Drug study

Generic name, Brand name and Therapeutic class GN: Isosorbide Mononitrate BN: Monoket TC: Anti-anginal

Dosage and Mechanism of Frequency Action 30mg/ tab -Thought to reduce PO cardiac oxygen OD demand by decreasing preload and after load. Drug also may increase blood flow through the collateral coronary vessels.

Indication -Acute angina attacks -To prevent situations that may cause angina attacks

Contraindication -Hypersensitivity -Severe Hypotension -Glaucoma -Increased ICP -Shock -Blood volume depletion

Adverse effect CNS: Headache, weakness and dizziness CV: Hypotension, tachycardia, palpitations, ankle edema, flushing and fainting EENT: sublingual fainting GI: Nausea and vomiting Skin: Rash

GN: Enalapril Maleate BN: Vasotec TC: Anti-hyprtensive

5mg/ tab PO OD

-May inhibit ACE, preventing conversion of angiotensin I angiotensin II, a potent vasoconstrictor.

-Hypertension -To manage symptomatic heart failure -Asymptomatic left ventricular dysfunction

-Hypersensitivity -Pregnant women -Patients with Renal failure -Patients with aortic stenosis

CNS: Asthenia, headache, dizziness, fatigue and vertigo CV: Hypotension,

Nursing Considerations -Monitor blood pressure and heart rate, intensity and duration of drug response. -Advise patient that drug may cause headache especially at the beginning of the therapy. -Caution patient to avoid alcohol because it may worsen low blood pressure effects. -Tell the patient to minimize dizziness upon standing up and by changing upright position slowly. -Instruct patient to report breathing difficulty, swelling of face, eyes, tongue and mouth. -Advice patient to report signs of

GN: Carvedilol BN: Coreg TC: Antihypertensive

6.25mg/tab PO BID

Less angiotensin II decreases peripheral arterial resistance, decreasing aldosterone secretion reducing sodium and water retention hence lowering blood pressure. -Nonselective betablocker with alpha blocking activity.

chest pain and angina pectoris GI: diarrhea, nausea and vomiting Hema: bone marrow depression Respi: dyspnea Skin: Rash -Hypertension -Mild to severe heart failure -Chronic to stable angina -Idiopathic cardiomyopathy -Hypersensitivity -Hypertensive patients with left sided heart failure -Patients with thyroid disease -Breast feeding women CNS: dizziness, fatigue, depression and insomnia CV: hypotension, syncope, angina pectoris, fluid overload and chest pain EENT: abnormal and blurred vision GI: diarrhea, nausea and melena Respi: cough, rales and lung edema

infection such as fever or sore throat. - Advice patient to avoid salt substances -Closely monitored blood pressure response to drug.

-Inform the patient that improvement of heart failure symptoms might take several weeks of drug therapy -Advice diabetic patient to report changes in glucose level -Inform patient who wears contact lenses that their eyes may be dry. -Tell the patient to take the drug with food. -Inform the patient that they may feel low blood pressure when standing.

CN: Metronidazole BN: Flagyl TC: Anti-protozoal

375mg PO OD

GN: Paracetamol BN: Ibruprofen TC: Analgesics

500mg/tab PO TID

Direct-acting trichomonicide and amebicide that works inside and outside the intestines. It is thought to enter the cells of microorganism that contains nitroreductase, forming unstable compounds that bind to cell DNA and inhibit synthesis, causing cell death. Paracetamol may cause analgesia by inhibiting CNS prostaglandin synthesis.

-Intestinal -Hypersensitivity amebiasis -Patients with CNS -Trichomoniasis disorder -Bacterial infection -To prevent postoperative infections

CNS: headache, fever, vertigo, dizziness, syncope and weakness CV: edema EENT: rhinitis, sinusitis and pharyngitis GI: nausea, epigastric pain, vomiting, constipation and diarrhea

-Observe patient with edema -Tell the patient to avoid alcohol while taking the drugs -Tell the patient that they may experience metallic taste and dark or red brown urine

-Pain -Fever -Headache -Overextension -Arthritic pain

-Hypersensitivity

Hema: Neutropenia, Pancytopenia and hemolytic anemia Metabolic: hypoglycemia Skin: rash, urticaria Hepatic: Liver damage and jaundice

-Take with food or milk to minimize GI upset. -Report cyanosis, shortness of breath and abdominal pain as these are signs of toxicity. -Report paleness, weakness and heart beat skips - Report abdominal pain, jaundice, dark urine, itchiness or

clay-colored stools. .-Report pain that persists for more than 3-5 days -Avoid alcohol. -This drug is not for regular use with any form of liver disease. GN: Celecoxib BN: Celebrex TC: NSAID 400mg/ Capsule PO OD Prostaglandins are chemicals that are important contributors to the inflammation of arthritis that causes pain, fever, swelling and tenderness. Celecoxib blocks the enzyme that makes prostaglandinsresult ing in lower concentrations of prostaglandins. -Colorectal polyps -Adjunctive treatment to decrease number of adenomatous -Hypersensitivity -Patients with severe hepatic impairment -History of asthma CNS: dizziness, drowsiness, headache, insomnia and fatigue CV: peripheral edema EENT: sinusitis and rhinitis GI: nausea, vomiting, constipation, diarrhea and abdominal pain -Assess patients allergic reaction to the drug -Instruct the patient to take drug with food or milk. -Advised the patient to immediately report bloody stool.