REPORTS

3869
S
Identification of Double-stranded Genomic DNA Spanning All
Chromosomes with Mutated KRAS and p53 DNA in the Serum
Exosomes of Patients with Pancreatic Cancer. Christoph Kahlert,
Sonia A. Melo, Alexei Protopopov, Jiabin Tang, Sahil Seth, Moritz Koch,
Jianhua Zhang, Juergen Weitz, Lynda Chin, AndrewFutreal,
and Raghu Kalluri
Also classified as Molecular Bases of Disease
Also classified as Cell Biology
BIOENERGETICS
4307 Redox Control of Human Mitochondrial Outer Membrane
Protein MitoNEET [2Fe-2S] Clusters by Biological Thiols and
Hydrogen Peroxide. Aaron P. Landry and Huangen Ding
Also classified as Metabolism
CELL BIOLOGY
3936 mRNA Decapping Enzyme 1a (Dcp1a)-induced Translational
Arrest through Protein Kinase R (PKR) Activation Requires the
N-terminal Enabled Vasodilator-stimulated Protein Homology
1 (EVH1) Domain. Jonathan D. Dougherty, Lucas C. Reineke,
and Richard E. Lloyd
Also classified as Protein Synthesis and Degradation
4032
S
Endoplasmic ReticulumStress Promotes Macrophage-derived
FoamCell Formation by Up-regulating Cluster of
Differentiation 36 (CD36) Expression. Shutong Yao, Cheng Miao,
Hua Tian, Hui Sang, Nana Yang, Peng Jiao, Jiju Han, Chuanlong Zong,
and Shucun Qin
Also classified as Signal Transduction
4083 p53/TAp63 and AKT Regulate Mammalian Target of Rapamycin
Complex 1 (mTORC1) Signaling through Two Independent
Parallel Pathways in the Presence of DNADamage. Maren Cam,
Hemant K. Bid, Linlin Xiao, Gerard P. Zambetti, Peter J. Houghton,
and Hakan Cam
Also classified as Signal Transduction
4135 SIRT4 Protein Suppresses Tumor Formation in Genetic Models
of Myc-induced B Cell Lymphoma. Seung Min Jeong, Annie Lee,
Jaewon Lee, and Marcia C. Haigis
Also classified as Metabolism
4161 Clusterin Is a Ligand for Apolipoprotein E Receptor 2 (ApoER2)
and Very LowDensity Lipoprotein Receptor (VLDLR) and
Signals via the Reelin-signaling Pathway. Christian Leeb,
Christine Eresheim, and Johannes Nimpf
Also classified as Neurobiology
4262 Drosophila TRPML Forms PI(3,5)P
2
-activated Cation Channels
in Both Endolysosomes and Plasma Membrane. Xinghua Feng,
Yu Huang, Yungang Lu, Jian Xiong, Ching-On Wong, Pu Yang, Jintang
Xia, De Chen, Guangwei Du, Kartik Venkatachalam, Xuefeng Xia,
and Michael X. Zhu
Also classified as Molecular Bases of Disease
4395
S
Interaction between Microtubules and the Drosophila Formin
Cappuccino and Its Effect on Actin Assembly. Elizabeth A. Roth-
Johnson, Christina L. Vizcarra, Justin S. Bois, and Margot E. Quinlan
Also classified as Enzymology
DEVELOPMENTAL BIOLOGY
3842 6 Integrin Transactivates Insulin-like Growth Factor Receptor-
1 (IGF-1R) to Regulate Caspase-3-mediated Lens Epithelial Cell
Differentiation Initiation. Subhasree Basu, Suren Rajakaruna,
Adle De Arcangelis, Liping Zhang, Elisabeth Georges-Labouesse,
and A. Sue Menko
Also classified as Signal Transduction
4273 Generation and Characterization of Function-blocking Anti-
ectodysplasin A (EDA) Monoclonal Antibodies That Induce
Ectodermal Dysplasia. Christine Kowalczyk-Quintas, Laure Willen,
Anh Thu Dang, Heidi Sarrasin, Aubry Tardivel, Katharina Hermes, Holm
Schneider, Olivier Gaide, Olivier Donz, Neil Kirby, Denis J. Headon,
and Pascal Schneider
Also classified as Molecular Bases of Disease
On The Cover
Lowmolecular weight hyaluronic acid (green) associates with TLR4 (blue) and initiates pathways leading to cPLA
2
(PLA2G4A, purple) activation and
PGE
2
(white/red) production in monocytes and macrophages. The background shows high molecular weight hyaluronan strands within the extra-
cellular matrix. Cover art was prepared by Ethan Tyler, based on the Protein Data Bank (1CJY, 2BVK, 3FXI, and 2J67) and PubChem (CID 5280360)
structures. For details see the article by Sokolowska et al., pages 44704488.
