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Abstract
cause neuronal damages, apart from with intakes of brain detoxifying herbs which involves a long
term duration and is a lengthly process, or upregulations of systemic misfolded protein clearance
pathways with increased intakes of hydroxy-DHA < Torres, et al, 2015 >. As such, cancer remains
as one of the major causes of suffering, morbidity and mortality in many countries.
Mycomedicinals are effective in their curatives as they function to prevent many of cancers
intravasations, extravasations, angiogenesis and destruction against the biosystem such as through
invasions, metastasis, penetrations, and most importantly alongside the anticancer mechanisms, they
also mediate immune enhancements, immune system regulations, myeloid progenitor
differentiations, maturations and upregulations. Some of the mycomedicinals discussed have been
extensively studied in these antitumor mechanisms, functions and aspects.
Medicinal mushrooms : antitumor with effectiveness and efficacy against diseases.
Kabanoanatake, Inonotus Obliquus
Description
Common names include : Chaga and Birch Mushroom. Found growing in cold, northern regions of
the Boreal forests of Alaska, Finland, Poland, Siberia, Western Siberia, the Baltic, Eastern Europe,
Scandinavia, North America and within the Northern Taiga forests of Russia. Growth occurs upon
trunks of alder or beech, while medicinal mushrooms are only harvested from these mycelium and
fruiting bodies that bloom upon trunks of birch trees. Each only found growing on birch trees some
distance apart from the next. Only about a single woody conk of this mushroom is found growing
wild lodged within trunks of these birches, found upon a single tree out of every thousand birches.
Heights of iv to v feet in length, about x pounds and above in weight. Bears a sweet flavor and is
tumor shape in resemblance. Gnarled surface is hard, dark, cracked and charred, with an interior
cork in shades of yellow to brown tones, these have veins in shades of cream and are striated.
Bioactive constituents
Contains polyphenols, ergosterols, glucans, proteins, amino acids, minerals, ash, vitamins,
carbohydrates and fats.
Functions
Medicinal properties include antioxidative with high o ii anion scavenging activities< Nakajima et al,
2007 >, antinociceptive, being a very strong antitumor, tumor mitosis inhibitor, anti-inflammatory,
immunomodulating, upregulates the immune system increasing their activities and migrations
towards tumor locations, antiviral as it has been found to inhibited influenza and HIV type i
protease, along with being hepatoprotective.
Ailments applications
Harvested and effective in treatments of Hodgkins disease, cancers of pulmonary, lip, skin, breast,
gastric, stomach, parotid glands and rectal regions, tuberculosis, cardiac ailments, ulcers, gastritis,
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liver disease, stomach, intestinal disorders, stomachache, and parasitic removals. Also effective as a
pain reliever, tonic and blood purifier, as well as functioning as an internal and external cleanser.
In accordance to traditional chinese medicine, this mushroom functions to remove harmful wind,
smooths the flow of internal qi energy while strengthening the spirit and mind.
Himematsutake, Kawariharatake, Agaricus Brasiliensis
Description
Common names include : Cogumelo Piedade and Sun mushroom. Blooming well within sultry,
humid climates, wet with daily tropical rains; in regions such as Japan, Southeastern United States,
South America and Piedade, near Sao Paulo, Brazil. Growth occurs within lignicolous debris high
soils, alpine meadows, rain forests, mixed woods, deciduous and conifer forest, along forest edges,
and upon sandy salty seashores.
Mildly sweet in flavor it has a fleshy and convex shape, equal in hard and short stalk lengths and
golden brown vii ii cm wide cap diameter. Smooth basidiospores are small and dark brown about
v x iv m in size. They contain fruiting bodies that are large with a pileus in shades of white, yellow
or brown along with pink free lamellae that turn brown with the years.
Bioactive constituents
High in proteins, essential amino acids : alanine, aspartic acid, glutamic; steroids, ergosterol,
polyphenoloxidase < Matsumoto-Akanuma, et al, 2011 >, minerals : magnesium, phosphorous,
potassium; fibers, sodium pyruvate, sodium glutamate, laccase, ash, antitumor polysaccharides <
Mizuno, et al, 1990 >, high quantums of glucans, lectins, vitamins : B i, B ii, niacin, sugars :
glucose, arabitol, mannitol, fructose, trehalose and carbohydrates along with containing key
digestive enzymes : protease, amylase and trypsin.
Functions
Found to be immune enhancing, immunomodulatory, antioxidative, antiallergic, anticancer,
antimutagenic and antiangiogenisis. They contain quantums of beta glucan polysaccharides which
upregulates and stimulates NK, macrophages and T-cells, along with upregulating immunocyte
recruiting cytokines such as secretory lymphokines, and interleukin i and ii; ergosterol which
inhibits neovascularization and angiogenesis thus inhibiting further tumor growths and
developments, metastasis and their subsequent emergence or further reoccurrences.
Ailment applications
Medicinally effective in treatments such as HIV, hepatitis, bacterial septicemia, alopecia,
hepatoprotective effects thus preventing liver toxicity, reduce blood pressure, hyperlipidemia,
lowering of cholesterol during states of hypercholesterolemia, aids in reversal of arteriosclerosis,
rheumatoid arthritis, diabetes, systemic lupus, atopic dermatitis and dermatitis.
It is effective against countering the effects of excessive physical and emotional stress, osteoporosis,
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peptic ulcer, polio, malignant ulcers of the larynx, Ehrlichs ascites carcinoma, sigmoid colon cancer,
ovarian cancer, breast cancer, gynecological cancer and lung cancer. Protects against radiation and
chemotherapy effects.
Traditional chinese medicinal properties include it as being of neutral temperature.
Agaricus bisporus
Description
Also known as the : White Button Mushroom. Temperatures between xxii xxv C is the optimal
growth climate as growth is inhibited at high temperatures of xxxv C and above. Growing wild in
grasslands of Pennsylvania, most regions of United States of America, Europe and India.
Basidiomycetes that are edible, common in American and Italian cuisine these are small, short with a
cylindrical vi cm stem, stout and about ii- iv inches in overall diameter. They are white, fleshy and
resemble little buttons in appearance. Ranging in shades from white to light brown tones. Consisting
of a pale grey to brown shades of button caps with radiating narrow gills beneath. Crowded gill
shades change with the years, from a pretty pink hue at initial blossoming they progress to shades of
reds and brown tones before finally turning white at the edges and darkish brown in colors.
Consisting of many tiny iv.v v.v x v vii.v m, ovoidal to roundish spores producing prints of dark
brown tones.
Bioactive constituents
Nutritionally these are low in calories and fat, containing essential vitamins such as provitamin d ii,
vitamin c, phenols < Mami, ei al, 2013 > high in antioxidants with high superoxide free radicals
savaging actions, glucans, ergosterol, vitamin D, lypopolysaccharides, exopolysaccharides <
Mahapatra, et al, 2013 >, glycoproteins, phenols, proteins, high antioxidative falvonoids,
fucogalactans, fucomannogalactans, mannogalactans, sodium, phosphorus, essential vitamins,
potassium, and minerals, pyrocatechol, conjugated linoleic acid, protocatechuic acid and 2aminophenoxazine-3-1.
Functions
Found effective as an antioxidant with high ferrous ion chelations and superoxide scavenging
abilities < Babu, et al, 2013 >, effective against cancers as they consist of aromatase inhibitors,
antiestrogenic factors, antiproliferative Gal 13GalNAc , along with immunostimulating,
immunomodulating and dendritic cell enhancing functions, upregulations of lymphocytes, T cells,
NK cells, B cells, increases cytokines : interleukin < IL >ii, x, xii, TNF and interferon gamma
expressions, enhances differentiation of monocytic THP-cells into functional macrophages,
enhances phagocytosis and is an effective anti hepatic steatosis.
Ailment applications
Medicinal properties include treatments for facilitating blood clotting as they enhance
v
hemagglutination, autoimmune diseases such as rheumatoid arthritis, cirrhosis and sepsis due to
their anti inflammatory heterogalactan effects, as a mild analgesic due to antinociceptive effects,
against cancers mainly of the breast and in hepatocellular carcinomas as they contain d glucans
that are cytotoxic towards these cancerous hepatocytes and anti viral, antifungal and antimicrobial
action against pathogenic bacteria infections such as Staphylococcus aureus.
Tochucaso, Cordyceps sinensis
Description
Common name : Caterpillar Mushroom. Growth occurs at high altitudes within cold alpine habitats
with low oxygen and temperatures. Endoparasitoids whereby parasitic growth occurs upon the
backs of Lepidoptera ghost moth larvae in the form of threadlike hyphae after spreads from spores.
After winter v years later, perithecial stroma then emerges from the soil after the host is lysed and it
is this portion that contains most of the medicinal properties. However due to the nature of its
growth and uncertain locations of emergence, most medicinal fungi of this variety are lab cultivated
by mycelial fermentation. Commonly found naturally occurring in cold mountains of Tibet,
Himalayas, Nepal, Bhutan, and some parts of asia.
Ascomycete fungi are long and orange brown, some are straight others are curved. Has a thicker
stem like base tubular endosclerotium portion and a slimmer dark brown iv x cm upper long and
slim fusiform, clavate or sublanceolate stroma portion. Granular fertile head of the stroma contains
ordinally arranged ostioles of the embedded ovoid perithecia. Growth of these fungi species occurs
by disseminations of their spores, some land upon the month larvae they prey upon while others are
ingested when the larvae feed upon the fungi. Subattenuated at each end portion, these
multiseptate, hyaline, filiform ascospores are tiny with lengths of just about v - xii m.
Bioactive constituents
Containing antioxidants, protein, carbohydrate, fiber, fat, ergosterol, vitamins E, K, B i, B ii, B xii
along with trace elements of iron, copper, antitumor selenium, aluminum, titanium, magnesium,
calcium, sodium, potassium, manganese, chromium, silicon, nickle < Holliday, et al, 2008 > and ash.
Bioactive components include polysaccharides such as H2O2 preventive antioxidative CME-i <
Wang, et al, 2011>, cordycepin which prevents senescence from genotoxicity < Gu, et al, 2013 >,
cordycepic acid < Lee, et al, 2012 >, polysaccharides ergosterol, adenosine, guanosine, adenine,
uridine, hypoxanthine, mannitol and uracil.
