13 BCP Toxicity

I U C L I D
D a t a s e t
Existing Chemical Substance ID: 109706
CAS No. 109706
EINECS Name 1bromo3chloropropane
EINECS No. 2036971
Molecular Formula C3H6BrCl
Dataset created by: EUROPEAN COMMISSION European Chemicals Bureau
This dossier is a compilation based on data reported by the European
Chemicals Industry following Council Regulation (EEC) No. 793/93
on the Evaluation and Control of the Risks of Existing Substances.
All (nonconfidential) information from the single datasets, submitted
in the IUCLID/HEDSET format by individual companies, was integrated
to create this document.
The data have not undergone any evaluation by the European Commission.
Creation date: 18FEB2000
Number of Pages: 25
Chapters: all
Edition: Year 2000 CDROM edition
Flags: nonconfidential
(C) 2000 EUROPEAN COMMISSION
European Chemicals Bureau
date: 18FEB2000
1. General Information Substance ID: 109706
______________________________________________________________________________
1.0.1 OECD and Company Information
1.0.2 Location of Production Site
1.0.3 Identity of Recipients
1.1 General Substance Information

Substance type: organic
Physical status: liquid
1.1.1 Spectra
1.2 Synonyms
TRIMETHYLENE CHLOROBROMIDE
Source: ALBEMARLE PPC S.A. THANN
Trimethylenechlorobromide
Source: OrionYhtym Oy, Fermion Espoo
1.3 Impurities
1.4 Additives
1.5 Quantity
1.6.1 Labelling
1.6.2 Classification
1.7 Use Pattern
1.7.1 Technology Production/Use
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1.8 Occupational Exposure Limit Values
Type of limit:
Limit value:
Remark: No data of OEL values available
1.9 Source of Exposure
1.10.1 Recommendations/Precautionary Measures
1.10.2 Emergency Measures
1.11 Packaging
1.12 Possib. of Rendering Subst. Harmless
1.13 Statements Concerning Waste
1.14.1 Water Pollution
1.14.2 Major Accident Hazards
1.14.3 Air Pollution
1.15 Additional Remarks

Remark: This material must be considered as a hazardous waste or
material. Therefore, it must be disposed of in a "permitted"
hazardous waste facility in compliance with national and/or
local regulations. It should be handled in a manner
acceptable to good waste management practice. Incineration
is the recommended method of disposal.
1.16 Last Literature Search
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1.17 Reviews
1.18 Listings e.g. Chemical Inventories
3/25
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2. Physicochemical Data Substance ID: 109706
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2.1 Melting Point
Value: ca. 59 degree C
Method: other
Year: 1989
GLP: no data
(1)
Value: 58.9 degree C
Method: other
Year: 1979
GLP: no data
(2)
Value: = 58.9 degree C
2.2 Boiling Point
Value: ca. 141 degree C
Method: other
Year: 1989
GLP: no data
(1)
Value: = 143.3 degree C
Value: 143.4 degree C at 1012.32 hPa
Method: other
Year: 1979
GLP: no data
(3)
2.3 Density
Type: density
Value: ca. 1.5969 g/cm3 at 20 degree C
Method: other
Year: 1979
GLP: no data
(4)
Type: density
Value: = 1.6 g/cm3 at 20 degree C
2.3.1 Granulometry
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2.4 Vapour Pressure
Value: ca. 12.987 hPa at 32 degree C
Method: other (measured)
Year: 1989
GLP: no data
(1)
Value: = 13.3 hPa at 32.4 degree C
Method: other (measured)
2.5 Partition Coefficient
2.6.1 Water Solubility

Value: = 0
2.6.2 Surface Tension
2.7 Flash Point

Value: = 57 degree C
Type:
Method: other
Year:
Remark: DIN 51755
2.8 Auto Flammability
2.9 Flammability
2.10 Explosive Properties

