How does keme work?

According to the reports from the Kyoto University, Dr. A.

Kawata, dedicated to human growth research, discovered
that human height is not exclusively pre-determined by
genetic action alone, but is also strongly influenced by
the effects of certain hormones on the development
of the cartilaginous portions of the 62 bones of the
lower body, as well as the 24 separate and moveable
bones constructing the spinal column. keme,
designed by computer following Human Engineering
concepts, has been found to stimulate the nerve
points of the feet effectively, which in turn stimulates
the pituitary gland for increased production of
growth hormones. Increased production of growth
hormones means greater growth of the cartilaginous
portions of the bones in the lower body, making real
gain height.

Intensive scientific research also proved that most young

adults can still grow a few inches taller
even after the bones in their lower body have become
ossified (commonly known as "bone plate is fused"). This is
because besides the length of the femur bone (thighbone),
shinbone, and other bones in the lower body, the length of
the spinal column in the upper body also significantly
contributes to human height (about 35% of the total
height). Human spinal column consists of 33 separate
bone segments known as vertebrae held together by
ligaments (tough and fibrous tissue). Out of these 33
vertebrae, only the lowest 9 are fused into two immovable bones, the sacrum
and the coccyx, forming the back of the pelvis. All the other 24 vertebrae are
permanently movable and thus will never be fused. These 24 vertebrae
are the 7 cervical (neck), 12 thoracic (back of chest), and 5 lumbar (loin).
Cartilaginous pads called disks are located between each of these 24
vertebrae. The thickness of the disks determines the length of the spinal
column and directly influences the height. There are 25 disks in all, their
combined length accounting for 25% of your total height. Since these
disks are non-fusible cartilages, they can constantly grow thicker under
the stimulation of growth hormones during a lifetime. The thicker these
disks are, the longer your spinal column is and the taller you become.
Even if each disk grows only 0.25 cm (0.1 inch) thicker, which is the
length of this line in quotes "_", you will grow 0.25 * 25 = 6.25 cm (2.5
inches) taller! Hundreds of experiments have shown that the increased
production of growth hormones induced by the usage of keme will also
greatly encourage the growth of the discal portion of the vertebrae
(those 25 disks) and thus increase the length of the spinal column,
making it possible to gain height even after the fusion of the bones in
the lower body. For anyone whose lower bones are not completely fused,
1
 keme will encourage the growth of bones in both lower and
upper body and help the user to achieve even greater results
(more than 3.5 inches). So the earlier one starts to use keme, the better
results he/ she will get.

How to use keme?

• Simply place the most convex part of the
stimulator insole against the most concave part of
the foot and cut away the extra part of the insole
along the closest dotted line to exactly fit your foot.
• Walk, with moderate speed, for a minimum
of 20 - 30 minute period twice everyday, once in
the morning and once at night before going to bed.
It should be emphasized that for
best effect, the inside of the sole of
your foot should be well stimulated.
• The result of keme is directly
proportional to the frequency and
duration of its usage. So the best
way to use keme is to simply put it
into your shoes and wear it
wherever you go!

Important Notes :
• During the early phase of application of keme you may not be
used to the feeling, or it may hurt a little bit. In such cases, it is advised
that your application schedule should become a little more flexible to
accommodate this.
• When using keme, one may carry on with one's normal
activities, but active sports (such as jogging, basketball, and stretch
exercise) are encouraged.
• Pay special attention to your nutritional needs, especially the
intake of proteins, fibers, and vitamins. Foods like fish, unsaturated
meat, fruits, vegetables, and milk are especially recommended.
• Remember to get enough sleep (7 - 8 hours a day) and rest.

2
 Final Note:

The earlier you start using keme, the better its results.
Do not push your action to "tomorrow", since "tomorrow"
means "tomorrow" again. Allowing a single day slipping away
will make it a little harder for yourself to reach your goal.

What else does keme do?

Other results demonstrated by the experiments are the astounding effects of
nerve point reflex stimulation by using keme at the sole of the feet in case of
pathological disorders. Employing natural foot stimulation and massage
concepts, keme is also able to:

• enable better
• increase metabolism
digestion
• ensure smoother
• increase blood circulation
breathing
• reduce tiredness • retard aging
• improve the body's natural • promote general
curative powers good health

More importantly, it gives you the desired inches without poisoning your
body with chemicals. It is also effective as a beauty gadget and helps
you cut down on unwanted fat.

