Antimicrobial actions of -mangostin against oral streptococci.

Home Latest PubMed Articles Canadian journal of microbiology Antimicrobial actions of -mangostin against oral streptococci.

Summary
T e increasing pre!alence of dental caries is ma"ing it more of a major #orld ealt problem. Caries is t e direct result of acid production by cariogenic oral bacteria$ especially %treptococcus mutans. &e# and better antimicrobial agents acti!e against cariogenic bacteria are badly needed$ especially natural agents deri!ed directly from plants. 'e a!e e!aluated t e in ibitory actions of ()-mangostin$ a *ant one purified from et anolic e*tracts of t e tropical plant +arcinia mangostana L.$ by repeated silica gel c romatograp y. ()-Mangostin #as found to be a potent in ibitor of acid production by %., mutans -A./0$ acti!e against membrane en1ymes$ including t e 23H45-ATPase and t e p osp oenolpyru!ate, - sugar p osp otransferase system. ()-Mangostin also in ibited t e glycolytic en1ymes aldolase$ glyceralde yde-6-p osp ate de ydrogenase$ and lactic de ydrogenase. +lycolysis by intact cells in suspensions or biofilms #as in ibited by ()-mangostin at concentrations of .7 and .78, ,9mol,:L-.$ respecti!ely$ in a pH-dependent manner$ #it greater potency at lo#er pH !alues. ;t er targets for in ibition by ()-mangostin included 3i5 malolactic fermentation$ in!ol!ed in al"ali production from malate$ and 3ii5 &A<H o*idase$ t e major respiratory en1yme for %., mutans. T e o!erall conclusion is t at ()-mangostin is a multitarget in ibitor of mutans streptococci and may be useful as an anticaries agent.

Affiliation Journal Details

Name: Canadian journal of microbiology ISSN= .>?8-67@/ Pages= 7.@-7/

Links

PubMed %ource= ttp=AA###.ncbi.nlm.ni .go!ApubmedA7.6/?@B6 <;C= ttp=AAd*.doi.orgA.8...60A#.8-.77

!S" Definitions
#ral e$icine

A branc of dentistry dealing #it diseases of t e oral and paraoral structures and t e oral management of systemic diseases. 3Hall$ ' at is ;ral Medicine$ Any#ayD Clinical -pdate= &ational &a!al <ental Center$ Marc .00.$ p@-?5

%iri$ans Streptococci
A large eterogeneous group of mostly alp a- emolytic streptococci. T ey coloni1e t e respiratory tract at birt and generally a!e a lo# degree of pat ogenicity. T is group of species includes %TEFPT;C;CC-% MCTC%G %TEFPT;C;CC-% M-TA&%G %TEFPT;C;CC-% ;EALC%G %TEFPT;C;CC-% %A&+-C%G %TEFPT;C;CC-% %;HEC&-%G and t e %TEFPT;C;CC-% MCLLFEC +E;-P. T e latter are often betaemolytic and commonly produce in!asi!e pyogenic infections including brain and abdominal abscesses.

#ral "ygiene
T e practice of personal ygiene of t e mout . Ct includes t e maintenance of oral cleanliness$ tissue tone$ and general preser!ation of oral ealt .

&'romogranin A
A type of c romogranin # ic #as first isolated from CHE;MA22C& CFLL% of t e A<EF&AL MF<-LLA but is also found in ot er tissues and in many species including uman$ bo!ine$ rat$ mouse$ and ot ers. Ct is an acidic protein #it >6. to >>/ amino acid residues. Ct contains fragments t at in ibit !asoconstriction or release of ormones and neurotransmitter$ # ile ot er fragments e*ert antimicrobial actions.

#ral

anifestations

<isorders of t e mout attendant upon non-oral disease or injury.

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