P1630

Superior skin effect by facial mask

Yukio Heki, Procter and Gamble Japan KK, Kobe, Japan; Kesyin Hsueh, PhD,
Procter and Gamble Japan KK, Kobe, Japan; Ohgata Hiroyuki, MBBS, Procter and
Gamble Japan KK, Kobe, Japan
Background: Fabric substrateebased facial mask has been an important supplement
of skin care regiment for Asian women. Most users always recognize clearly
excellent skin efcacy and in-use experience. This investigation result elucidates the
potential skin effect mechanisms via clinical designs and trials.
Objective: In vivo research designs to better understand and quantitate the mask
effects on facial skin care efcacy and experience.
Methods: Clinical preparation: in vivo study with chronic and acute application of
mask with formula, involving multiple or single visit of randomized Japanese
panelists (n 50), 32 to 52 years of age, who had applied basic skin care regimen as
baseline control. Protocols: DANNE three-dimensional facial topography analysis
comparing cotton and other substrate masks , active skin penetration by tape
stripping method, Comeometer, VISIA, Optical Coherent Tomography comparing
liquid only and various substrate masks. Formula: key formula and functional
ingredient investigated include Niacinamide, glycerin, cosmetic-grade humectants,
and typical skin care formula chasses. Mask: engineering substrates composed of
hydrophilic cotton spunlace, hydrophilic rayon spunlace, and hydrophobic stretch-
able polyolen microber spunlace.
Results: In vivo active penetration through the stratum corneum is found signif-
icantly higher in volume and rate for mask and formula combination (220 index).
This is supported by substrate occlusive evaporating effect and formula retention
and gradual release to the skin during application. Parallel clinical means conrm
superior stratum corneum hydration effect and acute appearance improvements of
masks impregnated with formula. The newly engineered substrate of special micro
bers and with hydrophilicity gradient is demonstrated to accelerate ux and
transport more effectively actives and moisture into epidermis (125 index). DANNE
three-dimensional facial topography analysis also reveals signicant facial rming
and cheek contour line lift-up effects with the combination of formula and
engineering substrate masks. The clinical trial results are further correlated with
grading of visual perception system of VISIA images and users experience survey.
Commercial support: Sponsored by Procter and Gamble.
P1631
Multiple mechanisms of action of azelaic acid: New ndings
Zoe Draelos, MD, Dermatology Consulting Services, High Point, NC, United
States
Introduction: The multiple mechanisms of action of azelaic acid (AZA) 15%gel give it
the potential to treat various dermatologic conditions in addition to rosacea, for
which it is approved in the United States, and to simultaneously treat concomitant
skin conditions that rosacea patients have often to deal with.
Objective: To present preliminary ndings of some new studies that show
comedolytic and antioxidant effects of AZA 15% gel, and the possible benets of
multiple mechanisms of action in the treatment of rosacea across different skin types
and in patients with concomitant dermatologic conditions. In a recent study,
patients treated with AZA 15% gel showed a reduction in comedone counts
comparable to patients treated with 5%benzoyl peroxide. In another, ongoing study,
AZA 15% gel was shown to decrease oxidative stress as measured by the develop-
ment of apoptotic cells following exposure to ultraviolet B light radiation. In a study
of the treatment of rosacea across different skin types and in patients with
concomitant skin conditions, AZA 15% gel was found to be highly efcacious in
reducing inammatory facial lesions in patients with a variety of skin types and
colors, and in those with associated skin conditions, including seborrheic dermatitis
and perioral dermatitis. Part of this broad efcacy may be attributed to the
simultaneous antiinammatory, antimicrobial, and antikeratinizing effects of AZA.
Conclusion: AzA has proven clinically versatile in treating skin conditions in addition
to rosacea, as well as simultaneously treating different conditions because of its
multiple mechanisms of action.
Commercial support: Sponsored by Intendis, Inc.
P1632
Hydradermabrasion: An innovative modality for nonablative facial
rejuvenation
Bruce Freedman, Plastic Surgery Associates of Northern Virginia, McLean, VA,
United States
Background: Hydradermabrasion is a relatively new procedure that combines
crystal free microdermabrasion immediately followed by the pneumatic application
of a rejuvenating serum. This study analyzed the histologic and clinical changes
associated with hydradermabrasion.
Methods: Twenty female volunteers between 34 and 52 years of age with Fitzpatrick
skin phototypes I to IV underwent a series of six facial hydradermabrasion
treatments spaced 7 to 10 days apart. The applied serum contained polyphenolic
antioxidants including camellia sinensis and horse chestnut seed extract. Skin
biopsies, photographs, and skin antioxidant levels, as determined by Raman
Spectroscopy, were obtained before and after the study.
Results: Compared to controls, the treated skin demonstrated signicantly increased
epidermal and papillary dermal thickness and increased broblast density (P\.01).
Hyalinization of the papillary dermis with newly deposited collagen fibers and
lessening of solar elastosis were observed. After hydradermabrasion, skin antioxi-
dant levels increased 30% (P \.01). These changes were supported clinically with
reductions in pore size, dyspigmentation, and fine rhytides. Patients also noted
improved skin texture and tone. There were no reported complications.
Conclusion: Hydradermabrasion effectively improved skin quality both clinically
and histologicly. There were no changes to suggest that pneumatic serum applica-
tion adversely affected dermal components. After hydradermabrasion, skin poly-
phenolic antioxidant levels were increased. This procedure is benecial for those
desiring nonablative facial rejuvenation.
Commercial support: None identified.
P1633
The role of 0.02% tretinoin cream in preventing and reversing
photodamage
Leon Kircik, Derm Research, Louisville, KY, United States
Retinoids have many diverse and important functions in the skin and as a therapeutic
class have made signicant contributions to dermatologic therapy. Because of their
biologic diversity, retinoids are used to treat a variety of dermatologic disorders
including acne, psoriasis, hyperpigmentation, and rosacea, and photodamage. The
application of tretinoin to the skin initiates a series of events that can both prevent
and repair photodamage. When applied topically to the skin, tretinoin enters the cell
and binds to nuclear hormone receptors including retinoic acid receptors (RARs)
and retinoid X receptors (RXRs). This activated retinoid-receptor complex regulates
gene transcription allowing retinoids to inhibit or activate certain gene expression.
The signicance of this mechanism has lead to the established clinical use of
tretinoin for the reduction of ne facial wrinkles, mottled hyperpigmentation, and
skin roughness. Tretinoin cream 0.02%, which remains the only agent for the
mitigation of ne lines and wrinkles approved by the US Food and Drug
Administration, has been studied in four well controlled, multicenter clinical trials
and one single-center, randomized, controlled trial. However, only one long-term
clinical trial was conducted using tretinoin cream 0.02% to determine the effects of
its application on the skin after 52 weeks of treatment. This scientic poster will
provide an overview of the available clinical data and clinical observations that
support the role that tretinoin 0.02% cream may play in reducing the signs and
symptoms of photoaging and will include the results of a long-term clinical
observation and skin biopsy results of patients treated in a clinical practice setting.
Commercial support: Educational grant will be provided by OrthoNeutrogena to
cover production costs.
AB86 J AM ACAD DERMATOL MARCH 2009