Mevalonic acid pathway

Terpenoids is a form of the compound with large structural diversity in natural products derived and
isoprene units (C5) which is coupled to a model head to tail (head-to-tail), whereas isoprene units
derived from the metabolism of acetic acid by mevalonic acid pathway (mevalonic acid : MVA). The
reaction is as follows:

Figure 1. Line acetate in the formation of IPP that is a brick forming terpenoids via mevalonic acid
(Dewick, 1997)

TERPENOID
In general, the biosynthesis of terpenoids with the three basic reactions are:
1. Formation of active isoprene derived from acetic acid via mevalonic acid

2. Pengganbungan head and tail of two isoprene units will form a mono-, seskui-, di-, and polyterpenoids sester 3. Merger tail and tail of unit C-15 or C-20 produces triterpenoids and steroids
The mechanism of reaction steps biosynthesis of terpenoids are acetic acid after activated by
coenzyme A did Claisen condensation type of acid generating acetoacetate. The resulting compound
with acetyl coenzyme A did aldol type condensation produces branched carbon chains as found in
mevalinat acid. subsequent reactions is phosphorylation, elimination of phosphoric acid and
decarboxylation produce Isopentenyl pyrophosphate (IPP) which subsequently berisomerisasi be
Dimethyl allyl pyrophosphate (DMAPP) by isomerase enzyme. IPP as active isoprene units joined
head to tail with DMAPP and this merger is the first step of the polymerization of isoprene to
produce terpenoids.
(The mechanism of reaction steps terpenoid biosynthesis is acetic acid after activated by coenzyme
A did Claisen condensation type of acid generating acetoacetate. The resulting compound with
acetyl coenzyme A did aldol type condensation produces branched carbon chains as found in
mevalinat acid. Subsequent reactions is phosphorylation, elimination of phosphoric acid and
decarboxylation produce Isopentenyl pyrophosphate (IPP) which subsequently berisomerisasi be
Dimethyl allyl pyrophosphate (DMAPP) by isomerase enzyme. IPP as active isoprene units joined
head to tail with DMAPP and this merger is the first step of the polymerization of isoprene to
produce terpenoids.)

This incorporation occurs because electrons attack of the double bond carbon atoms IPP terhhadap
of electron-deficient DMAPP followed by removal of pyrophosphate ion that produces geranil
pyrophosphate (GPP)
yes it is compound between for all compound monoterpenoid.
Subsequent incorporation of one unit of IPP and GPP by the same mechanism produces Farnesil
pyrophosphate (FPP) which is the intermediate compound for all compounds sesquiterpenoids.
diterpenoid compounds derived from geranil-geranil Pirofosffat (GGPP) derived from the
condensation of one unit of IPP and GPP by the same mechanism.
The mechanism of the biosynthesis of terpenoid compounds are as follows: