amino acid transport systems in isolated basal plasma membrane of human placenta. Am J Physiol 1990; 259:C47.

115. Moe AJ, Smith CH: Anionic amino acid uptake by microvillous membrane vesicles from human placenta. Am J Physiol 1989; 257:C1005. 116. Noorlander CW, de Graan PN, Nikkels PG, et al: Distribution of glutamate transporters in the human placenta. Placenta 2004; 25:489. 117. Matthews JC, Beveridge MJ, Malandro MS, et al: Activity and protein localization of multiple glutamate transporters in gestation day 14 vs. day 20 rat placenta. Am J Physiol 1998; 274:C603. 118. Cariappa R, Heath-Monnig E, Smith CH: Isoforms of amino acid transporters in placental syncytiotrophoblast: plasma membrane localization and potential role in maternal/fetal transport. Placenta 2003; 24:713. 119. Novak D, Matthews J.: Glutamate transport by Rcho-1 cells derived from rat placenta. Pediatr Res 2003; 53:1025. 120. Novak D, Quiggle F, Artime C, Beveridge M.: Regulation of glutamate transport and transport proteins in a placental cell line. Am J Physiol Cell Physiol 2001; 281:C1014. 121. Smith CH, Adcock EW, Teasdale F, et al: Placental amino acid uptake: Tissue preparation, kinetics, and preincubation effect. Am J Physiol 1973; 224:558. 122. Smith CH, Depper R: Placental amino acid uptake. II. Tissue preincubation, fluid distribution and mechanisms of regulation. Pediatr Res 1974; 8:697. 123. Longo LD, Yuen P, Gusseck DJ: Anaerobic glycogen-dependent transport of amnio acids by the placenta. Nature 1973; 243:531. 124. Karl PI, Alpy KL, Fisher SE: Amino acid transport by the cultured human placental trophoblast: effect of insulin on AIB transport. Am J Physiol 1992; 262:c834. 125. Karl PI: Insulin-like growth factor-1 stimulates amino acid uptake by the cultured human placental trophoblast. J Cell Physiol 1995; 165:83. 126. Glazier JD, Sibley CP, Carter AM: Effect of fetal growth restriction on system A amino acid transporter activity in the maternal facing plasma membrane of rat syncytiotrophoblast. Pediatr Res 1996; 40:325. 127. Mahendran D, Donnai P, Glazier JD, et al: Amino acid (system A) transporter activity in microvillous membrane vesicles from the placentas of appropriate and small for gestational age babies. Pediatr Res 1993; 34:661. 128. Moores Jr RR, Vaughn PR, Battaglia FC, et al: Glutamate metabolism in fetus and placenta of late-gestation sheep. Am J Physiol 1994; 267:R89.

129. Vaughn PR, Lobo C, Battaglia FC, et al: Glutamine-glutamate exchange between placenta and fetal liver. Am J Physiol 1995; 268:E705. 130. Cetin I, Fennessey PV, Quick Jr AN, et al: Glycine turnover and oxidation and hepatic serine synthesis from glycine in fetal lambs. Am J Physiol 1991; 260:E371. 131. van der Vusse GJ, van Bilsen M, Glatz JF, et al: Critical steps in cellular fatty acid uptake and utilization. Mol Cell Biochem 2002; 239:9. 132. Campbell FM, Dutta-Roy AK: Plasma membrane fatty acid-binding protein (FABPpm) is exclusively located in the maternal facing membranes of the human placenta. FEBS Lett 1995; 375:227. 133. Campbell FM, Bush PG, Veerkamp JH, Dutta-Roy AK: Detection and cellular localization of plasma membraneassociated and cytoplasmic fatty acidbinding proteins in human placenta. Placenta 1998; 19:409. 134. Larque E, Demmelmair H, Berger B, et al: In vivo investigation of the placental transfer of (13)C-labeled fatty acids in humans. J Lipid Res 2003; 44:49. 135. Bildirici I, Roh CR, Schaiff WT, et al: The lipid droplet-associated protein adipophilin is expressed in human trophoblasts and is regulated by peroxisomal proliferator-activated receptorgamma/retinoid X receptor. J Clin Endocrinol Metab 2003; 88:6056. 136. Gimeno RE, Hirsch DJ, Punreddy S, et al: Targeted deletion of fatty acid transport protein-4 results in early embryonic lethality. J Biol Chem 2003; 278:49512. 137. Dancis J, Jansen V, Kayden HJ, et al: Transfer across perfused human placenta. 3. Effect of chain length on transfer of free fatty acids. Pediatr Res 1974; 8:796. 138. Honda M, Lowy C, Thomas CR: The effects of maternal diabetes on placental transfer of essential and non-essential fatty acids in the rat. Diabetes Res 1990; 15:47. 139. Haggarty P, Page K, Abramovich DR, et al: Long-chain polyunsaturated fatty acid transport across the perfused human placenta. Placenta 1997; 18:635. 140. Haggarty P: Placental regulation of fatty acid delivery and its effect on fetal growtha review. Placenta 2002; 23(Suppl A):S28. 141. Stammers J, Stephenson T, Colley J, Hull D.: Effect on placental transfer of exogenous lipid administered to the pregnant rabbit. Pediatr Res 1995; 38:1026. 142. Hoggard N, Haggarty P, Thomas L, Lea RG: Leptin expression in placental and fetal tissues: does leptin have a functional role?. Biochem Soc Trans 2001; 29:57.

143. Madsen EM, Lindegaard ML, Andersen CB, et al: Human placenta secretes apolipoprotein B-100containing lipoproteins. J Biol Chem 2004; 279:55271. 144. Faber JJ, Thornburg KL: Fetal homeostasis in relation to placental water exchange. Ann Rech Vet 1977; 8:353. 145. Dancis J, Kammerman BS, Jansen V, et al: Transfer of urea, sodium, and chloride across the perfused human placenta. Am J Obstet Gynecol 1981; 141:677. 146. Faber JJ, Thornburg KL: Placental Physiology, New York: Raven Press; 1983:95. 147. Faber J, Thornburg K.: The forces that drive inert solutes and water across the epitheliochorial placentae of the sheep and the goat and the haemochorial placentae of the rabbit and the guinea pig. Placenta 1981; 2:203. 148. Battaglia F, Prystowsky H, Smisson C, et al: The effect of the administration of fluids intravenously to mothers upon the concentrations of water and electrolytes in plasma of human fetuses. Pediatrics 1960; 25:2. 149. Reynolds SRM: Multiple simultaneous intervillous space pressures recorded in several regions of the hemochorial palcenta in relation to functional anatomy of the fetal cotyledon. Am J Obstet Gynecol 1968; 102:1128. 150. Seeds AE: Water metabolism in the fetus. Am J Obstet Gynecol 1965; 92:727. 151. Anderson DF, Faber JJ: Water flux due to colloid osmotic pressures across the haemochorial placenta of the guinea pig. J Physiol 1982; 332:521. 152. Wilbur WJ, Power GG, Longo LD: Water exchange in the placenta: a mathematical model. Am J Physiol 1978; 235:R181. 153. Sebire NJ, Talbert D: The dynamic placenta: II. Hypothetical model of a fetus driven transplacental water balance mechanism producing low apparent permeability in a highly permeable placenta. Med Hypotheses 2004; 62:520. 154. Brownbill P, Bell NJ, Woods RJ, et al: Neurokinin B is a paracrine vasodilator in the human fetal placental circulation. J Clin Endocrinol Metab 2003; 88:2164. 155. Ma T, Yang B, Verkman AS: Cloning of a novel water and urea-permeable aquaporin from mouse expressed strongly in colon, placenta, liver, and heart. Biochem Biophys Res Commun 1997; 240:324. 156. Hasegawa H, Lian SC, Finkbeiner WE, Verkman AS: Extrarenal tissue distribution of CHIP28 water channels by in situ hybridization and antibody staining. Am J Physiol 1994; 266:C893.