The Journal of Biological Chemistry
Copyright 2014 by the American Society for Biochemistry and Molecular Biology, Inc
11200 Rockville Pike, Suite 302, Rockville, MD 208523110 U.S.A.
TABLE OF CONTENTS
CONTENTS ARE ARRANGED BY SUBJECT CATEGORIES
Full Instructions to Authors are found on the web at www.jbc.org
JBCHA3 289(7) 38284545 (2014)
Paper of the Week Authors Choice S Article contains supplemental material
iv JOURNAL OF BIOLOGICAL CHEMISTRY VOLUME 289 NUMBER 7 FEBRUARY 14, 2014
ENZYMOLOGY
3913 The Drug Diazaborine Blocks Ribosome Biogenesis by
Inhibiting the AAA-ATPase Drg1. Mathias Loibl, Isabella Klein,
Michael Prattes, Claudia Schmidt, Lisa Kappel, Gertrude Zisser, Anna
Gungl, Elmar Krieger, Brigitte Pertschy, and Helmut Bergler
4106 The UHRF1 Protein Stimulates the Activity and Specificity of
the Maintenance DNA Methyltransferase DNMT1 by an
Allosteric Mechanism. Pavel Bashtrykov, Gytis Jankevicius, Renata
Z. Jurkowska, Sergey Ragozin, and Albert Jeltsch
Also classified as DNA and Chromosomes
4367
S
Enhanced Amino Acid Selection in Fully Evolved Tryptophanyl-
tRNA Synthetase, Relative to Its Urzyme, Requires Domain
Motion Sensed by the D1 Switch, a Remote Dynamic Packing
Motif. Violetta Weinreb, Li Li, Srinivas Niranj Chandrasekaran, Patrice
Koehl, Marc Delarue, and Charles W. Carter, Jr.
Also classified as Molecular Biophysics
GENE REGULATION
3923 miR-186 Inhibits Muscle Cell Differentiation through Myogenin
Regulation. Antonis Antoniou, Nikolaos P. Mastroyiannopoulos,
James B. Uney, and Leonidas A. Phylactou
Also classified as RNA
4009 The CUL7/F-box and WDRepeat Domain Containing 8 (CUL7/
Fbxw8) Ubiquitin Ligase Promotes Degradation of
Hematopoietic Progenitor Kinase 1. Hua Wang, Yue Chen, Ping
Lin, Lei Li, Guisheng Zhou, Guangchao Liu, Craig Logsdon, Jianping
Jin, James L. Abbruzzese, Tse-Hua Tan, and Huamin Wang
Also classified as Protein Synthesis and Degradation
4018 Human Krppel-related 3 (HKR3) Is a Novel Transcription
Activator of Alternate Reading Frame (ARF) Gene. Jae-Hyeon
Yoon, Won-Il Choi, Bu-NamJeon, Dong-In Koh, Min-Kyeong Kim,
Myung-Hwa Kim, Jungho Kim, Sujin Susanne Hur, Kyung-Sup Kim,
and Man-Wook Hur
Also classified as Cell Biology
4326 Control of Foxo1 Gene Expression by Co-activator P300. Anne
R. Wondisford, Lishou Xiong, Evan Chang, Shumei Meng, David
J. Meyers, Mingsong Li, Philip A. Cole, and Ling He
Also classified as Metabolism
GLYCOBIOLOGY ANDEXTRACELLULAR MATRICES
4001 The -PrismLectin Domain of Vibrio cholerae Hemolysin
Promotes Self-assembly of the -Pore-forming Toxin by a
Carbohydrate-independent Mechanism. Sreerupa Ganguly,
Amarshi Mukherjee, Budhaditya Mazumdar, Amar N. Ghosh,
and Kalyan K. Banerjee
Also classified as Protein Structure and Folding
IMMUNOLOGY
4126 Ubiquitination Regulates Expression of the Serine/Arginine-
rich Splicing Factor 1 (SRSF1) in Normal and Systemic Lupus
Erythematosus (SLE) T Cells. Vaishali R. Moulton, Andrew
R. Gillooly, and George C. Tsokos
Also classified as Gene Regulation
4295 Recognition of Malondialdehyde-modified Proteins by the
C Terminus of Complement Factor HIs Mediated via the
Polyanion Binding Site and Impaired by Mutations Found in
Atypical Hemolytic Uremic Syndrome. Satu Hyvrinen, Koji
Uchida, Markku Varjosalo, Reija Jokela, and T. Sakari Jokiranta
Also classified as Molecular Bases of Disease
4316 The Role of Ets2 Transcription Factor in the Induction of
MicroRNA-155 (miR-155) by Lipopolysaccharide and Its
Targeting by Interleukin-10. Susan R. Quinn, Niamh E. Mangan,
Brian E. Caffrey, Michael P. Gantier, Bryan R. G. Williams, Paul
J. Hertzog, Claire E. McCoy, and Luke A. J. ONeill
Also classified as Gene Regulation
LIPIDS
4244
S
The Endoplasmic ReticulumCoat Protein II Transport
Machinery Coordinates Cellular Lipid Secretion and
Cholesterol Biosynthesis. Lee G. D. Fryer, Bethan Jones, Emma
J. Duncan, Claire E. Hutchison, Tozen Ozkan, Paul A. Williams, Olivia
Alder, Max Nieuwdorp, Anna K. Townley, Arjen R. Mensenkamp, David
J. Stephens, Geesje M. Dallinga-Thie, and Carol C. Shoulders
Also classified as Metabolism
4470

LowMolecular Weight Hyaluronan Activates Cytosolic

Phospholipase A
2
and Eicosanoid Production in Monocytes
and Macrophages. Milena Sokolowska, Li-Yuan Chen, Michael
Eberlein, Asuncion Martinez-Anton, Yueqin Liu, Sara Alsaaty, Hai-Yan
Qi, Carolea Logun, Maureen Horton, and James H. Shelhamer
Also classified as Immunology
MEMBRANE BIOLOGY
4233 Lipid Bilayer Modules as Determinants of K

Channel Gating.