Result: other
Remark: 3.2 vol% / 8.6 vol%
2.11 Oxidizing Properties
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3. Environmental Fate and Pathways Substance ID: 109706
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3.1.1 Photodegradation
3.1.2 Stability in Water
3.1.3 Stability in Soil
3.2 Monitoring Data (Environment)
3.3.1 Transport between Environmental Compartments
3.3.2 Distribution
3.4 Mode of Degradation in Actual Use
3.5 Biodegradation
3.6 BOD5, COD or BOD5/COD Ratio

Method: other: APHA Standard Method 219, 1971
Year: 1979 GLP: no data
Concentration: g/l related to
Method: other: ASTM D 125267, 1974
Remark: BOD was conducted in accordance with the standard dilution
method of the American Public Health Association No. 219,
1971, at 20 +/ degrees C. for 5 days. One deviation was
the addition of 0.5 mg/liter of allylthiourea in each test
to prevent nitrification. The 500 ml test solutions were
seeded with a filtered 10 ml volume of effluent from a
biological sanitary waste treatment plant. Stirring was
applied to thorougly mix. In duplicate, tests on a mixture
of glutamic acid and glucose were run to assure activity of
the inoculum.
COD was conducted in accordance with the standard
potassium dichromate method in ASTM D 125267.
Theoretical oxygen demand was determined to be 0.81
grams/gram. BOD5 was determined to be 0.02 g/g or 3% of
theoretical oxygen demand. COD5 was determined to be 0.84
g/g or 104% of theoretical.
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3. Environmental Fate and Pathways Substance ID: 109706
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(5)
3.7 Bioaccumulation
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4. Ecotoxicity Substance ID: 109706
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AQUATIC ORGANISMS
4.1 Acute/Prolonged Toxicity to Fish
Type: static
Species: Carassius auratus (Fish, fresh water)
Exposure period: 24 hour(s)
Unit: g/l Analytical monitoring: yes
LC50: ca. 75000
Method: other: standard methods followed
Test substance: no data
Remark: This study used goldfish averaging 3.3 grams in weight and
6.2 cm in length. Dissolved oxygen was recorded as greater
than 4.0 mg/liter and the pH of the fresh (local tap) water
used in the test was 7.0. Standard methods of the American
Public Health Association, 1971 for static tank acute
toxicity tests were used. A volatile comment was made,
thus aeration was minimized. LC50 was recorded as 75000
ug/liter.
(6)
Type: other
Species: Carassius auratus (Fish, fresh water)
Exposure period: 24 hour(s)
Unit: mg/l Analytical monitoring:
LC50: = 75
Method:
Year: GLP:
Test substance:
4.2 Acute Toxicity to Aquatic Invertebrates
4.3 Toxicity to Aquatic Plants e.g. Algae
4.4 Toxicity to Microorganisms e.g. Bacteria
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4. Ecotoxicity Substance ID: 109706
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4.5 Chronic Toxicity to Aquatic Organisms
4.5.1 Chronic Toxicity to Fish
4.5.2 Chronic Toxicity to Aquatic Invertebrates
TERRESTRIAL ORGANISMS
4.6.1 Toxicity to Soil Dwelling Organisms
4.6.2 Toxicity to Terrestrial Plants
4.6.3 Toxicity to other NonMamm. Terrestrial Species