157. Damiano A, Zotta E, Goldstein J, et al: Water channel proteins AQP3 and AQP9 are present in syncytiotrophoblast of human term placenta. Placenta 2001; 22:776. 158. Stulc J: Placental transfer of inorganic ions and water. Physiol Rev 1997; 77:805. 159. Moe AJ: Placental amino acid transport. Am J Physiol 1995; 268:C1321. 160. Lajeunesse D, Brunette MG: Sodium gradientdependent phosphate transport in placental brush border membrane vesicles. Placenta 1988; 9:117. 161. Balkovetz DF, Leibach FH, Mahesh VB, et al: Na+-H+ exchanager of human placental brush-border membrane: Identification and characterization. Am J Physiol 1986; 251:C852. 162. Wang H, Huang W, Fei YJ, et al: Human placental Na+-dependent multivitamin transporter. Cloning, functional expression, gene structure, and chromosomal localization. J Biol Chem 1999; 274:14875. 163. Prasad PD, Ramamoorthy S, Leibach FH, Ganapathy V.: Characterization of a sodiumdependent vitamin transporter mediating the uptake of pantothenate, biotin and lipoate in human placental choriocarcinoma cells. Placenta 1997; 18:527. 164. Clarson LH, Greenwood SL, Mylona P, Sibley CP: Inwardly rectifying K(+) current and differentiation of human placental cytotrophoblast cells in culture. Placenta 2001; 22:328. 165. Page KR, Ashworth CJ, McArdle HJ, et al: Sodium transport across the chorioallantoic membrane of porcine placenta involves the epithelial sodium channel (ENaC). J Physiol 2003; 547:849. 166. Bara M, Challier JC, Guit-Bara A.: Membrane potential and input resistance in syncytiotrophoblast of human term placenta in vitro. Placenta 1988; 9:139. 167. Powell TL, Lundquist C, Doughty IM, et al: Mechanisms of chloride transport across the syncytiotrophoblast basal membrane in the human placenta. Placenta 1998; 19:315. 168. Doughty IM, Glazier JD, Greenwood SL, et al: Mechanisms of maternofetal chloride transfer across the human placenta perfused in vitro. Am J Physiol 1996; 271:R1701. 169. Doughty IM, Glazier JD, Powell TL, et al: Chloride transport across syncytiotrophoblast microvillous membrane of first trimester human placenta. Pediatr Res 1998; 44:226. 170. Driver PM, Rauz S, Walker EA, et al: Characterization of human trophoblast as a mineralocorticoid target tissue. Mol Hum Reprod 2003; 9:793. 171. Sibley CP, Glazier JD, Greenwood SL, et al: Regulation of placental transfer: the Na(+)/H(+) exchangera review. Placenta 2002; 23(Suppl A):S39.

172. Persson A, Johansson M, Jansson T, Powell TL: Na(+)/K(+)-ATPase activity and expression in syncytiotrophoblast plasma membranes in pregnancies complicated by diabetes. Placenta 2002; 23:386. 173. Care AD, Ross R, Pickard DW, et al: Calcium homeostasis in the fetal pig. J Devel Physiol 1982; 4:85-106. 174. Fisher GJ, Kelly LK, Smith CH: ATP-dependent calcium transpsort across basal plasma membranes of human placental trophoblast. Am J Physiol 1987; 252:C38. 175. Borke JL, Caride A, Verma AK, et al: Calcium pump epitopes in placental trophoblast basal plasma membranes. Am J Physiol 1989; 257:c341. 176. Belkacemi L, Bedard I, Simoneau L, Lafond J: Calcium channels, transporters and exchangers in placenta: a review. Cell Calcium 2005; 37:1-8. 177. Brunette MG, Leclerc M.: Ca2+ transport through the brush border membrane of human placenta syncytiotrophoblasts. Can J Physiol Pharmacol 1992; 70:835. 178. Kamath SG, Kelley LK, Friedman AF, Smith CH: Transport and binding in calcium uptake by microvillous membrane of human placenta. Am J Physiol 1992; 262:C789. 179. Belkacemi L, Simoneau L, Lafond J.: Calcium-binding proteins: distribution and implication in mammalian placenta. Endocrine 2002; 19:57. 180. Desoye G, Hartmann M, Jones CJ, et al: Location of insulin receptors in the placenta and its progenitor tissues. Microsc Res Tech 1997; 38:63. 181. Malassine A, Alsat E, Besse C, et al: Acetylated low density lipoprotein endocytosis by human syncytiotrophoblast in culture. Placenta 1990; 11:191. 182. Wittmaack FM, Gafvels ME, Bronner M, et al: Localization and regulation of the human very low density lipoprotein/apolipoprotein-E receptor: trophoblast expression predicts a role for the receptor in placental lipid transport. Endocrinology 1995; 136:340. 183. Wyne KL, Woollett LA: Transport of maternal LDL and HDL to the fetal membranes and placenta of the Golden Syrian hamster is mediated by receptor-dependent and receptorindependent processes. J Lipid Res 1998; 39:518. 184. Fuchs R, Ellinger I.: Endocytic and transcytotic processes in villous syncytiotrophoblast: role in nutrient transport to the human fetus. Traffic 2004; 5:725. 185. Loh TT, Higuchi DA, van Bockxmeer FM: Transferrin receptors on the human placental microvillus membrane. J Clin Invest 1980; 65:1182.

