Antibiotics cure disease by kiiiing or in uring bacteria. The first antibiotic was peniciiiin, discovered accidentaiiy from a moid cuiture. Today, over 100 different antibiotics are avaiiabie to cure minor, as weii as iife-threatening infections.
Antibiotics cure disease by kiiiing or in uring bacteria. The first antibiotic was peniciiiin, discovered accidentaiiy from a moid cuiture. Today, over 100 different antibiotics are avaiiabie to cure minor, as weii as iife-threatening infections.
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Antibiotics cure disease by kiiiing or in uring bacteria. The first antibiotic was peniciiiin, discovered accidentaiiy from a moid cuiture. Today, over 100 different antibiotics are avaiiabie to cure minor, as weii as iife-threatening infections.
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Durng mena the manknd has been sub|ect to nfectous dseases
whch carred away mons ves and were a prncpa cause of death. In 1929 the Engsh mcroboogst A.Femng has opened the frst antbotc - pencn. It began one of the most oustandng openng XX century. The new era n boogy and drug - an era of antbotcs began. Snce 40th years the medca products kng or nterferng growth of mcroorgansms, have wdey come n medca practce. Abty of antbotcs successfuy to strugge wth nfectous dseases, before consdered fatay dangerous, has been percevedas panacea. However, soon after the begnnng of use of antbotcs physcans have faced wth a probem - the bactera toerant to ther acton began to appear. Unfortunatey, every year the number mcroorgansms steady grows. In many respects t s connected by that, overookng about the care, many peope appy antbotcs under own dscreton. Antibiotics Definition Antbotcs are among the most frequenty prescrbed medcatons n modern medcne. Antbotcs cure dsease by kng or n|urng bactera. The frst antbotc was pencn, dscovered accdentay from a mod cuture. Today, over 100 dfferent antbotcs are avaabe to cure mnor, as we as fe-threatenng nfectons. Athough antbotcs are usefu n a wde varety of nfectons, t s mportant to reaze that antbotcs ony treat bactera nfectons. Antbotcs are useess aganst vra nfectons (for exampe, the common cod) and funga nfectons (such as rngworm). Your doctor can best determne f an antbotc s rght for your condton. Antbotcs are drugs that are used to treat nfectons caused by bactera and other organsms, ncudng protozoa, parastes, and fung. Purpose Many treatments for cancer destroy dsease-fghtng whte bood ces, thereby reducng the body's abty to fght nfecton. For exampe, badder, pumonary, and urnary tract nfectons may occur wth chemotherapy. Snge-ceed organsms caed protozoa are rarey a probem for heathy ndvduas. However, they can cause serous nfectons n ndvduas wth ow whte bood ce counts. Because of the dangers that nfectons present for cancer patents, antbotc treatment often s ntated before the exact nature of the nfecton has been determned; nstead, the choce of antbotc may depend on the ste of the nfecton and the organsm that s key to be the cause. Often, an antbotc that ks a broad spectrum of bactera s chosen and severa antbotcs may be used together. Description The common antibiotics that are used during cancer treatment include: Atovaquone (Mapren): antprotozoa drug used to prevent and treat a very serous type of pneumona caed Pneumocysts carn pneumona (PCP), n ndvduas who experence serous sde effects wth SMZ-TMP (Sufamethoxazoe/Trmethoprm, brand name Bactrm). Aztreonam (Azactam): monobactam antbotc used to treat gram- negatve bactera nfectons of the urnary and ower respratory tracts and the femae organs, and nfectons that are present throughout the body (systemc nfectons or septcema). Cefepme (Maxpme), ceftazdme (Ceptaz, Fortaz, Tazcef, Tazdme), and ceftraxone sodum (Rocephn): members of a group of antbotcs caed cephaosporns used to treat bactera nfectons of the urnary and ower respratory tracts, and nfectons of the skn, bones, |onts, pevs, and abdomen. Cprofoxacn (Cpro): fuoroqunoone antbotc used to treat certan gram-negatve and gram-postve bactera and some mycobactera. Cndamycn phosphate (Ceocn): used to treat gram-postve and gram-negatve bactera nfectons and, n