Advanced Explanations For keme The exact process used by keme to stimulate the
pituitary gland into producing more growth hormone and help you grow taller is very
advanced. The original research paper for keme's invention was more than 30 pages
long, full of pictures, diagrams, and terminologies. However, in order to help you
better understand the mechanisms, functionalities and benefits of this great grow taller
device, we simplified and organized the professional research information into the
following advanced explanations for keme. To fully understand, you should carefully
read the following sections step by step (please do not skip any section). After you
finish reading you can understand the exact answers to the following advanced
questions about keme and growing taller in general. Question 1: What exactly is
growth hormone and how does it affect human growth? Question 2: What exactly is
3
pituitary gland and how does it exactly control the secretion of growth hormone?
Question 3: Why does NOT keme stimulate the exact nerve points directly correspond
to the pituitary gland (the spots under your big toes)? Question 4: How exactly does
the application of keme stimulate pituitary gland into producing more growth
hormone? Question 5: Why is the application of keme different from taking any form
of artificial growth hormone directly? Question 6: Why is the application of keme the
most natural and effective way to increase your growth hormone level? Question 7:
Why does the application of keme help you lose fat, gain muscles, and grow taller at
the same time? Question 8: Why does the application of keme bring you dozens of
essential health benefits other than helping you grow taller? Question 9: What are the
differences between keme and all the other height increasing programs? Question 10:
Why can you benefit from the application of keme regardless of your age? Ready to
learn the truth about human growth? O.K., let's begin! Endocrine System - The Big
Picture You Should Look At First When we talk about human growth, most people
only know that pituitary gland is the master of growth. But actually pituitary gland is
only a small part of a complex system inside of your body - the Endocrine System.
Just like your heart can only work inside of your chest, pituitary gland can only
function in the context of this system. The endocrine system is made up of specialized
cells, glands and hormones. Acting like a communication network, endocrine system
responds to stimuli by releasing hormones, the chemical messengers that carry
instructions from endocrine glands to target cells throughout the body. The target cells
read and follow the hormones' instructions, sometimes building a protein or releasing
another hormone. These actions lead to many bodily responses such as a faster heart
beat or muscle and bone growth. Glands are functional units of hormone secreting
cells located in various regions of the body making up the endocrine system. Each
gland has specific functions that help to maintain the normal internal environment and
promote the survival of the organism. Although there are some diffuse endocrine
tissues, as in the gastrointestinal epithelium, there are several major control centers or
glands within the endocrine system, including: hypothalamus, pituitary gland, adrenal
gland, thyroid, parathyroid, pancreas, testes, ovary, and pineal (see the illustration
below). Out of these endocrine glands, the ones which control or regulate human
growth are hypothalamus, pituitary gland, adrenal gland and pancreas. In addition to
these glands, another important organ - liver, also plays a significant role in
facilitating the growth process. Functional Anatomy of the Hypothalamus and
Pituitary Gland The hypothalamus is a region of the brain that controls an immense
number of bodily functions. It is located in the middle of the base of the brain, and
encapsulates the ventral portion of the third ventricle. The pituitary gland, also known
as the hypophysis, is a roundish organ that lies immediately beneath the
hypothalamus, resting in a depression of the base of the skull called the sella turcica
("Turkish saddle"). In an adult human, the pituitary is roughly the size and shape of a
garbonzo bean. The above image shows these anatomical relationships between
hypothalamus and pituitary gland. Careful examination of the pituitary gland reveals
that it composed of two distinctive parts: The anterior pituitary (adenohypophysis) is a
classical gland composed predominantly of cells that secrete protein hormones. The
posterior pituitary (neurohypophysis) is not really an organ, but an extension of the
hypothalamus. It is composed largely of the axons of hypothalamic neurons which
extend downward as a large bundle behind the anterior pituitary. It also forms the so-
called pituitary stalk, which appears to suspend the anterior gland from the
hypothalamus. The image on the right shows a frontal view of a sheep pituitary gland
and hypothalamus. The posterior gland can be seen peeking out behind the anterior
4
gland. The anterior and posterior pituitary have separate embryological origins. In
many mammals, there is also an intermediate lobe (pars intermedia) between the
anterior and posterior pituitary. A key to understanding the endocrine relationship
between hypothalamus and anterior pituitary is to appreciate the vascular connections
between these organs. As we will emphasized a little later, secretion of hormones
from the anterior pituitary is under strict control by hypothalamic hormones. These
hypothalamic hormones reach the anterior pituitary through the following route: A
branch of the hypophyseal artery ramifies into a capillary bed in the lower
hypothalamus, and hypothalmic hormones destined for the anterior pituitary are
secreted into that capillary blood. Blood from those capillaries drains into
hypothalamic-hypophyseal portal veins. Portal veins are defined as veins between two
capillary beds; the hypothalamic-hypophyseal portal veins branch again into another
series of capillaries within the anterior pituitary. Capillaries within the anterior
pituitary, which carry hormones secreted by that gland, coalesce into veins that drain
into the systemic venous blood. Those veins also collect capillary blood from the
posterior pituitary gland. This pattern of vascular connections is presented in the
diagram below. Note also the hypothalamic-hypophyseal portal vessels in the image
of a real pituitary gland seen above. The utility of this unconventional vascular system
is that minute quantities of hypothalamic hormones are carried in a concentrated form
directly to their target cells in the anterior pituitary, and are NOT diluted out in the
systemic circulation. Overview of Hypothalamic and Pituitary Hormones The
pituitary gland is often portrayed as the master gland of the body. Such praise is
justified in the sense that the anterior and posterior pituitary secrete a battery of
hormones that collectively influence all cells and affect virtually all physiologic
processes. The pituitary gland may be the king, but the power behind the throne is
actually the hypothalamus. As mentioned before, some of the neurons within the
hypothalamus - neurosecretory neurons - secrete hormones that strictly control
secretion of hormones from the anterior pituitary. The hypothalamic hormones are
referred to as releasing hormones and inhibiting hormones, reflecting their influence
on anterior pituitary hormones. Hypothalamic releasing and inhibiting hormones are
carried directly to the anterior pituitary gland via hypothalamic- hypophyseal portal
veins. Specific hypothalamic hormones bind to receptors on specific anterior pituitary
cells, stimulating or inhibiting the release of the hormone they produce (as illustrated
in the image on the right). The following table summarizes the major hormones
synthesized and secreted by the hypothalamus and pituitary gland, along with
summary statements about their major functions and corresponding regulators.
Hypothalamus Hormone Released Hormone Structure Hormone Function Hormone
Regulator Hypothalamic Releasing Hormones Peptides Acts on the anterior lobe of
the pituitary gland to stimulate the release of certain pituitary hormones. Blood Levels
of Specific Substances Hypothalamic Inhibiting Hormones Peptides Acts on the
anterior lobe of the pituitary gland to inhibit the release of certain pituitary hormones.
Blood Levels of Specific Substances Pituitary Gland Hormone Released Hormone
Structure Hormone Function Hormone Regulator Anterior Pituitary Growth Hormone
(GH) Protein Stimulates muscle and bone growth; Promotes protein synthesis and fat
mobilization. Hypothalamic Hormones Prolactin Protein Promotes production and
secretion of milk in humans after childbirth. Hypothalamic Hormones Thryoid-
Stimulating Hormone (TSH) Glycoprotein Stimulates production and secretion of
thyroid hormones. Blood Thyroxine Levels; Hypothalamic Hormones
Adrenocorticotropic Hormone (ACTH) Polypeptide Stimulates adrenal cortex to
secrete cortisol and other steroids. Corticotropin-Releasing Hormone (CRH) from the
5
Hypothalamus; Blood Cortisol Levels Posterior Pituitary Antidiuretic Hormone
Peptide Increases water absorption from kidney; Raises blood pressure. Blood
Osmolarity Oxytocin Peptide Stimulates contraction of pregnant uterus & release of
breast milk after childbirth. Nervous System As seen in the table above, the anterior
pituitary synthesizes and secretes 6 major hormones, among these growth hormone is
the most important one to us because it directly regulates our muscle and bone
growth. Physiologic Effects of Growth Hormone Growth hormone (as illustrated in
the image below) is also known as somatotropin. It is a protein hormone of 191 amino
acids that is synthesized and secreted by cells called somatotrophs in the anterior
pituitary. It is a major participant in control of several complex physiologic processes,
including muscles and bone growth. A critical concept in understanding growth
hormone activity is that it has two distinct types of effects (as illustrated in the
below): Direct effects are the result of growth hormone binding its receptor on target
cells. Fat cells (adipocytes), for example, have growth hormone receptors, and growth
hormone stimulates them to break down triglyceride and supresses their ability to take
up and accumulate circulating lipids. Indirect effects are mediated primarily by an
insulin-like growth factor-1 (IGF-1), a hormone that is secreted from the liver and
other tissues in response to growth hormone. A majority of the growth promoting
effects of growth hormone is actually due to IGF-1 acting on its target cells. Keeping
this distinction in mind, we can conclude two major roles of growth hormone and its
byproduct IGF-1 in physiology: Effects on muscle and bone Growth. Growth is a very
complex process, and requires the coordinated action of several hormones. The major
role of growth hormone in stimulating body growth is to stimulate the liver and other
tissues to secrete IGF-1. IGF-1 is the key player in muscle growth. It stimulates both
the differentiation and proliferation of myoblasts (muscle cells). It also stimulates
amino acid uptake and protein synthesis in muscle and other tissues. Moreover, IGF-1
stimulates proliferation of chondrocytes (cartilage cells), resulting in bone growth. So
Growth hormone has a direct effect on bone growth by stimulating differentiation of
chondrocytes. Metabolic Effects. Growth hormone has important effects on protein,
lipid and carbohydrate metabolism. In some cases, a direct effect of growth hormone
has been clearly demonstrated, in others, IGF-1 is thought to be the critical mediator,
and some cases it appears that both direct and indirect effects are at play.
Carbohydrate metabolism: Growth hormone is one of a battery of hormones that
serves to maintain blood glucose within a normal range. Growth hormone is often said
to have anti-insulin activity, because it suppresses the abilities of insulin to stimulate
uptake of glucose in peripheral tissues and enhance glucose synthesis in the liver.
Protein metabolism: In general, growth hormone stimulates protein anabolism in
many tissues. This effect reflects increased amino acid uptake, increased protein
synthesis and decreased oxidation of proteins. Fat metabolism: Growth hormone
enhances the utilization of fat by stimulating triglyceride breakdown and oxidation in
adipocytes. The amount of growth hormone in your blood determines the speed and
easiness to convert digested food into energy and utilize it. Therefore, growth
hormone is the most important substance to keep your weight at a desirable level.
Teenagers naturally produce much more growth hormone than middle aged people, so
they can still stay fit even they eat lots of food. In the contrast, people who lack
growth hormone (older people) will tend to gain weight by just consuming a little
food. The following image is a visual summary of the important points we have
covered so far: the relationship between hypothalamus and pituitary gland, as well as
the functions of growth hormone and IGF-1. Negative Feedback Circuit Controls
Growth Hormone Secretion Production of growth hormone is primarily controlled by
6
a mechanism called Negative Feedback Circuit (although it can also be affected by
other factors including stress, exercise, nutrition, and sleep). Feedback circuits are at
the root of most control mechanisms in physiology, and are particularly prominent in
the endocrine system. Instances of positive feedback certainly occur, but negative
feedback is much more common. Negative feedback is seen when the output of a
pathway inhibits inputs to the pathway. The heating system in your home is a simple
Negative Feedback Circuit. When the furnace produces enough heat to elevate
temperature above the set point of the thermostat, the thermostat is triggered and shuts
off the furnace (heat is feeding back negatively on the source of heat). When
temperature drops back below the set point, negative feedback is gone, and the
furnace comes back on. In our case Negative Feedback Circuit is used extensively to
regulate secretion of growth hormone. As mentioned above, the release of growth
hormone by pituitary gland is actually controlled by hypothalamus. More accurately,
two hypothalamic hormones ultimately control all the production of growth hormone:
Growth hormone-releasing hormone (GHRH) is a peptide that stimulates both the
synthesis and secretion of growth hormone. Somatostatin (SS) is a peptide produced
by several tissues in the body, including the hypothalamus. Somatostatin inhibits
growth hormone release in response to GHRH and to other stimulatory factors such as
low blood glucose concentration. The Negative Feedback Circuit uses these two
hypothalamic hormones to control the secretion of growth hormone. The basic
mechanisms for the negative feedback control in this system (as illustrated in the
image on the right) are: GHRH (Growth Hormone Releasing Hormone) secreting
neurons in the hypothalamus detect the low blood concentration of growth hormone
