FP MD 7100 Biostatistics II University of Utah Department of Family and Preventive Medicine Spring Semester, 2014 Lecture: W 1:00 pm~3:50

pm Instructor: Jaewhan Kim, Ph.D. Email: jaewhan.kim@utah.edu Classroom Location: DFPM 203 Office Hours: M. 12:30 pm 2:00pm Office phone: 801-587-3027

Required Textbook and Software: Statistical Modeling for Biomedical Researchers. 2nd Edition, William Dudley Dupont, 2009; Cambridge University Press. Stata Data Sets, Log Files and Do Files used in the text can be found at http://biostat.mc.vanderbilt.edu/dupontwd/wddtext/ .An electronic version of the textbook is available online at http://site.ebrary.com/lib/utah/Doc?id=10070217. Regression Methods in Biostatistics. 1st Edition, Eric Vittinghoff et. al. 2005; Springer Stata/IC 13 (one-year or perpetual license), can be ordered through Statss Direct -ship GradPlanTM at http://www.stata.com/order/new/edu/gradplans/gp-direct.html. Optional Texts: Statistics with Stata 10. Lawrence C. Hamilton, 2009; Duxbury Press. A Handbook of Statistical Analysis Using STATA. Sophia Rabe-Hesketh and Brian Everitt, 2000; CRC Press. Prerequisite: Biostatistics I (FP MD 6100) and Instructor's consent Course Objective: Biostatistics II explores the use of statistical modeling for analysis of health and medical data. Expanding upon the foundation laid in Biostatistics I, this course focuses on the analysis of data using a variety of regression and analysis of variance techniques, including: linear regression, logistic regression, proportional hazards regression, Poisson regression, fixed effects analysis of variance, and repeated measures analysis of variance. Examples and exercises throughout the course will utilize the Stata statistical software. The primary emphases of the course will be on the theoretical basis for each modeling technique, the commands to run these tests using Stata, appropriate interpretation of the results, and techniques for building multivariable models. Learning Objectives: Students will meet the following objectives at the conclusion of the semester. 1) Design and execute the calculations or statistical tests appropriate to advanced biostatistical modeling. 2) Interpret the findings and draw appropriate conclusions for each statistical modeling approach covered during the semester. 3) Identify the assumptions for each method of statistical modeling.

4) Select an appropriate modeling approach for a given data analysis problem from the materials covered during the semester. 5) Apply the best biostatistical analysis for situations requiring advance modeling and multi-variable analyses.

Homework: Homework will be submitted for each chapter covered. Students are to keep a copy of their completed homework for reference. Homework will be due 2 sessions past when the problems are assigned. In addition, there are going to be homework related to data practice which requires you to manage and analyze with some data.
Exams: The examinations will have the following types of questions: multiple choice questions; short answers; setting up and solving a problem from provided data; theoretical derivation; interpretation of results from output; a computer portion. If your answer is complete and correct you receive full credit; if you set up the problem correctly, but got the wrong answer due to a minor calculation error, you will receive partial credit. Note: The final exam is comprehensive. Project: Each student will be required to complete a project. This project provides students with the experience of working with a real analysis project. Students must individually utilize a dataset selected by students. Project should be written in article form, resulting in a report of at least 5 pages in contents. Each project should be in a publishable format, which includes: 1) A study question 2) A hypothesis/hypotheses 3) Data and regression descriptions 4) Assumption violations 5) Regression results including tables and figures 6) Interpretation of results 7) Conclusions The projects will be due in class on the day of the final exam. And, students will present their projects at the end of the semester. Make-up exam policy: You will be allowed to make-up exams within one week of the scheduled exam with prior approval (that is, the arrangements need to be made BEFORE the day of the exam) for an acceptable reason. These exams will be taken in the Testing Center (extension 1-8744; located in 498 SSB). There is a $5 fee for using Testing Center services. You will be required to supply a photo ID before being allowed to take the test. Testing Center hours are: M, W, F 8:00 am 3:00 pm, and T, Th 5:00 pm 8:30 pm. Any exceptions to this policy will require consultation with and approval from the instructor.

