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Definitions
Epidemiology
Risk Factors
Role of Ischaemia
Cardiomyopathies
Valvular Disease
Drugs
• Short QT syndrome
o Genetically heterogenous disorder – characterised by
marked abbreviation of QT interval (<300 ms) and high
incidence of atrial and ventricular arrhythmias and
sudden death in young patients? Gain of function
mutation of KCNE2 (IKr) (shortens action potential and
QT interval) (Brugada et al 2004 Circulation 109:30-35)
o Clinical manifestations wide – range from palpitations
and dizziness to sudden death. AD mode of inheritance.
(Gaita F et al Circulation 2003; 108:965-970)
o QT interval is shortened by increases in heart rate,
hyperthermia, increased calcium or potassium plasma
levels, acidosis or alterations of autonomic tone (Gaita F
et al Circulation 2003; 108:965-970)
o Lone AF in young individuals might be related to short
QT syndrome (Gaita F et al Circulation 2003; 108:965-
970)
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