and Insulin-like Growth Factor-1 (IGF-1), and in a response these neurons secrete
GHRH, which is then carried directly to the anterior pituitary gland via hypothalamic-
hypophyseal portal veins. Once arrived at anterior pituitary gland, GHRH stimulates
the activities of somatotrophs (cells which secrete growth hormone) so these cells
start releasing growth hormone. Released growth hormone binds to receptors on
targeted cells in the body, promoting carbohydrate metabolism, protein synthesis and
fat mobilization. Growth hormone also stimulates the liver and other tissues to secrete
Insulin-like Growth Factor-1 (IGF-1). IGF-1 in turn acts on its target cells, i.e.,
chondrocytes (cartilage cells) and myoblasts (precursors of muscle cells) to stimulate
muscle and bone growth. Increasing growth hormone level soon negatively feeds back
to inhibit GHRH secretion. When blood concentration of growth hormone increases
above a certain threshold, GHRH-secreting neurons in the hypothalamus are inhibited
and stop secreting GHRH, while SS-secreting neurons in the hypothalamus are
stimulated and start secreting SS, which is then carried directly to the anterior
pituitary gland via hypothalamic- hypophyseal portal veins. Once arrived at anterior
pituitary gland, SS inhibits the activities of somatotrophs (cells which secrete growth
hormone) so these cells stop releasing growth hormone. Growth hormone's byproduct
- IGF1 also triggers the Negative Feedback Circuit. Increased growth hormone level
stimulates liver to secrete IGF-1. High blood levels of IGF-1 not only stimulates the
release of SS from the hypothalamus, but also by directly suppresses the somatotrophs
in the pituitary gland. The combined effect is the immediate turn-off of growth
hormone secretion. As growth hormone levels decrease below the threshold, negative
feedback is relieved, GHRH secretion starts again, leading to growth hormone
secretion... and the circle restarts again. Integration of all the factors that affect growth
hormone synthesis and secretion lead to a pulsatile pattern of release. The natural
concentration of growth hormone in blood are very low, because usually the body
only secrets growth hormone up to a level to maintain homeostasis and once a steady
7
state is achieved growth hormone secretion is stopped by the Negative Feedback
Circuit. Therefore, the only effective way to increase the secretion of growth hormone
is to minimize the effect of the Negative Feedback Circuit by creating a natural
Positive Feedback Circuit. The Application of keme Creates A Natural Positive
Feedback Circuit to Stimulate Growth Hormone Secretion Positive feedback is seen
when the output of a pathway stimulates inputs to the pathway. An example of
positive feedback is the phenomenon of autacatalysis, which occurs in some digestive
enzymes such as pepsin. Pepsin is a protein-digesting enzyme that works in the
stomach. However, the stomach does not secrete pepsin; it secretes an inactive form,
called pepsinogen. When one pepsinogen molecule becomes activated, it helps to
activate other pepsinogens nearby, which in turn can activate others. In this way, the
number of active pepsin molecules can increase rapidly, by using positive feedback.
In your case, you need a Positive Feedback Circuit that minimizes the effect of your
body's Negative Feedback Circuit and maximizes your pituitary gland's secretion of
growth hormone. Here is where our great keme device comes to serve you: the
application of keme will create a natural Positive Feedback Circuit by stimulating the
activities of Adrenal gland, Pancreas, and liver. keme actually uses the same principle
as the famous Chinese acupuncture, which is called reflexology. Your feet can be
seen as mirror images of your body. The following picture on the left is a quick look
at how your body matches to the sole of your feet. Notice how the shape and curve of
your feet match the shape and curve of your body. The following picture on the right
shows that the spinal column is reflected in the inside curve of the foot. Studies have
shown that the curve of an individual's foot matches the curve of his/ her spinal
column with mathematical precision. Have a look at your own foot and those around
you! Stimulation in any part of your feet mirrors in turn will stimulate the
corresponding part of the body. Reflexology is the application of pressure, movement,
and stimulation to your feet to affect corresponding parts of your body. Pressure
applied to the feet generates a signal through the peripheral nervous system. From
there it enters the central nervous system where it is processed in various parts of the
brain. It is then relayed to the internal glands and organs to stimulate the necessary
adjustments in their activities and functions. Before you use keme, you place the most
convex parts of the stimulator device against the most concave parts of your feet.
Referring to the foot reflexology chart above, the nerve points corresponding to your
adrenal gland, pancreas, and livers locate at the most concave parts of your feet.
When you walk with keme, keme applies the principle of reflexology: the convex
parts of the device constantly stimulate the nerve points corresponding to your adrenal
gland, pancreas, and livers, thus in turn stimulate the activities of these important
glands and organ to create a natural Positive Feedback Circuit to increase growth
hormone secretion. The detailed mechanisms used to create the Positive Feedback
Circuit are explained below. Firstly, the application of keme stimulates adrenal gland
to increase metabolism, while decrease glucose (major form of sugar) and insulin
levels in blood. Adrenal gland (as illustrated in the image on the right), which are also
called suprarenal glands, are small, triangular glands located on top of both kidneys.
An adrenal gland is made of two parts: the outer region is called the adrenal cortex
and the center region is called the adrenal medulla. The adrenal cortex produces
hormones necessary for fluid and electrolyte (salt) balance in the body such as
cortisone and aldosterone, which are not within our concern. However, the adrenal
medulla, if under stimulation, produce two very important hormones: epinephrine and
norepinephrine, which increase the heart rate and force of heart contractions,
facilitates blood flow to the muscles and brain, assists in pulmonary ventilation (better
8
breathing), increase overall metabolism rate, and most importantly, decrease blood
concentrations of glucose and insulin. Insulin (as illustrated in the image on the right)
is a small protein containing 51 amino acids. Insulin is secreted by pancreas in
response to high blood concentrations of glucose. Glucose (major form of sugar) is
liberated from dietary carbohydrate such as starch or sucrose by hydrolysis within the
small intestine, and is then absorbed into the blood. High concentrations of glucose in
blood stimulate release of insulin, and insulin acts on cells throughout the body to
stimulate uptake, utilization and storage of glucose. If the blood concentrations of
glucose are low, little or no insulin will be secreted. Thus by stimulating the adrenal
gland, the application of keme increases the overall metabolism and decreases the
insulin levels in the blood. An increased metabolism helps create a Positive Feedback
Circuit to increase the secretion of growth hormone because the existing growth
hormone in the blood can be quickly carried to its targeted cells and used up to grow
muscle and bone. This will decrease the blood concentration of growth hormone and
thus trigger neurons in the hypothalamus to secrete GHRH that stimulates pituitary
gland into secreting more growth hormone. A decreased blood concentration of
insulin also helps create a Positive Feedback Circuit because insulin is the biggest
inhibitor for growth hormone's secretion. Recall an important point in the above
section of the Negative Feedback Circuit: besides growth hormone itself, its
byproduct, Insulin-like Growth Factor-1 (IGF-1) also triggers the Negative Feedback
Circuit to inhibit the secretion of growth hormone. Insulin-like Growth Factor-1 (IGF-
1), as the name suggests, are structurally very similar to the insulin molecule.
Essentially an IGF-1 is about two thirds of an insulin. Since they are almost the same,
high blood concentrations of insulin has essentially the same effect as high blood
concentrations of IGF-1 - to inhibit the secretion of growth hormone! Therefore, by
decreasing the blood concentrations of both growth hormone and insulin, the
application of keme removes the two main causes that trigger the Negative Feedback
Circuit, and starts a Positive Feedback Circuit that leads to increase the secretion of
growth hormone. Secondly, the application of keme stimulates pancreas to secrete
glucagon and further enhances the Positive Feedback to increase the secretion of
growth hormone. The pancreas (as illustrated in the image on the right) houses two
distinctly different tissues. The bulk of its mass is exocrine tissue and associated
ducts, which produce an alkaline fluid loaded with digestive enzymes which is
delivered to the small intestine to facilitate digestion of foodstuffs and has little to do
with the secretion of growth hormone. Scattered throughout the exocrine tissue are
several hundred thousand clusters of endocrine cells which produce the hormones
insulin and glucagon. Glucagon (as illustrated in the left image below) is a linear
peptide of 29 amino acids which has the opposite effect of insulin. That is, glucagon
has the effect of increasing blood glucose levels. Knowing that glucagon's major
effect is to increase blood glucose levels, it makes sense that glucagon is secreted in
response to low blood concentrations of glucose. Although pancreas secretes both
insulin and glucagon, it can not secrete both of them at the same time. Exactly which
hormone is secreted by pancreas at a certain time is determined by the blood
concentrations of glucose. When the blood concentrations of glucose are high, the
pancreas secretes insulin; when the blood concentrations of glucose are low, the
pancreas secretes glucagon (as illustrated in the right image below). Since the
stimulation of adrenal gland has caused low blood concentrations of glucose, pancreas
secretes glucagon when it is also stimulated by keme. In contrast to insulin, glucagon
is a stimulator for the secretion of growth hormone. Therefore, by stimulating
pancreas to secrete more glucagon, the application of keme further enhances the
9
Positive Feedback Circuit that increases the secretion of growth hormone. Finally, the
application of keme stimulates liver to secrete IGF-1 in response to the extra growth
hormone secreted by the pituitary gland and induce another cycle of the Positive
Feedback Circuit. Growth hormone binds to cells in the liver, and these cells release
IGF-1 into the blood. Increased metabolic rate and blood circulation resulted from
stimulating the adrenal gland carry IGF-1 to its targeted cells and stimulate muscle
and bone growth. This in return decreases blood concentration of growth hormone
and IGF-1, thus completing a circle of the Positive Feedback Circuit. Then the
process returns to step one, where low blood concentration of growth hormone and
IGF-1 further trigger another positive feedback and signal hypothalamic to release
more GHRH that stimulates pituitary gland to secrete even more growth hormone.
The Positive Feedback Circuit will continue like this as long as you keep using keme
to stimulate the activities of adrenal gland, pancreas, and liver. Moreover, such
Positive Feedback Circuit is completely natural and safe since the extra growth
hormone and IGF-1 are immediately transported to their targeted cells and consumed
in stimulating muscle and bone growth. After you stop using keme, the Positive
Feedback Circuit is interrupted and your body's Negative Feedback Circuit will soon
stop the extra secretion of growth hormone. Answers to All the Advanced Questions
After reading all of the above advanced explanations, you should be able to
understand the answers to the following advanced questions. Question 1: What
exactly is growth hormone and how does it affect human growth? Answer: Growth
hormone, also known as somatotropin, is a protein hormone of 191 amino acids that is
synthesized and secreted by cells called somatotrophs in the anterior pituitary. Growth
hormone facilitates metabolism and controls muscle and bone growth. Question 2:
What exactly is pituitary gland and how does it exactly control the secretion of growth
hormone? Answer: Pituitary gland is a small gland located at the base of the brain. It
consists of two different lobes - anterior and posterior pituitary. Its anterior pituitary
produces numerous hormones, including the most important growth hormone.
Nevertheless, pituitary gland can not be seen as the master gland of the endocrine
system, because its activities are directly controlled by a region of the brain called
hypothalamus. So strictly speaking, it is not pituitary gland, but hypothalamus which
controls the secretion of growth hormone. By detecting the blood concentrations of
growth hormone and Insulin-like Growth Factor-1 (IGF-1), hypothalamus secretes
Growth Hormone Releasing Hormone (GHRH) or Somatostatin (SS) to stimulate or
inhibit pituitary gland's activities of producing growth hormone. The blood
concentrations of growth hormone and IGF-1 are in turn regulated by a mechanism
called Negative Feedback Circuit in your body: when there is little growth hormone
or IGF-1 present in blood, hypothalamus stimulates pituitary gland to secrete some
growth hormone; but as soon as the growth hormone level raises a little higher,
hypothalamus inhibits pituitary gland to secrete any more growth hormone. In short
the pituitary gland only secrets growth hormone up to a level to maintain homeostasis
because once a steady state is achieved growth hormone secretion is stopped by the
Negative Feedback Circuit. Question 3: Why does NOT keme stimulate the exact
nerve points directly correspond to the pituitary gland (the spots under your big toes)?
Answer: This should be very clear right now: it is hypothalamus, not pituitary gland
that actually controls the secretion of growth hormone, so directly stimulating
pituitary gland would have little result on increasing the growth hormone secretion.
Moreover, hypothalamus only responds to the blood concentration of the growth
hormone and IGF-1, which is strictly regulated by the Negative Feedback Circuit. The
only effective way to increase the secretion of growth hormone is to minimize the
10
effect of the Negative Feedback Circuit by creating a natural Positive Feedback
Circuit, so the blood concentrations of growth hormone and IGF-1 stay low even
when extra amount of growth hormone is secreted by the pituitary gland. As
aforementioned, the application of keme will create such a natural Positive Feedback
Circuit by stimulating the activities of adrenal gland, pancreas, and liver. And because
the nerve points corresponding to adrenal gland, pancreas, and liver locate at the most
concave parts of your feet, keme stimulates these parts of your feet instead of the