Species: other: Xenopus laevis
Endpoint: mortality
Expos. period: 48 hour(s)
Unit: other: ug/l
LC50: 41000
Method: other
Remark: Three to four week clawed toads were used in this static
study in fresh water. Temperature was maintained at 20
degrees C. Concentrations were not measured. LC50 was
reported as 41000 ug/liter.
(7)
4.7 Biological Effects Monitoring
4.8 Biotransformation and Kinetics
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5. Toxicity Substance ID: 109706
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5.1 Acute Toxicity
5.1.1 Acute Oral Toxicity
Type: LD50
Species: rat
Sex:
Number of
Animals:
Vehicle:
Value: 1100 1200 mg/kg bw
Method: Directive 84/449/EEC, B.1 "Acute toxicity (oral)"
Year: 1993 GLP: yes
Test substance: as prescribed by 1.1 1.4
Remark: Groups of 10 (5 male, 5 female) Sprague Dawley rats were
gavaged with a single dose of neat test article at either
0.8, 1.0, or 1.6 grams/kg body weight. There were deaths in
male and female rats at 1.0 grams/kg and above. Deaths
occurred within 4 hours to day 7. Slight body weight
changes were noted in all animals that died. Macroscopic
exam of animals that died revealed pale liver, dark spleen,
and congested large intestine blood vessels in one male
dosed at 1 gram/kilogram. One male and one female dosed at
1.6 grams/kilogram had slight congestion of the blood
vessels of the glandular stomach, and the female also had
congested intestinal vessels.
Clinical signs included piloerection and increased
salivation in all rats within 5 minutes. Other signs
included hunched posture, waddling gait, lethargy, decreased
respiratory rate, ptosis, pallor of extremities, swollen
nictating membranes, ataxia, prostration, and body tremors.
Surviving animals had normal external appearance and
behavior by day 3 (0.8 g/kg) or day 4 (1.0 g/kg).
At necropsy of surviving animals, one female had a pale
mottled liver (0.8 g/kg).
When a fixed slope of 8.2 was assumed, the acute median
lethal dose for both sexes and its 95% confidence limts
were estimated to be 1.1 (1.0 to 1.3) grams/kg body weight.
Estimate for males alone was 1.1 (0.9 to 1.4) g/kg and for
females alone was 1.2 (1.0 to 1.5 grams/kilogram body
weight.
(8)
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Type: LD50
Species: rat
Sex:
Number of
Animals:
Vehicle:
Value: 680 mg/kg bw
Method: other
Remark: Five groups of ten rats (5 male, 5 female) were gavaged with
test article at doses of 250, 625, 700, 775, and 1000 mg/kg
body weight. Test article was carried in 0.25%
methylcellulose. The 250 mg/kg dose group showed increased
salivation and slight piloerection. The salivation was
greater in the 650 mg/kg group. Overt symptomology was
present in higher dose groups. Mortality was 2 of 10 in the
635 mg/kg group, 5 of 10 in the 700 mg/kg group, and all of
the rats in the 775 and 1000 mg/kg groups. Necropsy
findings in some rats that died included reddened
intestinges, and clear pleural fluid. LD50 was calculated
by the method of Litchfield and Wilcoxon, 1949. Oral LD50
with 95% confidence limits was 680 mg/kg (621 to 745 mg/kg).
(9)
Type: LD50
Species: rat
Sex:
Number of
Animals:
Vehicle:
Value: 930 1100 mg/kg bw
Method: other
Remark: In short term experiments in female albino rats gavaged with
test article, LD50 was found to be 1,100 (9871227) mg/kg.
LD16 was 940 mg/kg and LD84 was 1290 mg/kg. Most deaths
occurred within two days. Clinical signs included
depression, lack of activity progressing to muscular
weakness. Necropsy findings included congestion of
internal organs and reduced thickness of gastric wall with
hemorrhagic zones. Microscopic exam showed dystrophic
changes of parenchymatous organs and congestion and edema of
the stomach.
Male rats had an LD50 of 930 mg/kg.
(10)
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Type: LD50
Species: rat
Sex:
Number of
Animals:
Vehicle:
Value: = 930 mg/kg bw
Method:
Year: GLP:
Test substance:
Type: LD50
Species: mouse
Sex:
Number of
Animals:
Vehicle:
Value: 1290 mg/kg bw
Method: other
(11)
5.1.2 Acute Inhalation Toxicity
Type: LC50
Species: rat
Sex:
Number of
Animals:
Vehicle:
Exposure time: 60 minute(s)
Value: > 13.92 mg/l
Method: other
Year: 1976 GLP: no
Test substance: other TS
Remark: Five male and five female Sprague Dawley rats were used in
this acute inhalation study. An airstream containing a
saturated vapor of the test article was passed through a
26.5 liter test chamber containing the rats. The saturated
vapor was generated by passing a 2 liter per minute
airstream through a midget bubbler containing the test
material. Total airflow through the chamber was 4 liters
per minute. The bubbler was weighed before and after the
exposure period of 60 minutes. A total of 3.34 grams of
test material was delivered to give an overall nominal
chamber concentration of 13.92 mg/liter at 1 atmosphere
pressure and 23 degrees C.
There were no deaths within 15 days. Clinical signs
noticed during exposure were tearing and eye closure. This
behavior subsided after the exposure period. Other inlife
observations included nasal discharge, wheezing, soft stool
and urinary incontinence, but these effects varied in
frequency and were not thought compound related. Body
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weights and necropsy findings did not reveal test article
related toxicity.
(12)
Type: LC50
Species: rat
Sex:
Number of
Animals:
Vehicle:
Exposure time: 4 hour(s)
Value: 7.27 mg/l
Method: other
Remark: An LC50 of 7.27 (7.007.55) mg/liter was determined in
female albino rats inhaling vapors of test article for 4
hours. LC16 was 6.8 mg/liter and LC84 was 7.8 mg/liter.
Concentration analysis of air samples was performed by the
method of F.D. Krivoruchko (1967). Male rats had an LC50 of
6.5 mg/liter. Clinical signs were similar to those seen in
the oral studies. Necropsy findings included congestion of
internal organs and pulmonary hemorrhages. Microscopic
examination revealed fatty degeneration of the liver and
albuminoid degeneration of the kidneys. Congestion and
irritation of the bronchial mucosa, fatty degeneration of
the heart, and edema and swelling of neural tissue of the
brain were seen.
(10)
Type: LC50
Species: rat
Sex:
Number of
Animals:
Vehicle:
Exposure time:
Value: 5.668 mg/l
Method: other
(13)
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Type: LC50
Species: mouse
Sex:
Number of
Animals:
Vehicle:
Value: 7.27 mg/l
Method: other
Remark: No toxic effect noted.
(14)
Type:
Species:
Sex:
Number of
Animals:
Vehicle:
Exposure time:
Value:
Method:
Year: GLP:
Test substance:
5.1.3 Acute Dermal Toxicity
Type: LD50
Species: rat
Sex:
Number of
Animals:
Vehicle:
Value: > 2000 mg/kg bw
Method: other: EEC 84/449/EEC B.3
Year: 1992 GLP: yes
Remark: A group of 10 rats (5 male, 5 female) were clipped of back
hair over an area not greater than 10% of the total body
surface. Neat test article was applied as a single
application of 2.0 g/kg body weight to the intact skin under
a dressing and was allowed to remain for 24 hours. Removal
of test article was made with warm water. There were no
deaths within 15 days of application. Increased locomotor
activity and respiratory rate were seen immediately after
dosing. Sites of application showed no irritation.
Slightly lower body weight gains were noted on some days in
some animals. No abnormalities were noted at necropsy.
(15)
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Type: LD50
Species: rabbit
Sex:
Number of
Animals:
Vehicle:
Value: 3000 mg/kg bw
Method: other: 16 CFR 1500.40
Remark: This acute dermal toxicity study used four New Zealand White
rabbits per dose group. Hair was clipped over at least 30%
of the body surface area, and two rabbits of each dose
group had abrasions penetrating the stratum corneum
prepared over the area of exposure. Dose groups were 2.0,
2.8, 4.0, and 5.7 grams/kg body weight. Test article was
applied under an impervious sleeve for 24 hours. After 24
hours, test article was wiped from the skin and dermal
reactions scored. One animal of four died in the 2.0 and
2.8 grams/kg groups. All animals died at higher dose
levels. Slight to moderate erythema and edema were noted
in all animals at 24 hours. Clinical signs in the first 24
hours included ataxia and prostration. Muscle tremors were
noted at 2.0 and 2.8 mg/kg. In the higher dose groups,
tachypnea, corneal and conjunctival redness and dilation of
the pupils were noted. All surviving animals were free of
clinical signs by day 2.
LD50 was estimated by means of logarithmicprobit graph
paper (Miller and Tainter, 1944). LD50 with 95% confidence
levels was 3000 grams/kilogram body weight (2.2 to 3.8
grams/kg).
(16)
5.1.4 Acute Toxicity, other Routes
Type: other
Species: mouse
Sex:
Number of
Animals:
Vehicle:
Route of admin.: other: tail skin
Value:
Method: other
Remark: Four hour exposure of mice to test article via the tail did
not cause deaths within a 14 day observation period.
However, pronounced hyperemia of the tail skin was observed,
progressing to necrosis on the second or third day,
followed by sloughing of the necrotic tissue.
(10)
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5.2 Corrosiveness and Irritation
5.2.1 Skin Irritation
Species: rabbit
Concentration:
Exposure:
Exposure Time:
Number of
Animals:
PDII:
Result: not irritating
EC classificat.: not irritating
Method: Directive 84/449/EEC, B.4 "Acute toxicity (skin irritation)"
Year: 1992 GLP: yes
Remark: Three rabbits were administered 0.5 ml of test article to
the intact skin under a semiocclusive dressing for a period
of 4 hours before removal of test article with warm water,
and observed for 5 days. Reactions were very slight to
well defined, but had resolved by day 5. Edema scores were
"1" for all rabbits on days 3 and 4 and "0" at all other
points. Mean redness scores were "0" on day 1, "0.67" on
day 2, "2" on day 3, "1" on day 4 and "0" on day 5. It was
concluded that the test article did not require labelling
with risk phrase R38.
(17)
Species: rabbit
Concentration:
Exposure:
Exposure Time:
Number of
Animals:
PDII:
Result:
EC classificat.:
Method: other: FHSA 16 CFR 1500.41
Remark: Six New Zealand White rabbits were clipped of hair over the
back and sides. Two test sites per rabbit were prepared,
one site was abraded. Neat test material (0.5 ml) was
applied under gauze on the test site, and the animals
wrapped with an occlusive dressing. After 24 hours, the
wrappings and gauze were removed. Mean erythema scores for
intact and abraded skin were 1.17 at 24 hours and 1.0 at 72
hours. Mean edema scores for intact skin were 1.33 for 24
and 72 hour readings. Mean edema score for 24 hours on
abraded skin was 1.83 and at 72 hours was 1.67.
Primary Dermal Irritation Index was 2.63.
(18)
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5.2.2 Eye Irritation
Species: rabbit
Concentration:
Dose:
Exposure Time:
Comment:
Number of
Animals:
Result: not irritating
EC classificat.: not irritating
Method: Directive 84/449/EEC, B.5 "Acute toxicity (eye irritation)"
Year: 1993 GLP: yes
Remark: Three rabbits were each administered a single ocular dose of
0.1 ml test substance and observed over a 7 day period.
Effects were temporary corneal opacity (one animal),
transient dulling of the cornea (1 animal), transient
iridial inflammation (one animal) and slight to well defined
conjunctival irritation. All reactions had resolved in 7
days. Interpretation was that the test article did not
require labelling with risk phrase R36.
(19)
Species: rabbit
Concentration:
Dose:
Exposure Time:
Comment:
Number of
Animals:
Result:
EC classificat.:
Method: other: FHSA 16 CFR 1500.42
Remark: Six New Zealand White rabbits had 0.1 ml of test article
instilled into the right eye without washout. Scoring for
ocular reaction was done on days 1 to 4 and day 8. Five of
six animals had positive scores for conjunctival irritation
at some reading. Corneal opacities were noted in three of
these eyes. One eye had an ulceration of the nictitating
membrane. All eyes were free of irritation by day 8.
Maximum Draize score was a "30" in one animal. Mean Draize
score was 17.
(20)
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Species: rabbit
Concentration:
Dose:
Exposure Time:
Comment:
Number of
Animals:
Result:
EC classificat.:
Method: other
Remark: When applied to the mucosa of rabbit eyes, test article
caused pronounced redness and purulent conjunctivitis that
cleared in 4 days.
(10)
5.3 Sensitization
5.4 Repeated Dose Toxicity