Functions
Effective as an analgesic, strong antioxidant with free radical scavenging effect, antioxidative which
aids in alleviating free radical induced stressors from hypoxic conditions < Singh, et al, 2013 >, while
preventing cells from undergoing apoptosis as the free radicals are downregulated along with
apoptotic genes thus decreasing the pro apoptotic signals and keeping cells viable during states of
hypoxia or ischemia < Buenz, et al, 2005 >; immune modulator, anticytotoxic activity, antitumor
activity, metastasis inhibition, tumor antiproliferation < Ko, et al, 2013 >, cytotoxic activity <
Matsuda, et al, 2009 >, inhibits proliferations of glomerular mesangials, antiproliferation activity, cell
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proliferation inhibition, gene expression inhibition, hemolysis inhibitory activity, lipid peroxide
formation inhibition, natural killer cell inhibition and tumor necrosis factor inhibition and as an antiinflammatory.
As it balances the immune system during an immunocompromised state, upregulations of the
immune system can also occur as it can upregulate and stimulates macrophages < Koh, et al, 2002 >,
enhances monocyte maturations, upregulates and activates immature dendritic cells < Li, et al, 2009
> while increasing their phagocytic activities < Khan, et al, 2010 > and synthesis of interferons TNF
, IL i , IL vi, and IL xii p70.
Ailment applications
Medicinal properties include upregulations of ATP productions along with increasing stamina <
Herda, et al, 2008 > thus aiding in sports and weakness after long periods of chronic ailments, aids
also in cachexia conditions of cancers; erectile dysfunctions, lifespan extensions < Panda, et al, 2010
>, respiratory disorders, lowering cholesterol, obesity as cordycepin inhibits the accumulations /
formations of adipocytes < Takahashi, et al, 2012 > strengthening the kidneys and liver, renal cell
protective while aiding in attenuating chronic kidney disease < Zhong, et al, 2011 >, nephropathy <
Zhao, et al, 2013 >, hepatocyte protection, cerebral ischemia prevention < Liu, et al, 2010 >, reduces
cerebral reperfusion injury, improves cerebralvasculature, improves cardiovascular, diabetes as it
regulates insulin sensitivity, cancer preventive and curative, steroidogenesis modulator,
upregulations of xvii - estradiol and aromatase < Huang, et al, 2004 >, reducing high plasma
cholesterol, inhibits excessive clot formations, as a tonic, hypotensive, vasorelaxant, anti
inflammatory < Shin, et al, 2009 >, rheumatoid arthritis < Noh, et al, 2009 >, leukopenia < Liu, et al,
2008 > and enhancing the immune system. Effective against pathogens and clears them from the
system due to it's antiviral, antibacterial, larvicidal and antifungal actions.
Traditional chinese medicine < tcm > has been using this mushroom for many years, it is classified as
sweet and warm, beneficial to the kidney and lung meridians while strengthening to the yang aspect
while it nourishes the yin. Apart from the treatment of diseases and ailments, it also helps in the
restoration of vitality during illness, fatigue < Koh, et al, 2003 > and exhaustion.
Kawaratake, Coriolus versicolor
Description
Common names : Trametes versicolor and Turkey Tail mushroom. Growth occurs often during
winter, is favored upon wooden stumps, branches, logs and dead or rotting logs, often growing wild
within woods and forest on trees such as the White Pine and Birch. Found in deciduous, hardwood
tree zones within regions of Europe, North America, Northern Hemisphere and china.
A Basidiomycotina species and an obligate aerobe with a velvety texture. Appearance resembles that
of a ball of puff, turkey's tail or the cerebral structure. Dark brown in color with white, wavy rims, i
iii mm thick, fleshy and rough, growing in a concentrated and compact turf of tiers. Some fruiting
bodies grow singly and appear like flat viii x v x 0.v i roundish, semi circular, ovoidal or triangular,
thin seashells.
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Apical portion has a variety of color tones ranging from shades of red, rust, yellow, green, gray hues
of light to dark brown and appearing in concentric ring regions. Very thin and fine hairs coat certain
parts of the mushroom. While many round pores in white and shades of faint brown hues appear at
about a frequency of ii v pores / mm, their spore sprints are in shades of white. Reproduction is
carried out by wind disseminations of fine white, cylindrical or oblong tiny iv vi x ii ii.v m
spores.
Bioactive constituents
Contains glucose, galactose, frucose, xylose, rhamnose and mannose along with the essential amino
acids valine, leucine, serine, glycine, threonine, aspartic acid, glutamic acid and alanine. Along with
species unique immunomodulating, anti cancer, antimetastatic and carcinogen preventive <
Kobayashi, et al, 1995 > polysaccharide krestin < PSK > < Kim, et al, 2013 >, polysaccharide K,
verisicolor polysaccharide, tumor growth and prolieferation inhibiting polysaccharopeptide < PSP >
< Brown, et al, 2012 >, immunopotentiating polysaccharopeptides < Cui, et al, 2003 >, beta-1,4glucan and polysaccharide peptide.
Functions
This polypore mushroom has been found to upregulate and stimulate the immune system < Chu, et
al, 2002 > and complement cascade, enhancing both the innate and adaptive immune systems,
upregulating NK, T, B cells, monocytes and macrophages, increasing IL I < Spelman, et al, 2006 >,
IL 2, 6, TNF alpha synthesis, upregulate synthesis and expressions of cytokines, interferons, Ig G,
inhibit tumor growths, prevents angiogenesis, suppresses oncogenes, inhibit metastasis through
preventing the process of cellular adhesion, migration and invasion, both intravasation and
extravasation, inhibits matrix metalloproteinases for preservation of cellular matrix integrity and
enhance apoptosis of transformed cells.
Increasing hypothalamus mediobasal neurons discharge frequencies mediated by polysaccharide
peptides < Guang-Di, et al, 1996 >, protective towards hepatocytes, it also has strong antioxidative
effects as it reduces cerebral lipid peroxidation and eliminates free radicals such as nitric oxide,
while preventing neuronal apoptosis brought about by neurotoxic nitric oxide bursts during
neurodegenerations < Kim, et al, 2011 >, along with upregulating productions of free radical
scavengers superoxide dismutase and glutathione peroxidase < Chen, et al, 2013 > while preventing
superoxide anions from forming < Kim, et al, 1999 >.
Ailment applications
Medical properties include treatments of cerebral ischemia, cerebral hypoxia, dysfunctions in
cerebral electrical activity at hypothalamic region affecting estrogen regulations, energy or appetite
control, increasing of appetite, endurance, energy, strength and stamina, improves chronic fatigue
syndrome, cardiac ischemia, pulmonary disorders, liver disorders, phlegm, impetigo, neoblastoma,
colorectal and gastric cancer, melanoma, lung cancer, sarcoma increasing chemotherapy
effectiveness; decreasing chemo / radiotherapy pain and side effects and prevents excessive clot
formations.
Effective as an antipathogen with antiviral actions against HIV type i, HPV, HSV i and ii, hepatitis,
viii
Epstein-Barr virus <EBV>, Coxsackie virus, Varicella-zoster virus, Barmah forest virus, influenza,
most viral infections, upper respiratory, digestive tract and urinary infections and antifungal against
ringworm.
Yamabushitake, Hericium Erinaceus
Description
Common names : Hedgehog Mushroom and Lion's Mane. Found in countries such as North
America, Japan, Korea and China. Shaped like a wing, resembling cerebral white matter tracks in
appearance with many beautiful, slim, long, cascading tendrils hanging down together from logs and
tree trunks. These slim, spike shaped spines are about i cm in lengths. Some spines grow together
forming a beautiful array of heart shaped wing structure, while other spines grow in accumulated
clusters of many of these feathers stacked and overlapping in clumps. Growth often occurs during
fall or the later months of summer season, appearing upon conifers or broadleaf hardwood trees or
such as it's favorite tree is the American Beech.
Bioactive constituents
Composed of high protein concentrations and moderate oxalate quantums. Bioactive components
include blood brain barrier permeable fruiting body's hericenones, terpenoids polysaccharides,
phenols, lectins, proteins and mycelium's erinacines H, I < Lee, et al, 2000 >. Along with
antioxidative D-arabinitol, threitol, heteropolysaccharide 1, 3, beta glucans, tetracosanic acid,
stearic acid, palmitic acid, behenic acid and a variety of other immunomodulating, T cell,
macrophages and dendritic cell enhancing along with increasing their synthesis and expressions of
cytokines IL 1 and TNF , < Khan, et al, 2013 > immunomodulating glucoxylan, heteroxyloglucan,
glucoxylan protein complexes and galactoxyloglucan protein complexes < Lindequist, et al, 2005 >;
anti cancer polysaccharides : 2hydroxymethyl5hydroxyethyl- pyranone, 4-chloro-3,5dimethoxybenzoic methyl ester, 4-chloro-3,5-dimethoxybenzoic-O-arabitol ester, 4-chloro-3,5dimethoxybenzoic acid and 6-methyl-2,5-dihydroxymethyl--pyranone.
Neuronal effects
Discovered to be blood brain barrier permeable and upregulates nerve growth factor < NGF >
secretions by glia cells within hippocampus through enhanced expressions of c-fos gene along with
upregulated phosphorylations of c-Jun N-terminal kinase < JNK > pathway < Mori, et al, 2008 >.
NGFs are also upregulated by enhancing their mRNA expressions due to hericenones and
diterpenoid erinacines < Ma, et al, 2010 >. When cholinergic neuron enhancing NGF quantums are
high; neurite growths, neuronal synthesis, growth, differentiations and viability occur. When low,
diabetes, neurodegenerative ailments such as Alzheimer's disease, dementia and cardiovascular
complications result.
NGF synthesis are increased by astroglia and neurons at hippocampus and locus coeruleus;
increases the production of myelin, enhances nerve regenerations < Wong, et al, 2010 >, enhancing
neurite extensions, enhancing firing activities of hippocampal CA 3 mossy fibers, increases the
quantum of neurotransmitters synthesized, prevents amyloid plaque formations, attenuates
peripheral neurological dysfunctions, prevents apoptosis of cholinergic neurons while healing them.
