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PATHOLOGICAL
PROCESSES
(DYSTROPHY, APOPTOSIS,
NECROSIS)
Dystrophy
One of the manifestations of
metabolic derangements in cells
is the intracellular accumulation
of abnormal amounts of various
substances.
Dystrophy
typical cellular pathologic
process caused by metabolic
disturbance of general or
cellular homeostasis,
manifested by functional and
structural changes of the cell
internal environment.
Classification of dystrophy
1. Protein dystrophy;
2. Lipid (fatty) dystrophy;
3. Carbohydrates dystrophy.
In function of provenience
dystrophies are classified in:
congenital dystrophy,
acquired dystrophies
In function of metabolic imbalance
exists protein, lipid, glycolic,
mineral dystrophies.
E.g.
- fatty change in the liver because
of intracellular accumulation of
triglyceride;
E.g.
alpha1-antitrypsin deficiency, in
which a single amino acid
substitution in the enzyme results
in defects in protein folding and
accumulation of the enzyme in the
endoplasmic reticulum
of the liver in the form of globular
eosinophilic inclusions.
3. An abnormal exogenous
4. Heredity
- the main cause of congenital
dystrophies , lead to enzymatic
disorders enzymopathies defect
or lack of cell enzymes.
e.g.
4. Exogenous factors
-
mechanical,
physical,
chemical,
biological,
cell hypoxia,
energy deficiency,
transmembrane and intracellular transport,
disturbance of nutritive substances,
exocytose deficiency of intracellular
substances.
APOPTOSIS
A mechanism of programmed cell
death, marked by:
shrinkage of the cell,
condensation of chromatin,
formation of cytoplasmic blebs,
fragmentation of the cell into
membrane-bound bodies eliminated
by phagocytosis.
APOPTOSIS
(programmed cell death)
It is an active processenergy
dependent;
Does not elicit inflammatory
response;
May be physiologic or pathologic.
cell (F).
Etiology of apoptosis
PHYSIOLOGIC causes:
PATHOLOGIC causes:
Irradiated tissues;
Cell death induced by cytotoxic Tlymphocytes;
Viral infections e.g. viral hepatitis;
Cell death in tumors.
Mechanisms of apoptosis
There are two mechanisms of
apoptosis:
Extrinsic pathway
Intrinsic pathway
Mechanisms of apoptosis
The extrinsic pathway is
activated by signals such
as Fas ligand (FasL) that,
on binding to the Fas
receptor, form a deathinducing complex by
joining the Fas-associated
death domain (FADD) to
the death domain of the
Fas receptor.
Mechanisms of apoptosis
The intrinsic pathway
(mitochondrion-induced
pathway ) is activated by
signals, such as reactive
oxygen species (ROS) and
DNA damage, that induce
the release of cytochrome
C from mitochondria into
the cytoplasm.
Diseases-apoptosis association
Apoptosis is linked to many pathologic
processes and diseases:
carcinogenesis;
cell death associated with viral
infections, such as hepatitis B and C;
neurodegenerative disorders such as
Alzheimer disease, Parkinson disease;
Congenital diseases cleft palate or cleft
(hare) lip.
Necrosis
cell death in an organ or tissue that is
still part of a living organism.
Necrotic cells are unable to maintain
membrane integrity and their contents
often leak out.
This may elicit inflammation
in the surrounding tissue.
Etiology
exogenous factors: mechanical,
biological, chemical, physical factors.
Dystrophies;
Inflammations;
Local microcirculatory modifications;
Hypoxia;
Dishomeostasis;
Metabolic imbalance;
Nervous and endocrine disturbances.
Necrosis periods.
Periods of necrobiosis
1) prenecrosis
2) period of dyeing
3) the period of death
4) post-mortem period.
Necrosis
Death of groups of
cells;
A passive process
not energy
dependent;
Elicits
inflammatory
response;
Always pathologic.
Apoptosis
Death of individual
cells
Active process
energy-dependent
Does not elicit
inflammatory
response
May be pathologic or
physiologic