Grading:

20% 20% 40% 10% 10%

First Midterm Second Midterm Final exam (comprehensive) Homework submission Project

Assume standard grading criteria for this course as follows: 93-100% 90-92% 87-89% 83-86% 80-82% = = = = = A AB+ B B-

ADA Policy: The University of Utah seeks to provide equal access to its programs, services and activities for people with disabilities. If you will need accommodations in this class, reasonable prior notice needs to be given to the instructor and the Center for Disability Services, 581-5020 (Voice or TDD; located in 162 UNION) to make arrangements for accommodations. All written information for this course can be made available in alternative format with prior notification.
Date 01/08 01/15 01/29 02/05 02/12 02/19 02/26 03/05 03/12 03/19 03/26 04/02 04/09 04/16 04/23 04/25 Topic Chapter 1: Introduction Introduction to Stata Chapter 2 & Chapter 3 Chapter 2 & Chapter 3 Chapter 2 & Chapter 3 1st Midterm in class Chapter 4 & Chapter 5 Chapter 4 & Chapter 5 Spring Break Chapter 6 & Chapter 7 2nd Midterm in class Chapter 6 & Chapter 7 Chapter 8 & Chapter 9 Chapter 8 & Chapter 9 Student's presentation with the project Final exam in class (1:00-3:00 pm)

*Policy related to encryption All non-encrypted USBs are strictly prohibited from being used in any University owned Computer. Please make sure all of your materials are put onto an encrypted USB before plugging it into the Division computers. *This course will cover the following competencies from ASPH: A. Principles of Public Health 1. Identify the behavioral determinants of complex public health issues, and apply behavioral theories to the development and implementation of program and policies.

2. Assess the impact of social, political, economic and cultural forces on the development and implementation of health policy options and programs. 3. Discuss the inter-relationships between political and economic forces, technology, environmental processes and behaviors on exposures to environmental risk factors and subsequent health outcomes. 4. Evaluate the influence of behavioral, social, cultural, political, economic, environmental factors on the initiation and persistence of health disparities among sub-populations. B. Core Functions of Public Health: Assessment, Program Development and Assurance 6. Utilize descriptive and inferential statistical methods and epidemiologic principles to: a. critically evaluate and interpret scientific evidence from published studies, b. clearly articulate a public health issue and formulate relevant research questions, c. design appropriate/effective methods for collecting health and risk factor data for community needs assessments, surveillance, research and program evaluation. d. measure and compare the health status of populations, e. evaluate public health interventions and f. provide a basis for making decisions and developing policy and recommendations. 7. Based on existing data and information, develop goals, measurable objectives, programmatic activities, and expected outcomes for a public health program.

MSPH Core Competencies At the time of graduation each MSPH student should meet the MPH Core Competencies, as well as competencies that reflect the skills to assist in and conduct public health assessment, evaluation and research. The addition Core Competencies for the MSPH degree are: 1. 2. Synthesize existing research and develop a testable research hypothesis. Be proficient in the use of a statistical programming language (SAS, STATA , R) for integrating data, preparing data for analysis, managing databases and conducting descriptive and inferential statistics. Describe the principles of the Human Subject Protection and apply these principles to the design and conduct of research.

3.

PhD in Public Health Core Competencies PhD students are expected to meet not only the MPH Core Competencies described above, but to also meet a set of more advanced core competencies reflecting the skills and knowledge needed to conduct high quality public health research that reflects the ethical treatment of individuals and communities in the conduct of human research. At the time of graduation each PhD student should meet the following PhD Core Competencies: 1. Synthesize existing research and develop a testable research hypothesis. 2. Apply the basic tenets of public health to research problems. 3. Create an appropriate study design to address a research question.

4. Describe the principles of the Human Subject Protection and apply these principles to the design and conduct of research. 5. Demonstrate required skills for data collection, management and analysis. 6. Based on research findings, develop relevant programmatic and policy recommendations. 7. Effectively communicate research ideas and findings orally and in writing.