Republic of the Philippines

CAVITE STATE UNIVERSITY

(CvSU)
Don Severino Delas Alas Campus
Indang, Cavite
(046) 4150-010 / 4150-011 (046) 4150-012

DRUG STUDY
NAME OF PATIENT: JN DATE OF ADMISSION: AUGUST 7, 2014
AGE: 33 YEARS OLD DIAGNOSIS: PTB
SEX: FEMALE
Drug Features
Mechanism of
Action
Indication

Contraindication

Effects Nursing Responsibilities
Generic Name:
Cefuroxime
Brand Name:
none
Classification:
anti-infectives
Sub Classification:
second-generation
cephalosporins
Dosage:
500 mg 1 tab
Route:
PO
Frequency:
BID
Form:
Film coated tablet
Binds to
bacterial cell
wall membrane,
causing cell
death.
Therapeutic
Effects:
Bactericidal
action against
susceptible
bacteria.
Spectrum:
Similar to that of
first-generation
cephalosporins
but has
increased
activity against
several other
gram-negative
pathogens
including:
Haemophilus
Treatment of:
Respiratory tract
infections, Skin and
skin structure
infections, Bone
and joint infections
(IV), Urinary tract
infections,
Gynecological
infections,
Septicemia (IV),
Otitis media (PO),
Meningitis (IV),
Lyme disease (PO).
Perioperative
prophylaxis (IV).
Contraindicated in:
Hypersensitivity to
cephalosporins;
Serious
hypersensitivity to
penicillins.
Use Cautiously in:
Renal impairment
(dose
reduction/increase
d dosing interval
recommended if
CCr 20 mL/min);
History of GI
disease, especially
colitis; Geriatric
patients (dose
adjustment may be
required due to
Side Effects &Adverse
Effects
CNS: SEIZURES (HIGH
DOSES). GI:
PSEUDOMEMBRANOUS
COLITIS, diarrhea,
nausea, vomiting,
cramps. Derm: rashes,
urticaria, diaper
dermatitis. Hemat:
bleeding, eosinophilia,
hemolytic anemia,
leukopenia. Local: pain
at IM site, phlebitis at IV
site. Misc: ALLERGIC
REACTIONS INCLUDING
ANAPHYLAXIS,
superinfection.
Check for doctors order
Carefully read product packaging to note
strength of solution, dosage/ route of
administration.
Observe 10 Rs in medicine
administration
Assessment:
Assess for infection (vital signs;
appearance of wound, sputum, urine,
and stool; WBC) at beginning of and
throughout therapy.
Before initiating therapy, obtain a history
to determine previous use of and
reactions to penicillins or
cephalosporins. Persons with a negative
history of penicillin sensitivity may still
have an allergic response.
Obtain specimens for culture and
sensitivity before initiating therapy. First
dose may be given before receiving
results.
Observe patient for signs and symptoms
of anaphylaxis (rash, pruritus, laryngeal
edema, wheezing). Discontinue the drug
and notify health care professional
immediately if these symptoms occur.
Keep epinephrine, an antihistamine, and
resuscitation equipment close by in the
event of an anaphylactic reaction.


influenzae
(including -
lactamase-
producing
strains),
Haemophilus
parainfluenzae,
Escherichia coli,
Klebsiella
pneumoniae,
Neisseria ,
Proteus,
Moraxella
catarrhalis,
Borrelia
burgdorferi. Not
active against
methicillin-
resistant
staphylococci or
enterococci.
age-related in
renal function);
Pregnancy and
lactation (has been
used safely).
Monitor bowel function. Diarrhea,
abdominal cramping, fever, and bloody
stools should be reported to health care
professional promptly as a sign of
pseudomembranous colitis. May begin
up to several weeks following cessation
of therapy.
Lab Test Considerations: May cause
positive results for Coombs' test.
May cause serum AST, ALT, alkaline
phosphatase, bilirubin, LDH, BUN, and
creatinine.
May rarely cause leukopenia,
neutropenia, and eosinophilia.
Patient/Family Teaching:
Instruct patient to take medication
around the clock at evenly spaced times
and to finish the medication completely,
even if feeling better. Missed doses
should be taken as soon as possible
unless almost time for next dose; do not
double doses. Advise patient that sharing
of this medication may be dangerous.
Pedi: Tell parents or cargeivers to use
calibrated measuring device with liquid
preparations.
Advise patient to report signs of
superinfection (furry overgrowth on the
tongue, vaginal itching or discharge,
loose or foul-smelling stools) and allergy.
Instruct patient to notify health care
professional if fever and diarrhea
develop, especially if stool contains
blood, pus, or mucus. Advise patient not
to treat diarrhea without consulting
health care professional.
SUBMITTED BY: ANGELICA CASSANDRA P. VILLENA CLINICAL INSTRUCTOR: EDERLYN P. DESTURA RN, MAN
YEAR & SEC. GRP: BSN 3 1 GRP 1
DATE: AUGUST 15, 2014