Species: rat Sex:
Strain:
Route of admin.: other: oral and inhalation
Exposure period:
Frequency of
treatment:
Post. obs.
period:
Doses:
Control Group:
Method:
Year: GLP:
Test substance:
Remark: A "subchronic toxicity test" by the method of Lim et al.
(1961) was conducted. There were no deaths in animals by
the 24th day when animals had received 9 x LD50. During the
next 4 days, animals tolerated daily doses nearly as high
as the LD50.
Two concentrations (0.045 and 0.0054 mg/liter) were used
in long term experiments using six animals per group.
Various effects were seen from the high concentration:
increased summation threshold index, decreased ability to
eliminate sulfobromophthalein from the blood, and increased
liver weight coefficients. Histologically, liver changes
included moderate albuminoid and fatty degeneration of the
parenchyma and focal proliferation of the interstitial
tissue cells. Few effects were seen as a result of the
lower concentration; histological effects were mild. After
a onemonth recovery period, the residual pathological
processes were hardly noticeable, and were of a
proliferative nature.
Anaphase analysis of bone marrow cells showed higher
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number of chromosome aberrations in animals exposed to 0.45
mg/liter than in the control animals. Changes in germinal
epithelium and a tendency towards reduction in testicular
weight coefficient and spermatzoa motility time were noted.
Degenerative changes were seen in spermatagonia and
spermatazoa.
(10)
5.5 Genetic Toxicity in Vitro
Type: Ames test
System of
testing: Salmonella typhimurium strains TA 1535, TA 1537, TA 1538,
TA100, and TA98
Concentration: 0.1 ul; 0.5 ul; 1.0ul; 5.0 ul; 10 ul of a 10% solution TA in
DMSO
Metabolic
activation: with and without
Result: negative
Method: other: Ames et al. 1975
Remark: Test article for this study was a 10% (v/v) solution in
DMSO. Five concentrations were tested in each strain.
Concentrations tested in units per plate were 0.1 ul, 0.5
ul, 1.0 ul, 5.0 ul, and 10.0 ul. The 10 ul per plate
concentration was toxic to TA 1537, TA 1538, and TA 98 in
the assay without metabolic activation. Other
concentrations were not toxic to any strain in either
assay. Metabolic activation involved preparation of S9
fraction from Aroclor 1254 induced adult male Sprague Dawley
rats.
Criteria for a valid test were met. The test agent did
not induce a significant increase in the number of point
mutations in Salmonella typhimurium strains in the presence
of an exogenous source of liver enzymes for metabolic
activation nor in the absence of the activating system for
the strains TA 1535, TA1537, TA1538, TA100, and TA 98.
(21)
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5.6 Genetic Toxicity in Vivo
Type: Dominant lethal assay
Species: rat Sex: male/female
Strain: SpragueDawley
Route of admin.: gavage
Exposure period: once daily, 5 days/week for 10 weeks
Doses: 25 mg/kg; 75 mg/kg; and 125 mg/kg body weight
Result:
Method: other: FDA modified
Remark: Three groups of ten male Sprague Dawley rats were given test
article orally at doses of 125, 75, and 25 mg/kg.
Concurrently, triethylenemelamine was given as a positive
control orally to a group of 10 male rats at a dose of 0.05
mg/kg. Vehicle control group of ten rats received 0.25%
methylcellulose. Each substance was administered once daily
for five days a week for ten consecutive weeks. After the
final dose, each male was cohoused with two virgin females
for seven days. The mating was repeated the following week
for a total of two mating periods. The femaes were
sacrificed at 14 days from the midweek of cohousing and
the number of the corpora lutea and live and dead implants
recorded. The test article did not produce dominant lethal
effects in the male rats at the doses administered as
measured by preimplantation and postimplantation losses.
Dominant lethal effects were seen in the positive control
group as a sinificant increase in postimplanatation deaths.
(22)
5.7 Carcinogenicity
5.8 Toxicity to Reproduction