186. Ellinger I, Schwab M, Stefanescu A, et al: IgG transport across trophoblast-derived BeWo cells: a model system to study IgG transport in the placenta. Eur J Immunol 1999; 29:733. 187. Bright NA, Ockleford CD, Anwar M.: Ontogeny and distribution of Fc gamma receptors in the human placenta. Transport or immune surveillance? J Anat 1994; 184(Pt 2):297. 188. Woollett LA: Origin of cholesterol in the fetal golden Syrian hamster: contribution of de novo sterol synthesis and maternal-derived lipoprotein cholesterol. J Lipid Res 1996; 37:1246. 189. Lin DS, Pitkin RM, Connor WE: Placental transfer of cholesterol into the human fetus. Am J Obstet Gynecol 1977; 128:735. 190. Sooranna SR, Moss J, Contractor SF: Comparison of the intracellular pathways of immunoglobulin-G and low density lipoprotein in cultured human term trophoblast cells. Cell Tissue Res 1993; 274:619. 191. Radulescu L, Antohe F, Jinga V, et al: Neonatal Fc receptors discriminates and monitors the pathway of native and modified immunoglobulin G in placental endothelial cells. Hum Immunol 2004; 65:578. 192. Douglas GC, King BF: Uptake and processing of 125I-labelled transferrin and 59Felabelled transferrin by isolated human trophoblast cells. Placenta 1990; 11:41. 193. Liu J, Shapiro JI: Endocytosis and signal transduction: basic science update. Biol Res Nurs 2003; 5:117. 194. Jayanthi LD, Samuvel DJ, Ramamoorthy S: Regulated internalization and phosphorylation of the native norepinephrine transporter in response to phorbol esters. Evidence for localization in lipid rafts and lipid raft-mediated internalization. J Biol Chem 2004; 279:19315. 195. Rosenfeld CR: Circulatory changes in the reproductive tissues of ewes during pregnancy. Gynecol Invest 1974; 5:252. 196. Longo LD, Ching KS: Placental diffusing capacity for carbon monoxide and oxygen in unanesthetized sheep. J Appl Physiol 1977; 43:885. 197. Bissonnette JM, Wickham WK: Placental diffusing capacity for carbon monoxide in unanesthetized guinea pigs. Respir Physiol 1977; 31:161. 198. Rosenfeld CR, Cox BE, Roy T, Magness RR: Nitric oxide contributes to estrogen-induced vasodilation of the ovine uterine circulation. J Clin Invest 1996; 98:2158. 199. Assali NS, Douglas RA, Barid WW, et al: Measurement of uterine blood flow and uterine metabolism. Am J Obstet Gynecol 1953; 66:248.

200. Metcalfe J, Romney SL, Ramsey LH, et al: Estimation of uterine blood flow and uterine metabolism. J Clin Invest 1995; 34:1632. 201. Lumbers ER: Effects of drugs on uteroplacental blood flow and the health of the foetus. Clin Exp Pharmacol Physiol 1997; 24:864. 202. Rosenfeld CR, Naden RP: Responses of uterine and nonuterine tissues to angiotensin II in ovine pregnancy. Am J Physiol 1995; 257:H17. 203. Rosenfeld CR: Mechanisms regulating angiotensin II responsiveness by the uteroplacental circulation. Am J Physiol Regul Integr Comp Physiol 2001; 281:R1025. 204. Meschia G: Circulation to female reproductive organs. In: Shepherd JT, Abboud FM, ed. Handbook of PhysiologyThe Cardiovascular System III. Peripheral Circulation and Organ Blood Flow, Bethesda: American Physiological Society; 1983:241. 205. Hendricks CH, Quilligan EJ, Tyler CW, Tucker CJ: Pressure relationships between the intervillous space and the amniotic fluid in human term pregnancy. Am J Obstet Gynecol 1959; 77:1028. 206. Gangula PR, Thota C, Wimalawansa SJ, et al: Mechanisms involved in calcitonin gene related peptide-induced relaxation in pregnant rat uterine artery. Biol Reprod 2003; 69:1635. 207. Lang U, Baker RS, Khoury J, Clark KE: Effects of chronic reduction in uterine blood flow on fetal and placental growth in the sheep. Am J Physiol Regul Integr Comp Physiol 2000; 279:R53. 208. Rudolph AM, Heymann MA: Circulatory changes during growth in the fetal lamb. Circ Res 1970; 26:289. 209. Wladimiroff JW, McGhie J.: Ultrasonic assessment of cardiovascular geometry and function in the human fetus. Br J Obstet Gynecol 1981; 88:870. 210. Makowski EL, Meschia G, Droegemueller W, Battaglia FC: Measurement of umbilical arterial blood flow to the sheep placenta and fetus in utero. Circ Res 1968; 23:623. 211. Berman Jr W, Goodlin RC, Heymann MA, Rudolph AM: Relationships between pressure and flow in the umbilical and uterine circulations of the sheep. Cir Res 1976; 38:262. 212. Le Bouteiller P: HLA-G: what's new?. Am J Reprod Immunol 1997; 38:146. 213. Athanassiades A, Lala PK: Role of placenta growth factor (PIGF) in human extravillous trophoblast proliferation, migration and invasiveness. Placenta 1998; 19:465.

214. Athanassiades A, Hamilton GS, Lala PK: Vascular endothelial growth factor stimulates proliferation but not migration or invasiveness in human extravillous trophoblast. Biol Reprod 1998; 59:643. 215. Thornburg KL, Bissonnette JM, Faber JJ: Absence of fetal placental waterfall phenomenon in chronically prepared fetal lambs. Am J Physiol 1976; 230:886. 216. Cohn HE, Piasecki GJ, Jackson BT: The effect of fetal heart rate on cardiovascular function during hypoxemia. Am J Obstet Gynecol 1980; 138:1190. 217. Cohn HE, Sacks EJ, Heymann MA, Rudolph AM: Cardiovascular responses to hypoxemia and acidemia in fetal lambs. Am J Obstet Gynecol 1974; 120:817. 218. Parer JT: Fetal oxygen uptake and umbilical circulation during maternal hypoxia in the chronically catheterized sheep. In: Longo LD, Reneau DD, ed. Fetal and Newborn Cardiovascular Physiology, Vol. 2. New York: Garland STPM Press; 1978:231. 219. Peeters LL, Sheldon RE, Jones Jr MD, et al: Blood flow to fetal organs as a function of arterial oxygen content. Am J Obstet Gynecol 1979; 135:637. 220. Gude NM, King RG, Brennecke SP: Autacoid interactions in the regulation of blood flow in the human placenta. Clin Exp Pharmacol Physiol 1998; 25:706. 221. Boura AL, Walters WA, Read MA, Leitch IM: Autacoids and control of human placental blood flow. Clin Exp Pharmacol Physiol 1994; 21:737. 222. Thaete LG, Dewey ER, Neerhof MG: Endothelin and the regulation of uterine and placental perfusion in hypoxia-induced fetal growth restriction. J Soc Gynecol Investig 2004; 11:16. 223. Galbraith RM, Kantor RRS, Ferra GB, et al: Differential anatomical expression of transplantation antigens within the normal human placental chorionic villus. Am J Reprod Immunol 1981; 1:331. 224. Sunderland CA, Naiem M, Mason DY, et al: The expression of major histocompatibility antigens by human chorionic villi. J Reprod Immuol 1981; 3:323. 225. Ober C, van der Ven K: Immunogenetics of reproduction: an overview. Curr Top Microbiol Immunol 1997; 222:1. 226. Murphy SP, Choi JC, Holtz R.: Regulation of major histocompatibility complex class II gene expression in trophoblast cells. Reprod Biol Endocrinol 2004; 2:52. 227. Hammer A, Hutter H, Dohr G.: HLA class I expression on the materno-fetal interface. Am J Reprod Immunol 1997; 38:150. 228. Moffett-King A: Natural killer cells and pregnancy. Nat Rev Immunol 2002; 2:656.

