A 67-year-old man presents with shortness of breath, chest pain, weight loss and night sweats. He worked in shipbuilding with asbestos exposure. Examination finds dullness and reduced breath sounds in the right lower lung. Malignant mesothelioma is the most likely diagnosis given his occupational exposure history and symptoms.
A 67-year-old man presents with shortness of breath, chest pain, weight loss and night sweats. He worked in shipbuilding with asbestos exposure. Examination finds dullness and reduced breath sounds in the right lower lung. Malignant mesothelioma is the most likely diagnosis given his occupational exposure history and symptoms.
A 67-year-old man presents with shortness of breath, chest pain, weight loss and night sweats. He worked in shipbuilding with asbestos exposure. Examination finds dullness and reduced breath sounds in the right lower lung. Malignant mesothelioma is the most likely diagnosis given his occupational exposure history and symptoms.
A 67-year-old retired man has been complaining of a 6-month history of increasing
shortness of breath, dull right-sided chest pain, loss of appetite and night sweats. He worked all his life in the ship-building industry where he was eposed to asbestos. He has ne!er smoked in his life. "n eamination he is slightly cyanosed but there is no clubbing. #amination of the lungs re!ealed dullness to percussion and reduced air entry at the right base. $hat is the most likely diagnosis% A &"'( ) )ronchial carcinoma & Recurrent pulmonary embolism ( *alignant mesothelioma # +uberculosis *alignant mesothelioma arising from the pleura was first recognised in the ,-./s, and during the ,-6/s much e!idence accumulated indicating a strong link between the condition and eposure to asbestos. +he risk is a function of the concentration of fibres and duration of eposure. #posure is greatest in those in!ol!ed in mining or 0uarrying the material, and in those who handle the raw fibres. *any workers engaged in the ship-building industry during the ,-1/s and ,-./s were eposed to asbestos, and more recently it has been in widespread use in the building industry. 2t is rare for mesotheliomas to de!elop within 3/ years of eposure and most patients were initially eposed 4/ or more years before clinical presentation. 2n the 5nited 6ingdom, although the risk was first recognised in the ,-6/s, it was not until the mid- ,-7/s that there was a significant reduction in eposure to asbestos. +he age of presentation is usually between ./ and 7/, although the incidence is increasing in older patients. +here is a male predominance, reflecting the greater likelihood of pre!ious occupational eposure, which should be sought with a careful lifetime occupational history. Symptoms due to local disease are mainly those of pain and breathlessness. 'ain may be pleuritic in nature, but is often a dull ache due to direct in!ol!ement of the chest wall. Shortness of breath is usually associated with a pleural effusion, although as the tumour progresses it gradually encases the lung. Systemic symptoms include tiredness, anoreia, weight loss and fe!er, and occasionally drenching sweats. 7inger-clubbing has been recorded but is rare. 'hysical findings in the chest are those of a pleural effusion, but with ad!anced disease there is progressi!e reduction in chest wall mo!ement. (irect etension through the chest wall can result in a palpable mass, and this may de!elop at the site of pre!ious biopsy. A 31-year-old medical student 8height ,6. cm, weight 79 kg: has been complaining of a few days; history of shortness of breath on eertion and of coughing up blood once. She is a few days away from her final eamination and smokes 3/ cigarettes per day. She takes no medication ecept for the oral contracepti!e pill. $hat is the most likely diagnosis% A Hyper!entilation syndrome due to stress ) +uberculosis & Recurrent pulmonary embolism ( Sarcoidosis # <oodpasture;s syndrome 'ulmonary embolism can present in di!erse ways. +he syndrome of pleuritic pain or haemoptysis, in the absence of circulatory collapse, is the most fre0uent mode of presentation of acute pulmonary embolism. 2t occurred in 6/= of patients recruited in a collaborati!e in!estigation, the 'rospecti!e 2n!estigation of 'ulmonary #mbolism (iagnosis 8'2"'#(:. A syndrome of dyspnoea in the absence of haemoptysis or pleuritic pain or circulatory collapse occurred in 3.=. &irculatory collapse 8systolic blood pressure less than 9/ mmHg or loss of consciousness: was an uncommon mode of presentation, occurring in ,.=. "besity and a high oestrogen content in oral contracepti!es ha!e been linked to thromboembolic e!ents. *ost patients with pulmonary embolism had smoked at one time or continued to smoke at the time of their pulmonary embolism. $hich of the following inter!entions is most likely to impro!e the 7#> , and prognosis of a cigarette smoker with spirometric e!idence of moderate &"'(% A +obacco-smoking cessation ) 7re0uent use of antibiotics for acute bacterial eacerbations of chronic bronchitis & (aily use of salmeterol to impro!e 7#> , ( ?ong-term oygen therapy at 3 l@min # (aily use of ipratropium bromide to impro!e 7#> , +here is no treatment that has been shown to significantly slow or alter the progression of &"'( ecept smoking cessation. +he single best thing patients with &"'( can do for themsel!es is to stop smoking. All other treatments are largely for symptom relief.&hronic obstructi!e pulmonary disease is a common chronic respiratory illness. 2t is steadily progressi!e and carries a large burden of mortality and morbidity. 2t causes about 4/,.// deaths per year in the 56. +he morbidity burden this raises for the AHS is huge. "f all emergency medical admissions, 3.= are due to acute respiratory infections and &"'( eacerbations comprise o!er half this total. +he cost in hospital care for these patients is about B.// million. Housing changes and alterations add to the social costs of this disease. &"'( is caused by tobacco smoking, hea!y eposure to occupational dusts and chemicals, air pollution, cannabis smoking 8which is now being recognised: and a , -antitrypsin deficiency. A ./-year-old smoker was diagnosed with a non-small-cell carcinoma. 2n!estigation re!ealed the presence of a 1 cm C 4 cm C 3 cm tumour on the left side in the lower lobe of his lung that has in!aded the !isceral pleura. +he ipsilateral hilar lymph node is also in!ol!ed, but there is no metastatic in!ol!ement of any distal organ. $hat is the stage of disease in this patient% A + 1 A / * / ) + 3 A / * / & + 3 A , * / ( + 4 A , * / # + 1 A , * / 2t is important to remember the criteria for staging carcinoma of the lung. As the tumour is more than 4 cm in the greatest dimension and has only in!aded the !isceral pleura, it is designated + 3 . *etastasis to the ipsilateral peribronchial and@or ipsilateral hilar lymph nodes makes the nodal stage A , . Absence of distal metastasis is called * / . 2t would be useful to go through the staging in detail for other possible combinations. A 44-year-old man is found to ha!e strongly positi!e aspergillus precipitins in his blood. $hat is the most likely diagnosis% A Allergic bronchopulmonary aspergillosis 8A)'A: ) &olonising aspergillosis & 2n!asi!e aspergillosis ( Asperger;s syndrome # +ype 2 hypersensiti!ity to Aspergillus fumigatus Aspergillus precipitins are 2g< antibodies typically found in colonising aspergillosis 8aspergilloma:, which occurs in areas of damaged lungs, eg ca!ities. +ype 2 hypersensiti!ity to Aspergillus fumigatus occurs in A)'A. 2n!asi!e aspergillosis occurs in immunocompromised patients. Asperger;s syndrome has nothing to do with aspergillus infection. A 4/-year-old woman who is a non-smoker comes to clinic with a 3-year history of a dry cough. *ore recently she has had episodes of flushing. #amination is normal, but her chest radiograph shows a smooth lesion at the origin of her right lower lobe bronchus. &+ scan confirms this and is otherwise normal. Dou perform the bronchoscopy and see a smooth red tumour. $hat would you do net% A )iopsy the tumour ) (iscuss her with the thoracic surgeons with a !iew to biopsy & (iscuss her with the thoracic surgeons with a !iew to tumour resection ( (iscuss her with the oncologists with a !iew to chemotherapy # Repeat the chest E-ray in 4 months +his woman has a pulmonary carcinoid tumour, which is an uncommon neuroendocrine primary lung tumour, accounting for ,F3= of all lung tumours. +hey are slow growing and benign, although there are more aggressi!e subtypes which can metastasise. &arcinoid syndrome occurs without metastases. &arcinoids are typically located endobronchially, so can cause wheeGe and cough. +hey can bleed profusely on biopsy, so this is not ad!ised. A person with an isolated pulmonary carcinoid should be referred for tumour resection, and histology may not be necessary prior to surgery if the clinical picture is typical. &hemotherapy can be used for metastatic carcinoids. Radiotherapy is not used. A 33-year-old man presented with shortness of breath, an increase in sputum production and a temperature of 47.