Ruhma Syeda, Jose S. Santos, and Mauricio Montal
Also classified as Molecular Biophysics
4405 Molecular Identification and Functional Characterization of the
Human Colonic Thiamine Pyrophosphate Transporter. Svetlana
M. Nabokina, Katsuhisa Inoue, Veedamali S. Subramanian, Judith
E. Valle, Hiroaki Yuasa, and Hamid M. Said
4417
S
A Functional, Genome-wide Evaluation of Liposensitive Yeast
Identifies the ARE2 Required for Viability (ARV1) Gene
Product as a Major Component of Eukaryotic Fatty Acid
Resistance. Kelly V. Ruggles, Jeanne Garbarino, Ying Liu, James
Moon, Kerry Schneider, Annette Henneberry, Jeff Billheimer, John
S. Millar, Dawn Marchadier, Mark A. Valasek, Aidan Joblin-Mills, Sonia
Gulati, AndrewB. Munkacsi, Joyce J. Repa, Dan Rader,
and Stephen L. Sturley
Also classified as Lipids
METABOLISM
4055
S
C1q/TNF-related Protein 4 (CTRP4) Is a Unique Secreted Protein
with Two TandemC1q Domains That Functions in the
Hypothalamus to Modulate Food Intake and Body Weight.
Mardi S. Byerly, Pia S. Petersen, Santosh Ramamurthy, Marcus
M. Seldin, Xia Lei, Elayne Provost, Zhikui Wei, Gabriele V. Ronnett,
and G. WilliamWong
4180 Anthrax Lethal Toxin Inhibits Translation of Hypoxia-inducible
Factor 1 and Causes Decreased Tolerance to Hypoxic Stress.
Weiming Ouyang, Chikako Torigoe, Hui Fang, Tao Xie,
and David M. Frucht
Also classified as Molecular Bases of Disease
4432
S
Structure-guided Development of Specific Pyruvate
Dehydrogenase Kinase Inhibitors Targeting the ATP-binding
Pocket. Shih-Chia Tso, Xiangbing Qi, Wen-Jun Gui, Cheng-Yang Wu,
Jacinta L. Chuang, Ingrid Wernstedt-Asterholm, Lorraine K. Morlock,
Kyle R. Owens, Philipp E. Scherer, Noelle S. Williams, UttamK. Tambar,
R. Max Wynn, and David T. Chuang
Also classified as Protein Structure and Folding
MICROBIOLOGY
4070
S
Repeating Structures of the Major Staphylococcal Autolysin
Are Essential for the Interaction with Human Thrombospondin
1 and Vitronectin. Thomas P. Kohler, Nicolas Gisch, Ulrike Binsker,
Martin Schlag, Katrin Darm, Uwe Vlker, Ulrich Zhringer,
and Sven Hammerschmidt
Also classified as Glycobiology and Extracellular Matrices
4191
S
MazF-induced Growth Inhibition and Persister Generation in
Escherichia coli. Arti Tripathi, Pooja C. Dewan, Shahbaz A. Siddique,
and Raghavan Varadarajan
Also classified as Protein Structure and Folding
FEBRUARY 14, 2014 VOLUME 289 NUMBER 7 JOURNAL OF BIOLOGICAL CHEMISTRY v
MOLECULAR BASES OF DISEASE
3978 Combined Effects of Ankylosing Spondylitis-associated ERAP1
Polymorphisms Outside the Catalytic and Peptide-binding
Sites on the Processing of Natural HLA-B27 Ligands. Adrian
Martn-Esteban, Patricia Gomez-Molina, Alejandro Sanz-Bravo,
and Jose A. Lopez de Castro
Also classified as Immunology
4095 Key Role of MicroRNA in the Regulation of Granulocyte
Macrophage Colony-stimulating Factor Expression in Murine
Alveolar Epithelial Cells during Oxidative Stress. Anne Sturrock,
Mustafa Mir-Kasimov, Jessica Baker, Jesse Rowley, and Robert Paine III
Also classified as Cell Biology
4116 The ZEB1 Transcription Factor Acts in a Negative Feedback
Loop with miR200 Downstreamof Ras and Rb1 to Regulate
Bmi1 Expression. Yongqing Liu, Ester Snchez-Till, Xiaoqin Lu,
Li Huang, Brian Clem, Sucheta Telang, Alfred B. Jenson, Miriam
Cuatrecasas, Jason Chesney, Antonio Postigo, and Douglas C. Dean
Also classified as Cell Biology
4145 Mammalian Target of Rapamycin (mTOR) Inhibition with
Rapamycin Improves Cardiac Function in Type 2 Diabetic Mice.