229. Parham P: NK cells and trophoblasts: partners in pregnancy. J Exp Med 2004; 200:951. 230. Thellin O, Coumans B, Zorzi W, et al: Tolerance to the foeto-placental graft: ten ways to support a child for nine months. Curr Opin Immunol 2000; 12:731. 231. Mellor AL, Sivakumar J, Chandler P, et al: Prevention of T celldriven complement activation and inflammation by tryptophan catabolism during pregnancy. Nat Immunol 2001; 2:64. 232. Brace RA, Wolf EJ: Normal amniotic fluid volume changes throughout pregnancy. Am J Obstet Gynecol 1989; 161:382. 233. Anderson DF, Faber JJ, Parks CM: Extraplacental transfer of water in the sheep. J Physiol 1988; 406:75. 234. Mesher EJ, Platzker AC, Ballard PL, et al: Ontogeny of tracheal fluid, pulmonary surfactant, and plasma corticoids in the fetal lamb. J Appl Physiol 1975; 39:1017. 235. Olver RE, Schneeberger EE, Walters DV: Epithelial solute premeability, ion transport and tight junction morphology in the developing lung of the fetal lamb. J Physiol 1981; 315:395. 236. Adamson TM, Boyd R, Platt H, Strang L.: Composition of alveolar liquid in the foetal lamb. J Physiol 1969; 204:159. 237. Walters DV, Olver RE: The role of catecholamines in lung liquid absorption at birth. Pediatr Res 1978; 12:239. 238. Perks AM, Cassin S: The effects of arginine vasopressin on lung fluid secretion in chronic fetal sheep. In: Jones CT, Nathanielsz PW, ed. The Physiological Development of the Fetus and Newborn, London: Academic Press; 1985:252. 239. Castro R, Ervin MG, Ross MG, et al: Ovine fetal lung fluid response to atrial natriuretic factor. Am J Obstet Gynecol 1989; 161:1337. 240. Gresham EL, Rankin JH, Makowski EL, et al: An evaluation of fetal renal function in a chronic sheep preparation. J Clin Invest 1972; 51:149. 241. Rabinowitz R, Peters MT, Vyas S, et al: Measurement of fetal urine production in normal pregnancy by real-time ultrasonography. Am J Obstet Gynecol 1989; 161:1264. 242. Canning JF, Boyd RDH: Mineral and water exchange between mother and fetus. In: Beard RW, Nathanielsz PW, ed. Fetal Physiology and Medicine, New York: Marcel Dekker; 1984:481. 243. Robillard JE, Weitzman RE: Developmental aspects of the fetal renal response to exogenous arginine vasopressin. Am J Physiol 1980; 238:F407.

244. Lingwood B, Hardy KJ, Coghlan JP, Wintour EM: Effect of aldosterone on urine composition in the chronically cannulated ovine foetus. J Endocrinol 1978; 76:553. 245. Harding R, Bocking AD, Sigger JN, Wickham PJ: Composition and volume of fluid swallowed by fetal sheep. Q J Exp Physiol 1984; 69:487. 246. Pritchard JA: Deglutition by normal and anencephalic fetuses. Obstet Gynecol 1965; 25:289. 247. Pritchard JA: Fetal swallowing and amniotic fluid volume. Obstet Gynecol 1966; 28:606. 248. Bradley RM, Mistretta CM: Swallowing in fetal sheep. Science 1973; 179:1016. 249. Abramovich DR: Fetal factors influencing the volume and composition of liquor amnii. J Obstet Gynaecol Br Commonw 1970; 77:865. 250. Harding R, Sigger JN, Poore ER, Johnson P.: Ingestion in fetal sheep and its relation to sleep states and breathing movements. Q J Exp Physiol 1984; 69:477. 251. Ross MG, Sherman J, Ervin M, et al: Stimuli for fetal swallowing: Systemic factors. Am J Obstet Gynecol 1989; 161:1559. 252. Abramovich DR, Page KR, Jandial L.: Bulk flows through human fetal membranes. Gynecol Invest 1976; 7:157. 253. Gilbert WM, Brace RA: The missing link in amniotic fluid volume regulation: intramembranous absorption. Obstet Gynecol 1989; 74:748. 254. Kalhan SC, D'Angelo LJ, Savin SM, Adam PAJ: Glucose production in pregnant women at term gestation: Sources of glucose for human fetus. J Clin Invest 1979; 63:388. 255. Morris Jr FH, Makowski EL, Meschia G, Battaglia FC: The glucose/oxygen quotient of the term human fetus. Biol Neonate 1975; 25:44. 256. Hay Jr WW, Myers SA, Sparks JW, et al: Glucose and lactate oxidation rates in the fetal lamb. Proc Soc Exp Biol Med 1983; 173:553. 257. Lemons JA, Schreiner RL: Amino acid metabolism in the ovine fetus. Am J Physiol 1983; 244:E459. 258. Widdowson EH, Spray CM: Chemical development in utero. Arch Dis Child 1951; 26:205. 259. Warshaw JB: Fatty acid metabolism during development. Semin Perinatol 1979; 3:31. 260. Schoenle E, Zopf J, Humbel RE, Groesch ER: Insulin-like growth factor I stimulates growth in hypophysectomized rats. Nature 1982; 296:252.

261. Jost A: Fetal hormones and fetal growth. Contr Gynecol Obstet 1979; 5:1. 262. Gluckman PD, Liggins GC: Regulation of fetal growth. In: Beard RW, Nathanielsz PW, ed. Fetal Physiology and Medicine, New York: Marcel Dekker; 1984:511. 263. Gluckman PD: Functional maturation of the neuroendocrine system in the perinatal period: Studies of the somatotrophic axis in the ovine fetus. J Dev Physiol 1984; 6:301. 264. Palmiter RD, Norstedt G, Gelinas RE, et al: Metallothionein-human GH fusion genes stimulate growth of mice. Science 1983; 222:809. 265. Browne CA, Thorburn CA: Endocrine control of fetal growth. Biol Neonate 1989; 55:331. 266. D'Ercole AJ, Stiles AD, Underwood LE: Tissue concentration of somatomedin C: Further evidence for multiple sites of synthesis and paracrine or autocrine mechanism of action. Proc Natl Acad Sci U S A 1984; 81:935. 267. King GL, Kahn CR, Rechler MM, Nissley SP: Direct demonstration of separate receptors for growth and metabolic activities of insulin and multiplication stimulating activity (an insulinlike growth factor) using antibodies to the insulin receptor. J Clin Invest 1980; 66:130. 268. Bennett A, Wilson DM, Liu F, et al: Levels of insulin-like growth factors I and II in human cord blood. J Clin Endocrinol Metab 1983; 57:609. 269. Adams SO, Nissley SP, Handwerger S, Rechler MM: Developmental patterns of insulinlike growth factor I and II synthesis and regulation in rat fibroblasts. Nature 1983; 302:150. 270. Hill DE: Fetal effects of insulin. Obstet Gynecol Ann 1982; 11:133. 271. Susa JG, Gruppuso PA, Widness JA, et al: Chronic hyperinsulinemia in the fetal rhesus monkey: Effects of physiologic hyperinsulinemia on fetal substrates, hormones, and hepatic enzymes. Am J Obstet Gynecol 1984; 150:415. 272. Philips AF, Dubin JW, Raye JR: Fetal metabolic responses to endogenous insulin release. Am J Obstet Gynecol 1981; 139:441. 273. Hay WW, Meznarich HK, Sparks JW, et al: Effect of insulin on glucose uptake in near-term fetal lambs. Proc Soc Exp Biol Med 1985; 178:557. 274. Oppenheimer CL, Pessin JE, Massague J, et al: Insulin action rapidly modulates the apparent affinity of the insulin-like growth factor II receptor. J Biol Chem 1983; 258:4824. 275. Sara VR, Hall K, Misaki M, et al: Ontogenesis of somatomedin and insulin receptors in the human fetus. J Clin Invest 1983; 71:1084.