Type: other: testicular function
Species: mouse Sex: male
Strain: CD1
Route of admin.: gavage
Exposure Period: 5 consecutive days
Frequency of
treatment: once daily for 5 days
Duration of test: six weeks
Doses: 300, 600, 1200 mg/kg/day
Control Group: yes, concurrent vehicle
NOAEL Parental: 600 mg/kg bw
Method:
Remark: A testicular funtion study was conducted in Charles River
CD1 mice to evaluate the effects of test article on
spermatogenesis. Sexually mature mice approximately 3
months of age at the start of the study were treated orally
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for 5 consecutive days with test article in corn oil at
doses of 300, 600, or 1200 mg/kg body weight per day. A
control group received 5 ml/kg of corn oil vehicle per day.
After dosing, 1/6 of each group (4 treated and seven
control rats) were sacrificed at the one week post
treatment date. This process was repeated over the next
five weeks. At sacrifice, a smear of the contents of the
cauda epididymidis was examined for spermatazoa and testes
weighed before fixing and histological exam.
Twenty of the 24 mice in the 1200 mg/kg dose group died
by the fifth dose. No effects attributable to treatment
were observed in mice given 600 mg/kg body weight or less in
the areas of clinical signs of toxicity, body weight,
spermatogenesis or testicular morphology.
(23)
5.9 Developmental Toxicity/Teratogenicity
5.10 Other Relevant Information

