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Introduct you five books about Emodin Emodin, guidechem, 518-82-1 BOOK 1: J Nat Prod. 1995 Sep;58(9):1365-71. Effect of anthraquinone derivatives on lipid peroxidation in rat heart mitochondria: structure-activity relationship. Huang SS, Yeh SF, Hong CY. Lipid peroxidation was induced in rat heart mitochondria with FeSO4 and the inhibitory effects of various anthraquinone derivatives were compared. Oxygen consumption and malondialdehyde formation were used to quantitate the amount of lipid peroxidation. Emodin(CAS NO:518-82-1), alizarin, and alizarin complexone significantly inhibited lipid peroxidation; their potency as inhibitors of lipid peroxidation was higher than that of alpha-tocopherol. BOOK 2: Cancer Res. 1995 Sep 1;55(17):3890-6. Suppressed transformation and induced differentiation of HER-2/neu-overexpressing breast cancer cells by emodin(CAS NO: 518-82-1). Zhang L, Chang CJ, Bacus SS, Hung MC. The amplification and overexpression of the HER-2/neu proto-oncogene, which encodes the tyrosine kinase receptor p185neu, have been observed frequently in tumors from human breast cancer patients and are correlated with poor prognosis. BOOK 3: Oncogene. 1998 Jun 4;16(22):2855-63. Tyrosine kinase inhibitors, emodin and its derivative repress HER-2/neu-induced cellular transformation and metastasis-associated properties. Zhang L, Lau YK, Xi L, Hong RL, Kim DS, Chen CF, Hortobagyi GN, Chang C, Hung We have previously shown that emodin suppresses tyrosine kinase activity of HER-2/neu-encoded p185neu receptor tyrosine kinase. In this study, we examine the relationship between the chemical structure and the activity of emodin and nine derivatives, and identified that one methyl, one hydroxy, and one carbonyl functional groups are critical for the biological activities of emodin. BOOK 4: Life Sci. 2007 Oct 13;81(17-18):1332-8. Epub 2007 Sep 19. Emodin-mediated protection from acute myocardial infarction via inhibition of inflammation and apoptosis in local ischemic myocardium. Wu Y, Tu X, Lin G, Xia H, Huang H, Wan J, Cheng Z, Liu M, Chen G, Zhang H, Fu J, Liu Q, Liu DX. Acute myocardial infarction (AMI) is associated with inflammation and apoptosis. Emodin plays an anti-inflammatory role in several inflammatory diseases. Recent studies have demonstrated that

emodin protects against myocardial ischemia/reperfusion injury. BOOK 5: Br J Pharmacol. 2010 Sep;161(1):113-26. Emodin, a natural product, selectively inhibits 11beta-hydroxysteroid dehydrogenase type 1 and ameliorates metabolic disorder in diet-induced obese mice. Feng Y, Huang SL, Dou W, Zhang S, Chen JH, Shen Y, Shen JH, Leng Y. This study demonstrated a new role for emodin as a potent and selective inhibitor of 11beta-HSD1 and its beneficial effects on metabolic disorders in DIO mice. This highlights the potential value of analogues of emodin as a new class of compounds for the treatment of metabolic syndrome or type 2 diabetes. Want to learn more information about Emodin, you can access the guidechem.com. Guidechem Chemical Network providing the most complete information of the chemical industry.