276. Cardell BS: The infants of diabetic mothers; A morphological study. J Obstet Gynecol Br Comm 1953; 60:834. 277. Siddiqi TA, Miodovnik M, Mimouni F, et al: Biphasic intrauterine growth in insulindependent diabetic pregnancies. J Am Coll Nutr 1989; 8:225. 278. Fowden AL, Comline RS: The effects of pancreatectomy on the sheep fetus in utero. Q J Exp Physiol 1984; 69:319. 279. Fowden AL: The role of insulin in fetal growth. J Dev Physiol 1989; 12:173. 280. Sperling MA, Christensen RA, Ganguli S, Anand R.: Adrenergic modulation of pancreatic hormone secretion in utero: Studies in fetal sheep. Pediatr Res 1980; 14:203. 281. Jones CT, Ritchie JWK, Walker D.: The effects of hypoxia on glucose turnover in the fetal sheep. J Develop Physiol 1983; 5:223. 282. Devaskar SU, Ganuli S, Styer D, et al: Glucagon and glucose dynamics in sheep: Evidence for glucagon resistance in the fetus. Am J Physiol 1984; 246:E256. 283. Gospodarowicz D: Epidermal and nerve growth factors in mammalian development. Ann Rev Physiol 1981; 43:251. 284. Poulsen SS, Kryger-Baggesen N, Nexo E.: Immunohistochemical localization of epidermal growth factor in the second-trimester human fetus. Histochem Cell Biol 1996; 105:111. 285. Amemiya K, Kurachi H, Adachi H, et al: Involvement of epidermal growth factor (EGF)/EGF receptor autocrine and paracrine mechanism in human trophoblast cells: functional differentiation in vitro. J Endocrinol 1994; 143:291. 286. Hofmann GE, Horowitz GM, Scott Jr RT, Navot D.: Transforming growth factor-alpha in human implantation trophoblast: immunohistochemical evidence for autocrine/paracrine function. J Clin Endocrinol Metab 1993; 76:781. 287. Lysiak JJ, Johnson GR, Lala PK: Localization of amphiregulin in the human placenta and decidua throughout gestation: role in trophoblast growth. Placenta 1995; 16:359. 288. Birdsall MA, Hopkisson JF, Grant KE, et al: Expression of heparin-binding epidermal growth factor messenger RNA in the human endometrium. Mol Hum Reprod 1996; 2:31. 289. Tanimura K, Nakago S, Murakoshi H, et al: Changes in the expression and cytological localization of betacellulin and its receptors (ErbB-1 and ErbB-4) in the trophoblasts in human placenta over the course of pregnancy. Eur J Endocrinol 2004; 151:93.

290. Toyoda H, Komurasaki T, Uchida D, Morimoto S.: Distribution of mRNA for human epiregulin, a differentially expressed member of the epidermal growth factor family. Biochem J 1997; 326(Pt 1):69. 291. Schilling B, Yeh J.: Transforming growth factor-beta(1), -beta(2), -beta(3) and their type I and II receptors in human term placenta. Gynecol Obstet Invest 2000; 50:19. 292. Schneider-Kolsky ME, Manuelpillai U, Waldron K, et al: The distribution of activin and activin receptors in gestational tissues across human pregnancy and during labour. Placenta 2002; 23:294. 293. Petraglia F: Inhibin, activin and follistatin in the human placentaa new family of regulatory proteins. Placenta 1997; 18:3. 294. Bigon E, Soranzo C, Minozzi C, et al: Large scale purification and immunological characterization of human placental nerve growth factor. Neurochem Res 1990; 15:1197. 295. Gilmore JH, Jarskog LF, Vadlamudi S.: Maternal infection regulates BDNF and NGF expression in fetal and neonatal brain and maternal-fetal unit of the rat. J Neuroimmunol 2003; 138:49. 296. Han VK, Carter AM: Spatial and temporal patterns of expression of messenger RNA for insulin-like growth factors and their binding proteins in the placenta of man and laboratory animals. Placenta 2000; 21:289. 297. Arceci RJ, Shanahan F, Stanley ER, Pollard JW: Temporal expression and location of colony-stimulating factor 1 (CSF-1) and its receptor in the female reproductive tract are consistent with CSF-1regulated placental development. Proc Natl Acad Sci U S A 1989; 86:8818. 298. Shorter SC, Vince GS, Starkey PM: Production of granulocyte colonystimulating factor at the materno-foetal interface in human pregnancy. Immunology 1992; 75:468. 299. Dame JB, Christensen RD, Juul SE: The distribution of granulocyte-macrophage colony stimulating factor and its receptor in the developing human fetus. Pediatr Res 1999; 46:358. 300. Sharkey AM, Charnock-Jones DS, Boocock CA, et al: Expression of mRNA for vascular endothelial growth factor in human placenta. J Reprod Fertil 1993; 99:609. 301. Shiraishi S, Nakagawa K, Kinukawa N, et al: Immunohistochemical localization of vascular endothelial growth factor in the human placenta. Placenta 1996; 17:111. 302. Hauser S, Weich HA: A heparin-binding form of placenta growth factor (PlGF-2) is expressed in human umbilical vein endothelial cells and in placenta. Growth Factors 1993; 9:259.

303. Ferriani RA, Ahmed A, Sharkey A, Smith SK: Colocalization of acidic and basic fibroblast growth factor (FGF) in human placenta and the cellular effects of bFGF in trophoblast cell line JEG-3. Growth Factors 1994; 10:259. 304. Zheng J, Vagnoni KE, Bird IM, Magness RR: Expression of basic fibroblast growth factor, endothelial mitogenic activity, and angiotensin II type-1 receptors in the ovine placenta during the third trimester of pregnancy. Biol Reprod 1997; 56:1189. 305. Arany E, Hill DJ: Fibroblast growth factor-2 and fibroblast growth factor receptor-1 mRNA expression and peptide localization in placentae from normal and diabetic pregnancies. Placenta 1998; 19:133. 306. Bowen JM, Chamley L, Mitchell MD, Keelan JA: Cytokines of the placenta and extraplacental membranes: biosynthesis, secretion and roles in establishment of pregnancy in women. Placenta 2002; 23:239. 307. Maruo T, Matsuo H, Murata K, Mochizuki M.: Gestational agedependent dual action of epidermal growth factor on human placenta early in gestation. J Clin Endocrinol Metab 1992; 75:1362. 308. Bass KE, Morrish D, Roth I, et al: Human cytotrophoblast invasion is up-regulated by epidermal growth factor: evidence that paracrine factors modify this process. Dev Biol 1994; 164:550. 309. Morrish DW, Bhardwaj D, Dabbagh LK, et al: Epidermal growth factor induces differentiation and secretion of human chorionic gonadotropin and placental lactogen in normal human placenta. J Clin Endocrinol Metab 1987; 65:1282. 310. Saito S, Sakakura S, Enomoto M, et al: Hepatocyte growth factor promotes the growth of cytotrophoblasts by the paracrine mechanism. J Biochem (Tokyo) 1995; 117:671. 311. Charnock-Jones DS, Sharkey AM, Boocock CA, et al: Vascular endothelial growth factor receptor localization and activation in human trophoblast and choriocarcinoma cells. Biol Reprod 1994; 51:524. 312. Graham CH, Lala PK: Mechanism of control of trophoblast invasion in situ. J Cell Physiol 1991; 148:228. 313. Morrish DW, Bhardwaj D, Paras MT: Transforming growth factor beta 1 inhibits placental differentiation and human chorionic gonadotropin and human placental lactogen secretion. Endocrinology 1991; 129:22. 314. Regenstreif LJ, Rossant J.: Expression of the c-fms proto-oncogene and of the cytokine, CSF-1, during mouse embryogenesis. Dev Biol 1989; 133:284.

315. Uzumaki H, Okabe T, Sasaki N, et al: Identification and characterization of receptors for granulocyte colonystimulating factor on human placenta and trophoblastic cells. Proc Natl Acad Sci U S A 1989; 86:9323. 316. Fairchild BD, Conrad KP: Expression of the erythropoietin receptor by trophoblast cellsin the human placenta. Biol Reprod 1999; 60:861. 317. Garcia-Lloret MI, Morrish DW, Wegmann TG, et al: Demonstration of functional cytokineplacental interactions: CSF-1 and GM-CSF stimulate human cytotrophoblast differentiation and peptide hormone secretion. Exp Cell Res 1994; 214:46. 318. Peters TJ, Chapman BM, Wolfe MW, Soares MJ: Placental lactogen-I gene activation in differentiating trophoblast cells: extrinsic and intrinsic regulation involving mitogen-activated protein kinase signaling pathways. J Endocrinol 2000; 165:443. 319. Kita N, Mitsushita J, Ohira S, et al: Expression and activation of MAP kinases, ERK1/2, in the human villous trophoblasts. Placenta 2003; 24:164. 320. Corso M, Thomson M.: Protein phosphorylation in mitochondria from human placenta. Placenta 2001; 22:432. 321. Fowden AL: The insulin-like growth factors and feto-placental growth. Placenta 2003; 24:803. 322. Yamamoto H, Flannery ML, Kupriyanov S, et al: Defective trophoblast function in mice with a targeted mutation of Ets2. Genes Dev 1998; 12:1315. 323. Johnston DJ, Thompson JM, Hammond K.: Additive and nonadditive differences in postweaning growth and carcass characteristics of Devon, Hereford, and reciprocal-cross steers. J Anim Sci 1992; 70:2688. 324. Hill DJ, Petrik J, Arany E.: Growth factors and the regulation of fetal growth. Diabetes Care 1998; 21(Suppl 2):B60. 325. Hayashi M, Hamada Y, Ohkura T.: Elevation of granulocyte-macrophage colony stimulating factor in the placenta and blood in preeclampsia. Am J Obstet Gynecol 2004; 190:456. 326. Polliotti BM, Fry AG, Saller DN, et al: Second-trimester maternal serum placental growth factor and vascular endothelial growth factor for predicting severe, early-onset preeclampsia. Obstet Gynecol 2003; 101:1266. 327. Hofmann GE, Drews MR, Scott Jr RT, et al: Epidermal growth factor and its receptor in human implantation trophoblast: immunohistochemical evidence for autocrine/paracrine function. J Clin Endocrinol Metab 1992; 74:981.

328. Maruo T, Matsuo H, Oishi T, et al: Induction of differentiated trophoblast function by epidermal growth factor: relation of immunohistochemically detected cellular epidermal growth factor receptor levels. J Clin Endocrinol Metab 1987; 64:744. 329. Garcia-Lloret MI, Yui J, Winkler-Lowen B, Guilbert LJ: Epidermal growth factor inhibits cytokine-induced apoptosis of primary human trophoblasts. J Cell Physiol 1996; 167:324. 330. Chen CF, Kurachi H, Fujita Y, et al: Changes in epidermal growth factor receptor and its messenger ribonucleic acid levels in human placenta and isolated trophoblast cells during pregnancy. J Clin Endocrinol Metab 1988; 67:1171. 331. Alsat E, Haziza J, Scippo ML, et al: Increase in epidermal growth factor receptor and its mRNA levels by parathyroid hormone (1-34) and parathyroid hormone-related protein (1-34) during differentiation of human trophoblast cells in culture. J Cell Biochem 1993; 53:32. 332. Fujita Y, Kurachi H, Morishige K, et al: Decrease in epidermal growth factor receptor and its messenger ribonucleic acid levels in intrauterine growthretarded and diabetes mellitus complicated pregnancies. J Clin Endocrinol Metab 1991; 72:1340. 333. Groenen LC, Nice EC, Burgess AW: Structure-function relationships for the EGF/TGFalpha family of mitogens. Growth Factors 1994; 11:235. 334. Muhlhauser J, Crescimanno C, Kaufmann P, et al: Differentiation and proliferation patterns in human trophoblast revealed by c-erbB-2 oncogene product and EGF-R. J Histochem Cytochem 1993; 41:165. 335. Bunn HF, Jandl JH: Control of hemoglobin function within the red cell. N Engl J Med 1970; 282:1414. 336. Barbera A, Galan HL, Ferrazzi E, et al: Relationship of umbilical vein blood flow to growth parameters in the human fetus. Am J Obstet Gynecol 1999; 181:174. 337. Cheung CY, Brace RA: Developmental expression of vascular endothelial growth factor and its receptors in ovine placenta and fetal membranes. J Soc Gynecol Investig 1999; 6:179. 338. Nguyen M, Camenisch T, Snouwaert JN, et al: The prostaglandin receptor EP4 triggers remodelling of the cardiovascular system at birth. Nature 1997; 390:78. 339. Harrington B, Glazier J, D'Souza S, Sibley C.: System A amino acid transporter activity in human placental microvillous membrane vesicles in relation to various anthropometric measurements in appropriate and small for gestational age babies. Pediatr Res 1999; 45:810. 340. Sunderland CA, Redman CWG, Stirrat GM: HLA A, B, C antigens are expressed on nonvillous trophoblast of the early human placenta. J Immunol 1981; 127:2614.