Type: other: testicular effects
Remark: Toxicity of 1chloro3bromopropane was evaluated in male
albino Wistar rats for testicular effects. The control
group of 20 animals were given arachis oil vehicle. Test
groups (10 per group) were exposed by gavage to 40 or 160
mg/kg/day of test article for 14 days. Animals were
sacrificed on day 15 for pathological exam. No significant
differences between control and treated animals were seen in
body weights, body weight gains, testes weights, morphology
or in detailed macroscopic and microscopic examination of
the kidneys, testes, epididymides, ductuli efferentes, and
vasa deferentes.
(24)
5.11 Experience with Human Exposure
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date: 18FEB2000
6. References Substance ID: 109706
______________________________________________________________________________
(1) RhonePoulenc Inc. Material Safety Data Sheet, Princeton
N.J., 1989.
(2) Weast, R.C., ed., Handbook of Chemistry and Physics, 60th
edition, Boca Raton, Florida, CRC Press Inc., 1979
edition, Boca Raton, Florida: CRC Press Inc., 1979. C446.
edition, Boca Raton, Florida. CRC Press, Inc., 1979.C446.
(5) Bridie, A.L., Wolfe, C.J.M., and Winter, M. "BOD and COD of
Some Petrochemicals," Water Research, 13, 627630, 1979.
(6) Bridie, A.L., Wolff, C.J.M., Winter, M., "The Acute Toxicity
of Some Petrochemicals to Goldfish," Water Res. 13(7):
623626. as reported in the AQUIRE database.
(7) DeZwart, D., and Sloof, W. "Toxicity of Mixtures of Heavy
Metals and Petrochemicals to Xenopus laevis," Bull.
Environ. Contam. Toxicol., 38(2):345351, 1987 as cited in
AQUIRE database.
(8) Rhone Poulenc, France, unpublished studies,
"1Bromo3chloropropane Acute Oral Toxicity to the Rat,"
conducted at Huntingdon Research Centre, 1993.
(9) Ethyl Corporation, unpublished data, "Acute Oral LD50
Determination in Rats," conducted at Pharmakon Laboratories,
1979
(10) Eytingon, A.I., "Characteristics of the General Toxic,
Gonadatropic, and Mutagenic Effects of
1,3chlorobromopropane," Toksikologiya Novykh
Promyshlennykh Khimicheskikh Veshchestv, No. 12, pp 93100,
1971.
(11) Registry of Toxic Effects of Chemical Substances, 19851986,
citing Toxicometric Parameters of Industrial Toxic
Chemicals Under Single Exposure, Moscow, 1982.
(12) Ethyl Corporation, unpublished data, "Acute Inhalation
Study Compound TMCB," conducted by Bio/dynamics Inc.,
1976.
citing Gigiena Truda i Professionalnye Zabolevaniia, USSR.
19 (9) 36, 1975.
citing Toxicometric Parameters of Industrial Toxic
ChemicalsUnder Single Exposure, Moscow, 1982.
23/25
date: 18FEB2000
6. References Substance ID: 109706
______________________________________________________________________________
"1Bromo3chloropropane Acute Dermal Toxicity to the rat,"
(16) Ethyl Corporation, unpublished data, "Acute Dermal Toxicity
Study Compound TMCB," conducted by Bio/dynamics Inc., 1977.
"1Bromo3chloropropane Skin Irritation to the Rabbit,"
(18) Ethyl Corporation, unpublished data, "Primary Dermal
Irritation Compound TMCB," conducted by Bio/dynamics Inc.,
1976.
"1Bromo3chloropropane Eye Irritation to the Rabbit,"
(20) Ethyl Corporation, unpublished data, "Rabbit Eye Irritation
Study Compound TMCB," conducted by Bio/dynamics Inc., 1976.
(21) Ethyl Corporation, unpublished data, "Activity of TMCB in
the Salmonella/Microsomal Assay for Bacterial Mutagenicity,"
conducted by Microbiological Associates, 1978.
(22) Ethyl Corporation, unpublished data, "Dominant Lethal Assay
FDA Modified," conducted by Pharmakon Laboratories, 1980.
(23) Ethyl Corporation, unpublished data, "Effects from Five Days
of Treatment on Testicular Function in Mice," conducted by
International Research and Development Corporation, 1978.
(24) Tunstall Laboratory, Shell Oil Company, "Toxicity of Fine
Chemicals: Preliminary Studies for the Detection of
Testicular Changes in Rats," 1979 as reported in EPA
Document 878216424, Fiche No. OTS0510352.
24/25
date: 18FEB2000
7. Risk Assessment Substance ID: 109706
______________________________________________________________________________
7.1 Risk Assessment
25/25