POTENTIAL ROLE OF ATTENUATEDOXIDATIVE STRESS ANDALTERED
CONTRACTILE PROTEINEXPRESSION. Anindita Das, David Durrant,
Saisudha Koka, Fadi N. Salloum, Lei Xi, and Rakesh C. Kukreja
Also classified as Metabolism
4206 Role of Guanine Nucleotide Exchange Factor-H1 in
Complement-mediated RhoA Activation in Glomerular
Epithelial Cells. Flaviana Mouawad, Lamine Aoudjit, Ruihua Jiang,
Katalin Szaszi, and Tomoko Takano
Also classified as Cell Biology
4346 Signature Amyloid Profiles Are Produced by Different
-Secretase Complexes. Hermien Acx, Luca Chvez-Gutirrez,
Lutgarde Serneels, SamLismont, Manasi Benurwar, Nadav Elad,
and Bart De Strooper
Also classified as Enzymology
4377 The Cyp2c44 Epoxygenase Regulates Epithelial Sodium
Channel Activity and the Blood Pressure Responses to
Increased Dietary Salt. Jorge H. Capdevila, Nataliya Pidkovka,
Shaojun Mei, Yan Gong, John R. Falck, John D. Imig, Raymond
C. Harris, and Wenhui Wang
Also classified as Lipids
4455 Naturally Occurring Variants of the Dysglycemic Peptide
Pancreastatin. DIFFERENTIAL POTENCIES FOR MULTIPLE CELLULAR
FUNCTIONS ANDSTRUCTURE-FUNCTIONCORRELATION. Prasanna
K. R. Allu, Venkat R. Chirasani, Dhiman Ghosh, Anitha Mani, Amal K.
Bera, Samir K. Maji, Sanjib Senapati, Ajit S. Mullasari,
and Nitish R. Mahapatra
Also classified as DNA and Chromosomes
MOLECULAR BIOPHYSICS
4387 Single Molecule Analysis Reveals Coexistence of Stable
Serotonin Transporter Monomers and Oligomers in the Live
Cell Plasma Membrane. Andreas Anderluh, Enrico Klotzsch,
Alexander W. A. F. Reismann, Mario Brameshuber, Oliver Kudlacek,
Amy Hauck Newman, Harald H. Sitte, and Gerhard J. Schutz
Also classified as Neurobiology
4515 The Activity of GAT107, an Allosteric Activator and Positive
Modulator of 7 Nicotinic Acetylcholine Receptors (nAChR), Is
Regulated by Aromatic Amino Acids That Span the Subunit
Interface. Roger L. Papke, Nicole A. Horenstein, Abhijit R. Kulkarni,
Clare Stokes, Lu W. Corrie, Cheol-Young Maeng, and Ganesh A. Thakur
Also classified as Neurobiology
NEUROBIOLOGY
4173 The Nucleotide-binding Leucine-rich Repeat (NLR) Family
Member NLRX1 Mediates Protection against Experimental
Autoimmune Encephalomyelitis and Represses Macrophage/
Microglia-induced Inflammation. Timothy K. Eitas, Wei-Chun
Chou, Haitao Wen, Denis Gris, Gregory R. Robbins, June Brickey,
Yoshitaka Oyama, and Jenny P.-Y. Ting
Also classified as Immunology
4532 Analysis of the Hippocampal Proteome in ME7 Prion Disease
Reveals a Predominant Astrocytic Signature and Highlights the
Brain-restricted Production of Clusterin in Chronic
Neurodegeneration. Ayodeji A. Asuni, Bryony Gray, Joanne Bailey,
Paul Skipp, V. Hugh Perry, and Vincent OConnor
Also classified as Molecular Bases of Disease
PLANT BIOLOGY
3901
S
Ribosomal Protein S6, a Target of Rapamycin, Is Involved in the
Regulation of rRNA Genes by Possible Epigenetic Changes in
Arabidopsis. Yun-Kyoung Kim, Sunghan Kim, Yun-jeong Shin,
Yoon-Sun Hur, Woo-Young Kim, Myung-Sok Lee, Choong-Ill Cheon,
and Desh Pal S. Verma
Also classified as Signal Transduction
PROTEINSTRUCTURE ANDFOLDING
3828
S
Relationship between Ni(II) and Zn(II) Coordination and
Nucleotide Binding by the Helicobacter pylori [NiFe]-
Hydrogenase and Urease Maturation Factor HypB. Andrew
M. Sydor, Hugo Lebrette, Rishikesh Ariyakumaran, Christine Cavazza,
and Deborah B. Zamble
3856
S
PlasmodiumfalciparumMerozoite Surface Protein 3.