- H&. He suffers from recurrent chest infections three or four times a year. +his young man regularly produces copious amounts of sputum, more so in the morning. A slow, progressi!e clumsiness and instability set in during early childhood and he has been wheelchair-bound since the age of ,3 years. He grew up in foster care but found out that his uncle died young, wheelchair-bound. +here are coarse crackles bilaterally and a chest E-ray shows signs of bronchiectasis. $hat is the cause of this% A &ystic fibrosis ) Hypogammaglobulinaemia in ataia telangiectasia & Hereditary spinocerebellar degeneration ( $illiamsF&bell syndrome # *ounierF6uhn syndrome 'atients are typically progressi!ely ataic from an early age, with oculomotor apraia and chorioathetosis de!eloping later. 2t is inherited as an autosomal-recessi!e. +he clinical diagnosis is based on identification of the symptoms and multiple telangiectasia seen particularly in the conIuncti!a. a-7etoprotein le!els may be raised. &ell defects and humoral immunity with 2gA and 2g# deficiencies and defecti!e (AA repair results in recurrent infections and tumour susceptibility. (eath in the late teens or twenties from bronchiectasis is typical.2n the $illiamsF&bell syndrome there is a deficiency of the bronchial cartilage. +he *ounierF6uhn syndrome or tracheobronchomegaly is the Jadult e0ui!alent; of the congenital deficiency of bronchial cartilage. $hich of the following reflects the !alue of lung function tests% A 'eak epiratory flow rate is not dependent on age ) 2n a restricti!e disease, the flow-!olume loop is different in shape to normal & *#7 3.F7. 8l@min: is a poor measure of airway obstruction ( Are not needed as a routine in the management of asthma # +hey cannot differentiate between different causes of wheeGe +he most accurate correlation of the '#7R is with height. 2n a restricti!e pattern, the fF! loop is reduced in siGe but looks similar in shape to normal. *id-epiratory flow 8*#7: rate 8between 3.= and 7.= of the epired !ital capacity: is a good measure of airway obstruction. '#7R readings are an obIecti!e measure of airway obstructionK therefore it is ad!isable for any child to perform regular '#7Rs to assess lung function, pro!iding they can do it properly. A reduced forced epiratory flow of 3.F7. units 8l@min: is an indicator of which of the following% A Asthma ) )ronchial carcinoma & 6yphoscoliosis ( )ronchiectasis # $hooping cough +his is an indicator of small-airways disease. A 1,-year-old woman presents to the Accident L #mergency department with a sudden onset of pleuritic chest pain and breathlessness. A chest radiograph re!eals a large right-sided pneumothora. 'leural aspiration fails to result in ade0uate re- epansion of the lung and you therefore insert an intercostal tube connected to an underwater seal. After 31 hours of intercostal drainage the lung has not re-epanded despite the drain still swinging with respiration. $hat would you do net% A $ait another 31 hours ) Aegati!e suction should be started at F, to F3 cmH 3 " & High-!olume@low-pressure suction should be used ( Refer for immediate surgical inter!ention # Reposition chest drain 2f, at 19 hours, a pneumothora fails to re-epand or there is a persistent air leak 8bubbling present: then you should refer the patient to a respiratory specialist as negati!e suction may be re0uired. Aormal intrapleural pressure is F4.1 cmH 3 " during epiration, rising to F9 cmH 3 " during inspiration. +his should be started at F,/ to F3/ cmH 3 " 8F, to F3 k'a M F7.. to F,. mmHg: using a high-!olume@low-pressure suction system. 2f high-!olume@high-pressure suction is used then high-airflow suction may be generated, which can lead to air stealing, hypoaemia and@or the persistence of air leaks. 2f appropriate suction fails to result in ade0uate re-epansion by .F7 days in those without pre-eisting lung disease 8earlier if lung disease: then referral to a thoracic surgeon is indicated. $hich of the following is the best predictor for obstructi!e sleep apnoea% A Aeck siGe ) &hest siGe & Abdominal girth ( $aist to hip ratio # 5!ulopalatal distance Aeck siGe is the best predictor of "SA, with N 14 cm 8N,7 inches: being associated with an increased risk. +he mass loading from the obese or muscular neck o!erwhelms the residual dilator muscle action of the pharyn when the patient is asleep, causing airway obstruction and subse0uent apnoea. 'atients may also ha!e a small or set back mandible, which predisposes them to "SA as well. +ypically, patients also ha!e upper body obesity, which is the typical male fat pattern. A 6--year-old woman with rheumatoid arthritis is referred with a history of recurrent chest infections, intermittent wheeGe and production of half an eggcup-full of phlegm daily, on occasions with a streak of blood. She is a retired secretary and has ne!er smoked. "n eamination she had coarse crepitations on both the bases. $hat is the most likely diagnosis% A &hronic bronchitis ) (iffuse interstitial lung fibrosis & &arcinoma of the lung ( +uberculosis # )ronchiectasis )ronchiectasis is associated with rheumatoid arthritis, occurring in 4F1= of patients with this condition. As with all other causes of bronchiectasis, it presents with recurrent chest infections and ecessi!e phlegm. Recurrent haemoptysis is a common feature. &hronic obstructi!e pulmonary disease 8&"'(: and lung cancer are unlikely in a non-smoker. +uberculosis should be ecluded as it can cause bronchiectasis and haemoptysis. Although interstitial fibrosis occurs in up to 3/= of patients with rheumatoid arthritis, it is not associated with sputum production or haemoptysis 8unless there is an associated cancer:. +his woman should undergo pulmonary function tests to assess the presence of airway obstruction, which is associated with bronchiectasis. A high-resolution computed tomography 8HR&+: scan of the lungs is the in!estigation of choice to confirm the presence of bronchiectasis. A 69-year-old man with bronchiectasis is found to ha!e acid-fast bacilli in his sputum. +he microbiology report suggests this may be an opportunistic or atypical mycobacterium. $hich of the following is the least likely infectious agent% A Mycobacterium kansasii ) Mycobacterium malmoense & Mycobacterium xenopi ( Mycobacterium leprae # Mycobacterium avium intracellulare Mycobacterium leprae is the causati!e organism of leprosy, whereas the rest are all Jopportunistic; mycobacteria, ie they may colonise structurally abnormal lung such as seen in patients with ca!itary disease, bronchiectasis or &"'(. Such patients may not always re0uire treatment. Howe!er, if treatment is re0uired, then it is usually for longer than the standard 6 months needed to treat pulmonary +) F but 8for the *R&' eam: you do not need to worry about comple treatment regimens. $hich pulmonary function test is the same in both restricti!e lung disease and obstructi!e lung disease% A Residual !olume ) +idal !olume & +otal lung capacity ( 7orced epiratory !olume in , second@forced !ital capacity 87#> , @7>&: ratio # 7orced epiratory !olume in , second 87#> , : +idal !olume M the amount of gas inspired or epired with each breath.Residual !olume M the !olume of air remaining in the lung after a maimal epiration 8cannot be measured with spirometry:.+otal lung capacity M the !olume of air remaining in the lung after a maimal inspiration.+otal lung capacity 8and more so, the residual !olume: is increased in obstructi!e lung disease due to air trapping. +he 7#> , @7>& ratio is O 7/= in obstructi!e lung disease and N 7/= in restricti!e lung disease. A .6-year-old retired man who smoked was diagnosed with smear-positi!e mycobacterium tuberculosis. He used to work as a stonemason. 2f there is an increased occupational risk of getting the infection, what is the cause% A 'neumoconiosis ) Asbestosis & Silicosis ( ?ead poisoning # )erylliosis Stonemasons, fettlers and slate-miners@-workers are at risk of de!eloping silicosis. Silica acts as a toin to macrophages, and so impairing their function. +his results in an increased risk of contracting a mycobacterium tuberculosis infection. A 6/-year-old patient was referred with a ,-year history of persistent cough producti!e of mucopurulent sputum throughout the year. He has been treated by his <' for recurrent chest infections. $hat is the most likely diagnosis% A 7ibrosing al!eolitis ) &arcinoma of the lung & Sarcoidosis Dour answer ( )ronchiectasis &orrect answer # Allergic asthma )ronchiectasis should be suspected when there is a history of persistent cough producti!e of mucopurulent or purulent sputum throughout the year. 'atients ha!e fre0uently been treated for recurrent chest infections and labelled as Jbronchitic;, often despite the absence of a history of smoking. 'atients may produce mucoid sputum early in their disease, de!eloping purulent sputum when they suffer an eacerbation associated with a !iral upper respiratory tract infection. Such eacerbations may be associated with pleuritic chest pain, haemoptysis, fe!er and sometimes wheeGe. +hose presenting as adults often recall a Jchesty cough; or JwheeGy bronchitis; associated with upper respiratory tract infections in childhood, followed by complete resolution of symptoms in their teens and early adult life before the symptoms return after a !iral trigger. 