Escolar Documentos
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Marketed Gel
Microemulsion
Based Gel
Drug Dispersion
in Buffer (pH 7.4)
Design and Evaluation of Micro emulsion Based Drug Delivery System K.R. Jadhav, et. al
ASIAN J. EXP. BIOL. SCI. VOl 1 (3) 2010
591
Microemulsion based gel formulation containing fluconazole was prepared with the aim of achieving maximum
release through the skin thus by passing its gastrointestinal adverse effect. Thus a microemulsion based gel
formulation was successfully prepared using isopropyl palmitate or light liquid paraffin, aerosol OT as surfactant,
sorbitan monooleate as cosurfactant, water and carbopol 940 as a gelling agent. Solubility study showed
fluconazole has higher solubility in microemulsion compared to in their corresponding plain oils. This leads to
increased drug loading. The flux of IPP based ME was better than LLP based ME in the in vitro release studies.
Thus IPP based ME was selected for gel formulation. The developed gel formulation showed higher flux as
compared to marketed gel and in vitro inherent flux study. In the skin irritation study the formulation was found
to be safe as indicated by histopathological findings. The in vitro anti fungal activity of fluconazole from
microemulsion based system was good as compared to that of marketed gel. Therefore the microemulsion based
gel of fluconazole was prepared to obtain improved patient compliance. Hence an attempt was made to increase
the skin permeation of fluconazole and skin tolerability.
ACKNOWLEDGEMENT
We would like to thank Centaur pharma Ltd, Mumbai for providing gift sample of fluconazole.
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CORRESPONDENCE TO AUTHOR: S.L. Shetye, Department of Pharmaceutics, Bharati Vidyapeeths College of
Pharmacy, CBD Belapur, Sector-8, Navi- Mumbai - 400614, India. E-mail: sulabhashetye@gmail.com