ndvduas who are aergc to sufadazne, toxopasmoss caused by a parastc protozoa. Gentamcn (gentamycn) sufate (generc name product, Garamycn, G-Mycn, |enamcn): amnogycosde antbotc used to treat serous nfectons by many gram-negatve bactera that cannot be treated wth other medcnes. Metrondazoe hydrochorde (Fagy, Metrc 21, Metro I.V., Protostat): used for anaerobc bactera and protozoa. Pentamdne (generc name product, Pentam 300): used to treat PCP f serous sde effects deveop wth SMZTMP. Pyrmethamne (Daraprm): antprotozoa medcne used together wth sufadazne to treat toxopasmoss; or n combnaton wth other medcnes for treatng md to moderate PCP, n ndvduas who cannot toerate the standard treatment. Sufadazne (generc name product): sufonamde antbotc used wth pyrmethamne to treat toxopasmoss. Sufamethoxazoe-Trmethoprm (SMZ-TMP) (generc name product, Bactrm, Cofatrm Forte, Cotrm, Septra, Sufatrm): the sufonamde antbotc, sufamethoxazoe, used n combnaton wth trmethoprm, to prevent and treat PCP and bactera nfectons, such as bronchts and mdde ear and urnary tract nfectons. Trmethoprm (generc name product, Prooprm, Trmpex): prmary used to prevent or treat urnary tract nfectons. Vancomycn hydrochorde (generc name product, Vancocn): gycopeptde antbotc used to treat a varety of serous gram- postve bactera nfectons for whch other medcnes are neffectve, ncudng strans of Staphyococcus that are resstant to most ora antbotcs. Most of these antbotcs k bactera by preventng them from makng proten for ther ce was. Cprofoxacn and metrondazoe prevent bactera from reproducng by nterferng wth ther abty to make new DNA. A of these drugs are approved for prescrpton by the U.S. Food and Drug Admnstraton. Recommended dosage Dosages of antbotcs depend on the ndvdua, the nfecton that s beng treated, and the presence of other medca condtons. For chdren, the dosage usuay s based on body weght and s ower than the adut dosage. To be effectve, an entre treatment wth antbotcs must be competed, even f the symptoms of nfecton have dsappeared. Furthermore, t s mportant to keep the eve of antbotc n the body at a constant eve durng treatment. Therefore, the drug shoud be taken on a reguar schedue. If a dose s mssed, t shoud be taken as soon as possbe. If t s amost tme for the next dose, the mssed dose shoud be skpped. Doubng up doses s generay not recommended. Average adult dosages of common antibiotics for cancer patients are as follows: Atovaquone: for PCP treatment, 750 mg ora suspenson twce a day, or tabets three tmes per day, for 21 days; for PCP preventon, 1, 500 mg ora suspenson, once a day; must be taken wth baanced meas. Aztreonam: 1-2 gm every 6-12 hours, n|ected nto a ven, over a 20-60 mnute-perod. Cefepme: 500 mg to 2 gm, n|ected nto a ven or musce, every 8- 12 hours for 7-10 days. Ceftazdme: 250 mg to 2 gm, n|ected nto a ven or musce, every 8-12 hours. Ceftraxone: 1-2 gm, n|ected nto a ven or musce, every 24 hours. Cprofoxacn: 500-750 mg of the tabet or suspenson, every 12 hours, for 3-28 days, taken two hours after meas wth 8 oz of water; bone and |ont nfectons usuay are treated for at east 4-6 weeks; 200-400 mg n|ected every 8-12 hours. Cndamycn: 150-300 mg of capsue or souton, every sx hours; 300-600 mg every sx to eght hours or 900 mg every eght hours, n|ected nto a ven or musce. Gentamcn: dosage determned by body weght, every 8-24 hours for at east 7-10 days, n|ected nto a ven or musce. Metrondazoe: for bactera nfectons, 7.5 mg per kg (3.4 mg per b) of body weght up to a maxmum of 1 gm, every sx hours for at east seven days (capsues or tabets); 15 mg per kg (6.8 mg per b) for the frst dose, foowed by haf that dosage every sx hours for at east seven days (n|ected nto a ven); for protozoa nfectons caused by amebas, 500-750 mg of ora medcne, three tmes per day for 5-10 days; for trchomonass, 2 gm for one day or 250 mg three tmes per day for seven days (ora medcne); extended- reease tabets for vagna bactera nfectons, 750 mg once a day for seven days. Pentamdne: for treatng PCP, 4 mg per kg (1.8 mg per b) of body weght, once per day for 14-21 days, n|ected nto a ven over one to two hours, whe yng down. Pyrmethamne: for toxopasmoss, 25-200 mg tabets, taken wth other medcne, for severa weeks. Sufadazne: for bactera and protozoa nfectons, 2-4 gm for the frst dose, foowed by 1 gm every four to sx hours (tabets). SMZ-TMP: 800 mg of sufamethoxazoe and 160 mg of trmethoprm, (tabet or ora suspenson), every 12 hours for bactera nfectons and every 24 hours for preventon of PCP; dosage based on body weght for PCP treatment; n|ectons based on body weght, every sx, eght or 12 hours for bactera nfectons and every sx hours for PCP treatment. Trmethoprm: 100 mg tabet every 12 hours for 10 days; for preventon of urnary tract nfectons, once a day for a ong perod. Vancomycn: 7.5 mg per kg (3.4 mg per b) of body weght, or 500 mg-1 gram, n|ected or taken oray, every 6-12 hours. Precautions Stomach or intestinal problems or colitis (inflammation of the colon) may affect the use of: Atovaquone Cephaosporns Cndamycn Kidney or liver disease may affect the use of: Aztreonam Cefepme Ceftazdme Cprofoxacn Cndamycn Gentamcn Metrondazoe Pentamdne Pyrmethamne Sufadazne SMZ-TMP Trmethoprm Vancomycn Central nervous system or seizure disorders may affect the use of: Cprofoxacn Metrondazoe Pyrmethamne Anemia (low red blood cell count) or other blood disorders may affect the use of: Metrondazoe Pentamdne Pyrmethamne Sufadazne SMZ-TMP Trmethoprm Cprofoxacn may not be sutabe for ndvduas wth tendnts or wth skn senstvtes to sunght. Gentamcn may not be sutabe for peope wth hearng probems, myasthena gravs, or Parknson's dsease. Metrondazoe may not be sutabe for ndvduas wth heart dsease, ora or vagna yeast nfectons, or a hstory of acohosm. Pentamdne may not be sutabe for ndvduas wth heart dsease, beedng dsorders, or ow bood pressure. Pentamdne may affect bood sugar eves, makng contro of dabetes metus or hypogycema (ow bood sugar) dffcut. Vancomycn may not be approprate for ndvduas wth hearng probems. Many antbotcs shoud not be taken durng pregnancy or whe breast- feedng. Oder ndvduas may be more susceptbe to the sde effects of sufadazne, SMZ-TMP, or trmethoprm. Sde effects Some ndvduas may have aergc reactons to antbotcs. If symptoms of an aergc reacton (such as rash, shortness of breath, sweng of the face and neck), severe darrhea, or abdomna crampng occur, the antbotc shoud be stopped and the ndvdua shoud seek medca advce. Because antbotcs can affect bactera that are benefca, as we as those that are harmfu, women may become susceptbe to nfectons by fung when takng antbotcs. Vagna tchng or dscharge may be symptoms of such nfectons. A patents may deveop ora funga nfectons of the mouth, ndcated by whte paques n the mouth. In|ected antbotcs may resut n rrtaton, pan, tenderness, or sweng n the ven used for n|ecton. Antbotcs used n cancer patents may have numerous sde effects, both mnor and severe; however, most sde effects are uncommon or rare. The more common side effects of atovauone! aztreonam! cephalosporins! ciproflo"acin! clindamycin! gentamicin! metronidazole! and S#$%T#& include: nausea and vomtng darrhea oss of appette Eatng actve cutured yogurt may hep counteract darrhea, but f a patent has ow whte bood ces, ths remedy s not recommended. For md darrhea wth cephaosporns, ony darrhea medcnes contanng kaon or attapugte shoud be taken. Wth cndamycn, darrhea medcnes contanng attapugte shoud be taken severa hours before or after the ora antbotc. Darrhea foowng antbotcs ke cndamycn may ndcate a bactera nfecton that needs addtona therapy, and a physcan shoud be consuted. 'ther side effects of atovauone may include: fever skn rash cough headache nsomna 'ther side effects of ciproflo"acin may include: abdomna pan ncrease n bood tests for kdney functon dzzness or ght-headedness nfammaton or tearng of a tendon drowsness nsomna Other common sde effects of cndamycn ncude abdomna pan and fever. Sde effects may occur up to severa weeks after treatment wth ths medcne. Gentamcn and vancomycn may cause serous sde effects, partcuary n edery ndvduas and newborn nfants. These ncude kdney damage and damage to the audtory nerve that contros hearng. Other, more common sde effects of gentamcn may ncude: changes n urnaton ncreased thrst musce twtchng or sezures headache ethargy (hen gentamicin is in)ected into a