Seminar on Behavioral Endocrinology, HCS 7372 Behavioral Neuroendocrinology (Principles of Hormone/Behavior Relations) Synopsis Human and animal

behavior displays a great range of variability within the same subject. In fact behavior is a response of the organism to the environment, motivated and modulated by the organism’s internal states, which, in turn, vary according to sex, developmental stage, metabolic need, circadian rhythms, and other biological and -for humans- psychological variables. Hormones, their synthesis and receptor systems, are the chemical means of internal state modulation. This course is an introduction to the relationship between the endocrine system and behavior, with a special emphasis on the hypothalamus-hypophysis-body gland axes. Topics will include neuroendocrine control of feeding, reproduction, chronic stress, and learning and memory. Textbook Neuroendocrinology in Physiology and Medicine, eds. Conn and Freeman, Humana Press Recommended books 1) Guyton and Hall, Human Physiology 2) Principles of Hormone/Behavior Relations, Pfaff, Phillips, Rubin, Elsevier Academic Press Tests and gradings Course attendance is not mandatory but is strongly recommended. Grading will be the average of a midterm test (on the first half of the course) and a final test (on the second half of the course). Students are encouraged to read the corresponding chapters before or right after the corresponding class presentation in order to retain best the material. Tests will be either or both short answers or multiple choice tests. Students are encouraged to actively participate to class discussion and ask questions on the corresponding topics. Pre-requisites Although no pre-requisites are necessary, and each class will be prepared as a stand-alone presentation, it is recommended that students have basic knowledge of membrane biophysics and physiology, anatomy, and neurochemistry.

session Class 1 Class 2 Class 3 Class 4 Class 5 Class 6 Class 7 Class 8 Class 9 Class 10 Class 11 Class 12 Test 1 Class 13 Class 14 Class 15 Class 16 Class 17 Class 18 Class 19 Class 20 Class 21 Class 22 Class 23 Class 24 Test 2

Schedule Aug 24 Aug 24 Sept 14 Sept 14 Sept 21 Sept 21 Sept 28 Sept 28 Oct 5 Oct 5 Oct 12 Oct 12 Oct 19 Oct 26 Oct 26 Nov 2 Nov 2 Nov 9 Nov 9 Nov 16 Nov 16 Nov 23 Nov 23 Nov 30 Nov 30 Dec 7

Topic-assignment The brain-hypothalamus-pituitary-body gland axes: basic, G-proteins principles of transmitter release (ch. 58, 74, 75 from Guyton and Hall) The hypothalamus as a major integrative center (5) The hypothalamus as an endocrine organ (ch. 1 Conn and Freeman) Hypothalamic hormones (3 C&F) Neurotransmitters as regulators of hypothalamic function (4) Endocrine targets in the brain (6) Electrophysiology of hypothalamic neurons (ch. 30 Conn & Freeman) Anatomical markers of Activity in Hypothalamic Neurons (31 CF) Neuroendocrine regulation of pituitary function: general principles (7) Neuroendocrine regulation of reproductive cyclicity (8) Neuroendocrine regulation of growth hormone secretion (11) Neuroendocrine regulation of puberty (12) Test on the first half of the program Neuroendocrine regulation of thyroid function (13) Regulation of the stress response by corticotrophin-releasing factor receptors (15) Neuroendocrine regulation of sexual behavior (16) Neuroendocrine regulation of maternal behavior (17) Control of food intake (19) Neuroendocrine regulation of learning and memory (20) Neuroendocrine correlates of aging (21) Influence of light and the pineal gland on biological rhythms (23) Neuroendocrine control of circadian rhythms (25) Neuroendocrine immunology (29) Hypothalamic disease (27) Disorders of hypothalamus-pituitary axis (28) Test on the second half of the program

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