5pper respiratory tract symptoms such as postnasal drip are common, and in about 4/= of cases there is a history of chronic sinusitis. 'atients with bronchiectasis also suffer from undue tiredness, which many find more troublesome than the producti!e cough. An anious, 3.-year-old saleswoman presented with mild shortness of breath on eertion, which had come on gradually o!er se!eral months. +he symptom was intermittent and seemed to get worse in the e!ening. She has also been on treatment for depression o!er the last 3 months. "n eamination she looked depressed and there was no positi!e physical finding in any of the systemic eaminations. Dou now ha!e the results of the in!estigationsP bloods, normalK chest E-ray and lung function tests, normalK #&<, normal. $hat is the likely diagnosis% A Angina ) #atonF?ambert syndrome Dour answer & *yasthenia gra!is &orrect answer ( Somatisation disorder # +2A +his is a case of myasthenia gra!is. *uscle weakness may not be apparent on a single eamination, so the eamination should be repeated. *ost affected is the ocular and shoulder-girdle muscle. Respiratory and proimal lower limb muscles may be in!ol!ed early in the disease. )reathlessness may de!elop early and cause sudden death. Swallowing problems, slurred speech and difficulty in chewing may be caused by bulbar in!ol!ement. Asymmetrical in!ol!ement of the eternal ocular muscle may mimic cranial ner!e palsy. 'upillary refle is normal. *ild ptosis and weak facial muscles make patients appear depressed. +halamic enlargement may be seen in Iust ,.= of patients. *yasthenia gra!is is autoimmune in origin. A 16-year-old meat-factory worker is found to ha!e Q fe!er pneumonia. $hich of the following statements is correct% A He re0uires high-dose penicillin for his treatment Dour answer ) His occupation is not important for the diagnosis & +here is no long-term se0uel of the disease ( +he organism responsible is Coxiella pneumoniae # +he organism is usually inhaled from infected dust &orrect answer Q fe!er is due to Coxiella burnetii and is ac0uired through contact with animals. +he organism is !ery resistant to drying and is inhaled from infected dust. 2t is not notifiable, but can occur in outbreaks in farming communities and in abattoirs. A chest E-ray may show multi-lobar consolidation. +reatment is with prolonged courses of tetracyclines. Rarely, infection can be persistent leading to chronic symptoms including fatigue, malaise and sweats. 2n cases of chronic disease, culture-negati!e endocarditis should be suspected. ?engthy antibiotic courses can be curati!e. A 16-year-old cardiologist attended a local conference last weekend and fell ill with a fe!er of up to 1/ H& that lasted for 3 days. He had associated shortness of breath and dry cough. 2n addition, he had loose motions for a day. His blood results showed deranged ?7+s and hyponatraemia. His $)& count was ,/.3 C ,/ - @l. )ibasal consolidation was seen on his E-ray. $hat would be the most effecti!e treatment for his condition% A Amoicillin ) &efuroime & &larithromycin ( 7lucloacillin # &iprofloacin +his is a case of legionella pneumonia and the preferred treatment is with the macrolide, clarithromycin. &iprofloacin can also be effecti!e and rifampicin can be used. ?egionella outbreaks are seen in pre!iously fit indi!iduals staying in hotels or institutions where the shower facilities and@or the cooling system are contaminated with the organism. +he incubation period is 3F,/ days. 7lu-like symptoms, fe!er, malaise and myalgia typically precede a dry cough and dyspnoea. #trapulmonary symptoms include anoreia, diarrhoea and !omiting, hepatitis, renal failure, confusion and coma. A chest E-ray shows bibasal consolidation, sometimes with a small pleural effusion. )lood results show lymphopenia without significant lymphocytosis, hyponatraemia and deranged ?7+s. 5rinalysis may show haematuria. (iagnosis is by the urinary antigen test, which is highly specific. 2t is important to remember that the organism does not show up on <ram-staining. Dou are fast-bleeped to see a ./-year-old woman on the medical ward. She was admitted earlier that day with a swollen lower leg following her return from a holiday in Australia. Her d-dimers were raised and she was started on subcutaneous unfractionated heparin. She is now short of breath, pale, clammy, bradycardic and hypotensi!e. Her #&< shows sinus tachycardia. +he house officer has gi!en her i! fluids, but her blood pressure is continuing to fall. $hat would you consider doing net% A 2ntra!enous heparin ) 7urther i! fluids & +hrombolysis ( #chocardiogram # >@Q scan +his is a woman who has a high clinical probability of ha!ing had a massi!e pulmonary embolus 8'#:. She has respiratory and cardio!ascular compromise from this '# and is likely to die without treatment. 2n!estigation with either echocardiogram showing pulmonary hypertension or &+ showing a clot8s:, would be reasonable to confirm the diagnosis, but this woman is rapidly deteriorating. She is not well enough for a >@Q scan. She has had i! fluids and unfractionated heparin already, with no effect. +hrombolysis can be used for acute pulmonary emboli causing circulatory collapse and there is emerging e!idence to support this treatment. +he risk@benefit analysis must be considered, but in a patient who is at imminent risk of arrest@death, gi!e alteplase ,// mg o!er ,.. hours peripherally. 8see )+S guidelines for the management of suspected acute pulmonary embolism. Thorax 3//4,.986:,17/:. A 67-year-old patient with lung cancer complains of difficulty breathing, coughing and swelling of his face, neck, upper body and arms. Superior !ena ca!a syndrome is diagnosed. $hich of the following treatments is most likely to be successful% A &orticosteroids ) Radiotherapy & Surgery ( &hemotherapy # Antihypertensi!e drugs Superior !ena ca!a syndrome 8S>&S: is a collection of symptoms caused by the partial blockage of the !ein that carries blood from the head, neck, chest and arms to the heart. Symptoms that may indicate this syndrome include difficulty breathing, coughing and swelling of the face, neck, upper body and arms. 2n rare instances, patients may complain of hoarseness, chest pain, difficulty swallowing and coughing up blood. 'hysical signs of S>&S include swelling of the neck or chest !eins, collection of fluid in the face or arms and rapid breathing. +he syndrome of superior !ena ca!a obstruction is relie!ed in about 9/= of sufferers, but usually re0uires a more con!entional course of .F,/ fractions of radiotherapy. 'ain from bone secondaries can be relie!ed in more than ./= of sufferers by a single fraction of 9 <y, often gi!en at the same time as a clinic !isit. )rain metastases generally respond poorly to radiotherapy. A 19-hour trial of deamethasone, 1 mg orally four times daily, is recommended as initial management. A 46-year-old woman with systemic sclerosis de!elops breathlessness on eertion. Her pulmonary function tests show normal spirometry but a decreased gas transfer factor 8+?&", transfer factor for carbon monoide: and transfer coefficient 86&":. $hich of the following is the most likely eplanation for this abnormality% A 7ibrosing al!eolitis ) 'ulmonary !ascular disease & Se!ere thoracic skin thickening ( 'leural in!ol!ement # Respiratory muscle weakness 2solated decreases in gas transfer are typical of pulmonary !ascular disease, eg !asculitis, recurrent pulmonary embolism 8'#:. 2n fibrosing al!eolitis you would also epect to see decreased lung !olumes with a restricti!e ratio 8N 9/=: on spirometry. +he other three answers would all gi!e a picture of Jetrapulmonary restriction; with a restricti!e ratio, low +?&" but normal@high 6&" 8same cardiac output going through smaller al!eolar !olume:. A 36-year female i! drug user presents with a producti!e cough and fe!er of 3F4 days; duration She had flu last week. "ther than a leucocytosis and high &R', her blood results are normal. A chest E-ray shows bilateral ca!itating pneumonia. $hat is the most probable cause of her pneumonia% A 'neumococcal pneumonia ) Staphylococcal pneumonia & Pneumocystis carinii pneumonia ( 6lebsiella pneumonia # 7ungal pneumonia 2n general, staphylococcal pneumonia follows a !iral infection F usually with flu-like symptoms. +his type of pneumonia is fre0uently seen in i! drug abusers and patients with central line. 2t is also common in those patients with an underlying disease, eg leukaemia, lymphoma or cystic fibrosis. E-rays show bilateral ca!itating bronchopneumonia. 