Amfepramone

1
Amfepramone
Amfepramone
Systematic (IUPAC) name
(RS)-2-diethylamino-1-phenylpropan-1-one
Clinical data
AHFS/Drugs.com
monograph
[1]
MedlinePlus
a682037
[2]
Pregnancy cat. B
Legal status Schedule IV (US)
Routes Oral
Identifiers
CAS number
134-80-5
[3]

ATC code
A08AA03
[4]
PubChem
CID 7029
[5]
DrugBank
DB00937
[6]
ChemSpider
6762
[7]

UNII
19V2PL39NG
[8]

KEGG
D07444
[9]

ChEBI
CHEBI:4530
[10]

ChEMBL
CHEMBL1194666
[11]

Synonyms Diethylpropion
Chemical data
Formula C
13
H
19
NO
Mol. mass 205.30 g/mol
(what is this?) (verify)
[12]
Amfepramone (INN, other names diethylcathinone and diethylpropion, trade names Anorex, Linea, Nobesine,
Prefamone, Regenon, Tepanil, Tenuate), is a stimulant drug of the phenethylamine, amphetamine, and cathinone
chemical classes that is used as an appetite suppressant.
Amfepramone
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Pharmacology
Amfepramone itself lacks any affinity for the monoamine transporters and instead functions as a prodrug to
ethcathinone. Ethcathinone (and therefore amfepramone as well) is a very weak dopaminergic and serotonergic, and
is approximately 10x and 20x stronger on norepinephrine in comparison, respectively. As a result, ethcathinone and
amfepramone can essentially be considered norepinephrine releasing agents (NRAs).
Abuse
Amfepramone is believed to have relatively low abuse potential., but recently there have been reports of teens and
adults in the UK abusing this drug, known as "tombstones" to the abusers.
Legality
Amfepramone is classified as a Schedule IV controlled substance in the United States. In the UK Amfepramone is a
class C drug and as a medicine, it is a Schedule 3 Controlled Drug which requires safe custody.
Chemistry
1. Propiophenone is brominated to produce -bromopropiophenone.
2. This is reacted with diethylamine to yield the product, diethylpropion.
References
[1] http:/ / www. drugs. com/ monograph/ diethylpropion-hydrochloride. html
[2] http:/ / www. nlm. nih.gov/ medlineplus/ druginfo/ meds/ a682037. html
[3] http:/ / www. nlm. nih.gov/ cgi/ mesh/ 2009/ MB_cgi?term=134-80-5& rn=1
[4] http:/ / www. whocc.no/ atc_ddd_index/ ?code=A08AA03
[5] http:/ / pubchem. ncbi. nlm.nih. gov/ summary/ summary. cgi?cid=7029
[6] http:/ / www. drugbank. ca/ drugs/ DB00937
[7] http:/ / www. chemspider.com/ Chemical-Structure.6762. html
[8] http:/ / fdasis.nlm. nih. gov/ srs/ srsdirect. jsp?regno=19V2PL39NG
[9] http:/ / www. kegg. jp/ entry/ D07444
[10] https:/ / www.ebi.ac. uk/ chebi/ searchId.do?chebiId=CHEBI:4530
[11] https:/ / www.ebi.ac. uk/ chembldb/ index.php/ compound/ inspect/ CHEMBL1194666
[12] http:/ / en. wikipedia. org/ w/ index. php?title=Special:ComparePages& rev1=456687601& page2=Amfepramone
Article Sources and Contributors
3
Article Sources and Contributors
Amfepramone Source: http://en.wikipedia.org/w/index.php?oldid=590558605 Contributors: Anypodetos, Arcadian, Arch dude, Aschwole, Beetstra, Benrr101, C.d.rose, C6541, ChemNerd,
Chemgirl131, Chowbok, Chris Capoccia, Code6840, Crazy-Chemist, Ddhix 2002, Deli nk, Derek.cashman, ERcheck, Edgar181, Fuzzform, Fvasconcellos, Harbinary, J, Keyyyyzzzz, Loserkore,
Louisajb, MadSurgeon, Marqueed, Meodipt, Nirmos, Ntsimp, Nuklear, Pashihiko, PerfectlyInsane, Pluscount, Pupplesan, Rjwilmsi, Rmky87, Samiam1611, Schaefer, SwampFox556, The Right
Honourable, Thunderwolf66102, Tomas e, Turkeyphant, Vaccinationist, Verdafolio, 38 anonymous edits
Image Sources, Licenses and Contributors
File:Amfepramone.svg Source: http://en.wikipedia.org/w/index.php?title=File:Amfepramone.svg License: Public Domain Contributors: Benrr101
File:Yes check.svg Source: http://en.wikipedia.org/w/index.php?title=File:Yes_check.svg License: Public Domain Contributors: Anomie
File:X mark.svg Source: http://en.wikipedia.org/w/index.php?title=File:X_mark.svg License: Public Domain Contributors: User:Gmaxwell
License
Creative Commons Attribution-Share Alike 3.0
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