PATHOPHYSIOLOGY

PREDISPOSING FACTORS PRECIPITATING FACTORS

AGE RACE GENDER PHARMACOLOGIC BODY LACK OF PHYSICAL DIET HIGH

INTAKE WEIGHT EXCERCISE BILIRUBIN

INCREASED
RISK WITH
FEMALE
AGE FAIR-SKINNED ASIANS & MALE OBESITY GALLBLADDER HIGH FAT HIGH HIGH HIGH
S
(EUROPEANS, AFRICAN CONTRACTION STARCH PROTEIN CHOLESTEROL
HISPANICS, AMERICAN
NATIVE HORMONAL
AMERICANS) CONTRACEPTIVES

PRESENCE OF PRODUCTION
PROGESTERONE ESTROGEN OF LIVER
ENZYMES

INCREASED RISK FOR INCREASED CHOLESTEROL

MULTIPAROUS AND PREGNANT SECRETION
WOMEN INCREASED INCREASED INCREASE
LIPASE AMYLASE SGOT-AST
& LDH
LEVELS
CYSTIC DUCT
INCREASED BILE DIMINISHED GALLBLADDER OBSTRUCTION
SECRETION EMPTYING

BILIARY
STASIS INCREASED BILE
SECRETION BACK FLOW
(COMPENSATORY)

OVERCONCENTRATION AND PANCREATITIS

SUPERSATURATON OF BILE

INFECTION
INDIGESTION*

FORMING OF GALLSTONES CHOLECYSTITIS

CONSTIPATION (CHOLELITHIASIS)**
 FORMING OF GALLSTONES
(CHOLELITHIASIS)**

SYMPTOMATIC ASYMPTOMATIC

SILENT
ATTACK
GALLBLADER (+) MURPHY’S SIGN INDIGESTION* UPPER UNABLE TO FIND
DYSPEPSIA ABDOMINAL COMFORTABLE
/EPIGASTRIC POSITION
PAIN

NAUSEA VOMITNG

SOB AT BACK
NIGHT PAIN

BILIARY
COLIC