muscle! vein! or the spinal fluid! the following side effects may occur: eg cramps skn rash fever sezures Sde effects from gentamcn may deveop up to severa weeks after the medcne s stopped. #ore common side effects of metronidazole include: mouth dryness unpeasant or metac taste dzzness or ght-headedness headache stomach pan Sugaress candy or gum, bts of ce, or a sava substtute may reeve symptoms of dry mouth. Pentamdne, pyrmethamne, sufonamdes, SMZTMP, and trmethoprm can ower the number of whte bood ces, resutng n an ncreased rsk of nfecton. These drugs aso can ower the number of bood pateets that are mportant for bood cottng. Thus, there s an ncreased rsk of beedng or brusng whe takng these drugs. Serious side effects of pentamidine may include: heart probems ow bood pressure hgh or ow bood sugar other bood probems decrease n urnaton sore throat and fever sharp pan n upper abdomen Some of these symptoms may not occur unt severa months after treatment wth pentamdne. Pyrmethamne and trmethoprm may ower the red bood ce count, causng anema. Leucovorn or the vtamn foc acd may be prescrbed for anema. Some ndvduas become more senstve to sunght when takng sufonamdes, SMZ-TMP, or trmethoprm. Other common sde effects of sufonamdes and SMZTMP ncude: dzzness tchng skn rash headache mouth sores or sweng of the tongue fatgue If vancomycn s n|ected nto a ven too qucky, t can cause fushng and a rash over the neck, face, and chest, wheezng or dffcuty breathng, and a dangerous decrease n bood pressure. Interactons Many prescrpton and non-prescrpton medcnes can nteract wth these antbotcs. Therefore, t s mportant to consut a compete st of known drug nteractons. Among the more common or dangerous nteractons: Antbotcs that ower the number of bood pateets, wth bood thnners (antcoaguants), such as warfarn Aztreonam and metrondazoe wth acoho; t s mportant not to consume acoho unt at east three days after treatment wth these antbotcs Cprofoxacn wth antacds, ron suppements, or caffene Pentamdne or pyrmethamne wth prevous treatments wth x rays or cancer medcnes (ncreased rsk of bood ce damage) Trmethoprm wth duretcs to remove excess fud n the edery Many medcnes can ncrease the rsk of hearng or kdney damage from gentamcn. These ncude: cspatn combnaton pan medcne wth acetamnophen and asprn or other sacyates (taken reguary n arge amounts) cycosporne nfammaton or pan medcne, except narcotcs thum methotrexate other medcnes for nfecton The following drugs may increase the ris* of liver effects with sulfadiazine or S#$%T#&: acetamnophen, ong-term, hgh-dose (eg Tyeno) brth contro ps contanng estrogens dsufram (Antabuse) other medcnes for nfecton Antibiotics are useless to apply at: 1. A fu - these condtons are caused by vruses, on whch antbotcs do not render any acton; 2. To the rased temperature - antbotcs are not febrfuga and anesthetzng prescrptons; 3. Infammatory processes - antbotcs have no ant-nfammatory acton; 4. Cough - there s a set of the reasons of cough: vrus nfectons, an aergy, the broncha asthma, the rased senstvty of broncha tubes an envronment both many others, and ony sma share of cough s connected to mcroorgansms; 5. Frustraton of ntestnes - t s absoutey not necessary, that the gven condton s an attrbute of an ntestna nfecton. Infrngement of a char many reasons, startng from smpe ntoerance of any product and fnshng food when n an organsm the actvator gets not, and deveoped t can cause toxn. Besdes t s necessary to note, that the ma|orty of ntestna nfectons are caused by vruses, but even f the actvator - bactera appcaton of antbotcs qute often ncreases duraton of dsease; 6. To appy antbotcs t s necessary under strct ndcatons and ony then when the doctor w estabsh the dagnoss of an nfectous dsease. A prescrptons of ths cass, unfortunatey, are not unversa and competey not harmess. Each antbotc has the spectrum of acton, .e. operates ony on the certan mcroorgansms senstve to t. Ony the doctor can defne, what antbotc s necessary at ths or that dsease. REFERENCE: http://www.heathne.com/gaecontent/antbotcs-1#4 http://abxst.com/ ANTIBIOTIC S NCM 106A Submtted by: Kerwin Ian S. Mempin BSN IV-| Submtted to: Filomena Demoni NCM 106A Advser