341. Faulk WP, Hsi B-L: Immunology of human trophoblast membrane antigens. In: Loke YW, Whyte A, ed. Biology of Trophoblast, New York: Elsevier; 1983:535. 342. Szulman AE: The ABH blood groups and development. Curr Top Dev Biol 1980; 14:127. 343. Faulk WP: Immunobiology of human extraembryonic membranes. In Wegman TG, Gill TJ (eds): Immunology of Reproduction. NewYork, Oxford, 1983, p 253. 344. Klopper A: The new placental proteins. Placenta 1980; 1:77. 345. Rocklin RE, Kitzmiller JL, Farvoy MR: Maternal fetal relation. II. Further characterization of an immunologic blocking factor that develops during pregnancy. Clin Immunol Immunopathol 1982; 22:305. 346. Beer AE: Immunologic aspects of normal pregnancy and recurrent spontaneous abortion. Semin Reprod Endocinol 1988; 6:163. 347. Taylor C, Faulk WP: Prevention of recurrent abortions with leukocyte transfusions. Lancet 1980; ii:68. 348. Beer AE, Quebberman JF, Ayers JW, Haines RF: Major histocompatibility antigens maternal and paaternal immune responses and chronic habitual abortion in humans. Am J Obstet Gynecol 1981; 141:987. 349. Komlos L, Zamir R, Joshua H, Halbrecht I.: Common HLA antigens in couples with repeated abortions. Clin Immunol Immunopathol 1977; 7:330. 350. Redline RW, Lu CY: Role of local immunosupression in murine fetoplacental listerosis. J Clin Invest 1987; 79:1234. 351. Jacoby DR, Olding LB, Oldstone MD: Immunologic regulation of fetal-maternal balance. Adv Immunol 1984; 35:157. 352. Torry DS, McIntyre JA, Faulk WP: Immunobiology of the trophoblast: mechanisms by which placental tissues evade maternal recognition and rejection. Curr Top Microbiol Immunol 1997; 222:127. 353. Rudolph AM: Homeostasis of the fetal circulation and the part played by hormones. Ann Rech Vet 1977; 8:405. 354. Pitkin RM, Reynolds WA: Fetal ingestion and metabolism of amniotic fluid protein. Am J Obstet Gynecol 1975; 123:356. 355. Charlton V, Reis B.: Effects of gastric nutritional supplementation on fetal umbilical uptake of nutrients. Am J Physiol 1981; 241:E178.

356. Charlton VE, Rudolph A.: Digestion and absorption of carbohydrates by the fetal lamb in utero. Pediatr Res 1979; 13:1018. 357. Charlton V, Johengen M.: Effects of intrauterine nutritional supplementation on fetal growth retardation. Biol Neonate 1985; 48:125. 358. Wesson D, Muraji T, Kent G, et al: The effect of intrauterine esophageal ligation on growth of fetal rabbits. J Pediatr Surg 1984; 19:398. 359. Trahair JF, Harding R, Bocking AD, et al: The role of ingestion in the development of the small intestine in fetal sheep. Q J Exp Physiol 1986; 71:99. 360. Avila C, Harding R, Robinson P.: The effects of preventing ingestion on the development of the digestive system in the sheep fetus. Q J Exp Physiol 1986; 71:99. 361. Pierro A, Cozzi F, Colarossi G, et al: Does fetal gut obstruction cause hydramnios and growth retardation?. J Pediatr Surg 1987; 22:454. 362. Cozzi F, Wilkinson A.: Intrauterine growth rate in relation to anorectal and oesophageal anomalies. Arch Dis Child 1969; 44:59. 363. Edelstone DI, Holzman IR: Fetal intestinal oxygen consum-ption at various levels of oxygenation. Am J Physiol 1982; 242:H50. 364. Lester R, Jackson BT, Smallwood RA, et al: Fetal and neonatal hepatic function II. Birth Defects 1976; 12:307. 365. Bristow J, Rudolph AM, Itskovitz J, Barnes R: Hepatic oxygen and glucose metabolism in the fetal lamb. Response to hypoxia. J Clin. Invest 1983; 71:1047. 366. Jouppila P, Kirkinen P, Eik-Nes S, Koivula A: Fetal and intervillouos blood flow measurements in late pregnancy. In: Kurjak A, Kratochwil A, ed. Recent Advances in Ultrasound Diagnosis, Amsterdam: Excerpta Medica; 1981:226. 367. Rudolph AM: Hepatic and ductus venosus blood flows during fetal life. Hepatology 1983; 3:254. 368. Anderson DF, Bissonnette JM, Faber JJ, Thornburg KL: Central shunt flows and pressures in the mature fetal lamb. Am J Physiol 1981; 241:H60. 369. Gresores A, Rosenfeld CR, Magness RR, Roy T.: Metabolic clearance rate of angiotensin II in fetal and pregnant sheep. Pediatr Res 1992; 31:60A. 370. Thornburg KL, Morton MJ: Filling and arterial pressures as determinants of RV stroke volume in the sheep fetus. Am J Physiol 1983; 244:H656.

371. Pinson CW, Morton MJ, Thornburg KL: An anatomic basis for right ventricular dominance and arterial pressure sensitivity. J Dev Physiol 1987; 9:253. 372. Thornburg KL, Morton MG: Filling and arterial pressures as determinants of left ventricular stroke volume in fetal lambs. Am J Physiol 1986; 251:H961. 373. Cheng JB, Goldfien A, Cornett LE, Roberts JM: Identification of B-adrenergic receptors using [3H] dihydroalprenolol in fetal sheep heart: Direct evidence of qualitative similarity to the receptors in adult sheep heart. Pediatr Res 1981; 15:1083. 374. Andersen PAW, Manning A, Glick KL, Crenshaw Jr CC: Biophysics of the developing heart III. A comparison of the left ventricular dynamics of the fetal and neontal heart. Am J Obstet Gynecol 1982; 143:195. 375. Fisher DJ, Heymann MA, Rudolph AM: Regional myocardial blood flow and oxygen delivery in fetal, newborn and adult sheep. Am J Physiol 1982; 243:H729. 376. Fisher DJ, Heymann MA, Rudolph AM: Myocardial oxygen and carbohydrate consumption in fetal lambs in utero and in adult sheep. Am J Physiol 1980; 238:H399. 377. Timor-Tritsch IE, Dierker LJ, Hertz RH, et al: Studies of antepartum behavioral state in the human fetus at term. Am J Obstet Gynecol 1978; 132:524. 378. Martin Jr CB: Behavioral states in the human fetus. J Reprod Med 1981; 26:425. 379. Visser GHA, Goodman JDS, Levine DH, Dawes GS: Diurnal and other cyclic variations in human fetal heart rate near term. Am J Obstet Gynecol 1982; 142:535. 380. Dawes GS, Fox HE, Leduc BM, et al: Respiratory movements and rapid eye movement sleep in the foetal lamb. J Physiol 1972; 220:119. 381. Natale R, Clewlow F, Dawes GS: Measurement of fetal forelimb movements in the lamb in utero. Am J Obstet Gynecol 1981; 140:545. 382. Blanco CE, Dawes GS, Walker DW: Effect of hypoxia on polysynaptic hindlimb reflexes of unanesthetized foetal and newborn lambs. J Physiol 1983; 339:453. 383. Chan K, Dodd PA, Day L, et al: Fetal catecholamine, cardiovascular, and neurobehavioral responses to cocaine. Am J Obstet Gynecol 1992; 167:1616. 384. Connors G, Hunse C, Carmichal L, et al: Control of fetal breathing in human fetus between 24 and 34 weeks gestation. Am J Obstet Gynecol 1989; 160:932. 385. Hohimer AR, Bissonnette JM, Richardson BS, Machida CM: Central chemical regulation of breathing movements in fetal lambs. Respir Physiol 1983; 52:99.