'neumothora, effusion and empyema are fre0uent. 2ntra!enous antibiotics should be administered properly. +he drug of choice is flucloacillin. Klebsiella spp. also cause ca!itating pneumonia, particularly of the upper lobes, and most commonly in the elderly. A 4/-year-old asylum seeker has been complaining of cough, fe!er and weight loss. +he chest E-ray shows a large, upper lobe lesion, the sputum shows acid-fast bacilli that are confirmed as Mycobacterium tuberculosis by polymerase chain reaction 8'&R:. (rug therapy with isoniaGid, rifampicin, ethambutol and pyraGinamide has been started under directly obser!ed therapy 8("+:. (uring the net 1 weeks the disease is still progressing. $hat is the most likely reason% A 2nfection with multi-resistant tuberculosis ) 2nfection with atypical mycobacteriae & 5nderlying bacterial pneumonia ( &arcinoma of the lung # Aspiration pneumonia *ultidrug-resistant tuberculosis is defined as resistance to rifampicin and isoniaGid with or without resistance to other anti-+) drugs. +he treatment of patients with drug- resistant tuberculosis should only be carried out by specialist physicians with appropriate eperience in the management of such cases. 2nitial drug resistance is uncommon 8O 3=: in pre!iously untreated $hite patients born in the 56. Higher le!els of resistance occur in ethnic minority groups, particularly those of the 2ndian subcontinent and )lack-African ethnic origin, with isoniaGid resistance occurring in 1F6= of such patients. H2>-positi!ity, independent of ethnic group, is also a marker for increased drug resistanceP a positi!e H2> result increases at least fourfold the chances of single- or multiple-drug resistance compared with an H2>-negati!e indi!idual.+reatment is comple, time-consuming and demanding for both the patient and the physician. Such treatment should only be carried out by physicians with substantial eperience in managing comple resistant cases, and only in hospitals with appropriate isolation facilities. +his may re0uire transfer of the patient to an appropriate unit. +reatment of such patients has to be planned on an indi!idual basis and needs to include reser!e drugs. Such treatment must be closely monitored because of increased toicity, but, more importantly, full compliance is essential to pre!ent the emergence of further drug resistance. +herefore all such treatment must be directly obser!ed throughout, both on an in-patient and an out-patient basis. +reatment should start with fi!e or more drugs to which the organism is, or is likely to be, susceptible and continue until sputum cultures become negati!e. (rug treatment then has to be continued with at least three drugs to which the organism is susceptible on in !itro testing for a minimum of a further - months and perhaps up to or beyond 31 months, depending on the in !itro drug-resistance profile, the a!ailable drugs and the patient;s H2> status. &onsideration may also ha!e to be gi!en to resection of pulmonary lesions under drug co!er. A 6/-year-old man who has a 4/-pack year smoking history comes to clinic with worsening shortness of breath o!er the last 6 months. He works as a baker and keeps racing pigeons. "n eamination, he is clubbed, has saturations of -,= on air and has widespread fine inspiratory crepitations. His chest radiograph shows reticulonodular shadowing and his &+ scan confirms reticulation, mainly subpleural and some honeycombing. $hat is the diagnosis% A 'ulmonary sarcoidosis ) 5sual interstitial pneumonitis & Hypersensiti!ity pneumonitis ( "ccupational asthma # ?angerhans; cell histiocytosis (yspnoea, clubbing and inspiratory crepitations are the classic features of usual interstitial pneumonitis. &hest E-ray will show reticulation, which is classically subpleural in distribution on &+. 'ulmonary sarcoidosis does not gi!e clubbing and crepitations would be associated with end-stage fibrotic disease. +he &+ appearances would be those of nodularity, including fissural nodularity. +he &+ in hypersensiti!ity pneumonitis showsP ground-glass shadowing, with reticular and nodular patternsK in occupational asthma, possibly non-specific features of air trappingK and in ?angerhans;cell histiocytosis it shows nodules and cystic lesions. A 1--year-old woman has been admitted with haemoptysis and epistais, the chest E- ray shows multiple rounded lesions with al!eolar shadowing. Serum is c-AA&A positi!e. $hat is the most likely diagnosis% A +uberculosis ) &arcinoma of the lung & #chinococcosis ( $egener;s granulomatosis # Systemic lupus erythematosus Almost all the patients so diagnosed ha!e e!idence of granulomatous lung disease at presentation, which is often accompanied by al!eolar capillaritis. +he bronchi can also be affected and bronchial stenoses occur as late manifestations. Symptoms include cough, dyspnoea, haemoptysis and chest pain, which can be pleuritic. Signs on chest eamination depend on the nature of the pulmonary lesions and include fine crepitations and bronchial breathing or, less commonly, pleural rubs and signs of pleural effusions. 'ulmonary granulomas are usually diagnosed from chest E-ray and &+ scans. +hey may appear as single or multiple rounded lesions, which can ca!itate. )ronchoscopy often re!eals granulomatous inflammation and the diagnosis can sometimes be made from bronchial biopsies. A 6.-year-old man who has a 1/-pack year history of smoking is referred to the clinic with haemoptysis. He has no other symptoms. His chest radiograph shows an ill- defined 3-cm opacity at the periphery of his left lower lobe. After checking his routine blood tests and spirometry in clinic, which test would you arrange net% A )ronchoscopy ) &+ scan of the chest & '#+ scan ( Repeat chest radiograph in , month from now # Sputum cytology ?ung cancer is the most likely diagnosis in this man. A &+ scan is the best test to perform initially to locate, characterise and stage the lesion if it is cancer. Histological confirmation would then be sought, with either a bronchoscopy if the lesion is proimal or a &+ or ultrasound-guided biopsy if it is peripheral. A positron-emission tomography 8'#+: scan would determine whether there are distant metastases and is performed after the &+. Sputum cytology can be used to pro!ide a histological diagnosis, but a tissue biopsy is fa!oured by the pathologists. 'neumonia can cause haemoptysis and chest radiograph abnormalities, but it can also be associated with a proimal carcinoma. Dou should ha!e a low threshold for performing a &+ scan initially in a high-risk patient. Dou are called to see a ./-year-old woman who is ha!ing difficulty breathing following a laparoscopic cholecystectomy. She is making a lot of noisy inspiratory effort. Dou notice she is taking warfarin long term for thromboembolic disease, salbutamol and inhaled steroids for asthma and penicillamine for rheumatoid arthritis. $hich test might be the most helpful in diagnosing her current problem% A 'eak flow ) Spirometry with transfer factor measurement & Spirometry with flow !olume loops ( &hest E-ray # &+ chest +his woman has stridor due to cricoarytenoid arthritis. +his is seen in studies in up to 7.= of patients with rheumatoid arthritis. 2t can cause sore throat, hoarse !oice and stridor, but is often asymptomatic. Howe!er, symptoms may be worse in the postoperati!e period. 2t is unrelated to any lung fibrosis. 7low !olume loop can be abnormal, as can direct laryngoscopy and HR&+ 8high-resolution &+ scan: of the laryn. 2t may need urgent tracheostomy and steroids, both oral and Ioint inIection. A 4.-year-old woman who was pre!iously fit and well presents with breathlessness that has been getting worse o!er 4 or 1 months. Her sister died a few years ago with a lung disease. "n eamination, her Iugular !enous pressure is raised and she has a palpable hea!e at the left sternal edge. $hat would be your pro!isional diagnosis% A 7amilial primary pulmonary hypertension ) +ricuspid regurgitation & &hronic pulmonary thromboembolism ( &onstricti!e pericarditis # 'ulmonary !enous hypertension 'rimary pulmonary hypertension presents with breathlessness, fatigue, angina 8due to right !entricular ischaemia: or presyncope@syncope. About 6= of all patients with primary pulmonary hypertension ha!e a family history of the condition, which ehibits an autosomal-dominant pattern of inheritance with incomplete penetrance. 'hysical signs include ele!ated R>', left parasternal hea!e, pansystolic murmur 8tricuspid regurgitation: and right !entricular S1, peripheral oedema. An important differential diagnosis of primary pulmonary hypertension is chronic pulmonary thromboembolism. A 4/-year-old man from the Russia is seen in the emergency department. He was diagnosed with pulmonary tuberculosis 1 months ago in Russia and is taking rifampicin and isoniaGid. He comes because of a producti!e cough, fe!ers, weight loss and malaise. $hat would you like to do net% A Send a sputum sample and arrange to see him in out-patients ) Admit him to hospital, send a sputum sample and start him on amoicillin & Admit him to hospital, send a sputum sample and start him on pyraGinamide ( Admit him to hospital, send a sputum sample and start him on amoicillin and pyraGinamide # Admit him to hospital, send a sputum sample and start him on pyraGinamide, amikacin and ethambutol +he concern with this man is one of multidrug-resistant tuberculosis. He is failing on his current regime and has clinical features of acti!e tuberculosis. +reatment failure is usually due to poor compliance, which can lead to the de!elopment of drug resistance. "ther risk factors for resistant disease areP pre!ious anti-+) treatment, H2> infection and contact with drug-resistant +). Although he may ha!e a superimposed simple bacterial infection, this should not deter from in!estigating and treating him for +), as most of the antibiotics used for +) will co!er the usual bacterial chest pathogens. A single drug should ne!er be added to a failing +) regime. Add two or three, ideally ones to which the organism is known to be sensiti!e and which the patient has not pre!iously taken. Send sputum for culture and polymerase chain reaction 8'&R: testing before starting further treatment. 