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The high antioxidant activities protect the entire cerebral structure from oxidative stress induced
injuries as well such as neuronal apoptosis brought about by cerebral reperfusion injuries, reduction
of inflammatory interleukins, downregulates endoplasmic reticulum stress, preventing and healing
neuronal injuries brought about by strokes or ischemia. Erinacine is also a primary afferent neurons
-opioid receptor agonist, thus upon receptor activations, it decreases sensations of pain, functioning
as an analgesic, lowers mood perceptions, and exerts sedative effects of reduced consciousness and
motor control.
Functions
It has also been found to reduce toxicity from beta amyloid peptide accumulates in Alzheimer's
disease, Parkinson's disease < Kim, et al, 2014 >, improve cognitive disorders, speed up the wound
healing process, gastric mucosa ulcers < Wong, et al, 2013 > hypoglycemic effect aiding in
treatments of diabetes, neuroprotective, cardioprotective, hepatocyte protective, enhance
hemagglutinations, hypolipidemic, lowering of blood pressure as it inhibits angiotensin 1 converting
enzyme, strong antioxidant along with free radical scavenging, antimicrobial against Salmonella
spp , Shigella spp, Bacillus spp, Plesiomonas spp and Enterococcus spp.
Ailment applications
Medicinally effective in the treatments of dementia, Alzheimer's disease, Parkinson's disease,
declines in spatial memory, dysfunctions in visual recognition memory, cognitive impairments,
neurodegenerative conditions, depression, anxiety, peripheral nerve regeneration, stroke, ischemia <
Lee, et al, 2014 > ischemic reperfusion injuries, myocardial infarction, cardiovascular ailments,
thrombosis, aneurysms, high blood pressures, hypotension, anti inflammatory, liver disease, cancers,
imbalances of the immune system, dysfunctions in lipid metabolism, lowers triglycerides, lowers
cholesterol and in treatments of gastric ulcers.
Maitake, Grifola frondosa
Description
Common names : Dancing mushroom and Signorina mushroom. Found growing wild in countries
such as Northeastern Japan, North America, Italy, Europe and China. Often found in clusters
growing wild within northern temperate forest and woods upon oak tree at their bases, during the
seasons of autumn and fall. Other trees that they grow upon include conifers, pines, persimmon
trees, larch, beech, elm, chestnut, sycamore and maple. Growth has also been discovered along
roots, dead trees, logs and stumps.
A polypore, basidiomycete multiple-capped mushroom with i to iii pores per mm upon the decurrent
hymenium with an offset or indistinct curled or semi ovoidal top cap. It has a white spore print.
Cluster of fruiting bodies are big, growing till about 100 cm and weighing up to xx kg. Wave
marginated caps are about lengths of ii - vii cm.
Blooming in shades of light tan, tan, grey or brown these hues become darker if growth occurs
beneath direct sunlight, their curled edges are rimed in pure white with undersides appearing in
shades of white. Internal slim tubes beneath the caps point ground wards, their inner lengths are
x
about iii mm and are visible as fine pores upon surfaces, growing smaller, finer and more tapered
near the circumference edges. Creamy white axial stalks are branch like, rather short and non
visible from the top view when covered by waves of clustered caps, growing stronger and tougher
with the years.
Antioxidants
High in superoxide and free radicals scavenging, high reducing capacity, strong hydrogen donating,
hydrogen abstraction inhibition, metal-chelating, transition metal bindings, stimulations of chain
initiation, terminations of free radical chain reactions, peroxides decomposing antioxidants such as
ferrous ions chelating phenols, superoxide anion scavenging < Yeh, et al, 2011 > and heavy metal
chelating polyphenols gallate and BHT, antitumor, antibacterial, antihypertensive, antirheumatic,
antiallergic, and anti-inflammatory phenols, alpha tocopherol, beta carotene, free radical scavenging
ascorbic acid and transition metal chelating, free radical scavenging, glutathione and superoxide
dismutase antioxidant maintaing flavonoids.
Bioactive constituents
High in vitamins such as Niacin, B i, B ii, B iii, B vi, B xii, C, mushroom or fungi specific
ergosterol / provitamin D2, minerals magnesium, potassium, calcium, folic acid, unsaturated fatty
acids, phosphatidylserine and phospholipids, protein, protease Lys-N; insoluble, various amino
acids, cell wall rodlet forming and water surface tension lowering, hydrophobin HGFI < Yu, et al,
2008 > and proteopolysaccharides.
Consists of free radical scavenging and potent anti tumor polysaccharides, lectins with high binding
affinity towards cellular carbohydrates thus preventing tumors from forming cellular aggregations
and high fibers.
Other bioactive chemicals within include anti tumor grifolan, alpha glucosidase inhibitor, protein
stabilizing trehalose synthesis and phosphorylation mediating trehalose synthase < Saito, et al, 1998
>, mycelia and fruiting body derived, macrophage and T cells activating, tumor inhibiting, NK
secretions of TNF alpha expression upregulating, glucans exert high immunopotentiating and
immunomodulating effects, strong antitumor < Rajamahanty, et. al, 2009 >, NK and dendritic cell
upregulations, antibacterial and anti fungal effects these are contained within polysaccharide Dfraction < Kodama, et al, 2002 > : beta- 1,6 glucan and beta-1,3 glucan, purified and more potent
than it's carcinostatic D fraction precursor from which it is derived, studies have found D-fraction
to be effective in cancer regressions as well as in the antiproliferations and growth inhibitions along
with their subsequent declines in prostate cancer cell lines < Pyo, et al, 2008 >, MD-fraction :
soluble beta-<1,3> <1,6>-glucan, curdlan < Masuda, et al, 2011 >, X-fraction : beta- 1,6 glucan and
alpha-1,4 glucan, blood glucose regulating SX-fraction, inactivation of and inhibition of herpes
simplex virus type-1 replication : protein NH <2>-REQDNAPCGLN-COOH and neuroactive
MEK/ERK1/2 pathway stimulating lysophosphatidylethanolamine.
Neuronal effects
Discovered to increasing NGF upregulations within the central nervous system and peripheral
nervous systems which activate key cell signaling pathways : MEK/ERK i/ii and P xiii K/Akt
xi
stimulating branchings, neurite extension outgrowths and elongations through neuritogenesis <
Seow, et al, 2013 >, these mushroom extracts can also function as agonist, mediating bindings to the
same NGF tyrosine receptor : TrkA which initiates the neuritogenesis cascade pathway. If receptors
expressions were upregulated as well there would be a corresponding neuritogenesis increased
enhancements triggered by both NGF and mushroom extract bindings. Extracts also enhances
expressions of neuron specific proteins, is neuro protective, increasing neuronal survivals,
stimulating neuronal stem cell growths, developments and differentiations.
Functions
Studies have also found that maitake extracts especially their polysaccharides have the strongest
antitumor, antimetastasis < Masuda, et al, 2008 >, antiproliferative effect upon tumor cells, cancer
preventive and immunomodulatory activity as compared to other medicinal mushrooms. It enhances
both the innate and adaptive immune system, stimulating both cellular and humoral immunity,
initiates the complement cascade, regulates and modulates the immune system, upregulates
phagocytosis of monocytes and neutrophils, upregulating IgA expressions, increases cellular
proliferations of macrophages, monocytes, NK, T < Deng, et al, 2009 >, Tc, Th i, dendritic cells and
antigen presenting cells, increases ratios of Th / Ts cells, increases expressions of GM-CSFR,
upregulates lymphocyte and NK cell activities, enhances NK cell toxicity activations, potentiates Th
cell activities, enhances and upregulates granulopoiesis.
Maitake extracts have also been found to increases the production of cytokines by macrophages,
upregulates synthesis of antiviral, cell growth / differentiation regulating, dna fragmenting which aid
in downstream signaling cascades that regulate cell cycle pathways and antitumor interferons,
lymphokines and interleukins : macrophage activating INF gamma, stimulation of IL i secretions,
NK activating IL ii, IL vi, IL x, IL xii < Vetvicka, et al, 2014 > NK cell activating IL xii induction of
apoptosis in cancer cells; slows, declines and inhibits tumor growths and proliferations along with
initiating hemorrhagic tumor cell necrosis and tumor lysis by enhancements of NK's perforin
bindings, prevents metastasis through NK cell proliferations and suppression of cellular adhesion
mediating E-selectin and ICAM i expressions and angiogenesis through vascular endothelial growth
factors inhibitions.
Extracts prevent the initial transformations of healthy cells to tumor subtypes, moderate
cyclooxygenase inhibitions, increases antiviral cytokine and macrophage activating TNF alpha < Yu,
et al, 2009 > and inhibits virus some of which are of the cancer initiating oncogenic variety.
Antiviral effects
MD fractions are effective against HIV while decreasing accompanying opportunistic infections in
patients, HSV-i as replications and viral penetrations are inhibited, along with inhibiting
accompanying HSV-i induced neovascularization, HSV i has also been implicated in the further
developments of Alzheimers disease in entities with the genetic predispositions, thus with these
extracts that can control and downregulate viral replications, the accompanying risk of developing
beta amyloid infiltrates characteristics of alzheimer's disease of which theses plagues have a common
protein sequence with HSV i < Fernandes, 2014 > is also lowered; stomal keratitis and blepharitis;
hepatitis B, influenza, hay fever, listeriosis and many various strains of viral induced infections.
Ailment applications
xii
Mycomedicinal treatments include increasing sensitivities of insulin, lowering of blood sugar levels
in diabetes, prevents formation of advanced glycosylation end < AGE > products < sugar
attachments to lipids / proteins > and their additional cross linkage accumulates with other proteins /
adipocytes / hemoglobin in diabetics with high adipocytes concentrates and high blood sugar which
is accompanied by increased quantums of reactive oxidative species and free radicals as well; further
exacerbating AGE formations.
AGE also coagulates the cardiac and kidney regions, inhibiting the proper filtrations of blood and
impairing kidney functions with excessive accumulates. Glycations can also circulate within the
vessels and arteries and may end up being loaded within the cerebral structure leading to ailments
such as impaired cerebral blood circulations, strokes, cerebral ischemias, neurofibrillary blockages
and tangles along with initiation of Alzheimers disease.
