COURSE MBT 401: Nanobiotechnology: Elective Course I

(4 Credits, Level II, 3 L, 1T)

Unit 1 15L
1. Introduction to nanoscience
Introduction to nanoscience; History and scope, interdisciplinary nature,
structure of nanomaterials, length scales de Broglie wavelength & exciton
Bohr radius, quantum wires, quantum dots, fullerenes, graphite, carbon
nanotubes, inorganic nanowires, nanoparticles, core-shell nanoparticles
2. Nanomaterials synthesis
Top-down and bottom-up approaches, chemical precipitation, vapor deposition,
hydrothermal method, pyrrolysis, Sputtering, laser ablation, electric-arc, sol-gel
processing, lithography, natural synthesis in organism, natural inorganic,
micelle, bio-based protocol
Unit 2 15L
1. Nanomaterials characterization
Electron microscopy SEM, TEM, EDAX, X-ray diffraction atomic force
microscopy, confocal microscopy, UV-Visible spectroscopy, photoluminescence
spectroscopy, FTIR spectroscopy, UV and X-ray photoelectron spectroscopy,
particle size analysis, charge distribution analysis (charge on the surface,
estimation).
2. Nanotechnology Applications Materials domain
Nanoscale materials, fabrication at the nanoscale, Molecular Beam Epitaxy,
Nano transfer printing, Scanning probe based techniques for nanomaterial
synthesis, MEMS and NEMS, selforganization, nanoscale (opto)electronics and
magnetic Fullerenes, Nanosensors: characterization, perception,
electrochemical sensors, physical sensors, thin-films nanoscale devices
Transistors, FETs, quantum dots, lasers and others, Microfluidics, Nanofuel
cell, Nanoemulsions and coatings, Microcastings

Unit 3 15L
1. Nanotechnology Applications Biology domain
Bionanomachines composed of protein, nucleic acids, lipids, polysaccharides,
recombinant DNA technology, protein folding, self assembly, biomolecular
motors, traffic across membranes, biomolecular sensing, self replication,
nanobiosensors, nanoimplants, biorobotics, functionalization of nanoparticles
for biological applications.
2. Applications of AFM, SEM and Raman Spectroscopy in biology
Scanning tunneling microscopy, atomic force microscopy, magnetic- force
microscopy (MFM), scanning near field optical microscopy (SNOM), etc.
Applications: microscopy, AFM/FFM and various measurement techniques,
friction and adhesion, self assembled monolayers
Unit 4 15L
1. Applications in cancer biology
Characteristics of tumor tissues, drug delivery to tumors, physicochemical
properties of nanoparticles in cancer therapy, surface treatment of coating of
nanoparticle polymers for encapsulation, site specific delivery of
chemotherapeutic agents using nanoparticles, passive targeting, targeting
lymph nodes with nanoparticles, increasing bioavailability of a compound,
active targeting, magnetically directed targeting to tumor tissue, ligand
directed active targeting, targeted drug delivery using magnetic nanoparticles,
nanoviral gene therapy, hyperthermia, computer aided drug design, anti-AIDS
drugs, general medicine to personalized medicine, immunotoxins targeted cell
killers, drugs delivered with liposomes, artificial blood, gene therapy


2. Applications in Food Industry
Nano-food, food processing, packaging and safety, nano-capsules and
nanocomposites used in food industry.
3. Applications in Environment Protection
Environmental benefits of nanotechnology, nanotechnology in water treatment.
4. Applications in Microbiology
Microbial synthesis of nanoparticles, nanomaterial enabled microbial control,
application of nanotechnology in the study of cell structure; bacteria and virus.
5. Applications in Agriculture
Crop improvement, nanoagrochemicals, nanosensors for on-farm monitoring,
plant disease monitoring, plant disease diagnosis.
References
1. T. Pradeep, Nano, The Essentials, Understanding Nanoscience and
Nanotechnology, Tata McGraw-Hill Publishing Company Limited, 2007
2. J. W. M. Bulte, M.M.J. Modo, Nanoparticles in Biomedical Imaging: Emerging
Technologies and Applications, Springer Science Business Media, LLC, 2008
3. C.A. Mirkin and C.M. Niemeyer, Nanobiotechnology- II, More Concepts and
Applications, WILEY-VCH, Verlag Gmb H&Co, 2007
4. V. Renugopalakrishnan and R. V. Lewis Eds. BionanotechnologyProteins to
Nanodevices, Springer.
5. D. S. Goodsell, Bionanotechnology Lessons from Nature John Wiley & Sons,
Inc
6. Bhushan Ed.,Handbook of nanotechnology, Springer.
7. A C. Yih and I. Talpasanu Eds. Micro and Nano Manipulations for Biomedical
Applications
8. Tuan VoDinh. Ed. Nanotechnology in Biology and Medicine: methods, device
and applications. CRC Press.