Hypersensitivity

Type Molecule Antigen Type Effector Mechanism Reaction Diseases

I– IgE Soluble (i.e venom, IL-4, 5, 13 stim B cells to Allergic rhinitis, asthma, Anaphylaxis, Allergies (strong
Immediate pollen, foods, make IgE systemic anaphylaxis and rapid response to 2nd
dander, drugs) Allergen x-links IgE on Mast exposure)
cells – activation and
degranulation (Histamine,
PGE, leukotrienes)
II – Ab IgG/M Cell or ECM Ab deposit in tissue space – Drug allergies Hemolytic anemia, pernicious
Mediated associated Opsonization, Local anema, erythroblastosis fetalis,
Dzs inflammation (recruit cells, Rheumatic Fever,
produce ROI, proteases) Goodpasture’s, Graves’,
FcR+ phagocytes and NK Myasthenia Gravis
cells
III – Immune IgG Soluble Ag Immune complexes aggregate Vasculitis, Serum SLE, RA, polyarteritis nodosa,
Complex aggregates – circulating in blood and deposit into vascular Sickness (in vessels), Poststrep glomerulonephritis,
Mediated Immune space Arthus rxn (intradermal) Serum sicknes, Arthus Rxn
Dzs complexes Immune complexes activate
complement system – PMN
recruitment
IV – T cell TH1 Soluble MØ activation, IL-12, IFN-γ, Contact dermatitis, TB Contact dermatitis (i.e poison
Mediated TNF-α (Inflammation) rxn ivy), PPD, MS, Type I DM,
Dzs (DTH) TH2 Soluble Eosinophil activation, IL-4, Chronic asthma and Guillan-Barré, Hashimoto’s
-5, -13 allergic rhinitis (**diff Thyroiditis, GVHD,
(Inflammation) than type I)
CTL Cell associated CTL-mediated cytotoxicity Contact dermatitis

Cyclosporine – inhibits T cell gene tx and cell activation