Thus when AGE complexes are inhibited from forming through blood sugar and adipocyte lowering
functions, these extracts can prevent occurrences of atherosclerotic plaque accumulates, glycations
coagulation of vasculature, vascular damages, endothelial dysfunction, arterial stiffening, fibrosis,
loss of cardiomyocyte and vascular muscle tones, hypertension, strokes, cerebral impairments,
increased oxidative stress, impaired smooth muscle relaxing of vessel walls by AGE inhibitions of
endothelium's nitric oxide or prematured agings as glycations tend to accumulate beneath the skin
forming lots of glycated cross linkages causing prematured wrinklings, due to skin's extensive
vasculature and capillary networks whereby they pass through interacting with the surrounding
structures.
Interactions of AGE and RAGE cell receptors also bring about an entire negative cascade of
ailments as they affect gene expressions and signaling pathways such as arterial stiffness, increasing
inflammations and mediation of cellular injuries, apoptosis, tissue damage and autoimmune
conditions. Thus extracts are also cellular protective in diabetics susceptible to high AGE quantums,
improving endothelial, vascular, arterial and cardiovascular conditions, structures and functions.
Pyridoxal-5-phosphate in vitamin B6 also aids in preventing AGE formations, DNA damages from
the free radicals generated by AGE, along with inhibitions of excessive platelet aggregations.
Effective in treatments of Alzheimers disease, dementia, neurodegenerations, stroke, cerebral
ischemia / hypoxia, cerebral reperfusion injuries, regenerations of injured neurons, immune
enhancements, cancer and the prevention of its recurrence; lessens the toxicity of chemotherapy
along with it's pain and various side effects, while increasing it's effectiveness against tumor
growths.
Effective in treatments of polycystic ovary syndrome as it induces and enhances ovulation, enhances
wellness and vitality, chronic fatigue syndrome, stress reductions, hypertension < Talpur, et al, 2002
> as it decreases and prevents high blood pressure, attenuates high cholesterol, hyperlipidemia,
decreases high vascular adipocyte accumulates; obesity as it increases lipid metabolisms, inhibits
triglycerides accumulations < Minamino, et al, 2008 > and inhibits transcription factor peroxisome
proliferator activated receptor gamma expressions, one of the regulators in the signaling cascade
thus preventing B2C1 pre white adipocytes from differentiating into matured, triglyceride storing
white adipocytes; fatty liver disease, hepatocyte protective for the treatments of liver ailments,
ulcerative colitis as it is improved by high -glucans concentrations, atherosclerosis < Mori, et al,
2008 >, improves the cardiovascular system, cardio protective from reductions in E-selectin thus
xiii
decreasing adhesive bindings of monocytes to aortic vascular surfaces < Martin, 2010> extracts also
reduces NF- b bindings thus inhibiting iNOS expressions along with inhibiting COX i and COX
ii, atherosclerosis, reduces chronic inflammatory conditions, overall cellular healing and necrosis
preventions of traumatized injured cells and tissue.
Mannentake, Rokkakushi, Reishi
Description
Common name : Ganoderma lucidum. Hot and humid subtropical regions favor growth. Growing
wild in the forest and woods of nature near surface soils or soils with buried roots beneath. Regions
of growth occur upon logs, deciduous trees trunks, stumps, dead wood and plants. Growth occurs
upon willow, magnolia, plum trees, elm, oak, locust, maple and sweet gum trees. Found in North
and South American, Europe, Japan, Korea and South China,
A polypore basidiomycetous with double walled basidiospores. Large, kidney-shaped, brilliant,
glossy, shiny thick walled pilocystidia embedded in an extracellular melanin matrix, dark brown to
brown soft and flat exterior with a cork-like woody, polysaccharide chitin containing outer wall that
is fibrous, tough and relatively hard in texture.
Its fruit is in a variety of hues such as shades of red white, blue/green, yellow, black and purple in
color. Some are shaped like hearts others have many lobes while some are more ovoidal.
There are six varieties classified by their various colors, white : Shiroshiba, hot in flavor improving
lungs and the various associated ailments; blue : Aoshiba, sour in taste it aids the eyesight, functions
as a nerve calming tonic and aids in liver dysfunctions; red : Akashiba, bitter in taste it enhances the
memory, improves vitality and internal organ health; yellow : Kishiba, sweet in flavor it enhances
spleen functions; black : Kuroshiba, salty in taste, it improves, enhances and protects the kidneys;
and purple : Murasakishiba, sweet in flavor it improves facial complexions and functions of joints,
musculatures and ears.
Neuroactive constituents
Neuroactive neurite growth enhancing and antioxidative triterpenoids include : methyl ganoderic
acid A, ganoderic acid Me, ganoderic acid S i, ganolucidic acid A, 7-oxo-ganoderic acid Z; 4,4,14trimethyl-5-chol-7,9-dien-3-oxo-24-oic acid and lucidenic acid.
Bioactive constituents
Contains high fiber, protein, immune system function stimulating and hemagglutination enhancing
lectins, carbohydrate, fat, ash, vitamins and minerals, potassium, calcium, phosphorus, magnesium,
manganese, iron, zinc, copper, strontium; immunopotentiating, antitumor, antioxidant and
antimutagenic germanium and vitamins A, B i, B ii, C, D.
High in lysine and leucine along with all essential amino acids, silica, sulfur, saponin, nucleosides: 5deoxy-5' methylsulfinylad-nosine, adenosine; laccase < Lyashenko, et al, 2011> and sodium.
xiv
Bioactive molecules include antioxidant, immunomodulating along with macrophage and dendritic
cell maturation initiating < Lin, et al, 2009 >, hepatoprotective, wound healing < Lin, et al, 2014 >
and immunosuppressive mycelia isolated peptide LZ-viii, fruiting body isolated antifungal
ganodermin protein, lipid-lowering and antioxidant terpenoids, triterpenoids < Ma, et al, 2011 >:
renal antioxidant defense upregulating and renal cell protective methanol, ganoderic acids A and B,
ganoderic acid C ii, C vi, D, F, G, H, J, K M i and antitumor, prostate cancer effective ganoderic
acid DM < Johnson, et al, 2014 >.
Functions
Ganoderic acids function as antitumor, antimetastasis < Radwan, et al, 2013 >, low-density
lipoproteins, blood pressure and triglyceride lowering : high tumor cytotoxicity, A which also
prevents tumor cell adhesion, migrations and subsequent invasions, AP 1 and NF-B transcription
factor inhibitions thus preventing urokinase type plasminogen activator secretions; B, AM i,
basophils histamine release inhibition, thus preventing excessive / chronic inflammations /
anaphylaxis reactions : C, C ii, C vi, direct tumor cytotoxicity and inhibitions of histamine release :
D; DM, E < Kikuchi, et al, 1986 >, F, G, H, I, J, K, L and antitumor T that inhibits both invasions
and metastasis whilst preventing matrix metalloproteinase < MMP > ix expressions < Chen, et al,
2010 > ; immune upregulating, inhibitions of tumor cell growth, extracellular matrix degradation
initiators, gelatinase MMP ii, ix downregulations leading to declines in invasion, angiogenesis and
metastasis inhibitions : Me; Mh, R, S, tumor cell extracellular matrix adhesion inhibition, growth
suppression; inhibition of invasions, metastasis < Chen, et al, 2013 > and enhancing genes regulated
by transcription factor NF-B which gives rise to tumorigenesis, via preventing its nuclear
translocation and thus the eventual resulting metastasis, invasions and angiogenesis inhibitions;
matrix metalloproteinase ix inhibitions; cell adhesion, migration, angiogenesis enhancing and extra
cellular matrix cleaving serine protease urokinase type plasminogen activator downregulations and
inhibitions of iNOS expressions which produces angiogenesis mediating endothelial growth factor
nitric oxide.
These inhibitions occur through upstream B breakdown inhibitions and inflammatory
downregulations through phospholipase A ii inhibitions: T; U, V, W, topoisomerase inhibitor and
tumor cell apoptosis initiator : X; Y, Z ; 12-hydroxyganoderic acid D, 12-acetoxyganoderic acid D,
3-acetylganoderic acid H, 12-acetoxyganoderic acid F, ganoderenic acid B, D, E, F, H < Kikuchi, et
al. 1985 >, K, elfvingic acid A, lucidumol B, methyl lucidenate G, 3-hydroxy-4,4,14-trimethyl7,11,15-trioxochol-8-en-24-oic acid, 7,15-dihydroxy-4,4,14-trimethyl-3,11-dioxochol-8-en-24-oic
acid, 12,15-bis< acetyloxy >-3-hydroxy-7,11,23-trioxolanost-8-en-26-oic acid, 12-hydroxy3,7,11,15,23-pentaoxo-lanost-8-en-26-oic acid and terpenoids : lucidone C < Nishitoba, et al, 1986 >,
lucidenic acid A < Nishitoba, et al, 1988 >, tumor cell apoptosis and growth inhibition lucidenic acid
B, C, D, D i, D ii, E, E i, E ii, F, G, L, N and ganolucidic acid A, B, D, along with triterpenoids :
ganoderiol A and B < Sato, et al, 1986 >, ganodermatriol, ganodermanontriol and neuronal survival
enhancing methyl ganoderic acid A, B < Nishitoba, et al, 1985 >, C and C ii.
Other triterpenoids include ganolucidic acid A, B, D, lucidenic acid A, N, D, E, F, ganoderenic acid
B, D, K, Elfvingic acid A, 12-hydroxy-3,7,11,15,23-pentaoxo-lanost-8-en-26-oic acid, 12hydroxyganoderic acid C2, 3-hydroxy-4,4,14-trimethyl-7,11,15-trioxochol-8-en-24-oic acid, 7,15dihydroxy-4,4,14-trimethyl-3,11-dioxochol-8-en-24-oic acid, 12,15-bis(acetyloxy)-3-hydroxy7,11,23-trioxolanost-8-en-26-oic acid, 12-hydroxyganoderic acid D, 12-acetoxyganoderic acid D, 3xv
acetylganoderic acid H and 12-acetoxyganoderic acid F < Yang, et al, 2007 >.