OLIGOMERIZATION, SELF-ASSEMBLY, ANDHEME COMPLEX
FORMATION. MaryamImam, Shailja Singh, Naveen Kumar Kaushik,
and Virander Singh Chauhan
Also classified as Cell Biology
4043
S
A Mechanismfor Actin Filament Severing by Malaria Parasite
Actin Depolymerizing Factor 1 via a LowAffinity Binding
Interface. Wilson Wong, AndrewI. Webb, Maya A. Olshina, Giuseppe
Infusini, Yan Hong Tan, Eric Hanssen, Bruno Catimel, Cristian Suarez,
Melanie Condron, Fiona Angrisano, Thomas NebI, David R. Kovar,
and Jake Baum
Also classified as Cell Biology
4334 Structure of Clostridiumdifficile PilJ Exhibits Unprecedented
Divergence fromKnown Type IV Pilins. Kurt H. Piepenbrink, Grace
A. Maldarelli, Claudia F. Martinez de la Pea, George L. Mulvey, Greg
A. Snyder, Leon De Masi, Erik C. von Rosenvinge, Sebastian Gnther,
Glen D. Armstrong, Michael S. Donnenberg, and Eric J. Sundberg
Also classified as Microbiology
4356
S
Transmission of Stability Information through the N-domain of
Tropomyosin Is Interrupted by a Stabilizing Mutation (A109L)
in the Hydrophobic Core of the Stability Control Region
(Residues 97118). J. Paul Kirwan and Robert S. Hodges
Also classified as Molecular Biophysics
4490

Programmed Cell Death Protein 5 Interacts with the Cytosolic

Chaperonin Containing Tailless Complex Polypeptide 1 (CCT)
to Regulate -Tubulin Folding. Christopher M. Tracy, Amy J. Gray,
Jorge Cuellar, Tanner S. Shaw, Alyson C. Howlett, Ryan M. Taylor, John
T. Prince, Natalie G. Ahn, Jose M. Valpuesta, and Barry M. Willardson
Also classified as Signal Transduction
4504 Conformational Itinerary of Pseudomonas aeruginosa 1,6-
Anhydro-N-acetylmuramic Acid Kinase during Its Catalytic
Cycle. John-Paul Bacik, Marjan Tavassoli, Trushar R. Patel, Sean
A. McKenna, David J. Vocadlo, Mazdak Khajehpour, and Brian L. Mark
vi JOURNAL OF BIOLOGICAL CHEMISTRY VOLUME 289 NUMBER 7 FEBRUARY 14, 2014
PROTEINSYNTHESIS ANDDEGRADATION
3888
S
N-terminal Hydrophobic Amino Acids of Activating
Transcription Factor 5 (ATF5) Protein Confer Interleukin 1
(IL-1)-induced Stabilization. Takanori Abe, Masaki Kojima,
Satoshi Akanuma, Hiromi Iwashita, Takashi Yamazaki, Ryuichi
Okuyama, Kenji Ichikawa, Mariko Umemura, Haruo Nakano, Shigeru
Takahashi, and Yuji Takahashi
Also classified as Immunology
3950 Degradation of Activated K-Ras Orthologue via K-Ras-specific
Lysine Residues Is Required for Cytokinesis. Kazutaka Sumita,
Hirofumi Yoshino, Mika Sasaki, Nazanin Majd, Emily Rose Kahoud,
Hidenori Takahashi, Koh Takeuchi, Taruho Kuroda, Susan Lee, Pascale
G. Charest, Kosuke Takeda, John M. Asara, Richard A. Firtel, Dimitrios
Anastasiou, and Atsuo T. Sasaki
Also classified as Cell Biology
4286 Eukaryotic Initiation Factor (eIF) 4F Binding to Barley Yellow
Dwarf Virus (BYDV) 3-Untranslated Region Correlates with
Translation Efficiency. Bidisha Banerjee and Dixie J. Goss
Also classified as Gene Regulation
4444 Role of HERP and a HERP-related Protein in HRD1-dependent
Protein Degradation at the Endoplasmic Reticulum.
Chih-Hsiang Huang, Yue-Ru Chu, Yihong Ye, and Xin Chen
SIGNAL TRANSDUCTION
3876 The C-terminal Domain of the Long Formof Cellular FLICE-
inhibitory Protein (c-FLIP
L
) Inhibits the Interaction of the
Caspase 8 Prodomain with the Receptor-interacting Protein 1
(RIP1) Death Domain and Regulates Caspase 8-dependent
Nuclear Factor B (NF-B) Activation. Iyo Matsuda, Kentaro
Matsuo, Yuka Matsushita, Yasushi Haruna, Masamitsu Niwa,
and Takao Kataoka
3960
S
Spatially Restricted GProtein-coupled Receptor Activity via
Divergent Endocytic Compartments. Frederic Jean-Alphonse,
Shanna Bowersox, Stanford Chen, Gemma Beard, Manojkumar
A. Puthenveedu, and Aylin C. Hanyaloglu
Also classified as Cell Biology
3991 Evolution of Mammalian Opn5 as a Specialized UV-absorbing
