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MGI PHARMA, INC. Document #: MSDS-006.

01
Material Safety Data Sheets Effective Date: September 07, 2005
Supersede Date: New
Page: 1 of 5



For Medical Emergencies / Toxicology questions: Contact Medical Affairs (1-800-562-5580 / 952-346-4958).
SECTION 1 IDENTITY

TRADE NAME: Decitabine (Dacogen
TM
)

SECTION 2 INGREDIENTS

DECITABINE

COMMON NAME Decitabine

THRESHOLD LIMIT NA
VALUES (UNITS)

CAS NUMBER 2353-33-5

CHEMICAL NAME 5-Aza-2-Deoxycytidine; 4-amino-1-(2-deoxy-beta-D-erythro-
pentafuranosyl)-1,3,5-triazin-2(1H)-one

MOLECULAR WEIGHT 228.21

CHEMICAL FAMILY Cytidine analog

FORMULA C
8
H
12
N
4
O
4

Potassium dihydrogen phosphate

COMMON NAME potassium phosphate, monobasic

CAS NUMBER 7778-77-0

CHEMICAL NAME potassium phosphate, monobasic

MOLECULAR WEIGHT 136.09

FORMULA H
2
KO
4
P

Sodium Hydroxide

COMMON NAME Caustic Soda

CAS NUMBER 1310-73-2

CHEMICAL NAME Sodium hydroxide

MOLECULAR WEIGHT 40.01
MGI PHARMA, INC. Document #: MSDS-006.01
Material Safety Data Sheets Effective Date: September 07, 2005
Supersede Date: New
Page: 2 of 5



For Medical Emergencies / Toxicology questions: Contact Medical Affairs (1-800-562-5580 / 952-346-4958).

FORMULA NaOH


SECTION 3 PHYSICAL AND CHEMICAL CHARACTERISTICS

ACTIVITY IN WATER Soluble

APPEARANCE Powder; white cake or loose solid

EXTINGUISHER MEDIA CO
2
, Dry Chem, Water Spray or appropriate foam.

IGNITION TEMPERATURE Not determined

SPECIAL FIRE FIGHTING Use NIOSH/MSHA approved self-contained breathing
apparatus and protective clothing to prevent contact with
skin and eyes.

FIRE AND EXPLOSION NA

SECTION 4 PHYSICAL HAZARDS

STABILITY ( ) Unstable ( X ) Stable

CONDITIONS TO AVOID NA

INCOMPATIBILITY Strong oxidizing agents.
(MATERIALS TO AVOID)

HAZARDOUS DECOMPOSITION Carbon monoxide, Carbon dioxide, Nitrogen oxides,
PRODUCTS Hydrogen chloride gas

HAZARDOUS POLYMERIZATION ( ) May Occur ( X ) Will Not Occur

SECTION 5 HEALTH HAZARDS

THRESHOLD LIMIT VALUE NA

SIGNS AND SYMPTOMS OF Toxicological properties are not fully understood.
OVEREXPOSURE Individuals must use prudent practices when handling and
storing. Adverse reactions include: myelosuppression,
nausea, vomiting, diarrhea, infection, alopecia, fever,
phlebitis, neuropathy, mucositis. Persons developing
hypersensitivity (anaphylactic) reactions must receive
immediate medical attention.

MGI PHARMA, INC. Document #: MSDS-006.01
Material Safety Data Sheets Effective Date: September 07, 2005
Supersede Date: New
Page: 3 of 5



For Medical Emergencies / Toxicology questions: Contact Medical Affairs (1-800-562-5580 / 952-346-4958).
ACUTE / CHRONIC REACTIONS May be harmful if inhaled, ingested or absorbed through
TO CONSIDER skin.

CHEMICAL LISTED AS NATIONAL TOXICOLOGY PROGRAM (X) Yes ( ) No
CARCINOGEN OR POTENTIAL I.A.R.C. Monographs ( ) Yes (X) No
CARCINOGEN OSHA ( ) Yes (X) No

TERATOGEN May cause congenital malformation in the fetus.

PERMISSIBLE EXPOSURE NA

EXPOSURE LIMIT USED NA

EMERGENCY AND FIRST AID
PROCEDURES

INHALATION: Remove to fresh air. If breathing is difficult, give oxygen.
Seek medical attention if necessary.

EYE Flush with water or sterile eye wash solution for 15
minutes. To assure adequate flushing of eyes, separate the
eyelids with fingers. Seek medical help if painful or
irritating.

SKIN Flush with water for 15 minutes. Wash with soap and
water until free of residue. Remove contaminated clothing
and shoes. Wash contaminated clothing before wearing.

INGESTION: Wash out mouth with water if person is conscious. Seek
prompt medical attention.

SECTION 6 SPECIAL PROTECTION INFORMATION

RESPIRATORY PROTECTION Yes

PROTECTIVE GLOVES Wear latex or nitril gloves when cleaning up spilled
product.

EYE PROTECTION Yes

OTHER PROTECTIVE NA
CLOTHING AND EQUIPMENT

MGI PHARMA, INC. Document #: MSDS-006.01
Material Safety Data Sheets Effective Date: September 07, 2005
Supersede Date: New
Page: 4 of 5



For Medical Emergencies / Toxicology questions: Contact Medical Affairs (1-800-562-5580 / 952-346-4958).
SECTION 7 SPECIAL PRECAUTIONS AND SPILL / LEAK PROCEDURES

PRECAUTIONS TO BE TAKEN Do not breathe dust. Do not get in eyes, on skin or cloth-
IN HANDLING AND STORAGE ing. Avoid prolonged or repeated exposure. Store as stated
in product labeling.

STEPS TO BE TAKEN IN CASE Small Spill Prevent exposure. Wear latex or nitrile
MATERIAL IS SPILLED OR gloves and safety glasses when cleaning up spilled product.
RELEASED Contain the spill. Clean up spilled material with a damp,
absorbent paper, pillow or pad and place in an appropriate
waste disposal container. Use care in the clean up of
broken glass. Spills can be deactivated with a 2M Sodium
Hydroxide solution. Decontaminate area using a bleach
solution or a product like Surface Safe(available from
SuperGen, Inc.).

Large Spill Trained personnel should wear respiratory
protection, appropriate gloves, eye protection, boots and
chemically resistant body protection. Avoid raising dust.
Ventilate area and wash spill site after material pick up is
complete. Spills can be deactivated with a 2M Sodium
Hydroxide solution.

SAFE DISPOSAL METHODS Dispose of in accordance with local, state and federal
regulations or the authority having jurisdiction.
Incineration in a permitted incinerator is the preferred
disposal method.

SECTION 8 TRANSPORTATION INFORMATION

Based on:
International Air Transport Association (IATA) Dangerous Goods Regulations, 44
th
Ed.

PROPER SHIPPING NAME Toxic Solid, Organic, n.o.s. (Decitabine)

HAZARD CLASS NUMBER 6.1 Toxic

UN IDENTIFICATION No. 2811

PACKING GROUP III

HAZARD / HANDLING LABELS NA
REQUIRED


MGI PHARMA, INC. Document #: MSDS-006.01
Material Safety Data Sheets Effective Date: September 07, 2005
Supersede Date: New
Page: 5 of 5



For Medical Emergencies / Toxicology questions: Contact Medical Affairs (1-800-562-5580 / 952-346-4958).
Change History:

DCR#
05-151