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Induction of Labor
Luis Sanchez-Ramos and Andrew M. Kaunitz
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Luis Sanchez-Ramos, MD
Professor, Division of Maternal-Fetal Medicine, University of Florida Health Science
Center, Jacksonville, Florida (Vol 2, Chap 71)
Andrew M. Kaunitz, MD
Professor and Assistant Chair, Department of Obstetrics and Gynecology, University of
Florida Health Science Center, Jacksonville, Florida (Vol 2, Chap 71; Vol 6, Chaps 15,
28)
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large doses and the impurity of the extract, numerous adverse effects
were reported. Gradually, as the number of reported cases of uterine
rupture increased, pituitary extract became discredited in many
centers.
Initially, oxytocin (pituitary extract) was administered via
intramuscular or subcutaneous routes. In 1943, Page suggested that
the pituitary extract oxytocin be given in the form of an intravenous
infusion,8 and in 1949, Theobald reported his initial results with this
form of administration.9 Fourteen years later in 1953, the structural
formula ofoxytocin was discovered, and synthetic oxytocin has been in
use since 1955.
In 1968, Karim and colleagues were the first to report the use of
prostaglandins for labor induction.10 Since then, the use of
prostaglandins, in different varieties and forms of administration, has
become a common method of labor induction.11 More recently, the
synthetic prostaglandin analogue misoprostol has gained acceptance
as an effective and safe method of labor induction.12
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CONCLUSION
Labor induction appears to be a safe alternative to spontaneous labor.
Regardless of the method employed, it is essential that the patient
and her obstetrician understand the rationale for inducing labor, the
risks of the method chosen, and the options that will be considered in
case of failed induction. The goal of labor induction must always be to
ensure the best possible outcome for mother and newborn.
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