spots under your big toes. Question 4: How exactly does the application of keme
stimulate pituitary gland into producing more growth hormone? The application of
keme stimulates the activities of adrenal gland, pancreas, and liver to create a natural
Positive Feedback Circuit, which minimizes the effect of the Negative Feedback
Circuit so the blood concentrations of growth hormone and IGF-1 stay low even after
pituitary gland secrets extra amount of growth hormone. The constant low blood
concentrations of growth hormone and IGF-1 cause hypothalamus to keep secreting
Growth Hormone Releasing Hormone (GHRH) which stimulates pituitary gland to
keep secreting growth hormone. The Positive Feedback Circuit also increases the
metabolism so the extra amount of growth hormone and its byproduct IGF-1 are
immediately transported to their targeted cells and used up in stimulating muscle and
bone growth. For more detailed explanation on how does keme work, read the above
section named "The Application of keme Creates A Natural Positive Feedback Circuit
to Stimulate Growth Hormone Secrtion". Question 5: Why is the application of keme
different from taking any form of artificial growth hormone directly? Answer: By
now you should understand that the secretion of growth hormone is mainly controlled
by the Negative Feedback Circuit, and the only effective way to increase the secretion
of growth hormone is to minimize the effect of the Negative Feedback Circuit by
creating a natural Positive Feedback Circuit. Taking any form of artificial growth
hormone can only make the Negative Feedback Circuit in your body much worse. The
presence of artificial growth hormone in your blood will immediately trigger the
Negative Feedback Circuit to terminate your natural secretion of growth hormone. On
the other hand, your metabolism is NOT increased and can NOT catch up the quick
build-up of artificial growth hormone, so your body can NOT transport or utilize this
"outside" growth hormone effectively. It may quickly end up with large amount of
artificial growth hormone accumulating at inappropriate parts of your body and cause
all kinds of serious side effects such as negative metabolic effects, hip disease,
pancreatitis, and even leukemia (a disease in which the body produces too many white
blood cells, causing weakness and sometimes leading to cancer and death). Even
worse, if you take artificial growth hormone for a prolonged period, your
hypothalamus will become insensitive to blood concentrations and weaken or even
lose the ability of stimulating pituitary gland to secrete natural growth hormone even
after you stop taking artificial growth hormone. So taking artificial growth hormone is
not only futile, but also dangerous. In contrast, the application of keme is very
effective in creating a Positive Feedback Circuit which minimizes the effect of the
Negative Feedback Circuit and increases the secretion of your natural growth
hormone. The application of keme also significantly increases your metabolism rate
so the extra amount of growth hormone and its byproduct IGF-1 are immediately
transported to their targeted cells and used up in stimulating your muscle and bone
growth. After you stop using keme, the Positive Feedback Circuit is interrupted and
your body's Negative Feedback Circuit will soon stop the extra secretion of growth
hormone so there will NEVER be any extra growth hormone flowing around in the
wrong parts of your body. Such effectiveness and safety measure makes the
11
application of keme totally different from taking any form of artificial growth
hormone directly. Question 6: Why is the application of keme the most natural and
effective way to increase your growth hormone level? Answer: Similar to the answer
to Question 5 above, the application of keme creates a natural Positive Feedback
Circuit to increase the natural secretion of growth hormone; it also increase your
metabolism to transport and utilize extra amount of growth hormone so your body can
enjoy the benefits of growth hormone (muscle and bone growth) while avoid any side
effect at the same time. Question 7: Why does the application of keme help you lose
fat, gain muscles, and grow taller at the same time? Answer: So far you must have
known that using keme is the best way to help you increase your growth hormone
level effectively and safely. The extra growth hormone induced by the application of
keme has two major physiologic effects: stimulates fat cells (adipocytes) to break
down fatty acid (triglyceride) and suppresses their ability to take up and accumulate
circulating lipids, as well as stimulates muscle and bone growth. Obviously, the two
effects are achieved at the same time: the first effect helps you lose fat and gain
muscles, the second effect helps you grow taller. Thus the application of keme helps
you lose fat, gain muscles, and grow taller at the same time. Question 8: Why does the
application of keme bring you dozens of essential health benefits other than helping
you grow taller? Answer: Besides stimulating adrenal gland, pancreas, and liver, the
application of keme also stimulates stomach colon (large intestine) and small intestine
to enable better digestion. As mentioned above, under stimulation adrenal gland
secretes epinephrine and norepinephrine, which increase the heart rate and force of
heart contractions, facilitates blood flow to the muscles and brain and assists in
pulmonary ventilation (better breathing). Thus the application of keme also helps you
prevent heart disease, increase blood circulation, and ensure smoother breathing.
Increased blood circulation, breathing, and metabolism in turn reduce tiredness,
improve the body's natural curative powers (enhance immune system), promote
general good health and retard aging. In addition, because keme applies the principle
of reflexology, it can bring most of reflexology's benefits as well, such as to reduce
stress and induce relaxation, help the body remove toxins and revitalize energy.
Therefore, the application of keme will bring you dozens of essential health benefits
other than helping you lose fat, gain muscles, and grow taller. And best of all, you can
get all of these benefits simultaneously from the application of keme! Question 9:
What are the differences between keme and all the other height increasing programs?
Answer: keme is better than all the other height increasing programs because it helps
you lose fat, gain muscles, and grow taller at the same time. Besides being extremely
effective and safe, keme is also very affordable, convenient, and easy for everyone .
Question 10: Why can you benefit from the application of keme regardless of your
age? Answer: There are at least Five Reasons for you to benefit from the application
of keme regardless of your age. Reason One, the application of keme will create a
natural Positive Feedback Circuit to stimulate your pituitary gland into secreting more
growth hormone regardless of your age. It is common knowledge that the levels of
both growth hormone and IGF-1 (insulin-like growth factor1) decline dramatically
with age. By the time the average person reaches age 60, the pituitary secretes only
25% of the growth hormone than at age 20. However, while it is true that your growth
hormone levels may decline with age, your pituitary's capacity to produce growth
hormone does NOT. The pituitary maintains its ability to produce adequate growth
hormone well into old age (70 or even older). So why do growth hormone and IGF-1
levels decline? The real reasons are: high glucose and insulin levels, decreased liver
function and decreased metabolism rate. As you age, the actives of your adrenal gland
12
and pancreas will decrease so they can not effectively lower blood concentrations of
glucose and insulin. High level of glucose and insulin will inhibit the secretion of
growth hormone. However, regardless of your age, the application of keme will
directly stimulate the activities of your adrenal gland and pancreas to effectively
lower the glucose and insulin level. Moreover, the Positive Feedback Circuit will
ensure the blood concentrations of glucose and insulin stay low while you are using
keme to stimulate the secretion of extra growth hormone. As mentioned above, most
of the benefits of growth hormone (such as muscle and bone growth) are due to its
byproduct named Insulin-like Growth Factor-1 (IGF-1), not to the growth hormone
itself. The liver is the organ responsible for converting growth hormone into IGF-1.
As you age, your liver's activity will decrease and only partial conversion of growth
hormone into IGF-1 will occur, which will in turn cause large amount of growth
hormone stay in your blood and quickly trigger the Negative Feedback Circuit to stop
the secretion of growth hormone. However, regardless of your age, the application of
keme will directly stimulate the activity of your liver to convert growth hormone to
IGF-1 and complete the Positive Feedback Circuit as described above. As you age,
your metabolism rate will slow down. Fast metabolism rate is necessary to transport
growth hormone and IGF-1 to their targeted cells and utilize them to grow muscle and
bone. A slow metabolism could cause growth hormone and IGF-1 to idle around in
your blood and quickly trigger the Negative Feedback Circuit. However, regardless of
your age, the application of keme will dramatically increase your metabolism rate to
facilitate the transportation and utilization of growth home and IGF-1. Therefore, no
matter how old you are, the application of keme will create a natural Positive
Feedback Circuit to stimulate your pituitary gland into secreting more growth
hormone. Reason Two, more than 10 years of scientific research and experiments also
proved that people who are over 30s can still grow permanently taller in the following
three different ways: The first way - now for the first time there is a revolutionary
nutritional supplement that can prolong your growth period by rejuvenating and
revitalizing your growth plates to keep them open longer so you can grow more, faster
and longer well after your puberty. This FDA approved nutritional supplement is
MFIII from Laboratories Dom AvMM of Switzerland. It is the best nutritional
supplement to help you grow taller because it can help rejuvenate and revitalize your
bones and growth plates, and help them return to a younger stage. The fundamental
truth about human growth is that the younger you are, the more and faster you can
grow. Most people can easily grow 12 - 15 inches (30 - 37.5 cm) during the first year
of their lives (age 0 - 1), can manage to grow 3 - 4 inches (7.5 - 10 cm) per year
during their puberties (age 12 - 14), but can hardly grow 1 - 2 inches per year after
their puberties. This is because as you age, your pituitary gland becomes inactive and
your growth plates gradually close (if your growth plates do not prematurely close
due to external distresses). So besides using keme to help reactivate your pituitary
gland, it is also important that you use MFIII to help rejuvenate and revitalize your
growth plates. MFIII is the best and only nutritional supplement that can do this for
you because it uses young cells from unborn sheep to help rejuvenate and revitalize
the corresponding old cells in your bones and growth plates (MFIII comes in hi-tech
extacts softgel capsules). The rejuvenated and revitalized growth plates can then be
kept open much longer, and it is much easier for your bones to keep growing longer.
This extended period of growth provides you with the best opportunity to grow to
your maximum potential height under the stimulation of sufficient growth hormone
produced by using keme. The second way - your spinal column can be extended by
another 1 - 2 inches (2.5 - 5 cm) by using keme along with certain stretching exercises
13
(which are included in 5 of our 40 Fantastic Free Bonuses). Besides the length of the
femur bone (thighbone), shinbone, and other bones in your lower body, the length of
the spinal column in your upper body also significantly contributes to your height
because it accounts for about 35% of your total height. Your spinal column consists of
33 separate bone segments known as vertebrae held together by ligaments (tough and
fibrous tissue). Out of these 33 vertebrae, only the lowest 9 are fused into two
immovable bones, the sacrum and the coccyx, forming the back of the pelvis. All of
the other 24 vertebrae are permanently movable and can NEVER be fused. These 24
vertebrae are the 7 cervical (neck), 12 thoracic (back of chest), and 5 lumbar (loin).
Cartilaginous pads called intervertebral discs are located between each of these 24
vertebrae. The thickness of these discs determines the length of the spinal column and
directly influences your height - there are 24 discs in all, their combined length
accounts for about 25% of your total height. Since these discs are non-fusible
cartilages, they can constantly grow thicker under the stimulation of sufficient growth
hormone during a lifetime. The thicker these discs are, the longer your spinal column
is and the taller you become. Even if each disc grows only 0.1 inch (0.25 cm) thicker,
which is the length of this line in quotes "_", you will still grow 0.1 X 24 = 2.4 inches
(6 cm) taller! Many experiments and users' experience have shown that the increased
production of growth hormone produced by using keme can also greatly encourage
the growth of the cartilaginous portions of those 24 disks, making them grow thicker
and in turn increasing the length of the spinal column by 1 - 2 inches (2.5 - 5 cm).
MFIII can further increase this result to 3 inches (7.5 cm) by rejuvenating and
revitalizing the intervertebral discs so each of them can grow even thicker under the
stimulation of sufficient growth hormone produced by using keme. Thus, the result of
keme/ MFIII makes it possible for your upper body to grow 1 - 3 inches (2.5 - 7.5 cm)
taller well after puberty. The third way - even after the growth plates in your lower
body are closed, both your bones and articular cartilages (which connect most bones)
in your lower body can still grow thicker under the stimulation of sufficient growth
hormone produced by using keme. The additional thickness of the bones can increase
your lower body height by 0.5 inch (1.25 cm). MFIII can further increase this result to
1 inch (2.5 cm) by helping rejuvenate and revitalize your bones to make them more
susceptible to the stimulation of growth hormone. The articular cartilages in your
lower body can also grow thicker - the additional thickness of the distal end of your
femur (bottom of your thigh bone at the knee) and the proximal end of your tibia (top
part of your shin bone at the knee) can increase your lower body height by another 0.5
- 1 inch (1.25 - 2.5 cm). MFIII can further increase this result to 2 inches (5 cm) by
help rejuvenate and revitalize these articular cartilages so they can grow even thicker
under the stimulation of growth hormone. Thus, the result of keme/ MFIII also makes
it possible for your lower body to grow 1 - 3 inches (2.5 - 7.5 cm) taller well after
puberty.

14
 Advanced Explanations For keme
The exact process used by keme to stimulate the pituitary
gland into producing more growth hormone and help you
grow taller is very advanced. The original research paper
for keme's invention was more than 30 pages long, full of
pictures, diagrams, and terminologies. However, in order to
help you better understand the mechanisms,
functionalities and benefits of this great grow taller device,
we simplified and organized the professional research
information into the following advanced explanations for
keme. To fully understand, you should carefully read the
following sections step by step (please do not skip any
section). After you finish reading you can understand the
exact answers to the following advanced questions about
keme and growing taller in general.

Question 1: What exactly is growth hormone and how

does it affect human growth?

Question 2: What exactly is pituitary gland and how does

it exactly control the secretion of growth hormone?

Question 3: Why does NOT keme stimulate the exact nerve

points directly correspond to the pituitary gland (the
spots under your big toes)?

Question 4: How exactly does the application of keme

stimulate pituitary gland into producing more growth
hormone?

Question 5: Why is the application of keme different from

taking any form of artificial growth hormone directly?

Question 6: Why is the application of keme the most

natural and effective way to increase your growth
hormone level?

Question 7: Why does the application of keme help you lose

fat, gain muscles, and grow taller at the same time?

Question 8: Why does the application of keme bring you

dozens of essential health benefits other than helping you
grow taller?

Question 9: What are the differences between keme and

all the other height increasing programs?

Question 10: Why can you benefit from the application of

15
 keme regardless of your age?

Ready to learn the truth about human growth? O.K., let's

begin!

Endocrine System - The Big Picture You Should

Look At First
When we talk about human growth, most people only know
that pituitary gland is the master of growth. But actually
pituitary gland is only a small part of a complex system
inside of your body - the Endocrine System. Just like your
heart can only work inside of your chest, pituitary gland can
only function in the context of this system. The endocrine
system is made up of specialized cells, glands and hormones.
Acting like a communication network, endocrine system
responds to stimuli by releasing hormones, the chemical
messengers that carry instructions from endocrine glands
to target cells throughout the body. The target cells read
and follow the hormones' instructions, sometimes building a
protein or releasing another hormone. These actions lead to
many bodily responses such as a faster heart beat or muscle
and bone growth. Glands are functional units of hormone
secreting cells located in various regions of the body making
up the endocrine system. Each gland has specific functions
that help to maintain the normal internal environment and
promote the survival of the organism. Although there are
some diffuse endocrine tissues, as in the gastrointestinal
epithelium, there are several major control centers
or glands within the endocrine system, including:
hypothalamus, pituitary gland, adrenal gland, thyroid,
parathyroid, pancreas, testes, ovary, and pineal (see the
illustration below). Out of these endocrine glands, the ones
which control or regulate human growth are hypothalamus,
pituitary gland, adrenal gland and pancreas. In addition
to these glands, another important organ - liver, also plays a
significant role in facilitating the growth process.

Functional Anatomy of the Hypothalamus and

Pituitary Gland
The hypothalamus is a region of the brain that controls
an immense number of bodily functions. It is located in the
middle of the base of the brain, and encapsulates the ventral
portion of the third ventricle.