Extracts also contain anti-inflammatory, chemopreventive, tumoricidal antitumorigenic and
hypolipidemic terpenes : < monoterpene > menthol, < tetraterpene > -carotene, anti-invasion and
antitumor lucidenic acids A, B, C and N < Weng, et al, 2007 >, ganoderals, ganoderiols, lanosterol,
squalene; tumor proliferation and metastasis inhibitor, lanostane.
Consisting of antitumor long chain fatty acids that induce tumor apoptosis while inhibiting their
proliferations and reductions of inflammatory TNF synthesis : heptadecanoic acid, nonadecanoic
acid, octadecenoic acid and hexadecanoic acids < Fukuzawa. et al, 2008 >; lipid pyrophosphatidic
acid, provitamin, anti aging cell cycle replication lifespan enhancing ergosterols : ganodermasides C
and D < Weng, et al, 2011 >, they are also vitamin D2's precursor the end product after exposures
and reactions with ultraviolet rays; fruiting bodies isolated glucosidase reversible inhibitor SKG-3
with extremely high efficacy and specificity; clotting duration prolonging metalloprotease; steroids,
nucleotides adenosine and guanosine along with their derivatives, nucleosides, glycoproteins; antiinflammatory, hypoglycemic, antiulcer, antitumorigenic and immunostimulating xylose; mannose,
galactose and fucose containing heteropolymers polysaccharopeptides along with sugars : D glucose,
D glucuronic acid and D glucuronolactone.
Consisting of polysaccharides that are strong antitumors < Sone, et al, 1985 >, antiinflammatory <
Liang, et al, 2014 >, stimulating natural immunity against tumors through enhancing of their
cytokine secretions, antibodies and immune reactions along with maturations < Liao, et al, 2013 >,
enhancing T lymphocytes cytotoxicities against tumors < Li-Zhen, et al, 2003 >, enhancing
maturations of B cells into antibody secreting plasma cells, such as the functions carried out by
stimuli occurring with an F iii fraction < Lin, et al, 2006 > and inducing the maturations of
interleukin secreting, antigen presenting dendritic cells < Chan, et al, 2007 >.
Found to be hypoglycemic through increasing insulin secretions < Zhang, et al, 2004 >, high in
antitumor activities < Sun, et al, 2013 >, tumor apoptosis initiating < Liang, et al, 2014 >, inhibiting
the adhesion of tumor cells to the cellular fibrinogen outer cellular layers and enhancing NK direct
cytotoxicities < Zheng, et al, 2011 >; along with inducing the maturation of monocytic precursor
cells into dendritic cells < Chan, et al, 2008 >, protecting otherwise short lived neutrophils with an
antiapoptotic effect that can prolong and enhance the immunological response against tumors or
pathogens, the activities of these neutrophils are also improved such as inflammatory moieties
secretion and an accelerations in their phagocytotic abilities which would aid in a better attack
against these cancer cells and pathogens < Hsu, et al, 2002 >, PS-G enhances neutrophil phagocytic
abilities thus upregulating immunity and increases their chemotaxis capabilities as well < Hsu, et al,
2003 >.
These immunoenhancing polysaccharides include : acidic polysaccharide GL-A fraction < Seito, et
al, 1989 >, antitumor apoptosis initiating, p38 activating along with intracellular calcium quantum
increasing polysaccharide Khz-cp < Kim, et al, 2014 >, antitumor polysaccharide GL-i < Miyazaki,
et al, 1981 >, Th i cell upregulating, dendritic cell maturation initiating, increasing synthesis and
expressions of interleukins and INF , polysaccharide PS-G < Jan, et al, 2011 >, polysaccharide F iii
that can upregulate the immune system, enhancing expressions and secretions of cytokines, induce
tumor apoptosis as well as their terminations via initiating leukemia cell lines differentiations into
macrophage lineages instead < Hsu, et al, 2009 >, along with polysaccharide metabolizing enzyme
xvi
neutrophils < Hsu, et al, 2012 >; upregulations of caspase iii, vii and ix activities, downregulations of
Bcl-ii and Bcl-xl expression while enhancing Bax thus upregulating the apoptotic cascade,
cyclooxygenase ii < COX >-ii enzyme expression and increased nitric oxide synthesis, mitochondrial
dysfunctions by upregulation of proapoptotic p xxxxxiii and Bax along with increasing cytochrome
c releases within cytosol thus enhancing tumor apoptotic events, mitochondria membrane potential
disruptions, inhibitions of phosphorylation of ERK i/ii and Akt signaling cascades, thus
downregulating downstream NF-B, c-Jun and c-Fos proto oncoproteins preventing further tumor
growths / metastasis, telomerase downregulations and dna degradations resulting in apoptosis of
tumors along with activations of dendritic cells and macrophages.
Increasing occurrences of macrophage phagocytosis; increasing spleen proliferations of
lymphocytes, heightening CD iv and CD viii productions, increases serum nitric oxide quantums,
enhancing B cells antigen presentations thus increasing T cell tumor recognitions and activities,
increasing T cell quantums, upregulating neutrophils activities through p xxxviii MAPK pathways,
while enhancements of NK cytotoxicities towards tumors and their secretions of INF < Kohguchi,
et al, 2004 > lead to preventions of metastatic tumor formations, neutrophil secretions of bglucuronidase and lysozymes are also upregulated.
Immunostimulating effects
Enhancements of the systemic defense mechanisms occur as polysaccharide fraction < F iii >
stimulates both the adaptive and innate immune system, immunomodulates, enhances immune
surveillance and response, upregulates and enhances the immune system which also results in a
direct attack against tumors and transformed cells by the immune system along with enhancing
DNA and RNA synthesis of splenocytes. G. Lucidum extracts increases the synthesis of cytokines
thus increasing productions of immune system cells and upregulating their overall quantums, some
of the cytokines upregulated include : IL i very effective against Candida spp, IL i, IL ii, IL vi, IL
x, IL xii, tumor necrosis factor < TNF >, interferon < IFN- >, perforin, granzyme B and colony
stimulating factors < CSFs > levels; natural killer < NK > cells and macrophages activities. Increases
the formations and maturations of high quantums of NK cells, T cells, Th, B lymphocytes, dendritic
cells, splenic mononuclear cells and CD iv/CD viii ratios.
Antiangiogenic effects
Antiangiogenic effects through 5 reductase inhibitions were exerted inhibiting tumor growths <
Liu, et al, 2007 > and facilitating their subsequent apoptosis. G. lucidum extracts also upregulates
Bax inducing tumor apoptosis and inhibits Erk i/ii and Akt signaling pathways leading to decreased
synthesis of angiogenesis enhancing vascular endothelial growth factor < VEGF > and transforming
growth factor < TGF >-i. Suppression of the transcription factors NF-B, and AP-i also resulted in
VEGF and < TGF >-i downregulations, while modulations of mitogen activated protein kinase and
Akt signaling inhibits further angiogenesis.
Antimetastatic effects
Metastasis of tumors are prevented by the NK cell activity upregulating beta glucans < beta-Dglucose >, while cell cycle inhibitions of tumor cells during Gi and S phase prevents their
proliferations or further growths through downregulations of cyclin D1 and upregulations of pxxi /
xix
Waf i, inhibitions of phosphatidylinositol and NF-B along with F/G-actin ratio modulations
stimulating actin remodeling preventing further tumor metastatic events and their usual process of
focal adhesions, cellular adhesion, colony formations, invasion, and migrations are thus halted.
Antioxidative effects
High antioxidant compositions suppress oxidative stress, protects dna from radiation damages and
against oxidative damages from H2O2O, inhibits dna strand breakages by hydroxyl free radicals,
high free radical scavenging of superoxide and hydroxyl radicals, contains superoxide dismutase
functionally similar polysaccharide peptide and protein bound polysaccharide which protects
immune system cells from oxidative stressors caused by reactive oxygen species <ros>. While
triterpenes enhances tumor selective cytotoxicity, increasing generations of ros by tumors thus
causing increased dna damages and subsequent apoptosis.
Antipathogenic effects
Phosphorylation of Erk i/ii resulting in downregulation of c-fos expressions, which leads to
subsequent inhibition of transcription factors AP-i and NF B with antiviral effects, hepatocyte
protective, enhancements of bone mineral densities, stimulates blood clotting as it initiates onsets of
red blood cell haemagglutinations, antimicrobial against Gram + and some of Gram - bacteria, found
to be very effective against strains of Escherichia spp, Bacillus spp, Micrococcus spp, Proteus spp,
Klebsiella spp, Helicobacter pylori, Staphylococcus spp and Salmonella app.
Antiviral effects were also discovered in studies, found to inhibit viral adsorption and replication
against herpes simplex virus type i < HSV-i >, herpes simplex virus type ii < HSV-ii > due to
blockage of viral charges thus preventing their subsequent attachments and further penetrations
within the cells < Li, et al, 2004 >, and vesicular stomatitis virus < VSV >while DNA polymerase
and inhibiting triterpenes lucidenic lactone and lucidenic acid O are effective against HIV-i
protease and reverse transcriptase activities.
Strong inhibitions of HIV protease are carried out by ganoderiol B and ganoderic acid B with
moderate inhibitory effects occurring mediated by ganoderic acid , ganolucidic acid A, lucidumol B
< (24S)-lanosta-7,9(11)-diene-3 beta,24,25-triol >, ganodermanontriol and ganodermanondiol with
milder protease inhibitory effects initiated by ganoderic acid A, C1, H, antimetastatic, antiinvasion
and antiadhesion ganoderiol A < Wu, et al, 2013 > and 3b-5a-dihydroxy-6b-methoxyergosta-7,22diene; while HIV viral replications are inhibited by ganodermanontriol and ganoderiol F; ganoderic
acid B, C1, H, also demonstrate HIV i protease inhibitory effects < Akbar, et al, 2011 >.
Antiviral ganoderic acid inhibits hepatitis B viral replications, stimulating the healing of herpes
lesions and wounds while polyoxygenated lanostanoid triterpenes, Lucidenic Acids P, Q and Methyl
Lucidenate P within inhibits carcinogen causative associated Epstein Barr virus. Antiviral activities
along with reduction of cellular injuries and toxicities were also found in studies to be effective
against vesicular stomatitis virus and influenza A.
Antifungal activities were also discovered in studies as the extracts were found to inhibit and
eliminated candida albicans < Chen, et al, 1992 >. They upregulate and increase the potency and
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differentiation of macrophages and neutrophil quantums along with other immune cells and their
cytokine secretion expressions especially IL i, interferons and cytokines, dendritic cells along with
their surface expressions of toll like receptor ii is also unregulated, these recognize fungal zymogens
and thus are able to mount a sufficient immune attack against them.
Neuronal effects
Studies have found extracts to be neuroprotective < Shen, et al, 2013 >, regulating intracellular
calcium by preventing excessive accumulations, preventing neuronal apoptosis, inhibiting activities
of acetylcholinesterase < Hasnat, et al, 2013 >, thus increasing Ach neurotransmitter quantums,
while protecting neurons from free radical damages through halting their chain reactions or initial
generations, especially after brain trauma or neuronal injuries such as stroke, ischemia or cerebral
reperfusion injuries. Cerebral vasculature circulations are also enhanced due to the vasodilating
effects, improvements in vessel tones and maintenance of vessel elasticities. Neurotransmitters
acetylcholine, serotonin, norepinephrin and dopamine are regulated with their activities enhanced,
thus improving brain function while stimulatory effects occur within the hippocampus regions
enhancing cognitions and memory processes. Slow brain waves are stimulated by extracts, these aid
in insomnia / anxiety / stress as they bring about relaxations.
Free radicals are the by products of heavy metal poisoning, neuronal injuries or cellular death,
however the excess accumulations of free radicals also lead to further neuronal injuries or the onset
of new cerebral diseases from the breakage of bonds that hold the chemical moieties together that
constitute these cells and their cellular components or their essential molecules, proteins are
denatured along with damages caused to the essential protective polyunsaturated phospholipid cell
bilayers.
Thus once free radical quantums are decreased, preventions of further neuronal injuries,
prematured cellular agings, neuronal death or neurodegenerative ailments onsets from the free
radical incurred neuronal damages or ros generated as a byproduct of these ailments such as
reperfusion injuries, cerebral ischemia, Alzheimers disease, Huntingtons disease, Parkinsons
disease, multiple sclerosis a condition that is also temperature dependent reflected by the high
incidence of occurrences in cold climates as blood flow in impeded due to cold temperatures and
thus circulation is slowed, concentrating excessive immune system cells at regions of myelin
increasing their susceptibilities to inflammations along with ros generations and inflammatory
cytokine releases thus contributing to their subsequent break downs, demyelinations and eventual
scar formations; amyotrophic lateral sclerosis and macular degenerations from excessive ros
mediated damages can also be brought about. Other high ros quantums associated ailments include
diabetes mellitus, cardiac infarctions, cardiac ischemia, acute hypertension, hemorrhagic shock,
atherosclerosis and rheumatoid arthritis.
Extracts activates antioxidant enzymes while being high in antioxidants that scavenge hydroxyl and
superoxide radicals, functioning as an effective hydrogen donor, singlet oxygen quenching, along
with inhibiting other reactive oxygen species, reducing phospholipid cell membrane bilayer
damaging lipid peroxidation thus preventing myelin destructions along with rbc haemolysis and a
good heavy metal chelator along with upregulating gene expressions of innate antioxidant activities
mediated by catalase, superoxide dismutase and glutathione peroxidase.
xxi
Lipid peroxidations < LPS > also induce protein denaturations, dna damages, increased neuronal
injuries, along with excessive microglial mediated inflammations, as lipid barriers start collapsing
and risk of intracellular pathogenic entries are high, thus initiating synthesis and release of
inflammatory cytokines IL i, IL vi, prostaglandin E ii and TNF , along with reactive oxygen
species and nitric oxide.
As inflammatory mediators are harmful towards neurons as well, especially when in excess, extracts
decreases these inflammations < Yoon, et al, 2013 > and resulting risks of neurodegenerations,
preventing further neuronal lysis and releases of synuclein in Alzheimers disease, reducing
inflammations and resulting neuronal injuries of dopaminergic neurons at the substantia nigra
region often degenerated in Parkinsons disease and Huntingtons disease, multiple sclerosis,
cerebral ischemia and brain injury / trauma by downregulating LPS induced NF-B and TLR
signaling pathways along with inhibiting expressions of inflammatory mediators, neurodegenerative
iNOS and COX-ii. Studies have found that dopaminergic neurons were protected from excessive
LPS induced, activated microglia stimulated neuroinflammations by extracts of G. lucidum, in a
dose dependent manner.
Attenuating of neurodegenerative ailments and neuronal dysfunctions
Aids in healing Alzheimers disease, neuroinflammations, epilepsy as studies have found that
extracts inhibits the excessive accumulations of calcium ions within hippocampal neuronal
cytoplasm while enhancing expressions of calcium binding, neuronal regulator CaMK II , thus
decreasing the excessive firings associated with onsets of seizures, Neurotrophin iv expressions are
also increased thus preventing neuronal injuries / apoptosis, excessive calcium toxicities, protections
from exitotoxins, neuronal morphology preservations, increasing quantums of choline
acetyltransferase within cholinergic neurons and enhancing cellular protections of hippocampal
cholinergic neurons, cortical neurons, dopaminergic neurons, noradrenergic neurons and striatal
GABA-ergic neurons, stimulations of neurite sprouting, formations of intercellullar neuromuscular
junctions and giving rise to neural plasticity during injuries / growth and developments.
N-Cadherin expressions were also found to be inhibited by the extracts thus preventing formations
of mossy fiber sprouts and new excitable circuitries occurrences mediated by granular cells within
dentate gyrus < Wang, et al, 2013 >, a common event after epilepsy to compensate for the injured,
dying and lysed neurons, along with the waning activities of current brain circuit; that if left in place
would worsen seizures as epileptiform discharges would be heightened thus increasing the onsets of
seizures. However once the brain cognitive sector afflicted with excessive discharges is shut down
for some time and circuits no long utilized, thus the cessations of seizures, sproutings and synaptic
plasticity is favored as it would give rise to developments of compensatory new brain cognitive
sectors and circuitries as an effective mechanism for new cognitive abilities.
Neurodegenerative ailments would also benefit with synaptic plasticity occurrences from the same
mechanism, studies found that neuritogenesis inducing G. lucidum < Phan, et al, 2013 > gives rise to
developments of the longest neurite sprouts, while other neuroprotective mycomedicinals that
enhance dendritic sproutings include Lignosus rhinocerotis, Hericium erinaceus which induces
dendritic sproutings more effectively than NGF, Pleurotus giganteus, Pleurotus pulmonarius,
cyathane diterpenoids scabronines A and G from Sarcodon scabrosus, Sarcodon cyrneus, Grifola
frondosa, Termitomyces albuminosus, amnesia attenuating Tremella fuciformis, cognition
xxii
enhancing activities and quantums of antioxidant catalase, superoxide dismutase and glutathione
peroxidase, increasing expression of IL ii, IL iv and IL x, stimulating MAPK, ERK i/ii and Akt
signaling cascades that function like NGF, for synthesis of axonal protein to enhance growth cone
formations along with neurite sproutings and neuronal growths and differentiations after peripheral
nervous system injuries, brain injuries and neurodegenerations along with their initial preventions of
occurrences.
Ailment applications
Other ailments G. lucidum is effective for include cardiac ischemia, heart disease, cardioprotective
while protecting from nonfunctional overreaching after extensive periods of intensive training
exercises, or overtraining thus affecting overall athlete performance in terms of continued sustained
performances, endurance and stamina < Rossi, et al, 2014 >, enhances blood volume perfusions and
microcirculations within vital organs, increases blood pressure < Kabir, et al, 1988 >, relaxes smooth
muscles, thrombosis, depression < Matsuzaki, et al, 2013 >, anxiety, autoimmune conditions,
modulation of the immune system, bacteriostasis, high cholesterol conditions as cholesterol
biosynthesis is inhibited by oxygenosterols ganoderol A, B, ganoderal A and ganoderic acid Y <
Hajjaj, et al, 2005 > and tonifying effects.
Enhancing of vital energy as it functions as a blood tonic upregulating the quantums of platelets,
hemoglobin and white blood cells, while enhancing mitochondria productions of ATP, antiaging,
strengthening cardiac function, inflammation, leukopenia, arthritis, bronchitis, asthma due to its
antihistamine effects, alleviating lower urinary tract symptoms < Noguchi, et al, 2008 >, ulcers,
ganoderic acids and triterpenes within are antihepatoma with tumor specific cytotoxicity inducing
cellular atrophies, lysis and apoptosis; whilst mycelia isolated proteoglycans < Yang, et al, 2006 >
function as a hepatoprotective for liver hepatocytes < Su, et al, 2013 > wounds or cellular / tissue
injuries, antiviral against chronic hepatitis B while healing the hepatocyte viral induced injuries.
Fruiting body extracts of antioxidative, antitumor, anti-inflammatory, immunomodulating
polysaccharides ganoderans A, B, C initiates a hypoglycemic effect and downregulates hepatic
PEPCK gene expression thus decreases blood glucose levels. Declines in oxidative stress, lipid
peroxidation, hepatic glycogen levels, elevations of circulating insulin, modulations of blood glucose
and hepatocyte glucose-metabolizing enzyme modulations were carried out by ganoderan B.
Effective in treatments of diabetes mellitus type ii as it aids in the control of blood glucose levels,
enhancing phosphorylations of AMPK thus stimulating glucose intake within adipocytes.
While polysaccharides upregulates collagenase activity and is effective in treatments of cirrhosis,
preventing excessive scar tissue or keloid formations that would further impair liver functions,
downregulating excessive collagen < i > mRNA expressions, actin within smooth musculatures,
along with metalloproteinase-i and metalloproteinase-xiii enzymes; restorations / increasing mucus
and prostaglandin productions thus attenuating the acidity while speeding wound healing in gastric
and duodenal ulcers, accelerations of wound healing < Cheng, et al, 2013 > during injuries / lesions
as collagen synthesis is upregulated for sufficient tissue remodeling to occur.
Free radicals are scavenged by flavonoids preventing further oxidative injuries to proteins,
molecules, wounded and newly differentiated cells that affect their cellular functions and integrities;
along with enhanced migrations of macrophages and endothelia cells towards the injured area
xxiv
mediated by glucans, while proliferations of fibroblast are upregulated towards the region of
injury, thus stimulating the wound healing processes of angiogenesis, collagen synthesis and
epithelialisations.
