2.

Mixing The ingredients are then loaded in a mass mixer and mixed for a particular time period which is than analyzed by QAD department . 3 . Filling & safety The blended ingredients are brought into the capsule filling area in IPC. The capsule filling area has a capsule filling machine which has assembled accordingly for different of apsule. The ingredients are loaded through drug hopper whereas empty gel tinge capsules are loaded from other hopper . the empty gel tinge capsule are then sealed and e ected by machine which are collected in double polyether lined fiber board drums. 4. Capsule Filling in process cheek (IP C! The following are in process chee! performed for capsules" a. #ize b. $eight %ariation test c. Disintegration test ". Capsule packing The capsule after filling and sealing are stored in capsule Quarantine &rom there it is sent to the pac!aging area for pac!ing. The machines are set by introducing new codes' rolls of P(C and alluminium foil bottle pac! as per re)uired for each batch.

PA*A+I,+ #! $trip packaging The tablets fromed by compression are enclosed in strip pac!ages . The strip utilizes the rolls of alluminium foils which are scaled together tablet with little application of heat' The coding is done stereotypically. After the strip pac!ing the strips are chec!ed for lea! in lea! test apparatus. The strips are then passed on to the secondary pac!agingarea through con%eyor belt. -oller heating temperature limit ./011c./211c 2! %lister packaging (Mo&el '( ))*! The tablet and capsule are pac!ed in 3lister pac!aging . 4ere the pac!aging materials used are P(C and alluminium foil which are sealed by little application of heat. After ' pac!aging the strips is tested I lea! Test apparatus and then passed on to the secondary pac!aging area through con%eyor belt.

56 3ottle pac!aging &irst the bottle are decartioning hall then passed for Air et cleaning of bottle . The bottle are then chec!ed under light and passed for filling . The bottle are filled by Triple 4ead &illing 7achine which is the following by capping and screwing .

II . #econdary 8 final pac!aging Area 4ere different pac!aging area. pac!aging line area assigned to different i.e one pac!aging line come from each strip pac!aging area one from blister pac!aging and one from bottle

All materials recei%ed through con%eyor from the primary pac!ing area are suitable chec!ed primary area are suitable chec!ed and boxes which pac!ed in cartons and suitable cooled sealed. Then operate the machine for pac!aging. -oller forming temperature 9 /21o c #ealing roller temperature 9 001o c Perform lea! test on /1 strips at a time

:. &inal pac!aging " The stripped capsule arri%ed at the secondary pac!aging area through the con%eyor belt from primary pac!aging area. #tripped capsules undergo manual inspection for any irregular printing or sealing or any damage. The they are pac!ed in cartoon which are subse)uently pac!ed in specified corrugated boxes and sealed. The boxes are then to the finished good storeroom.

III . D-; #;-<P

Dry syrups are oral dosage forms containing drug in a bottle in powder form which has to li)uefy administration. The general steps in%ol%ed in dry syrup manufacturing are . 0. #ifting and pul%erizing The acti%e ingredient and raw material are sifted through mechanical sifters and pul%erized through mill. 5. 3lending The sifted material are transferred to mass mixer and mixed for a particular time. The blended is then collected in IPC and shifted to in process )uarantine. 2. 3ottle washing The bottles are washed using et bottle' washing machine. =nsure that the bottle are cleaned thoroughly >. Drying The bottle are dried by !eeping in in%erter position in perforated trays. The bottles are then allowed to dry at room temperature. 3efore filling ensure that the bottle are dried completely by passing powder in few bottle and chec! for stic!ing of materials to bottle wall. :. Dry syrup 7achine used "Triple 4ead &illing 7achine. &irst of all the temperature and humidity of dry syrup and sealing area. ,ow assemble the machine and operate and fill the powder in clean dry bottles. ?. 3ottle sealing @modal 9-ATA7AT6 Ad ust the machine and seal the bottle using -APP Caps on sealing machine. After that put the clean measuring o%er the sealed and chec!ed bottle.

&BA$ DIA+-A7 #4A$I,+ #T=P# I, CAP#<B= 7&+.

#torage8-.7 $eighing In Process Chec!s #toring C polishing

&illing and #ealing

3lending QAD Analysis

=mpty +elatin Capsule

Physical Area Inspection

&inal Pac!ing

stripping

Dispatch

Bea! Test

F*+, -I./(.M +F C.P$0*1 FI**I2/ M.C3I21 Capsule 4opper $ith empty gelatin shells

Chute

&inger

-ectifier

Cap Plate

(acuum

Cap. 4olding Plate

Power or Drug 4opper

3ody Plate or Powder &illing