2f he has confirmed multidrug-resistant +), ensure he is on fi!e or more drugs to which the organism is likely to be susceptible. A 31-year-old thin man complains of constant daytime sleepiness. He mentions in!oluntary naps, often in the middle of acti!ity, which occur suddenly and without warning. He also caused an accident when he fell asleep while dri!ing home from work. +he patient works as an office manager and has no history of eposure to chemicals. $hich of the following treatments would be indicated% A Aortriptyline ) 7luoetine & (iaGepam ( *odafinil # &ontinuous positi!e airway pressure-breathing de!ice +his patient has narcolepsyP a sleep disorder causing hypersomnia, which usually starts in adolescence or young adulthood. +reatment in!ol!es the use of central ner!ous system stimulants such as modafinil to allow daytime functioning.&ontinuous positi!e airway pressure-breathing de!ices are used in the treatment of sleep apnoea. A typical patient with sleep apnoea is usually older, obese and there will be a long history of gradually worsening snoring with apnoeas, possibly witnessed by the spouse, who will probably ha!e mo!ed out of the bedroom because of the noise. +here is usually a history of fairly high alcohol intake and smoking. A .6-year-old woman, who is known to suffer from rheumatoid arthritis, complains she has had recurrent haemoptysis for o!er . years. She has ne!er smoked and only takes a non-steroidal anti-inflammatory agent. According to her, she coughs up phlegm e!ery day and at times this contains streaks of fresh blood. She has no known respiratory disease, but tends to get fre0uent chest infections that are relie!ed by a course of antibiotics. $hat is the most likely diagnosis% A ?ung cancer ) )ronchiectasis & +uberculosis ( 'ulmonary embolism # Atypical pneumonia Some 4F1= of patients with rheumatoid arthritis de!elop bronchiectasis. +his is characterised by recurrent haemoptysis. +he history of epectorating phlegm on most days and fre0uent chest infections are suggesti!e of the diagnosis. A high-resolution computed tomography 8&+: scan of her lungs will establish the diagnosis. A 7.-year-old man with a )*2 of 4, presents with a history of worsening breathlessness and cough of about ,-week duration. He is a smoker and still smoked 3/ cigarettes per day until he became ill this time. His arterial blood gases in room air are as followsP pH 7.31, p a 8" 3 : 6.3 k'a, p a 8&" 3 : -.9 k'a, bicarbonate 44 mmol@l. $hich of the following is the most likely diagnosis% A 'ulmonary embolus ) Acute asthma & "bstructi!e sleep apnoea 8"SA: ( Acute eacerbation of chronic obstructi!e pulmonary disease 8&"'(: # 'ulmonary oedema +his patient is in chronic type-3 respiratory failure. Although "SA can cause chronic respiratory failure, it is unusual to suffer chronic type-3 respiratory failure ecept in combination with some other illness like &"'(. His blood gas results are most compatible with a patient who has se!ere &"'( with an acute eacerbation. 2n se!ere asthma the picture is mostly of type-, respiratory failure. His history of smoking points more to &"'(. A .4-year-old woman with end-stage renal failure de!elops pulmonary tuberculosis. $hich one of the following drugs should be used in a reduced dose% A Rifampicin ) 2soniaGid & 'yraGinamide ( #thambutol # 'yridoine #thambutol is renally ecreted and therefore dose adIustment is necessary to minimise the risk of toic effects, ie optic neuropathy. 'yridoine is a !itamin supplement gi!en with isoniaGid to minimise the risk of peripheral neuropathy. +he remaining drugs are mainly metabolised in the li!er and may be gi!en in normal doses in renal failure. A 3--year-old office secretary has been suffering from intermittent pain and tenderness affecting her elbows, wrist and ankles for last 3 years. Symptomatic relief had being obtained from ASA2(s. 7or last 4 months she has been increasingly unwell, and with night sweats, fe!er and a weight loss of about 6.1 kg 8,1 lbs:. She also de!eloped a non-producti!e cough and left-sided pleuritic chest pain. She smoked 4/ cigarettes per day. "n eamination she had temperature of 47.9 H&. +he syno!ium was palpable o!er her wrist Ioints. "n respiratory eamination her left lower Gone was dull to percussion with decreased breath sounds. A chest E-ray confirmed a left-sided pleural effusion in addition to some fibrotic patches on both the upper Gones. Aspiration showed a straw-coloured fluid with a protein concentration of 16 g@l and a glucose concentration of ,.6 mmol@l. +he fluid contained many lymphocytes but no malignant cells. A culture was sterile on the fifth day. $hat is the probable cause of the pleural effusion% A Sarcoidosis ) Rheumatoid pleural effusion & +uberculosis ( 'leural effusion secondary to lung malignancy # ?ymphoma +wo main points for the diagnosis are the unilateral pleural effusion and upper Gone shadowing. Rheumatoid effusions are unusual in the young and are small and asymptomatic. +his woman may ha!e rheumatoid disease but this is not the cause of her effusion. ?ymphocyte predominance suggests lymphoma, carcinoma or tuberculosis. A low glucose concentration fa!ours an infection, malignancy or a rheumatoid condition. )ut the fibrotic shadow of the upper Gone clinches the diagnosis in this case and is typical of post-primary tuberculosis. Sarcoidosis shows upper Gone fibrosis with pleural effusion at end-stage only, and it is rare. Ao other feature fa!ours the diagnosis. A 3/-year-old woman complains of a sudden onset of dyspnoea associated with pleuritic chest pain. $hich assessment is the most accurate to confirm your diagnosis of pulmonary embolism% A d-(imer ) #chocardiography & >entilation@perfusion scan ( &ontrast-enhanced spiral computed tomography # 'ulmonary angiography Although pulmonary angiography is associated with serious complications in about ,= of patients, it remains the diagnostic reference test for pulmonary embolism.A negati!e d-dimer test is useful for ecluding pulmonary embolism in patients who are clinically thought to be at low risk, but a Jpositi!e; result does not establish the diagnosis. #chocardiography may show right !entricular dilatation and e!idence of pulmonary hypertension, which, in the proper clinical setting, may strengthen the clinical impression that a pulmonary embolism has occurred. +he 'rospecti!e 2n!estigation of 'ulmonary #mbolism (iagnosis 8'2"'#(: study emphasised the poor predicti!e !alue of scans reported as intermediate probability, a common occurrence in routine clinical practice. $hich lung disease is associated with the clinical obser!ations Jpink puffer; and Jblue bloater;% A &ystic fibrosis ) 'ulmonary fibrosis & &"'( ( Small-cell lung cancer # +uberculosis 'ink puffers ha!e a good respiratory dri!e. 7eatures includeP purse-lip breathing with intense dyspnoea, patient is often thin and elderly, little sputum produced, oedema and o!ert heart failure are rare complications. 2n!estigationsP blood gases are near normal until pre-terminally there is !ery se!ere airways obstruction, total lung capacity is increased, there is a reduction in transfer factor. )lue bloaters ha!e a poor respiratory dri!e. 7eatures includeP 0uite mild dyspnoea, patient often obese, large !olumes of sputum produced, infecti!e eacerbations, patient often oedematous, may de!elop cor pulmonale. 2n!estigationsP blood gases F hypercapnia, hypoaemia, ele!ated plasma bicarbonate, se!ere nocturnal hypoaemia, airways obstruction may only be moderate, transfer factor approimately normal. A young adult was referred because of cough and shortness of breath. An etrinsic allergic al!eolitis was diagnosed. )eside reduction of eposure to the allergen, which other therapy is most likely to be successful% A Antibiotics ) Aon-steroidal anti-inflammatory drugs & 2mmunoglobulins ( &orticosteroids # (esensitisation *anagement of the patient centres on reducing any further eposure to a minimum, but first the diagnosis must be secure. (esensitisation has no beneficial effect. 