Whilst expressions of inflammatory NF B, caspase iii and cellular apoptosis is reduced,
endothelium cell proliferations within vasculatures and microcirculations are enhanced along with
increasing mitosis, DNA synthesis and enhanced cellular proliferations by upregulating cell
quantums undergoing G ii - M and S cell cycle phrases thus extracts are effective towards healing <
Qian, et al, 2004 > slow or non healing diabetic wounds and open lesions, accelerating their
otherwise slow progressive healing speeds due to excess sugar accumulates outside the cells which
further injure them and low intracellular glucose quantums within reduced cellular energy
generations, inhibiting / decreasing mitochondria's ATP productions thus preventing proper wound
closures and the accumulated ulcerative lesions that consequently form as well.
Extracts are also effective in treatments of cancers, prostate cancer, liver disease, hepatitis,
nephritis, hypertension as it was found to contain DEAD / DEAH box helicase like protein, alpha /
beta hydrolase like protein, paxillin like protein and cystathionine beta synthase like protein, these
inhibit angiotensin converting enzyme activities, regulates actin remodeling of vascular smooth
musculature and prevents cardiac hypertrophy through inhibitions upon cell cycle cardiomyocyte
proliferations thus lowering blood pressure whilst exerting a vasodilatory effect < Ansor, et al, 2013
>; prevention of blood pressure spikes, neurasthenia, insomnia, hypercholesterolemia < Duk, 2010 >,
and dyslipidemia < Hu, et al, 2014 >.
Modulation of the immune system during states of immunodeficiencies or imbalances, bacteriostasis
thus effective during microbe infestations, exerting organ tonifying effects, antiaging with cellular
life cycle prolonging effects, strengthening of cardiac function, increasing memory, strokes /
aneurysms as it inhibits aggregations of platelets, as a poison neutralizer, lowering of high liver
triglycerides and obesity as it downregulates lipid accumulations within adipocytes and decreases
their differentiations through SREBP-i c, PPAR-g, and C/EBP-a transcription factors suppressions
along with downregulating adipogenesis and genes involved in lipid synthesis, transport and
storage : FAS, ACS i; FABP iv, FATP i and perillipin while plasma lipid and glucose quantums are
also decreased thus effective in diabetic conditions, obesity reductions and visceral fat removals.
Polycystic ovarian syndrome or other endocrine disorders such as hypersexuality, benign prostatic
hyperplasia, BRCA ii gene mutational prostate cancer of which triterpene, ganoderic acid DM is
highly cytotoxic and anti metastatic against tumor leading to their apoptosis, acne vulgaris,
hirsutism, Cushings syndrome and androgenic alopecia that occur due to an excess of androgen
secretions can also be treated, as triterpenoids ganoderol B, ganoderic acid G, ganoderic acid C ii
and ganodermanontriol within G. lucidum extracts decrease the productions of androgens thru
inhibiting testosterone conventions into DHT by downregulating quantums of it's converting
enzyme 5-alpha reductase < Grant, et al, 2012 > isozymes type i and ii.
Often utilized in tcm, it's herbal principles classify it as a Qi replenisher, enhancing vital energy thus
a revitalizing tonic. Utilized as a sedative and a tonic, for soothing and relaxing of the mind and
spirit, in the relieve of respiratory ailments such as cough and asthma; antiaging, dizziness, shortness
of breath, fatigue, cardiac palpitation / weakness, lung ailments, liver diseases, low / imbalanced
xxv
thus enhancing both innate and adaptive defense and surveillance system against tumor growth
onsets and developments, prevents pathogenic invasions by virus, microbes and fungi along with
their subsequent eliminations as cytokines and chemokine expressions are not correspondingly
enhanced by bindings due to the inactivation of upstaeam NF kb; excessive / chronic
neuroinflammations that might lead to fragile neuronal damages and their subsequent downstream
ailments however are not excessively stimulated and thus do not occur. Stimulations of cerebral
dendritic cells is another occurrence along with their cytokine releases of IL xii, TNF and IFN
thus enhancing the immunological reactions within.
Contained within are also the existence of high glucan immune stimulating and enhancing,
phagocyte potentiating, NK and macrophage quantum upregulating, stress reducing, infection
resisting, serum cholesterol reducing, hypoglycemia inducing, lowering of blood pressure, tumor
resistance enhancing, wound improving with healing of conditions such as ulcerative colitis as found
to occur in studies when these carbohydrate moieties were added to ill subjects; upregulating active
hexose correlated compound which aids in its antitumor, antimicrobial and antiviral activities,
hypercholesterolemic balancing, hypocholesterolemic attenuating eritadenine and immunoregulating
and enhancing arabinoxylan like polysaccharide with xylose and arabinose, highly antioxidative,
free radical scavenging, with bindings to free radicals ROS / NOS, lipid peroxidations along with
their high reducing powers and antiinflammatory, antioxidative ergothioneine < Ito, et al, 2011 >;
immunopotentiating, hepathocyte protective, antiarthritic, antiatherogenic and antiviral lenthionine.
While antioxidative protein latcripin iii induces cellular halts of tumor at s phrase of the cell cycle
pathway, thus inducing apoptosis of tumor cells, studies have discovered inhibitions occurring in
tumor growth along with decreases in their growth mass when these extracts were isolated and
added to tumor cells, thus increasing their tumoricidal and anti tumor activities < Ann, et al, 2014 >.
Immunomodulating KS ii < Lindequist, et al, 2005 > strong against tumors growths and
antipathogenic, along with polysaccharides and lignin LEM are contained within extracts.
Functions
Strong against tumors < Wu, et al, 2012 > as it inhibits their growth and reduces the size of
preexisting tumors. Effects upon the immune system also upregulate the antitumor properties as
they increase the proliferations of immune system cells. While immunoregulating effects occurs as
differentiations of immune suppressor cells are initiated as well. It functions as a cancer inhibitor
and as a preventative regent < Nagashima, et al, 2013 >, carries out immunoregulation while
enhancing immunosurveillance, increases productions of cytokines such as TNF , exhibits direct
cytotoxicity towards tumors, along with inducing apoptosis from triggering their apoptotic cascades,
studies have shown that direct induction of tumor cell death occurs when extracts were added and
these events took place in a dose concentration dependent manner with more apoptosis occurring as
the concentrations were heightened, phagocytic cells were also upregulated and activated while
enhancements and upregulations of macrophage activities also occur.
Reduces high blood pressure along with exerting regulatory effects which also aids in circulatory
flow conditions such as hypovolemia or poor blood circulations along with improving their
associated downstream disorders, upregulating erythrocyte and mononuclearcytes at the peripheral
vasculature regions for an immunoprotective and better circulatory along with enhanced perfusions
effect, arthritis, joint mobility disorders; ergothioneine within extracts exhibit an analgesic function
xxvii
decreasing pain within joints and articular regions thus improving fluidity of movements along with
mobilities, allergic asthma, autoimmune joint inflammation, gut inflammations < Mizuno, et al, 2009
>, antiatherogenic, hypolipedemic, decreases serum cholesterol levels, cardiovascular ailments,
hypertension, hypertension, antiinflammatory, atopic dermatitis while exerting strong antioxidative
properties.
Other effects include reductions of the risk of fractures and bone mass loss as it improves bone
mineral densities and related conditions such as osteoporosis, fragile and frail bone conditions such
as bone structural deformities or slipped disc; improves exhaustion, fatigue, weakness, a declined
constitution after long term illnesses or deliberated conditions after chronic ailments, thus
functioning well as a general health tonic.
Antipathogenic effects
Antiinfection effects occur as it contains protease inhibitions leading to various antiviral effects,
effective in the eradication of hepatitis, whilst found effective in studies conducted against polio
virus < Rincao, et al, 2012 >, HPV i as early stage viral replications are inhibited, extracts are also
effective in treatments against retroviruses HIV, influenza virus, vesicular stomatitis; antifungal;
antimicrobial against strains of streptococcus pneumoniae, streptococcus pyogenes, staphylococcus
aureus, mycobacterium tuberculosis and listeria monocytogenes; antimicrobial against tuberculosis,
anticarinogenic and prevents the formations of oral bioflim microbial formation colonizations by
Streptococcus mutans and Streptococcus sobrinus < Zaura, et al, 2011 >, carcinogenic dental caries
and tumor inducing gingivitis < Ciric, et al, 2011 >.
Ailment applications
Exacts exerts improvement of cardiac and blood circulatory conditions, prevention of aggregation of
platelets thus inhibiting excessive clot formations which aids in situations such as the occurrence of
thrombosis, cerebral strokes, coagulative strokes or aneurysms, respiratory ailments, liver
dysfunctions, cirrhosis, aids in lipocyte break downs and weight loss as studies have found extracts
effective in lowering the serum triacylglycerol quantums along with decreasing overall body fat and
weight thus applicable to obesity also equally effective in decreasing the liver stores of fatty
phospholipid accumulates and initiating their breakdowns thus helpful in fatty liver disease and its
associated disorders, hepatocyte protective, prevents liver stenosis, functions as a kidney tonic,
treatments of vitamin d deficiencies including rickets, flu, colds, accompanying skeletal defects and
bone mineral densities declines, dysfunctions and other associated disorders, along with mediating
cellular healing functions which aid in wound repair, healing and recovery.
Shiro kikurage, Tremella fuciformis
Description
Common names : Snow Mushroom, White Brain Mushroom, Silver Ear or White Jelly Leaf. Found
growing upon broadleaf trees such as the Sakura or Fagaceae tree with fruiting bodies located on
their falling, decaying or dead branches. Growth occurs in temperate, tropical and sub tropical
countries such as Japan, Brazil, Central, South and North America, Caribbean, Pacific Islands New
Zealand, Australia, sub Saharan Africa, Korea and parts southern and eastern of Asia such as
xxviii
multiple sclerosis, parkinson's disease, neuro borreliosis, amyotrophic lateral sclerosis and
Huntington's disease, likewise weak musculatures with poor circuitry connection will also be
improved with these additional ACh upregulates.