Pigment by a Single Amino Acid Mutation. Takahiro Yamashita,
Katsuhiko Ono, Hideyo Ohuchi, Akane Yumoto, Hitoshi Gotoh, Sayuri
Tomonari, Kazumi Sakai, Hirofumi Fujita, Yasushi Imamoto, Sumihare
Noji, Katsuki Nakamura, and Yoshinori Shichida
4219 Small GProteins Rac1andRas Regulate Serine/Threonine Protein
Phosphatase 5(PP5)Extracellular Signal-RegulatedKinase (ERK)
Complexes Involvedinthe FeedbackRegulationof Raf1. Matthew
D. Mazalouskas, Raquel Godoy-Ruiz, DavidJ. Weber, DannaB. Zimmer,
RichardE. Honkanen, andBrianE. Wadzinski
FEBRUARY 14, 2014 VOLUME 289 NUMBER 7 JOURNAL OF BIOLOGICAL CHEMISTRY vii
A
Abbruzzese, James L.,
4009
Abe, Takanori, 3888
Acx, Hermien, 4346
Ahn, NatalieG., 4490
Akanuma, Satoshi, 3888
Alder, Olivia, 4244
Allu, PrasannaK. R., 4455
Alsaaty, Sara, 4470
Anastasiou, Dimitrios, 3950
Anderluh, Andreas, 4387
Angrisano, Fiona, 4043
Antoniou, Antonis, 3923
Aoudjit, Lamine, 4206
Ariyakumaran, Rishikesh,
3828
Armstrong, GlenD., 4334
Asara, JohnM., 3950
Asuni, Ayodeji A., 4532
B
Bacik, John-Paul, 4504
Bailey, Joanne, 4532
Baker, Jessica, 4095
Banerjee, Bidisha, 4286
Banerjee, KalyanK., 4001
Bashtrykov, Pavel, 4106
Basu, Subhasree, 3842
Baum, Jake, 4043
Beard, Gemma, 3960
Benurwar, Manasi, 4346
Bera, Amal K., 4455
Bergler, Helmut, 3913
Bid, Hemant K., 4083
Billheimer, Jeff, 4417
Binsker, Ulrike, 4070
Bois, JustinS., 4395
Bowersox, Shanna, 3960
Brameshuber, Mario, 4387
Brickey, June, 4173
Byerly, Mardi S., 4055
C
Caffrey, BrianE., 4316
Cam, Hakan, 4083
Cam, Maren, 4083
Capdevila, JorgeH., 4377
Carter, Charles W., Jr., 4367
Catimel, Bruno, 4043
Cavazza, Christine, 3828
Chandrasekaran, Srinivas
Niranj, 4367
Chang, Evan, 4326
Charest, PascaleG., 3950
Chauhan, Virander Singh,
3856
Chvez-Gutirrez, Luca,
4346
Chen, De, 4262
Chen, Li-Yuan, 4470
Chen, Stanford, 3960
Chen, Xin, 4444
Chen, Yue, 4009
Cheon, Choong-Ill, 3901
Chesney, Jason, 4116
Chin, Lynda, 3869
Chirasani, Venkat R., 4455
Choi, Won-Il, 4018
Chou, Wei-Chun, 4173
Chu, Yue-Ru, 4444
Chuang, DavidT., 4432
Chuang, JacintaL., 4432
Clem, Brian, 4116
Cole, PhilipA., 4326
Condron, Melanie, 4043
Corrie, LuW., 4515
Cuatrecasas, Miriam, 4116
Cuellar, Jorge, 4490
D
Dallinga-Thie, GeesjeM.,
4244
Dang, AnhThu, 4273
Darm, Katrin, 4070
Das, Anindita, 4145
Dean, Douglas C., 4116
DeArcangelis, Adle, 3842
delaPea, ClaudiaF.
Martinez, 4334
Delarue, Marc, 4367
DeMasi, Leon, 4334
DeStrooper, Bart, 4346
Dewan, PoojaC., 4191
Ding, Huangen, 4307
Donnenberg, Michael S.,
4334
Donz, Olivier, 4273
Dougherty, JonathanD.,
3936
Du, Guangwei, 4262
Duncan, EmmaJ., 4244
Durrant, David, 4145
E
Eberlein, Michael, 4470
Eitas, TimothyK., 4173
Elad, Nadav, 4346
Eresheim, Christine, 4161
F
Falck, JohnR., 4377
Fang, Hui, 4180
Feng, Xinghua, 4262
Firtel, RichardA., 3950
Frucht, DavidM., 4180
Fryer, LeeG. D., 4244
Fujita, Hirofumi, 3991
Futreal, Andrew, 3869
G
Gaide, Olivier, 4273
Ganguly, Sreerupa, 4001
Gantier, Michael P., 4316
Garbarino, Jeanne, 4417
Georges-Labouesse,
Elisabeth, 3842
Ghosh, Amar N., 4001
Ghosh, Dhiman, 4455
Gillooly, AndrewR., 4126
Gisch, Nicolas, 4070
Godoy-Ruiz, Raquel, 4219
Gomez-Molina, Patricia,
3978
Gong, Yan, 4377
Goss, DixieJ., 4286
Gotoh, Hitoshi, 3991
Gray, AmyJ., 4490
Gray, Bryony, 4532
Gris, Denis, 4173
Gui, Wen-Jun, 4432
Gulati, Sonia, 4417
Gungl, Anna, 3913
Gnther, Sebastian, 4334
H
Haigis, MarciaC., 4135
Hammerschmidt, Sven,
4070
Han, Jiju, 4032
Hanssen, Eric, 4043
Hanyaloglu, AylinC., 3960
Harris, RaymondC., 4377
Haruna, Yasushi, 3876
He, Ling, 4326
Headon, Denis J., 4273
Henneberry, Annette,
4417
Hermes, Katharina, 4273
Hertzog, Paul J., 4316
Hodges, Robert S., 4356
Honkanen, RichardE.,
4219
Horenstein, NicoleA., 4515
Horton, Maureen, 4470
Houghton, Peter J., 4083
Howlett, AlysonC., 4490
Huang, Chih-Hsiang, 4444
Huang, Li, 4116
Huang, Yu, 4262