16
 The pituitary gland, also known as the hypophysis, is a
roundish organ that lies immediately beneath the
hypothalamus, resting in a depression of the base of the
skull called the sella turcica ("Turkish saddle"). In an adult
human, the pituitary is roughly the size and shape of a
garbonzo bean.

Careful examination of the pituitary gland reveals that it

composed of two distinctive parts:

The anterior pituitary

(adenohypophysis) is a
classical gland composed
predominantly of cells that
secrete protein hormones.

The posterior pituitary

(neurohypophysis) is not really
an organ, but an extension of
the hypothalamus. It is
composed largely of the axons
of hypothalamic neurons which
extend downward as a large
bundle behind the anterior
pituitary. It also forms the so-
called pituitary stalk, which
appears to suspend the
anterior gland from the
hypothalamus.

The image on the right shows a

frontal view of a sheep
pituitary gland and
hypothalamus. The posterior
gland can be seen peeking out
behind the anterior gland.

The anterior and posterior

pituitary have separate
embryological origins. In many
mammals, there is also an
intermediate lobe (pars
intermedia) between the
anterior and posterior pituitary.

A key to understanding the endocrine relationship between

hypothalamus and anterior pituitary is to appreciate the
vascular connections between these organs. As we will
emphasized a little later, secretion of hormones from the
anterior pituitary is under strict control by hypothalamic
hormones. These hypothalamic hormones reach the anterior
pituitary through the following route:

17
 • A branch of the hypophyseal artery ramifies
into a capillary bed in the lower hypothalamus, and
hypothalmic hormones destined for the anterior
pituitary are secreted into that capillary blood.

• Blood from those capillaries drains into

hypothalamic-hypophyseal portal veins. Portal
veins are defined as veins between two capillary beds;
the hypothalamic-hypophyseal portal veins branch
again into another series of capillaries within the
anterior pituitary.

• Capillaries within the anterior pituitary, which

carry hormones secreted by that gland, coalesce into
veins that drain into the systemic venous blood. Those
veins also collect capillary blood from the posterior
pituitary gland.

This pattern of vascular connections is presented in the

diagram below. Note also the hypothalamic-hypophyseal
portal vessels in the image of a real pituitary gland seen
above.

The utility of this unconventional vascular system is that

minute quantities of hypothalamic hormones are carried in
a concentrated form directly to their target cells in the
anterior pituitary, and are NOT diluted out in the systemic
circulation.

Overview of Hypothalamic and Pituitary

Hormones
The pituitary gland is often portrayed as the master gland
of the body. Such praise is justified in the sense that the
anterior and posterior pituitary secrete a battery of
hormones that collectively influence all cells and affect
virtually all physiologic processes.

The pituitary gland may be the king, but

the power behind the throne is actually
the hypothalamus. As mentioned before,
some of the neurons within the
hypothalamus - neurosecretory neurons
- secrete hormones that strictly control
secretion of hormones from the
anterior pituitary. The hypothalamic
hormones are referred to as releasing
hormones and inhibiting hormones,
reflecting their influence on anterior
pituitary hormones.

Hypothalamic releasing and inhibiting

hormones are carried directly to the

18
 anterior pituitary gland via
hypothalamic- hypophyseal portal veins.
Specific hypothalamic hormones bind to
receptors on specific anterior pituitary
cells, stimulating or inhibiting the
release of the hormone they produce (as
illustrated in the image on the right).

The following table summarizes the major hormones

synthesized and secreted by the hypothalamus and
pituitary gland, along with summary statements about their
major functions and corresponding regulators.

Hypothalamus

Hormone Hormone Hormone

Hormone Function
Released Structure Regulator

Acts on the anterior lobe of the

Hypothalamic Blood Levels
pituitary gland to stimulate the
Releasing Peptides of Specific
release of certain pituitary
Hormones Substances
hormones.

Acts on the anterior lobe of the

Hypothalamic Blood Levels
pituitary gland to inhibit the
Inhibiting Peptides of Specific
release of certain pituitary
Hormones Substances
hormones.

Pituitary Gland

Hormone Hormone Hormone Hormone

Released Structure Function Regulator

Stimulates
muscle and
bone growth;
Growth Hormone Promotes Hypothalamic
Protein
(GH) protein Hormones
synthesis and
fat
mobilization.

Promotes
production and
Hypothalamic
Prolactin Protein secretion of
Hormones
milk in humans
after childbirth.

Thryoid-Stimulating Glycoprotein Stimulates Blood Thyroxine

Hormone (TSH) production and Levels;
secretion of Hypothalamic

19
 thyroid
Hormones
hormones.

Corticotropin-
Stimulates
Releasing Hormone
adrenal cortex
Adrenocorticotropic (CRH) from the
Polypeptide to secrete
Hormone (ACTH) Hypothalamus;
cortisol and
Blood Cortisol
other steroids.
Levels

Increases
water
Antidiuretic absorption
Peptide Blood Osmolarity
Hormone from kidney;
Raises blood
pressure.

Stimulates
contraction of
pregnant
Oxytocin Peptide uterus & Nervous System
release of
breast milk
after childbirth.

As seen in the table above, the anterior pituitary synthesizes

and secretes 6 major hormones, among these growth
hormone is the most important one to us because it
directly regulates our muscle and bone growth.

Physiologic Effects of Growth Hormone

Growth hormone (as illustrated in the image below) is also
known as somatotropin. It is a protein hormone of 191
amino acids that is synthesized and secreted by cells called
somatotrophs in the anterior pituitary. It is a major
participant in control of several complex physiologic
processes, including muscles and bone growth.

20
 A critical concept in understanding growth hormone
activity is that it has two distinct types of effects (as
illustrated in the below):

• Direct effects
are the result of growth
hormone binding its
receptor on target
cells. Fat cells
(adipocytes), for
example, have growth
hormone receptors, and
growth hormone
stimulates them to
break down triglyceride
and supresses their
ability to take up and
accumulate circulating
lipids.

• Indirect effects
are mediated primarily
by an insulin-like
growth factor-1 (IGF-

21
 1), a hormone that is
secreted from the liver
and other tissues in
response to growth
hormone. A majority of
the growth promoting
effects of growth
hormone is actually due
to IGF-1 acting on its
target cells.

Keeping this distinction in mind, we can conclude two major

roles of growth hormone and its byproduct IGF-1 in
physiology:

1. Effects on muscle and bone Growth. Growth

is a very complex process, and requires the
coordinated action of several hormones. The major
role of growth hormone in stimulating body growth is
to stimulate the liver and other tissues to secrete IGF-
1. IGF-1 is the key player in muscle growth. It
stimulates both the differentiation and proliferation of
myoblasts (muscle cells). It also stimulates amino acid
uptake and protein synthesis in muscle and other
tissues. Moreover, IGF-1 stimulates proliferation of
chondrocytes (cartilage cells), resulting in bone
growth. So Growth hormone has a direct effect on
bone growth by stimulating differentiation of
chondrocytes.
2. Metabolic Effects. Growth hormone has
important effects on protein, lipid and carbohydrate
metabolism. In some cases, a direct effect of growth
hormone has been clearly demonstrated, in others,
IGF-1 is thought to be the critical mediator, and some
cases it appears that both direct and indirect effects
are at play.

• Carbohydrate metabolism: Growth

hormone is one of a battery of hormones that
serves to maintain blood glucose within a
normal range. Growth hormone is often said
to have anti-insulin activity, because it
suppresses the abilities of insulin to stimulate
uptake of glucose in peripheral tissues and
enhance glucose synthesis in the liver.

• Protein metabolism: In general,

growth hormone stimulates protein anabolism
in many tissues. This effect reflects increased
amino acid uptake, increased protein
synthesis and decreased oxidation of proteins.

• Fat metabolism: Growth hormone

enhances the utilization of fat by stimulating

22
 triglyceride breakdown and oxidation in
adipocytes.

The amount of growth hormone in your blood determines

the speed and easiness to convert digested food into energy
and utilize it. Therefore, growth hormone is the most
important substance to keep your weight at a desirable
level. Teenagers naturally produce much more growth
hormone than middle aged people, so they can still stay fit
even they eat lots of food. In the contrast, people who lack
growth hormone (older people) will tend to gain weight by
just consuming a little food.

The following image is a visual summary of the important

points we have covered so far: the relationship between
hypothalamus and pituitary gland, as well as the functions of
growth hormone and IGF-1.

Negative Feedback Circuit Controls Growth

Hormone Secretion
Production of growth hormone is primarily controlled by
a mechanism called Negative Feedback Circuit (although it
can also be affected by other factors including stress,
exercise, nutrition, and sleep).

Feedback circuits are at the root of most control mechanisms

in physiology, and are particularly prominent in the endocrine
system. Instances of positive feedback certainly occur, but
negative feedback is much more common. Negative feedback
is seen when the output of a pathway inhibits inputs to the
pathway. The heating system in your home is a simple
Negative Feedback Circuit. When the furnace produces
enough heat to elevate temperature above the set point of
the thermostat, the thermostat is triggered and shuts off the
furnace (heat is feeding back negatively on the source of
heat). When temperature drops back below the set point,
negative feedback is gone, and the furnace comes back on.

In our case Negative Feedback Circuit is used extensively to

regulate secretion of growth hormone. As mentioned above,
the release of growth hormone by pituitary gland is actually
controlled by hypothalamus. More accurately, two
hypothalamic hormones ultimately control all the
production of growth hormone:

• Growth hormone-releasing hormone

(GHRH) is a peptide that stimulates both the

23
 synthesis and secretion of growth hormone.

• Somatostatin (SS) is a peptide produced by

several tissues in the body, including the
hypothalamus. Somatostatin inhibits growth hormone
release in response to GHRH and to other stimulatory
factors such as low blood glucose concentration.

The Negative Feedback Circuit uses these two

hypothalamic hormones to control the secretion of
growth hormone. The basic mechanisms for the negative
feedback control in this system (as illustrated in the image on
the right) are:

• GHRH (Growth Hormone

Releasing Hormone) secreting
neurons in the hypothalamus
detect the low blood
concentration of growth hormone
and Insulin-like Growth Factor-1
(IGF-1), and in a response these
neurons secrete GHRH, which is
then carried directly to the
anterior pituitary gland via
hypothalamic- hypophyseal portal
veins. Once arrived at anterior
pituitary gland, GHRH stimulates
the activities of somatotrophs (cells
which secrete growth hormone) so
these cells start releasing growth
hormone.

• Released growth hormone

binds to receptors on targeted
cells in the body, promoting
carbohydrate metabolism, protein
synthesis and fat mobilization.
Growth hormone also stimulates
the liver and other tissues to
secrete Insulin-like Growth
Factor-1 (IGF-1). IGF-1 in turn
acts on its target cells, i.e.,
chondrocytes (cartilage cells) and
myoblasts (precursors of muscle
cells) to stimulate muscle and
bone growth.

• Increasing growth
hormone level soon negatively
feeds back to inhibit GHRH
secretion. When blood
concentration of growth hormone
increases above a certain
threshold, GHRH-secreting

24
 neurons in the hypothalamus are
inhibited and stop secreting
GHRH, while SS-secreting
neurons in the hypothalamus are
stimulated and start secreting
SS, which is then carried directly to
the anterior pituitary gland via
hypothalamic- hypophyseal portal
veins. Once arrived at anterior
pituitary gland, SS inhibits the
activities of somatotrophs (cells
which secrete growth hormone) so
these cells stop releasing growth
hormone. Growth hormone's
byproduct - IGF1 also triggers the
Negative Feedback Circuit.
Increased growth hormone level
stimulates liver to secrete IGF-1.
High blood levels of IGF-1 not
only stimulates the release of SS
from the hypothalamus, but also by
directly suppresses the
somatotrophs in the pituitary gland.
The combined effect is the
immediate turn-off of growth
hormone secretion.

• As growth hormone levels

decrease below the threshold,
negative feedback is relieved,
GHRH secretion starts again,
leading to growth hormone
secretion... and the circle restarts
again.

keme it is a Great Gift Idea!! Its not Magic,,, It is a Science

25
 ‫‪If you were interested feel free and don’t hesitate to request more‬‬
‫‪info. By email to : jordanmedics@gmail.com‬‬

‫السئلة المتوقعة من المتصلين للستفسار عن‬

‫الكيمي‬

‫ما هو الكيمي ؟ وماهي آلية عمله ؟‬ ‫‪.1‬‬

‫الكيمي هو عبارة عن ضبان ) ‪ (Insole‬مصنوع من البلسييتيك الرقيييق‬
‫وتنتشيير علييى سييطحه نتييوؤات بييارزة كروييية تعمييل علييى مبييدأ العلج‬
‫الصيني القديم الوخز بالبر ) التدليك والمساج ( لنقاط أعصاب معينيية‬
‫في أسفل القدم وذلك من خلل الضغط عليها بواسييطة تلييك النتييوؤات‬
‫فتعمل على تحفيز وتنشيط لتلك النقاط والييتي بييدورها تكييون مرتبطيية‬
‫بشكل مباشر بوظائف حيوية ومختلفة في جسم النسان فتؤثر على ‪-:‬‬

‫زيادة طول القامة‬ ‫•‬

‫تخفيف الوزن‬ ‫•‬
‫تنشيط الدورة الدموية‬ ‫•‬
‫تأخير مظاهر الشيخوخة‬ ‫•‬
‫تحسين عملية الهضم‬ ‫•‬
‫تخفيف آلم العمود الفقري‬ ‫•‬

‫لمعرفة التفاصيل والعديد من المميزات الخييرى يمكنكييم الطلع عليهييا‬

‫‪www.hi-‬‬ ‫مييييين خلل الموقيييييع اللكيييييتروني الخييييياص‪:‬‬
‫‪up.8m.com‬‬

‫كيف يؤثر الكيمي على زيادة طول القامة ؟‬ ‫‪.2‬‬

‫يوجد في وسط الكيمي منطقة مثلثة بارزة هذة المنطقة الخاصة تقييوم‬
‫بالضغط على تجويف القدم ) باطن القدم ( والذي يوجد به أكثر نقيياط‬
‫أعصاب مرتبطة بشكل مباشيير بالغييدة النخامييية المسييؤولة عيين افييراز‬
‫هرمون النمو فبالتالي من خلل تحفيز هذه المنطقيية يتييم زيييادة إفييراز‬
‫هرمون النمو في جسم النسييان بشييكل طييبيعي وبطيييئ تييدريجيا ممييا‬
‫) ‪ 8 -3‬سييم( خلل‬ ‫يؤدي إلى زيادرة تدريجييية فييي الطييول ميين‬
‫ستة أشهر ‪.‬‬

‫‪26‬‬
‫‪ .3‬كيف يساعد الكيمي بالحصول على زيادة في‬
‫الطول حتى بعد اكتمال نمو العظام؟‬
‫أول‪ :‬لنه بتنشيط الغدة النخامية كما أوضحنا سابقا سوف يترتب عليه‬
‫زيادة في إفراز هرمون النمو في الجسم فبالتالي بالنسبة لمن لييم يكتمييل‬
‫نمو العظام عندهم الصغار سنا بغض النظر عن عميير الطفييل فهييو سييوف‬
‫يساعدهم في الحصول على زيادة بييالطول بشييكل طييبيعي أي أن العظييام‬
‫لديهم تنمو بشكلها الطبيعي وتكون هناك احتمالية للحصول على أكييثر ميين‬
‫‪8‬سم وذلك لكونهم أصل فييي مرحليية النمييو العتيادييية ولكيين الكيمييي هنييا‬
‫عمل فقط على دور المساعدة لتنشيط وزيادة إفراز هرمون النمو لديهم‪.‬‬

‫ثانيييا ‪ :‬أمييا بالنسييبة للشييخاص البييالغين المكتملييين النمييو ) ‪ 20‬سيينة فمييا‬

‫فوق ( ففي هذه الحالة يترتب على زيادة إفراز هرمون النمو بالجسم نمييو‬
‫بسيط في حجم الغضاريف الموجودة في سلسلة العمود الفقييري وخاصيية‬
‫المنطقة السفلية منه وكذلك الغضاريف الموجودة في الرجل وبالتالي يتم‬
‫الحصول على طول متناسق في الجسم ككييل مييع العلييم أن هييذه الزيييادة‬
‫البسيطة في حجم الغضاريف هييي ميين الناحييية الصييحية ممتييازة وإيجابييية‬
‫وذلك لكونها تريييح وضييع الفقييرات وتمنييع أو تحمييي ميين الصييابة بييأمراض‬
‫العمود الفقري كالديسك الناتييج عيين تقييدم العميير وتآكييل تلييك الغضيياريف‬
‫الموجودة بين الفقرات ‪.‬‬

‫‪ .4‬كيف يتم اسععتعمال الكيمععي ؟ وهععل لععه عععدة‬

‫أحجام ؟؟‬
‫كما ذكرنا سييابقا أن الكيميي هيو عبيارة عين ضيبان بلسيتيكي كالضيبانات‬
‫الطبية المتواجييدة لييدى الصيييدليات وبالتييالي فإنهييا تخضييع لنفييس طريقيية‬
‫الستعمال وذلك من خلل وضيع الكيميي داخيل ) الحيذاء الرياضيي مثل أو‬
‫العادي ( ل يشيترط التقييد بنوعيية معينيه ‪ ،‬ميع ضيرورة مراعياة المنطقية‬
‫المثلثة والتي يجب أن تتوسط تجويف القدم ) باطن القدم ( وبعد ذلك يتم‬
‫قص الجزء المرقم والمخصص للقص والذي يزيد ميين عيين خييارج القييدم ‪،‬‬
‫ومن ثم لبد من المشي به لمدة تتراوح من ‪ 30 – 15‬دقيقة مرتين يوميا‬
‫وفي أثناء هذه الفترة لبد مين المشيي المتواصيل لن آليية عميل الكيميي‬
‫تعتمد على مبدأ الضغط لتحفيز النقاط المطلوب تنشيطها ‪.‬‬
‫أما بالنسبة لحجم الكيمي فهو يييأتي بحجييم أو مقيياس واحييد ثييابت للجميييع‬
‫) إنيياث أو ذكييورأو حييتى‬ ‫سواء تم أخده ميين قبييل‬
‫أطفييال ( بحيييث يقييوم كييل شييخص بقييص المنطقيية المخصصيية للقييص‬
‫لتتناسب مع مقاس قدمه بحيث يسهل استعماله بالشكل الصحيح للحصول‬
‫على أفضل النتائج ‪.‬‬