Neurite growths were also found to be enhances by administration of these extracts < Park, et al,
2007 > as they function like neuronal growth factors and promoted their elongations and subsequent
connections as found in cultured neuronal cells, thus aiding in successful nerve regenerations
facilitating synaptic plasticity formations during growth and developments or recovery after cerebral
injuries, along with restorations of peripheral nerve tracts truncated or worn with lower densities at
certain regions thus requiring some strong denser neuronal mass and bridges to reconnect the
weakened connection regions in between the synapses at their respective gap junctions, events that
might have occurred during illness or as a result of injury onsets. However ever after neuronal
regeneration occurs long term intake of the extracts along with other neurite sprouting herbs and
myelin growth enhancing substances are still required as nerve conduction velocities along the
regenerated regions are still lower than the norm.
As angiogenesis is required as part of the regenerative process for adequate perfusions so that the
neurites and dendrites can sprout, along with enhancing the densities of neuronal formations, blood
nourishers would also aid in hastening the recovery and neurogenesis procedure. It would be some
time till they can regain perfect functionality and densities once more with consistent conduction
velocities occurring along the entire innervation tract and be restore to the transmission speed that
used to occur before injury onset, thus giving rise to a total restoration in structures and
functionality of the innervated region affected.
Antipathogenic effects
Antipathogenic actions are exerted upon infections due to the immunostimulating and upregulating
properties, targeting both gram + and microbial strains as it inhibits their microbe quorum sensing
and communications along with subsequent bioflim formation pathways, eradicating spirochete
Borrelia spp initiated Lyme borreliosis and the associated neuroborreliosis / bacterimia; antifungi
towards eliminating pathogenic opportunistic, gram basiospore candida spp initiated candidiasis
infections often found as part of the microfloral within the gut, but in cases of excessive overgrowths
spread to digestive systems, lungs, cardiac, nails, skin, kidneys, urogenital regions, oral mucosal
membranes and even entering within the csf regions affecting the brain and causatives of urinary
tract infections of which neonates are prone to; along with antiviral effects against hepatitis.
Functions
Effective against tumors as a strong immunostimulant with bi directional immunomodulating effects
that regulate macrophage and monocytes synthesis and secretions of antibodies, interferons and
cytokines such as cell cycle mediated acquired radioresistance development inducing IL i which
enhances the inflammatory responses along with facilitating coagulations, fever onsets and the
synthesis of acute phrase proteins within the liver, IL i , IL ii a T cell growth factor, stimulant and
regulator, NK cell proliferation upregulations and activations, stimulating B cell activations and
antibody productions, lethal irradiation cellular protective IL vi which enhances B cell synthesis
along with their subsequent antibody productions, liver acute phrase protein synthesis; IL viii, TNF
an NK cells and leukocytes activator has antiviral properties, and increases MHC class i expressions
xxx
xxxi
Other ailments this is effective towards include protecting cells and tissue exposed to radioactive
damage or after tumor radiation and chemotherapy thus preventing further tumor developments or
transformations via reducing and repairing dna strand breaks, occurrences of chromosomal
aberrations, strand nicks or damages, inducing and enhancing dna repair, inhibiting occurrences of
genotoxicity, preventing free radical liberated harm to dna and cells, free radical scavenging
abilities, whilst protecting hematopoietic progenitor lineage cells and inducing the regrowth and
subsequent production of bone marrow stroma cells thus enhancing formation of immunocytes
while replacing dead / damaged cells and protecting newly developed s phrase cells from radiation
induced transformations within the mitotic cycle, thus enhancing their radioresistance during
growth and subsequently upon cellular maturations which will lead to more resilient cells.
Extracts also aid in improvements and curing ailments such as lesions incurred by gastric ulcer
disease, as a regent to decrease cellular cytotoxicity as it is cellular protective, while increasing the
quantums of antioxidant superoxide dismutase thus effective as a brain antioxidant as it passes
within the cerebral circulations and through the blood brain barrier, along with protecting neurons
from the assaults of free radicals within.
Due to high water retaining abilities it functions as a fluid replenisher and excessive heat dissipating
during conditions with low fluid volumes such as hypovolemia, dehydration, sore throats,
inflammations, chronic dry coughs, ailments with excessive dryness and heat retained within the
system and provides fluidity and moistures within regions of dry or desiccated organs such as the
brain, lungs and stomach.
Attenuates and restores irregular cardiac palpitations due to the blood pressure regulating and
balancing abilities, it dissipates excessive melanocyte accumulates thus displaying abilities to
improve skin microvasculature circulations, anti aging effects due to the chromosomal protections,
free radical neutralizations, cellular healing and improvements of its condition along with overall
health restorative functions.
Conclusion
It has been found that priming an entity's own immune system to recognize cancer antigens has
been very effective in their subsequent destruction as T cells would mount an attack against the
cancerous tissue, enhancing a robust immune response and successfully destroying them. Many
clinical trials have produced good results with high remission rates and low recurrences, however
there are some cases whereby patients still develop cancers after the initial cancer terminations and
these patients have short lifespans after the subsequent recurrences. Indicative of the entities
immune system being unable to terminate these cancerous cells completely or further mutations of
the cancers that recur, of which the immune system and initially recognition primed calls are unable
to destroy.
The effectiveness of treatments through upregulating and enhancements of the patients own
surveillance and immune system after recognition priming is also varied, with some systems totally
capable of completely eliminated these cancerous cells, whereas others produce various quantums of
effectiveness with some cancers gone at certain regions whilst others are diminished or reduced in
terms of their growths and cellular sizes, still some cases demonstrate tumor masses that undergo an
overall growth reduction, then they revert back to the original size, then with time, shrink again.
xxxii
Other cases occur with the immune response against cancer being too strong for the system to even
coupe with due to the high and chronic serious inflammations and fevers occurring within. This
could be indicative that this treatment protocol can be further refined, whereby the primed T cells
are specifically targeted only towards the exact location whereby the cancerous cells are situated at,
thus reducing the probability of a severe immune reaction that affects the entire system instead,
including cells and tissue unaffected by cancerous transformations. Region location targeting
towards cancer tissue locations can be further carried out if the first immune response is too
immense and the entities system is unable to cope with that. Yet to be tried out in clinical trials, thus
the effectiveness and long term results of this targeted approach are still unknown.
As the immune system mounts a very immense attack against cancer after their initial primings and
recognitions which are then transferred back to patient system, some entities undergo these
immense immune effects of inflammation from the attacks against cancer, however in the event
whereby the system is affected to a severe point, the inflammations can be attenuated with
inflammatory lowering medications and balanced with the aim of fine tuning it to a moderate
quantum instead, at the perfect state whereby the system can still mount a sufficient immunological
response necessary to eliminate these cancerous growths completely, yet at a safe magnitude to the
biosystem, keeping it within the margins of safety; thus creating a balance within and mediating
healing.
Another probability of such results occurring is that the priming of T cell recognitions are too
sudden thus the onsets trigger an excessive immune reaction mediated by presence of these
cancerous growths. An anticancer vaccine can be further developed whereby immune cells of the
system are primed gradually, whereby the vaccines are given at low dosages, in between intervals,
thus allowing the system time to adapt and be accustomed to these changes without giving rise to
any excessive immunological inflammatory responses, so that eventually they recognize and are able
to fight off cancers effectively and within safe limits of inflammatory states that the whole system
can safely undergo; should any cell within the system ever undergo transformations. However the
effectiveness of such a vaccine would ultimately still be influenced by subsequent cancer mutations
especially if further complicated by accompanying viral infections and the question would be about
whether the primed T cells can continually evolve, recognize these new mutations and mount a
sufficient immune attack against mutated cancer cells.
From results of the studies to date, it seems that the effectiveness and efficacy of this
immunotheraphy treatment is varied and based very much upon an individual entities immune
system and systemic condition. However as compared with other form of cancer treatments, for
example radiotherapy with a high rate of cancer metastasizing to other regions occurring, or
chemotherapy with variable effectiveness and curative results, some results have shown that these
produce complications elsewhere within the system as well, due to non specific cancer targeting, as
all cells are affected including non cancerous ones; some clinical trials have found a combinations of
these two methods rather effective in targeting cancers, however the recognition priming of the
patients own immune system to date has yielded the best results.
For a better outcome after cancer onsets, anticancer herbs such as the mycomedicinals would work
well along with various anticancer natural herbs, many of which function effectively and can be
taken in smooth synergy with mycomedicinals for an extremely strong anticancer effect, however
xxxiii
they are not discussed here as its beyond the scope of this article. These can be done along with
immune targeted treatments.
Prevention is always better than cure, if an entity's system is constantly primed with these effective
anticancer mycomedicinals / herbs along with a constantly healthy vegan diet < McCarty, 2014 > of
carcinogenic pesticide free < Borchers, et al, 2014 > and carcinogenic genetically modified < Cichosz,
et al, 2012 > free, fresh vegetables and fruits that are very effective against cancers and consisting of
effective molecules that mediate their initial preventions. Many studies have shown a low cancer
incidence amongst vegans < Tantamango-Bartley, et al, 2013 > along with reduced cardiovascular <
Huang, et al, 2012 >, ischemic heart disease < Crowe, et al, 2013 >, cerebrovascular < Li, 2014 > risk
and motility < Le, et al, 2014 >; while meat diets increase incidences of cancer developments <
Mahfouz, et al, 2014 > < Bastide, et al, 2015 > < Fallahzadeh, et al, 2014 > and the risk of infections
with carcinogenic viruses < Peretti, et al, 2015 > as well.
It has been shown through population analysis studies that many in china consume an excess of red
meat < Yin, et al, 2014 >, this also displays that a difference in dietary consumptions with heavy
meat diets brings about a population's occurrence of high cancer risk, their developments and
incidences < Li, et al, 2014 >, many incidences of transmissible infectious carcinogenic viruses such
as HPV were also found prevailing, accompanying certain types of cancers amid the populations
there < Wang, et al, 2015 >.
If carcinogens are obliterated, proper nutritions and a vegetarian diet adhered to, the onsets of
cancers even developing would be pale. Thus these mycomedicinals / herbs if taken long term,
which clinical trials and cell culture experiments have found to be safe and non toxic at their
respective moderate daily dosages are effective as an anticancer preventive / curative / recurrence
preventive after an initial healing.
xxxiv
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