2deally, affected indi!iduals change their rele!ant working, domestic and recreational en!ironment completely, but this may mean a profound loss of income or great epense, and is often unrealistic. Aor is it fully Iustified on purely medical grounds since continued eposure does not ine!itably lead to progressi!e disease. Affected indi!iduals who continue to work in the occupation responsible for their disease can often reduce their eposure substantially by changing the pattern of their particular duties. An alternati!e is to use industrial respirators, which filter out -9F--= of respirable dust from the ambient air. +hese are especially !aluable when eposures are intermittent and short, but they may be uncomfortably hot when worn for long periods or when there is hea!y work, and so compliance with their use may be poor. $hate!er course is followed, continuing eposure should be accompanied by regular medical sur!eillance. 2f there is no progression, it is reasonable for some eposure to continue. $hen there is progressi!e disease, eposure should cease. +his may in!ol!e a loss of earnings, and may entitle the affected worker to compensation. "ccasionally, indi!iduals with progressi!e disease may refuse to change their occupation or hobby, and their physician must weigh the possible ad!antages of long-term corticosteroid therapy against the risks Restricti!e lung diseases include which of the following% A #mphysema ) Asthma & &ystic fibrosis ( Se!ere scoliosis # Sarcoidosis #mphysema, asthma, cystic fibrosis and sarcoidosis J8can produce a mied obstructi!e@restricti!e pattern F better to choose another disease:; present an obstructi!e pattern with a low '#7R. Se!ere scoliosis compromises respiratory muscle action and can present as a restricti!e pattern in pulmonary function tests. JRe!ise; A 61-year-old woman is referred to the medical team from the orthopaedic ward. She underwent a right total-hip replacement si days ago. She is known to suffer from mild &"A( and is on regular inhaled steroids and a short-acting S 3 -agonist. She now complains of left-sided chest pain and is also dyspnoeic. Dour clinical diagnosis is pulmonary embolism 8'#:. $hich one of the following is not a feature of '#% A (yspnoea ) +achypnoea & Aew-onset atrial fibrillation ( 7e!er # )radycardia )radycardia is not a feature of '#. +achypnoea 8respiratory rate N 3/@min: is the commonest feature occurring in 9.= of patients. 7e!er is a fre0uent finding 841- ./=:. +achycardia occurs in 4/= of patients. Atrial flutter, fibrillation and premature beats are known to occur in patients with '#. $hich of the following is a feature in acute eacerbation of chronic bronchitis% A Respiratory acidosis is associated with a lowering of bicarbonate le!els ) #acerbation is usually due to anaerobic infection & Aminophylline@theophylline combinations form the first line of management ( An etensorFplantar response is common # "ygen therapy should be continued until the symptoms subside 2n respiratory acidosis, bicarbonate and hydrogen le!els are usually raised due to carbon dioide retention and the renal retention of bicarbonate. &ommonly, <ram- positi!e organisms cause an eacerbation of chronic bronchitis. Aminophylline and theophylline are indicated in patients with re!ersible chronic obstructi!e pulmonary disease 8&"'(: only if nebulised bronchodilators and steroids are ineffecti!e. "ygen therapy should aim for a p8" 3 : of 6/ mmHg, particularly for Jblue bloaters; 8with type-22 respiratory failure:. Any further increase will result in carbon dioide retention. #tensorFplantar responses are seen in &"'( due to carbon dioide retention, which results in carbon dioide narcosis. A 47-year-old man who speaks little #nglish comes to the +) clinic. His notes are missing but he is able to tell you that he has been on treatment for almost , year. $hat is the most likely reason he has been treated for this length of time% A 'ulmonary +) ) ?ymph-node +) & +) meningitis ( )ony +) # 'leural +) 2n the 56, all fully sensiti!e +) is treated for 6 months ecept for +) affecting the central ner!ous system, which is treated for ,3 months. *ulti-drug resistant +) 8*(R+): will re0uire longer courses of treatment, usually with a combination of less commonly used anti-+) drugs. (ecreased (?&" is seen in which of the following% A Heart failure ) Anaemia & 'ulmonary embolism ( #ercise # Acute poliomyelitis (?&", the diffusion capacity in the lung for carbon monoide, is decreased in any condition that reduces the effecti!e al!eolar surface area or affects the al!eolar membrane. #amples include pulmonary embolism and emphysema in which the al!eolar surface area is reduced. A 1--year-old woman has been admitted with haemoptysis and epistais, the chest E- ray shows multiple rounded lesions with al!eolar shadowing. ?aboratory parameters show a leucocytosis without eosinophilia but with microhaematuria, proteinuria as well as antineutrophil cytoplasmic antibodies 8c-AA&A:. $hich drug treatment is the most appropriate% A #rythromycin ) Ampicillin & &yclophosphamide in combination with corticosteroids ( &iclosporin # Aciclo!ir +he combination of prednisolone and cyclophosphamide is now established as the standard induction therapy for patients with generalised $egener;s granulomatosis or microscopic polyangiitis. +here is consensus on how corticosteroids should be used, but less so for cyclophosphamide. 'rednisolone is gi!en in doses of around , mg@kg per day initially, after which the dose is reduced rapidly, typically at weekly inter!als. &ontrolled trials show that the addition of pulses of methylprednisolone is unlikely to confer additional benefit. +raditionally, patients recei!ed daily oral cyclophosphamide 83 mg@kg per day:, but latterly intra!enous boluses ha!e pro!ed increasingly popular, gi!en in doses of /..F/.7. g@m 3 body surface area at inter!als of 3 weeks 8at least for short periods: to 3 months. A characteristic manifestation of cystic fibrosis includes which of the following% A )lockage of fallopian tubes ) Rectal prolapse & Restricti!e pattern of lung function tests ( (iabetes mellitus in later life # &irrhosis )lockage of the spermatic tubules and ducts results in subfertility. +he female fertility rate is diminished but the fallopian tubes are not affected. Rectal prolapse may occur secondary to malnutrition. An obstructi!e pattern is common in lung function tests due to airway in!ol!ement. ?ess than ,/= of patients de!elop diabetes secondary to pancreatic dysfunction 8eocrine function is affected more commonly:. &irrhosis occurs in less than .= of cases. A 7/-year-old man attends clinic. He is an e-smoker of ./ pack years. He has &"'(, with an 7#> , of 1/= predicted and minimal bronchodilator re!ersibility. He is breathless after walking .// metres and was keen to be referred to discuss the possibility of pulmonary rehabilitation. $hat do you tell him% A His eercise tolerance is too poor to be considered for the rehabilitation programme ) Rehabilitation will make little difference to the length of any future hospital stays & 7ollowing the rehabilitation programme, his lung function should impro!e ( 7ollowing the rehabilitation programme, his walking distance should impro!e # 2f his eercise tolerance did impro!e following pulmonary rehabilitation, this would be a long-lasting impro!ement +here ha!e been many randomised controlled trials to establish the effects of pulmonary rehabilitation. +his is a programme of aerobic lower etremity training combined with education, which has been found to pro!ide significant impro!ements in functional eercise, although little change in lung function testing. 'atients who ha!e completed pulmonary rehabilitation ha!e no fewer hospital admissions because of chest problems, but their hospital stays are likely to be shorter. (ecline in eercise tolerance and heath status occurs between 6 and ,3 months after the completion of a course. +he effect of sustained impro!ement with ongoing rehabilitation has yet to be e!aluated. $hich of the following is not a common symptom of lung cancer on presentation% A &ough ) &hest pain & &ough and chest pain ( &oughing blood # Shortness of breath &ough is the commonest symptom 8about 1,= of patients: at presentation, followed by chest pain in 33= of patients who ha!e later been diagnosed to ha!e lung carcinoma. About ,.= of patients present with both cough and chest pain. "nly 7= of patients present with the symptom of coughing up blood. 2n less than .= of cases they present with other symptomsP shortness of breath, hoarseness, weight loss, malaise and distant spread. A 43-year-old patient with asthma has been stable with inhaled salbutamol when re0uired. Recently she had to use her inhaler more fre0uently and also at night. $hat is the net step in her therapy% A 2nhaled S 3 -agonist at maimum dose ) Regular inhaled budesonide, inhaled salbutamol when re0uired & Addition of oral corticosteroids ( Addition of oral leukotriene-receptor antagonist # Addition of oral theophylline +his patient needs step 3 in the management of chronic asthma because she needs her S 3 -agonist inhaler more than once a day and also complains of night-time symptoms. Step 3 therapy consists of a regular standard-dose inhaled corticosteroid and an additional inhaled short-acting S 3 -agonist as re0uired. "ral leukotriene-receptor antagonists and theophylline are indicated in step 4 if the asthma is still not controlled. "ral corticosteroids should be added in step .. A ./-year-old man attends clinic with haemoptysis and a ,-week history of dyspnoea. #amination is unremarkable, but his chest radiograph shows bilateral fluffy shadows. 