‫كيف يساعد الكيمي على تخفيف الوزن ؟‬ ‫‪.5‬‬

‫‪27‬‬
‫وذلك من خلل تنشيطه لعملية اليض ) حرق الييدهون ( حيييث أن هييذه‬
‫العملية لدى الشخاص ذوي الييوزن الييزائد تكييون بطيئة أو غييير نشييطة‬
‫بشكل كاف مما يترتب عليه أن الشخص في هذه الحالة عند تناوله لي‬
‫وجبة طعام مهما كانت قليلة يقوم الجسييم بتخزييين الجييزء الكييبر منهييا‬
‫على شكل دهون متراكمة بدل من حييرق الفييائض عيين الحاجيية ‪ ،‬لييذلك‬
‫فإن الكيمي يعمل على تنشيط هذه الوظيفة بحيث تصييبح أكييثر فعالييية‬
‫ونشاطا مما يترتب عليه تخلييص الجسييم بشييكل تييدريحي ميين الييدهون‬
‫المتراكمة نتيجة حرقه لها أول بأول كما هو الحال لييدى الشييخاص ذوي‬
‫الوزن الطبيعي‬
‫وأيضا في حالة استعمال الكيمي من قبل شييخص نحيييف وزنييه طييبيعي‬
‫فإنه ليتأثر بأي فقدان للوزن لن هذه العملية هي بالساس فعالة لييديه‬
‫وتعمل بشكل متوازن ‪..‬‬

‫‪ .6‬كيععف يعمععل الكيمععي علععى تععأخير مظععاهر‬

‫الشيخوخة ؟‬
‫نظرا لنه يساعد على تنشيط الدورة الدموية بالجسم ككييل فهييو بهييذه‬
‫الحالة يوفر عملية ترويه دموية متوازنة لجميع خليا الجسم بحيث تبقى‬
‫دائما بوضع صحي ونشيط ‪.‬‬

‫متى تبدأ الستفادة من الكيمي ؟‬ ‫‪.7‬‬

‫تختلف الستجابة وسرعتها من شخص إلييى آخيير تبعييا لختلف طبيعيية‬
‫الجسام ‪ ،‬مع ضرورة النتباه بأن عمل الكيمي يعتمد علييى طريقيية العلج‬
‫الطبيعي وليس بييه أي مييادة دوائيية فهييو يحتياج لقلييل مين اليوقت ولكين‬
‫بشكل عام اعتبارا من الشهر الثاني يكون الجسم قد تهيأ للستجابة والتأثر‬
‫به ‪.‬‬

‫ملحظيية ‪ :‬لبييد ميين التقيييد بالتعليمييات الموجييودة فييي النشييرة المرفقيية‬

‫بالكيمي للحصول على أفضل النتائج وبأسرع وقت من حيث ‪:‬‬
‫ضرورة استعمال الكيمي مرتان يوميا لمدة تييتراوح بيين ) ‪15‬‬ ‫•‬
‫– ‪ ( 30‬دقيقة مرة صباحا ومرة مساء مع المشييي المتواصييل أثنيياء‬
‫لبسه واللتزام به يوميا دون النقطاع عنه وذلك لكييون الجسييم فييي‬
‫تلك الثناء يكون قد قطع مرحلة معينه فييي العلج فالنقطيياع يييؤدي‬
‫إلى العودة إلى نقطة الصفر عند بداية الستعمال ‪.‬‬
‫الهتمام بالغيذاء فيي هيذه المرحلية مين حييث تيوفير الميواد‬ ‫•‬
‫الغذائية اللزمة من كالسيوم وبروتين وفيتامينات ‪.‬‬
‫أخذ قسط كاف من الراحة يوميا ‪.‬‬ ‫•‬

‫‪28‬‬
‫‪ .8‬إذا كان المستخدم يريد فقط الحصول عععل ‪2‬‬
‫– ‪ 3‬سم فقط ؟؟‬
‫في تلك الحالة يتم استعمال الكيمييي إلييى أن يتييم الحصييول علييى تلييك‬
‫النتيجة وبعدها يتم التوقف عن استعماله ‪.‬‬

‫‪ .9‬هععل الزيععادة فععي طععول القامععة الععتي يتععم‬

‫الحصول عليها ثابته أم تزول بمجرد التوقععف عععن‬
‫استعمال الكيمي ؟‬
‫طبعا ثابته ‪ ..‬ل تزول أبدا بالتوقف عن استعماله‬

‫‪ .10‬كيععف يمكععن ملحظععة زيععادة طععول القامععة لععدى‬

‫المستخدم ؟‬
‫لبد قبل البدء باستعمال الكيمي معرفة الطول الحييالي للشييخص وميين‬
‫ثم بعد مرور شيهر تقريبيا ممكين البيدء بمراقبية التغيير التيدريجي فيي‬
‫طول القامة شهريا ‪..‬‬

‫‪.11‬هل يسبب الكيمي ألم عند لبسه ؟‬

‫من الممكن في بداية الستعمال الشعور بألم بسيط وذلك نظييرا لعييدم‬
‫العتييياد علييى هييذا الشييعور الناتييج ميين ضييغط ووخييز تلييك النتييوؤات‬
‫المنتشرة على سطحه ولكن مع مرور الوقت سوف يزول ذلك الشعور‬
‫ويعتاد عليه ‪..‬‬
‫ميع العليم أنييه مين الممكيين ارتيداء ) جييوارب قطنييية خفيفيية ( لتقليييل‬
‫الحتكاك بين القدم وبين الكيمي ولكن في هييذه الحاليية يتييوجب زيييادة‬
‫فترة الستعمال فمثل بدل من نصف ساعة يتم استعماله لساعة كامليية‬
‫لتعويض قلة الضغط المباشر بين القدم والكيمي ‪.‬‬

‫‪ .12‬هل يمكن استعمال الكيمي لساعات طويلة ؟‬

‫نعم حسب الرغبة ‪ ،‬فهييو ليييترتب علييى اسييتعماله لفييترات طويليية أي‬
‫أضرار تنتج لنه يعتبر كأداة رياضية للشخص حرية الفترة في استعمالها‬
‫‪..‬‬

‫‪29‬‬
 ‫‪.13‬هل للكيمي أية آثار جانبية ؟؟‬
‫طبعا ل ‪ ،،‬فهو كما ذكرنا عبييارة عيين ضييبان بلسييتيكي ويمكيين تصيينيفه‬
‫) كأداة رياضية ( تعمل فقط على تحفيز وتنشيط لنقاط أعصاب معينيية‬
‫موجودة بأسفل القدم عن طريق تدليك ووخز تلك المناطق المخصصيية‬
‫بواسييطة النتييوؤات الكروييية فهييو يعتمييد علييى العلج الطييبيعي ‪%100‬‬
‫والمساج فقط ‪..‬‬

‫‪.14‬هل للكيمي فترة صلحية ؟‬

‫ليس له أية فترة صلحية حتى بعد انتهاء الستة أشهر بييل ميين الممكيين‬
‫الستمرار ومواصلة استعماله حتى بعد الحصول على النتيجة المطلوبيية‬
‫للمحافظة على الناحية الصحية مين تنشيييط لليدورة الدموييية وتحسيين‬
‫للهضييم وغيرهييا ميين المميييزات العديييدة وطبعييا هييذا حسييب الرغبيية‬
‫الشخص‪.‬‬

‫‪.15‬من يستطيع استخدام الكيمي ؟‬

‫يتييم اسييتخدامه ميين قبييل الجميييع وبمختلييف العمييار )إنيياث ‪ /‬ذكييور ‪/‬‬
‫أطفال( فهو كما ذكرنا أداة رياضية قابلة للستخدام من أي شخص ‪..‬‬

‫‪ .16‬هل لستخدام الكيمي عمر معين ؟؟‬

‫بالنسبة لزيادة طول القامة فإن الحد القصى لحتمالية السييتفادة منييه‬
‫هي ‪ 35‬عاما فكمييا ذكرنييا أن الكيمييي بالنسييبة للبييالغين ل يعتمييد علييى‬
‫اطالة العظام كما هو الحال في الصغار سنا وانما يعمل على زيادة في‬
‫حجم الغضاريف الموجودة بين الفقرات وهي ل علقة لها بالعمر مطلقا‬
‫وأيضا علييى اعتبييار أن جسييم النسييان بعييد هييذا العميير تصييبح وظييائفه‬
‫الجسمية أقل نشاطا من السابق‬

‫أمييا بالنسييبة لبقييية المميييزات الخييرى الييتي تنتييج أيضييا ميين اسييتعمال‬
‫الكيمي فهي ليست مشروطة بأي عمر لكل الجنسين طبعا ‪....‬‬

‫‪For Sales and Export Queries‬‬

‫‪For more info contact‬‬

‫‪jordanmedics@gmail.com‬‬
‫‪voice – 0799991317‬‬
‫‪30‬‬
31