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Abstract
Determine the amount of salicylic acid in acetyl salicylic acid, trade named as Aspirin.
For this we would know the actual amount of salicylic used for each tablet of Aspirin.
The following are the reagents & requirements for the experiment; standard solution of
NaOH & HCl, solution of Aspirin, burette, pipette, conductometer & volumetric flasks.
Here we used conductometric titration between NaOH & Aspirin solution, where NaOH
solution is standardized by HCl of 0.1M.
Theory
Conductometry [1] is the technique by which quantitative analysis has been made for
analysis of different species using the electrical conductance between the two electrodes.
This basically based on ability of conductances of different solutions by their respective
ions in the solvents.
The volume of titration which is required to react completely with the analyzed substance
in the titrand is called Equivalence Point. The measure of ability of a solution to conduct
electricity is called its conductance[2].
Water is a very poor conductor of electricity. The presence of ionic species (electrolytes)
in water increases the conductance considerably. Solutions of electrolytes, like metallic
conductors, obey Ohm's law. Thus, the current I passing through a solution of a particular
electrolyte is proportional to the applied potential difference V as given by the equation:
V
I=
R
Here R is the resistance offered by the solution in ohms (W)
V
R=
Or I
The resistance is directly proportional to the length , of liquid through which the current
passes, and inversely proportional to its area of cross-section A. It therefore follows that:
ρ ×
R=
A
Here r is the constant of proportionality and is called the specific resistivity[2]. It is a
constant for an aqueous solution of a given electrolyte of fixed concentration at a
particular temperature. In SI units, resistivity has the units of ohm meter (W m). If area of
cross-section is increased, more ions will be able to flow and resistance will decrease.
The conductance L is defined as the reciprocal of the resistance expressed in units of W –1
or Siemens (S).
1
L=
R
Thus, the conductance of a homogenous body of uniform cross-section is proportional to
the cross-sectional area A and inversely proportional to the length , given by:
A A
L= =κ ×
ρ ×
Here the reciprocal of resistivity r is replaced by another constantk, which is called the
specific conductivity with units W –1m –1 or S m –1 which can be expressed as:
1 k
κ= = = ∴ k =
RA ρ R A
Here k is called the cell constant. [2]
Conductivity does not solely depend upon the number of ions present in unit volume of
the solution. Concentrated solutions of very soluble electrolytes show a maximum
conductivity value which then decreases on further concentration of the solution. The
reason lies in the fact that ionic distances becomes less as concentration increases. This
results in a greater attraction between positive and negative ions, and with a greater
reduction in ionic speeds. The phenomenon is called "ionic interference". [2]
Aspirin, or acetylsalicylic acid is a salicylate drug often used as an analgesic (to relieve
minor aches and pains), antipyretic (to reduce fever), and as an anti-inflammatory. It also
has an anti-clotting effect and is used in long-term, low doses to prevent heart attacks and
blood clot formation in people at high risk for developing blood clots. High doses of
aspirin may also be given immediately after an acute heart attack; these doses may inhibit
the synthesis of prothrombin and therefore produce a second and different anticoagulant
effect, although this is not well understood.
Aspirin is one of the most frequently used drugs in the treatment of mild to moderate
pain, including that of migraines, and fever. It is often combined with other analgesics,
even though this has never been shown to be more effective or less toxic than aspirin
alone. Aspirin has been used in addition to other non-steroidal anti-inflammatory drugs
and opioid analgesics in the treatment of pain associated with cancer. Aspirin can cause
blood loss. It can also cause heartburn.
Results
Weight of Aspirin = 0.5293 gm
Initial Final
Serial Difference
Volume of Volume of
No. (ml)
NaOH (ml) NaOH (ml)
1 0 4.5 4.5
2 4.5 8.9 4.4
3 8.9 13.3 4.4
Titration Reaction
NaOH + HCl ® NaCl + H2O
Concentration of NaOH
Concentration of HCl = M1 = 0.1 M
Volume of HCl solution = V1 = 5 ml
Volume of NaOH solution = V2 = 4.4 ml (from table)
Concentration of NaOH = M2 =?
Formula
M 1V1 M 2V M 1V1 n2
= M2 =
n1 n2 Þ V2 n1
Here n1 = n2 = 1
5 × 0.1 × 1
M2 = = 0.1136M
1 × 4.4
Titration Reaction
H O O O C N a O OO C
C C C C 3H
3H + NaOH ¾¾¾® + H2O
Sodiumoacetoxy
Aspirin
benzoic acid
Formula
M 1V1 M 2V M 1V1n2
= M2 =
n1 n2 Þ V2 n1
Here n1 = n2 = 1
0.1136 × 1.875 × 1
M2 = = 7.11 × 10 −3 M
1 × 30
· Percentage of Aspirin
0.29138
×100 = 55.05%
% weight = 0.5293
· Percentage Error
The standard value of the amount of aspirin estimated on the label for a single tablet is
300mg.
300 − 291.38
× 100 = 2.873%
% error = 300
Hence,
The amount of ascorbic acid is found to be 291.38mg in a single given tablet with an
error of 2.873%.
Discussion [1]
As mentioned earlier the purity of water is critical for the accuracy of our results.
Ordinary distilled water is not preferred. Specially pure water, known as conductance
water or conductivity water should be used for the preparation of solutions. The purest
water referred to as "ultra-pure" has a specific conductance of 0.05 mS / cm at 18°C. Air
must be rigidly excluded when it is being employed.
The water we utilized was not pure. It is most probable that it contained impurities
and stray electrolytes, which could cause variations in conductance by two ways:
a. Contribute the effects of their conductance directly
b. Cause ionic interference [2]
Conclusion
We conclude that the conductometric method is the best way to determine the
equivalence point, if there is a change in conductance is present in titrand solution.
Conductomertric titrations are useful for acid-base, precipitation, and complexation
titrations.
.
1 R.D. BRAUN, "Introduction to Chemical Analysis"
2
Chemical Process Principles
0.7
0.6
Specific Conductance (us/cm)
0.5
0.4
0.3
0.2
0.1
0
0 5 10 15 20 25 30 35 40
V olum e of Na OH a dde d (m l)
0.5
0.45
Specific Conductance (us/cm)
0.4
0.35
0.3
0.25
0.2
0.15
0.1
0.05
0
0 5 10 15 20 25 30 35
Volum e of Na OH a dde d (m l)
0.8
0.7
Specific Conductance (us/cm)
0.6
0.5
0.4
0.3
0.2
0.1
0
0 5 10 15 20 25 30
Volum e of NaOH adde d (m l)
→Addition of 0.5 ml of NaOH into Aspirin Solution
V o lu m e v /s S p .C o n d u c ta n c e
0.6
0.5
Specific Conductance (us/cm)
0.4
0.3
0.2
0.1
0
0 5 10 15 20 25
V o lu m e o f N a O H a d d e d (m l)