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I U C L I D

1.0.2 Location of Production Site

1.0.3 Identity of Recipients

1.1 General Substance Information

1.7 Use Pattern

1.7.1 Technology Production/Use

1.10.1 Recommendations/Precautionary Measures

1.10.2 Emergency Measures

1.12 Possib. of Rendering Subst. Harmless

1.13 Statements Concerning Waste

1.14.1 Water Pollution

1.14.2 Major Accident Hazards

1.14.3 Air Pollution

1.15 Additional Remarks

1.18 Listings e.g. Chemical Inventories

2.6.1 Water Solubility

2.7 Flash Point

2.10 Explosive Properties

3.1.2 Stability in Water

3.1.3 Stability in Soil

3.2 Monitoring Data (Environment)

3.3.1 Transport between Environmental Compartments

3.4 Mode of Degradation in Actual Use

3.6 BOD5, COD or BOD5/COD Ratio

3.8 Additional Remarks

4.3 Toxicity to Aquatic Plants e.g. Algae

4.4 Toxicity to Microorganisms e.g. Bacteria

4.5.2 Chronic Toxicity to Aquatic Invertebrates

4.6.2 Toxicity to Terrestrial Plants

4.6.3 Toxicity to other NonMamm. Terrestrial Species

4.8 Biotransformation and Kinetics

4.9 Additional Remarks

5.4 Repeated Dose Toxicity

5.8 Toxicity to Reproduction

5.10 Other Relevant Information

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