5rine dipstick is positi!e for blood and protein. $hat would you do net% A Send a serum AA&A and arrange to see him in clinic in , week ) 'erform pulmonary function tests and see him in , week for repeat tests & Arrange an out-patient renal ultrasound ( Admit him to the ward, check his renal function and send blood for autoantibodies # Admit him to the ward and start i! cyclophosphamide +he fluffy shadows on the chest E-ray could represent pulmonary oedema, interstitial lung disease, !asculitic lung disease or pulmonary haemorrhage. &+ may help to differentiate between these possibilities. &ombined with the positi!e urine dipstick, this man could ha!e an acti!e !asculitis with pulmonary haemorrhage and renal disease. He could ha!e $egener;s granulomatosis, <oodpasture;s syndrome or microscopic polyangiitis. He needs urgent admission and assessment. He may ha!e renal failure, he may de!elop respiratory failure and he may need to start urgent immunosuppression if a diagnosis of !asculitis is made. +his diagnosis is best made by biopsyP either of the kidneys, or an open lung biopsy, or of any skin lesion@nose lesion if present. 2deally, he should ha!e a tissue diagnosis before starting immunosuppressi!e treatment. A .9-year-old smoker with chronic bronchitis was successfully treated with antibiotics for a right upper lobe bronchopneumonia. After 6 weeks he was readmitted to hospital. +he chest E-ray shows signs of a pneumonia in the same place. $hat is the most likely reason% A &andida pneumonia ) 2mmunodeficiency & )ronchial carcinoma with post-stenotic pneumonia ( Sarcoidosis # +uberculosis Aon-resol!ing pneumonia is an indication of bronchogenic carcinoma. An ill-defined homogeneous or patchy consolidation in a segmental or non-segmental distribution may be an indication of bronchogenic carcinoma. 'atients with these findings are often initially treated for pneumoniaK the lack of response to antibiotic therapy suggests the diagnosis of a malignancy. +he opacity may contain air bronchograms and air al!eolograms. +his presentation is often seen with adenocarcinoma and bronchoal!eolar carcinoma. )ronchial stenosis and post-stenotic changes are commonly seen because most nonFsmall-cell carcinomas demonstrate intraluminal growth. Aarrowing of the main bronchi or a complete cut-off can be identified on chest E-rays. An endobronchial lesion commonly leads to partial or complete atelectasis and is the commonest sign of bronchogenic carcinoma. &omplete endobronchial obstruction can sometimes produce distal mucoid impaction, which may be !isible on plain chest E-rays as a tubular or branching opacity. +he nurses on the ward ask you to look at a chest drain that has been inserted in a patient for a pneumothora. +hey are concerned about whether it is still working. $hen the patient coughs, nothing happens. $hen he breathes in and out, the fluid in the tube mo!es up and down. $hat does this mean% A Air and fluid are draining from the pleural space ) 7luid alone is draining from the pleural space & Air is no longer draining from the pleural space as the drain is blocked ( Air is no longer draining from the pleural space, but the drain is still working # He needs to commence suction to the drain +he fluid le!el rising and falling in the drain Jswinging; shows it is still in contact with the pleural space and the fluid le!el is mo!ing with respiration. Air is not bubbling out of the drain when the patient coughs, as the air has stopped draining from the pleural space and the lung has re-inflated. 2f a drain does not bubble or swing, then it is blocked or kinked and is not working. $ith a simple pneumothora, there would be minimal fluid drainage from the chest. Suction is necessary if the drain is still bubbling, but the lung has not fully re-inflated on the chest E-ray. A 6.-year-old man complains of lethargy, fe!er, dry cough, headache, chest pain and increasing shortness of breath. He returned from a cruise 3 days ago. His chest E-ray shows bilateral infiltrates, the p8" 3 : is 9.4. k'a. $hat is the most appropriate therapy% A 2ntra!enous corticosteroids ) 2soniaGid & Ampicillin ( Amphotericin ) # #rythromycin +his patient has ?egionella pneumonia. +he most rele!ant factor is the ability of the antibiotic to penetrate intracellularly into al!eolar macrophages where the legionella organism hides and di!ides. A macrolide, such as erythromycin or clarithromycin, is at present recommended as the drug of first choice, in dosages of .//F,/// mg e!ery 6 h for erythromycin and .// mg twice daily for clarithromycin, being gi!en intra!enously if re0uired. 2n !itro and animal eperiments and clinical eperience support the efficacy of rifampicin and fluoro0uinolones. Rifampicin is often recommended as additional therapy to erythromycin, in a dose of 6// mg once or twice daily in patients with se!ere infection or who are deteriorating. <eneral supporti!e measures are particularly important, with attention to ade0uate hydration and correction of hypoaemia with the early use of assisted !entilation for ad!ancing respiratory failure.'re!entionP +he most important principle to follow is to a!oid holding water at temperatures between 3/ and 1. H&, which is the range in which legionella multiplication occurs. "ther pre!enti!e measures should be taken, ieP minimise colonisation, growth and release of legionellae into the atmosphereK physically or chemically treat water to kill the bacteriaK protect maintenance personnel who work on contaminated systems. $hich of the following statements applies to the peak epiratory flow rate% A 2t is a less sensiti!e parameter for assessing impro!ement to therapy in patients with acute bronchial asthma ) 2t measures small-airway resistance & 2t is more related to age than height ( ?ess than ./= of normal is an indication for aminophylline therapy in those with acute asthma # 2t is effort-dependent '#7R is a sensiti!e measurement of small-airway obstruction, although the maimal mid-epiratory flow rate is more changed in mild disease. +he ease of performing the '#7R at the bedside has made it more rele!ant in clinical practice. 2t is more related to height than age, and is effort-independent if the proper techni0ue is used. 2n which of the following respiratory disease is clubbing not a feature% A Asbestosis ) 7ibrosing al!eolitis & ?ung abscess ( )ronchitis # )ronchial carcinoma ?oss of the natural angle between the nail and the nailbed is seen in clubbing. An increased cur!ature of the nail de!elops later. &lubbing is seen in suppurati!e diseases such as long-standing bronchiectasis, acute lung abscesses and empyema. Howe!er, clubbing is not seen in uncomplicated bronchitis. &lubbing is also found in fibrosing al!eolitis and asbestosis, in malignant disease, particularly carcinoma of the bronchus and in pleural malignancy. 2f finger clubbing is associated with hypertrophic pulmonary osteoarthropathy, a painful osteitis of the distal ends of the long bones of the lower arms and legs, it is designated grade 2>. *alignancy is associated in -.= of these cases. A 37-year-old woman presented in AL# with a 3-week history of haemoptysis and a 4-day history of red-coloured urine. She had a similar problem 3 years ago but reco!ered fully. She looked pale and was tachycardic, her pulse was ,39 and regular and her )' was ,./@-6 mmHg. )ilateral crackles were present on auscultation. ?aboratory testing ga!e the following resultsP Hb, 7.. g@dlK $)&, ,4 C ,/ 6 @lK 'latelets, 19/ C ,/ 6 @lK &lotting, normalK Aa, ,1/ mmol@lK 6, 6.7 mmol@lK 5rea, 16 mmol@lK &reatinine, 6./ mmol@l. 5rine showed blood and protein. +he chest E-ray showed patchy interstitial shadowing in both lung fields. $hat is the probable diagnosis% A <oodpasture;s syndrome ) *icroscopic polyangiitis & $egener;s granulomatosis ( 'AA # +uberculosis +he patient is suffering a pulmonary haemorrhage, as shown on the chest E-ray. Associated renal in!ol!ement is present. +he changes can be caused by microscopic polyangiitis, $egener;s or <oodpasture;s syndrome. +he larger !essel !asculitides do not present in this way. *icroscopic polyangiitistends to recur more often than the other two, making this the probable diagnosis. A 33-year-old student is admitted to the emergency department, ha!ing been found by her flatmates to be unsteady on her feet and ha!ing problems with her memory. +hey tell you they ha!e been using old-fashioned gas fires as it has been so cold and you are wondering whether she could ha!e carbon monoide poisoning. $hich test will be the most helpful in determining this% A &linical eamination ) 'ulse oimetry & Arterial blood oygen le!el ( #haled breath test # &hest radiograph )reath carbon monoide le!els can be measured using de!ices intended for smoking cessation work. +hey can also be measured on a co-oimeter, measuring carboyhaemoglobin le!els. &linical eamination is unhelpful, as patients are not cyanosed, but a cherry-red colour. 'ulse oimetry appears normal, due to carboyhaemoglobin ha!ing similar absorption spectra to oyhaemoglobin. Arterial oygen le!els may be normal, as may a chest radiograph. +reatment for carbon monoide poisoning is to gi!e high le!els of inspired oygen, by !entilation 8or hyperbaric means if necessary:, to displace the carbon monoide and increase the amount of dissol!ed oygen. $hat is the most common cause of haemoptysis% A 2nfecti!e eacerbation of &"'( ) 'ulmonary infarction & +uberculosis ( <oodpasture;s syndrome # )ronchial carcinoma +he most common cause of haemoptysis is acute infection, in eacerbation of &"'( in particular. )ut other causes should be ecluded while in!estigating. )ronchial carcinoma, pulmonary infarction and tuberculosis are common causes. *assi!e haemoptysis of more than 3// ml of blood is present in cases of bronchiectasis and tuberculosis. 'ulmonary haemosiderosis, <oodpasture;s syndrome, microscopic polyangiitis, and trauma are some of the rarer causes worth remembering. $hich form of lung disease de!elops typically in people with a , -antitrypsin deficiency% A Atelectasis ) 'neumonitis & #mphysema ( 2nterstitial fibrosis # )ronchiectasis +he association of a , -antitrypsin with the de!elopment of premature emphysema has led to the wider conclusion that emphysema results from an imbalance between proteases and antiproteases within the lung. +he elastase and a , -antitrypsin balance clearly illustrates the processes in!ol!ed in the de!elopment of emphysema and the interplay between the en!ironmental and genetic factors that determine its onset. 'atients usually present with increasing dyspnoea and weight loss, with cor pulmonale and polycythaemia occurring late in the course of the disease. &hest E-rays typically show bilateral basal emphysema with paucity and pruning of the basal pulmonary !essels. $hich of the following is the best agent for treating chlamydia pneumonia% A &larithromycin ) 'iperacillin & &lindamycin ( Ampicillin # 2mipenem *acrolide antibiotics 8eg clarithromycin or erythromycin: are the treatment of choice for chlamydia and other atypical pneumonias. +he most fre0uent side-effects are nausea, !omiting and diarrhoea. 2t should be kept in mind that treatment is likely to be most effecti!e when gi!en o!er a long rather than a short time, suboptimal doses are a!oided and compliance is strict. A 6/-year-old man presents to the clinic complaining of a 6-month history of dyspnoea on eertion and a non-producti!e cough. "n eamination there is clubbing, and crepitations are heard at the lung bases. ?ung function tests show a reduced !ital capacity and an increased 7#> , @7>& ratio. $hat is the most likely diagnosis% A 7ibrosing al!eolitis ) &arcinoma of the lung & &"'( ( +uberculosis # )ronchiectasis &ryptogenic fibrosing al!eolitis may occur in any decade of life but is most commonly seen between the ages of ./ and 6/ yearsK it is slightly more fre0uent in males than females. A history of progressi!e breathlessness on eertion in the absence of wheeGe is typical. A dry cough may be present, but sputum production is unusual until the later stages of the disease. Haemoptysis is uncommon, but should suggest the de!elopment of lung malignancy that occurs with a 7- to ,1-fold relati!e risk in patients with cryptogenic fibrosing al!eolitis. &hest pain is uncommon. &onstitutional symptoms such as weight loss and lethargy are recognised. ?ung function tests show a restricti!e picture. $hich one of the following statement is true about the 7#7 3.=F7.= 8forced epiratory flow rate between 3.= and 7.= of the forced !ital capacity: in pulmonary function tests% A 2t reflects the status of the small airways ) 2t is not impaired in bronchiolitis obliterans & 2t is effort-dependent ( 2t is not affected in smokers # 2t is useful to identify tracheal obstruction +he 7#7 3.=F7.= primarily reflects the status of the small airways. 2t is more sensiti!e than the 7#> , for identifying early airway obstruction. 2t is effort-independent. 2t is impaired in bronchiolitis obliterans, smokers and reIection reactions in bone marrow, lung and heart transplants. Dou are asked to re!iew a patient with known asthma on the haematology ward. He is neutropenic from chemotherapy for Hodgkin;s lymphoma. He has a cough and a low- grade fe!er, sparse crepitations on chest eamination and his chest E-ray shows diffuse pulmonary shadowing. He has been on broad-spectrum antibiotics for , week with no impro!ement. His sputum has shown a few hyphae, but is culture-negati!e. )lood cultures ha!e been negati!e. Aspergillus precipitins are negati!e, as is an aspergillus skin-prick test. $hat is the diagnosis% A Allergic bronchopulmonary aspergillosis ) 2n!asi!e aspergillosis & Aspergilloma ( 'neumocystis pneumonia # Systemic candidosis +his man has in!asi!e aspergillosis, due to his immunosuppression. He has fungal hyphae in his sputum and a corresponding clinical and radiological picture. He is unable to mount an immune response and so precipitin and skin-prick tests are negati!e. Aspergilloma is a fungal ball in an area of pre!iously damaged lung tissue, such as old +). 2t causes high le!els of aspergillus antibody so precipitins are high, although the skin-prick test is negati!e as there is no 2g#-mediated allergy to aspergillus. Allergic bronchopulmonary aspergillosis has high 2g# and antibodies to aspergillus, so the skin-prick is positi!e and precipitins are high. 'neumocystis pneumonia 8'&': does not cause hyphae in the sputum. &andida can be identified and cultured from the sputum. 2t rarely causes obIecti!e e!idence of lung in!asion and is not recognised as ha!ing specific radiological features A 34-year-old woman with a lifelong history of atopy, hay fe!er and mild asthma attends her <'. "!er the last 4 months she has been waking in the early morning coughing and wheeGing, and it is slowly getting worse. She is taking inhaled salbutamol se!en times a day and is also using inhaled steroids 1// g twice a day. Her predicted peak flow rate is .// l@min and it is now 4./ l@min. $hat would you ad!ise her <' to do% A &all an ambulance and admit her to hospital ) Start an oral leukotriene-receptor antagonist, such as montelukast & Start her on oral theophylline ( Start an inhaled long-acting S 3 -agonist # ?end her a nebuliser to use at home +his is a woman with features of inade0uately controlled asthma. She has no features of an acute or life-threatening attack, so does not re0uire hospital admission. She is already taking a moderate dose of inhaled steroids, but needs add-on therapy. +he )ritish <uidelines on the *anagement of Asthma 8see Thorax 3//4, .98Suppl. ,:: recommend commencing a long-acting S 3 -agonist, such as salmeterol, if the patient is regularly taking an inhaled steroid. 2f they do not impro!e with this, or if additional therapy is still re0uired, oral theophylline or a leukotriene-receptor antagonist can then be tried. A nebuliser is not recommended in place of increasing her other therapies. A 31-year-old patient with haemophilia A has been complaining of fe!er and dry cough. An interstitial pneumonia was diagnosed. After 7 days; treatment with doycycline 3// mg@day his temperature was still 4- H& and a chest E-ray showed increased interstitial infiltrates. $hich is the most likely diagnosis% A &andida pneumonia ) *ycoplasma pneumonia & Pneumocystis carinii pneumonia ( "rnithosis # #trinsic allergic al!eolitis Pneumocystis carinii pneumonia typically presents with gradually increasing dyspnoea and cough o!er weeks, but sometimes as an acute illness with rapid deterioration o!er a few days. 'atients with haemophilia A were more susceptible to H2> due to fre0uent blood transfusions that were not screened in the past. +he chest E-ray usually re!eals diffuse ground-glass opacities, which strongly suggests the diagnosis, but it sometimes shows nodular opacities, lobar consolidation, or e!en a normal film. &ystic abnormalities and spontaneous pneumothoraces in patients with known or suspected H2> infection are usually caused by Pneumocystis carinii pneumonia. Pneumocystis carinii pneumonia is unlikely in a patient who has had a &(1T cell count abo!e 3// cells@Ul in the preceding 3 months in the absence of other H2>-associated symptoms. Approimately -/= of patients with Pneumocystis carinii pneumonia ha!e an ele!ated serum lactic dehydrogenase, but this may also occur with other pulmonary diseases. $hich drug therapy is indicated for a young adult with mild intermittent asthma 8no night-time symptoms, no trigger: as re0uired medication% A )udesonide inhaler ) Salbutamol inhaler & Salmeterol inhaler ( "ral cromoglycate # "ral leukotriene-receptor antagonists "ccasional-relief bronchodilators are indicated in step , in the treatment of chronic asthma, if relief is only needed once daily, if there are no night-time symptoms or no impaired lung function. Regular inhaled corticosteroids are added in step 3. Regular inhaled long-acting S 3 -agonists 8salmeterol: are added in step 4. "ral leukotriene- receptor antagonists can also be added in step 4 if the asthma is still not controlled.