386. Dawes GS, Gardner WN, Johnson BM, Walker DW: Breathing activity in fetal lambs: The effect of brain stem section. J Physiol 1983; 335:535. 387. Richardson BS, Patrick JE, Abduljabbar H.: Cerebral oxidative metabolism in the fetal lamb: Relationship to electrocortical state. Am J Obstet Gynecol 1985; 153:426. 388. Chao CR, Hohimer AR, Bissonnette JM: The effect of electrocortical state on cerebral carbohydrate metabolism in fetal sheep. Brain Res Dev Brain Res 1989; 49:1. 389. Jones MD, Sheldon RE, Peeters LL, et al: Fetal cerebral oxygen consumption at different levels of oxygenation. J Appl Physiol Respirat Envorion Exercise Physiol 1977; 43:1080. 390. Rosenberg AA, Jones Jr MD, Traystman RJ, et al: Response of cerebral blood flow to changes in PCO2 in fetal, newborn, and adult sheep. Am J Physiol 1982; 242:H862. 391. Martyn CN, Barker DJ, Osmond C.: Mothers' pelvic size, fetal growth, and death from stroke and coronary heart disease in men in the UK. Lancet 1996; 348:1264. 392. McCormack VA, dos SS, De Stavola BL, et al: Fetal growth and subsequent risk of breast cancer: results from long term follow up of Swedish cohort. BMJ 2003; 326:248. 393. Leadbitter P, Pearce N, Cheng S, et al: Relationship between fetal growth and the development of asthma and atopy in childhood. Thorax 1999; 54:905. 394. Barker DJ, Osmond C: Infant mortality, childhood nutrition, and ischaemic heart disease in England and Wales. Lancet 1986; 1:1077. 395. Rose G: Familial patterns in ischaemic heart disease. Br J Prev Soc Med 1964; 18:75. 396. Forsdahl A: Are poor living conditions in childhood and adolescence an important risk factor for arteriosclerotic heart disease?. Br J Prev Soc Med 1977; 31:91. 397. Barker D: The midwife, the coincidence, and the hypothesis. BMJ 2003; 327:1428. 398. Barker DJ, Winter PD, Osmond C, et al: Weight in infancy and death from ischaemic heart disease. Lancet 1989; 2:577. 399. Barker DJ, Osmond C, Golding J, et al: Growth in utero, blood pressure in childhood and adult life, and mortality from cardiovascular disease. BMJ 1989; 298:564. 400. Barker DJ: In utero programming of cardiovascular disease. Theriogenology 2000; 53:555. 401. Lau C, Rogers JM: Embryonic and fetal programming of physiological disorders in adulthood. Birth Defects Res C Embryo Today 2004; 72:300.

402. Hofman PL, Regan F, Jackson WE, et al: Premature birth and later insulin resistance. N Engl J Med 2004; 351:2179. 403. Schluchter MD: Publication bias and heterogeneity in the relationship between systolic blood pressure, birth weight, and catch-up growtha meta analysis. J Hypertens 2003; 21:273. 404. Hales CN, Barker DJ, Clark PM, et al: Fetal and infant growth and impaired glucose tolerance at age 64. BMJ 1991; 303:1019. 405. Barker DJ, Hales CN, Fall CH, et al: Type 2 (non-insulin-dependent) diabetes mellitus, hypertension and hyperlipidaemia (syndrome X): relation to reduced fetal growth. Diabetologia 1993; 36:62. 406. Hales CN, Barker DJ: The thrifty phenotype hypothesis. Br Med Bull 2001; 60:5. 407. Hales CN, Barker DJ: Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis. Diabetologia 1992; 35:595. 408. Ravelli AC, van der Meulen JH, Michels RP, et al: Glucose tolerance in adults after prenatal exposure to famine. Lancet 1998; 351:173. 409. Stanner SA, Bulmer K, Andres C, et al: Does malnutrition in utero determine diabetes and coronary heart disease in adulthood? Results from the Leningrad siege study, a cross sectional study. BMJ 1997; 315:1342. 410. Jensen RB, Chellakooty M, Vielwerth S, et al: Intrauterine growth retardation and consequences for endocrine and cardiovascular diseases in adult life: does insulin-like growth factor-I play a role?. Horm Res 2003; 60(Suppl 3):136. 411. Lewis RM, Forhead AJ, Petry CJ, et al: Long-term programming of blood pressure by maternal dietary iron restriction in the rat. Br J Nutr 2002; 88:283. 412. Langley SC, Jackson AA: Increased systolic blood pressure in adult rats induced by fetal exposure to maternal low protein diets. Clin Sci (Lond) 1994; 86:217. 413. Kind KL, Simonetta G, Clifton PM, et al: Effect of maternal feed restriction on blood pressure in the adult guinea pig. Exp Physiol 2002; 87:469. 414. Gopalakrishnan GS, Gardner DS, Rhind SM, et al: Programming of adult cardiovascular function after early maternal undernutrition in sheep. Am J Physiol Regul Integr Comp Physiol 2004; 287:R12. 415. Langley-Evans SC, Welham SJ, Jackson AA: Fetal exposure to a maternal low protein diet impairs nephrogenesis and promotes hypertension in the rat. Life Sci 1999; 64:965.

416. Burns SP, Desai M, Cohen RD, et al: Gluconeogenesis, glucose handling, and structural changes in livers of the adult offspring of rats partially deprived of protein during pregnancy and lactation. J Clin Invest 1997; 100:1768. 417. Klebanoff MA, Meirik O, Berendes HW: Second-generation consequences of small-fordates birth. Pediatrics 1989; 84:343. 418. Stewart RJ, Preece RF, Sheppard HG: Recovery from long-term protein-energy deficiency. Proc Nutr Soc 1973; 32:103A. 419. Drake AJ, Walker BR, Seckl JR: Intergenerational consequences of fetal programming by in utero exposure to glucocorticoids in rats. Am J Physiol Regul Integr Comp Physiol 2005; 288:R34. 420. Enders RH, Judd RM, Donohue TM, Smith CH: Placental amino acid uptake. III. Transport systems for neutral amino acids. Am J Physiol 1976; 230:706. 421. Steel RB, Smith CH, Kelly LK: Placental amino acid uptake. VI. Regulation by intracellular substrate. Am J Physiol 1982; 243:C46. 422. Paton JB, Fisher DE, Peterson EN: Cardiac output and organ blood flows in the baboon fetus. Biol Neonate 1973; 22:50. Menschen. Z Geburtsh Gynak 1962; 158:117. 72. Talbert D, Sebire NJ: The dynamic placenta: I. Hypothetical model of a placental mechanism matching local fetal blood flow to local intervillus oxygen delivery. Med Hypotheses 2004; 62:511. 73. Clapp III JF: The relationship between blood flow and oxygen uptake in the uterine and umbilical circulations. Am J Obstet Gynecol 1978; 132:410. 74. Wilkening RB, Meschia G.: Fetal oxygen uptake, oxygenations, and acid-base balance as a function of uterine blood flow. Am J Physiol 1983; 244:H749. 75. Itskovitz J, LaGamma EF, Rudolph LAM: The effect of reducing umbilical blood flow on fetal oxygenation. Am J Obstet Gynecol 1983; 145:813. 76. Itskovitz J, LaGamma EF, Rudolph AM: Baroreflex