Hur, Man-Wook, 4018
Hur, SujinSusanne, 4018
Hur, Yoon-Sun, 3901
Hutchison, ClaireE., 4244
Hyvrinen, Satu, 4295
I
Ichikawa, Kenji, 3888
Imam, Maryam, 3856
Imamoto, Yasushi, 3991
Imig, JohnD., 4377
Infusini, Giuseppe, 4043
Inoue, Katsuhisa, 4405
Iwashita, Hiromi, 3888
J
Jankevicius, Gytis, 4106
Jean-Alphonse, Frederic,
3960
Jeltsch, Albert, 4106
Jenson, AlfredB., 4116
Jeon, Bu-Nam, 4018
Jeong, SeungMin, 4135
Jiang, Ruihua, 4206
Jiao, Peng, 4032
Jin, Jianping, 4009
Joblin-Mills, Aidan, 4417
Jokela, Reija, 4295
Jokiranta, T. Sakari, 4295
Jones, Bethan, 4244
Jurkowska, RenataZ., 4106
K
Kahlert, Christoph, 3869
Kahoud, EmilyRose, 3950
Kalluri, Raghu, 3869
Kappel, Lisa, 3913
Kataoka, Takao, 3876
Kaushik, NaveenKumar,
3856
Khajehpour, Mazdak, 4504
Kim, Jungho, 4018
Kim, Kyung-Sup, 4018
Kim, Min-Kyeong, 4018
Kim, Myung-Hwa, 4018
Kim, Sunghan, 3901
Kim, Woo-Young, 3901
Kim, Yun-Kyoung, 3901
Kirby, Neil, 4273
Kirwan, J. Paul, 4356
Klein, Isabella, 3913
Klotzsch, Enrico, 4387
Koch, Moritz, 3869
Koehl, Patrice, 4367
Koh, Dong-In, 4018
Kohler, Thomas P., 4070
Kojima, Masaki, 3888
Koka, Saisudha, 4145
Kovar, DavidR., 4043
Kowalczyk-Quintas,
Christine, 4273
Krieger, Elmar, 3913
Kudlacek, Oliver, 4387
Kukreja, RakeshC., 4145
Kulkarni, Abhijit R., 4515
Kuroda, Taruho, 3950
L
Landry, AaronP., 4307
Lebrette, Hugo, 3828
Lee, Annie, 4135
Lee, Jaewon, 4135
Lee, Myung-Sok, 3901
Lee, Susan, 3950
Leeb, Christian, 4161
Lei, Xia, 4055
Li, Lei, 4009
Li, Li, 4367
Li, Mingsong, 4326
Lin, Ping, 4009
Lismont, Sam, 4346
Liu, Guangchao, 4009
Liu, Ying, 4417
Liu, Yongqing, 4116
Liu, Yueqin, 4470
Lloyd, RichardE., 3936
Logsdon, Craig, 4009
Logun, Carolea, 4470
Loibl, Mathias, 3913
Lopez deCastro, Jose A.,
3978
Lu, Xiaoqin, 4116
Lu, Yungang, 4262
M
Maeng, Cheol-Young,
4515
Mahapatra, NitishR., 4455
Majd, Nazanin, 3950
Maji, Samir K., 4455
Maldarelli, GraceA., 4334
Mangan, NiamhE., 4316
Mani, Anitha, 4455
Marchadier, Dawn, 4417
Mark, BrianL., 4504
Martn-Esteban, Adrian,
3978
Martinez-Anton, Asuncion,
4470
Mastroyiannopoulos,
Nikolaos P., 3923
Matsuda, Iyo, 3876
Matsuo, Kentaro, 3876
Matsushita, Yuka, 3876
Mazalouskas, MatthewD.,
4219
Mazumdar, Budhaditya,
4001
McCoy, ClaireE., 4316
McKenna, SeanA., 4504
Mei, Shaojun, 4377
Melo, SoniaA., 3869
Meng, Shumei, 4326
Menko, A. Sue, 3842
Mensenkamp, ArjenR.,
4244
Meyers, DavidJ., 4326
Miao, Cheng, 4032
Millar, JohnS., 4417
Mir-Kasimov, Mustafa,
4095
Montal, Mauricio, 4233
Moon, James, 4417
Morlock, LorraineK., 4432
Mouawad, Flaviana, 4206
Moulton, Vaishali R., 4126
Mukherjee, Amarshi, 4001
Mullasari, Ajit S., 4455
Mulvey, GeorgeL., 4334
Munkacsi, AndrewB., 4417
N
Nabokina, SvetlanaM.,
4405
Nakamura, Katsuki,
3991
Nakano, Haruo, 3888
NebI, Thomas, 4043
Newman, AmyHauck,
4387
Nieuwdorp, Max, 4244
Nimpf, Johannes, 4161
The Journal of Biological Chemistry
AUTHOR INDEX
viii JOURNAL OF BIOLOGICAL CHEMISTRY VOLUME 289 NUMBER 7 FEBRUARY 14, 2014
Niwa, Masamitsu, 3876
Noji, Sumihare, 3991
O
OConnor, Vincent, 4532
Ohuchi, Hideyo, 3991
Okuyama, Ryuichi, 3888
Olshina, MayaA., 4043
ONeill, LukeA. J., 4316
Ono, Katsuhiko, 3991
Ouyang, Weiming, 4180
Owens, KyleR., 4432
Oyama, Yoshitaka, 4173
Ozkan, Tozen, 4244
P
Paine, Robert, III, 4095
Papke, Roger L., 4515
Patel, Trushar R., 4504
Perry, V. Hugh, 4532
Pertschy, Brigitte, 3913
Petersen, PiaS., 4055
Phylactou, Leonidas A.,
3923
Pidkovka, Nataliya, 4377
Piepenbrink, Kurt H., 4334
Postigo, Antonio, 4116
Prattes, Michael, 3913
Prince, JohnT., 4490
Protopopov, Alexei, 3869
Provost, Elayne, 4055
Puthenveedu,
Manojkumar A., 3960
Q
Qi, Hai-Yan, 4470
Qi, Xiangbing, 4432
Qin, Shucun, 4032
Quinlan, Margot E., 4395
Quinn, SusanR., 4316
R
Rader, Dan, 4417
Ragozin, Sergey, 4106
Rajakaruna, Suren, 3842
Ramamurthy, Santosh,
4055
Reineke, Lucas C., 3936
Reismann, Alexander W. A.
