Cell lines

karyotype receptor

MDA MB 231

Aneuploid female (modal number =64)
Range =52 to 68 (Atcc website)
Range =59 to 66 (Atcc pdf)
Near-triploid range.
Normal chromosomes N8 and N15 were absent.
Epidermal growth factor (EGF),
Transforming growth factor
alpha (TGF alpha)

MCF 7
Modal number =82; range =66 to 87.
The stemline chromosome numbers ranged from
hypertriploidy to hypotetraploidy estrogen receptor
Hs578T
Hypotriploid (modal number =59)
Range 50 to 77
QM staining verified the absence of a Y chromosome. estrogen receptor not expressed
BT549
Modal number = 78; range = 73 to 80.
The cell line is aneuploid human female, with chromosome
counts in the hypertriploid range. The X chromosomes are
all abnormal.
HCC70 polyploid
progesterone receptor, not
expressed
T47D
Hypotriploid (modal chromosome=65) occurring at 50%
and polyploidy at 0.8%. 18 marker chromosomes -7 are
paired and 11 are single-copied
Calcitonin, androgen receptor,
estrogen receptor, progesterone
receptor, ; glucocorticoid
receptor, ; prolactin, ; calcitonin;
androgen receptor all expressed.
MDA MB 435s

modal number = 56; range = 55 to 62
The cell line is aneuploid human female (XX), with most
chromosome counts in the 55 to 60 range. Normal
chromosomes N6, N11, and N22 were absent, while
chromosomes N7, N13, N18 and N21 were single.
chromosome N2 was triple
BT474
Aneuploid human female (XO usually), with most
chromosome counts in the hypertetraploid range. Several
chromosomes (N11, N13, and N22) are absent, and others
are clearly under-represented (N9, N14, and N15).
Chromosome N7 over-represented.
MDAMB157
modal number =52 to 54;
range =52 to 69. Most of the karyotypes had 3 normal X
chromosomes. Normal chromosomes N1, N5, N13, N14,
N15, N16, N19, and N22 were not found.
MDAMB468
Modal number = 64; range = 60 to 67.
The cell line is aneuploid human, presumably female (X,
abnormal X) with most chromosome counts in the
hypotriploid range.; Normal chromosomes X, N2, N3, N7,
N8, N10, and N22 are clearly under-represented
epidermal growth factor (EGF);
transforming growth factor alpha
(TGF alpha)


Cell lines
karyotype receptor
HCC1143 Polyploid
SKBR3
Hypertriploid human cell line with the modal chromosome
number of 84, occurring in 34% of cells. Cells having 80
chromosomes also occurred at a high rate (28%); the higher
ploidy cells occurred at 7.3%. This cell line has a very
complex chromosome composition. Thirty-five to 40% of
chromosomes in a cell complement with a modal
chromosome number of 84 consisted of structurally altered
marker chromosomes. Most cells had about three normal
X chromosomes and five or more N7. The structurally
normal N1, N14 and N17 were generally absent.