F., 4387
Repa, JoyceJ., 4417
Robbins, GregoryR., 4173
Ronnett, GabrieleV.,
4055
Roth-Johnson, Elizabeth
A., 4395
Rowley, Jesse, 4095
Ruggles, KellyV., 4417
S
Said, HamidM., 4405
Sakai, Kazumi, 3991
Salloum, Fadi N., 4145
Snchez-Till, Ester, 4116
Sang, Hui, 4032
Santos, JoseS., 4233
Sanz-Bravo, Alejandro,
3978
Sarrasin, Heidi, 4273
Sasaki, AtsuoT., 3950
Sasaki, Mika, 3950
Scherer, PhilippE., 4432
Schlag, Martin, 4070
Schmidt, Claudia, 3913
Schneider, Holm, 4273
Schneider, Kerry, 4417
Schneider, Pascal, 4273
Schutz, GerhardJ., 4387
Seldin, Marcus M., 4055
Senapati, Sanjib, 4455
Serneels, Lutgarde, 4346
Seth, Sahil, 3869
Shaw, Tanner S., 4490
Shelhamer, James H.,
4470
Shichida, Yoshinori, 3991
Shin, Yun-jeong, 3901
Shoulders, Carol C., 4244
Siddique, Shahbaz A.,
4191
Singh, Shailja, 3856
Sitte, HaraldH., 4387
Skipp, Paul, 4532
Snyder, GregA., 4334
Sokolowska, Milena,
4470
Stephens, DavidJ., 4244
Stokes, Clare, 4515
Sturley, StephenL., 4417
Sturrock, Anne, 4095
Suarez, Cristian, 4043
Subramanian, Veedamali
S., 4405
Sumita, Kazutaka, 3950
Sundberg, EricJ., 4334
Sydor, AndrewM., 3828
Syeda, Ruhma, 4233
Szaszi, Katalin, 4206
T
Takahashi, Hidenori, 3950
Takahashi, Shigeru, 3888
Takahashi, Yuji, 3888
Takano, Tomoko, 4206
Takeda, Kosuke, 3950
Takeuchi, Koh, 3950
Tambar, UttamK., 4432
Tan, Tse-Hua, 4009
Tan, YanHong, 4043
Tang, Jiabin, 3869
Tardivel, Aubry, 4273
Tavassoli, Marjan, 4504
Taylor, RyanM., 4490
Telang, Sucheta, 4116
Thakur, GaneshA., 4515
Tian, Hua, 4032
Ting, JennyP.-Y., 4173
Tomonari, Sayuri, 3991
Torigoe, Chikako, 4180
Townley, AnnaK., 4244
Tracy, Christopher M.,
4490
Tripathi, Arti, 4191
Tso, Shih-Chia, 4432
Tsokos, GeorgeC., 4126
U
Uchida, Koji, 4295
Umemura, Mariko, 3888
Uney, James B., 3923
V
Valasek, MarkA., 4417
Valle, JudithE., 4405
Valpuesta, Jose M., 4490
Varadarajan, Raghavan,
4191
Varjosalo, Markku, 4295
Venkatachalam, Kartik,
4262
Verma, DeshPal S., 3901
Vizcarra, ChristinaL., 4395
Vocadlo, DavidJ., 4504
Vlker, Uwe, 4070
vonRosenvinge, ErikC.,
4334
W
Wadzinski, BrianE., 4219
Wang, Hua, 4009
Wang, Huamin, 4009
Wang, Wenhui, 4377
Webb, AndrewI., 4043
Weber, DavidJ., 4219
Wei, Zhikui, 4055
Weinreb, Violetta, 4367
Weitz, Juergen, 3869
Wen, Haitao, 4173
Wernstedt-Asterholm,
Ingrid, 4432
Willardson, BarryM., 4490
Willen, Laure, 4273
Williams, BryanR. G., 4316
Williams, NoelleS., 4432
Williams, Paul A., 4244
Wondisford, AnneR., 4326
Wong, Ching-On, 4262
Wong, G. William, 4055
Wong, Wilson, 4043
Wu, Cheng-Yang, 4432
Wynn, R. Max, 4432
X
Xi, Lei, 4145
Xia, Jintang, 4262
Xia, Xuefeng, 4262
Xiao, Linlin, 4083
Xie, Tao, 4180
Xiong, Jian, 4262
Xiong, Lishou, 4326
Y
Yamashita, Takahiro, 3991
Yamazaki, Takashi, 3888
Yang, Nana, 4032
Yang, Pu, 4262
Yao, Shutong, 4032
Ye, Yihong, 4444
Yoon, Jae-Hyeon, 4018
Yoshino, Hirofumi, 3950
Yuasa, Hiroaki, 4405
Yumoto, Akane, 3991
Z
Zhringer, Ulrich, 4070
Zambetti, GerardP., 4083
Zamble, DeborahB., 3828
Zhang, Jianhua, 3869
Zhang, Liping, 3842
Zhou, Guisheng, 4009
Zhu, Michael X., 4262
Zimmer, DannaB., 4219
Zisser, Gertrude, 3913
Zong, Chuanlong, 4032
FEBRUARY 14, 2014 VOLUME 289 NUMBER 7 JOURNAL OF BIOLOGICAL CHEMISTRY ix