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ACETONE
FIRE
REACTIVE
OTHER
DEGREE OF HAZARD
0 = Minimum Hazard
1 = Slight Hazard
2 = Moderate Hazard
3 = Serious Hazard
4 = Severe Hazard
COLOR CODING
HEALTH = BLUE
FIRE = RED
REACTIVITY = YELLOW
OTHER = WHITE
OTHER CODES
OX = Oxidizer
ACID = Acid
ALK = Alkali
COR = Corrosive
W = Use No Water
RCRA Number
Ketone
EPA Class
U002
Toxic Waste
Acetone
67-64-1
Flammable Liquid
26
Chemical Formula
UN 1090/UN 1091
C 3H6CO
Synonyms
Acetone
PEL:
1000 ppm
2400 mg/m3
STEL:
1000 ppm
2400 mg/m3
STEL:
Not
Established
Immediately Dangerous to
Life and Health (IDLH)
TLV:
750 ppm
1815 mg/m3
20,000 ppm
STEL:
1000 ppm
2400 mg/m3
133F (56C)
0.79
Molecular Weight
58.08
Freezing Point
2.00
-140F
Solubility
NFPA Classification
LEL: 2.5%
UEL: 12.8%
Autoignition Temperature
869F (465C)
Extinguishing Media
Wear full protective clothing and self-contained breathing apparatus (SCBA). Heat will build pressure
and may rupture closed storage containers. Fight fire from a distance if possible. Keep fire-exposed
containers cool with water spray. Vapors are heavier than air; they may travel a distance to flashback
and cause fire.
Unusual Fire and Explosion Hazards
Explodes when mixed with nitric-sulfuric acid mixture in narrow container. Violent explosion may occur when mixed with permonosulfuric acid. Poisonous gases are produced in fire.
1996 by CRC Press, Inc.
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Do not allow acetone to come into contact with any of the incompatible chemicals listed below. Avoid contact with fire or high heat sources. Acetone is highly volatile. Do not use in confined spaces.
Stability
Stable
Unstable
Nitric-sulfuric acid mixtures, oxidizers, acids, chromium trioxide, sulfuric acid-potassium dichromate; chloroform and a base (caustic soda); hydrogen peroxide; nitrosyl perchlorate; sodium hypobromate.
Conditions to Avoid
Hazardous
Polymerization
May Occur
Working in confined spaces or closed, poorly ventilated areas with acetone; combining with acids or oxidizers.
When heated to decomposition, acetone emits acrid, irritating smoke and fumes. Reacts to form explosive
peroxide products with 2-methyl-1,3-butadiene, hydrogen peroxide.
Inhalation?
Absorption (skin)?
Ingestion?
Health Hazards
INHALATION: Eye, nose, and throat irritant. Produces narcotic effects. Headache, nausea, dizziness,
muscle weakness, loss of coordinated speech, drowsiness, dryness in the mouth.
ABSORPTION: Skin contact can result in irritating rash or burning feeling. Can cause severe eye burns
leading to permanent damage. Can result in sensitization following repeated contact.
INGESTION:
Carcinogenicity
NTP Listed?
Unknown Human
Unknown Animal
No
OSHA Regulated?
Target Organs?
No
29 CFR 1910.1000
(Table Z-1)
Respiratory function impairments (asthma, etc.); Nervous disorders; Skin conditions (dermatitis).
Emergency and First-aid Procedures
Eye contact: Immediately flush large amounts of water for 15 minutes (minimum), occasionally lifting
eyelids, seek medical attention. Skin contact: Remove all contaminated clothing. Immediately wash
area with large amounts of soap and water. For inhalation: Remove the person from exposure. Provide
respiratory assistance and CPR. Transfer promptly to medical facility. If swallowed, seek medical attention immediately. Never try to give an unconscious person anything by mouth.
Remove all ignition sources. Restrict persons not wearing protective equipment from entering area of
spill or leak until clean-up is complete. Ventilate area. Absorb liquid in dry sand or other material and
deposit in sealed containers. Alert appropriate state or federal response agencies.
Preferred Waste Disposal Method
Acetone is highly volatile. Do not store with incompatible chemicals since violent reactions can occur.
Store in tightly closed containers in a cool, dark, well-ventilated area away from fire, sparks, and flame.
Use non-sparking tools on containers. Ground and bond metal containers during transfer operations.
Other Precautions and Warnings
Bulk storage of acetone is not recommended. Containers may explode in fire or under conditions of
extreme heat (do not store outdoors or in direct sunlight).
Exposures above 250ppm: MSHA/NIOSH approved full-facepiece respirator with organic vapor cartridge. Greater protection is obtained from a self-contained breathing apparatus (SCBA) with full facepiece and pressure demand or other positive pressure mode.
Ventilation
Eye Protection
Rubber Apron
Work/Hygiene Practices
Always wash hands thoroughly after using chemical; never bring food, drink, or smoking materials into
vicinity of chemicals.
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ACETONE
C2H6CO
CAS: 67-64-1
3
H 3C
CH3
Eye:
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While not always operationally feasible, isolating operations can also reduce exposure. Using respiratory
protection is less effective than the controls mentioned
above, but is still advisable whenever working with
acetone. A NIOSH-approved, full-facepiece organic
vapor respirator is sufficient for low exposures. A selfcontained breathing apparatus (SCBA) with full facepiece and pressure demand is the recommended respiratory protection of choice. If a full facepiece is not
available, then chemical goggles should be worn to
protect the eyes. Whenever a chemical splash hazard
exists, a face shield and a rubber apron should be worn.
To prevent hand and skin exposures, butyl rubber
gloves should be worn.
Administrative controls should also be in place to
minimize the potential for human exposures. These
may include written procedures or policies which specify the methods and techniques that will be practiced
whenever personnel are to work with acetone.
All personnel should receive training on the use,
hazards, protective measures, emergency actions, and
other precautions per 29 CFR 1910.1200 (Hazard
Communication), prior to the first assignment in an
area where acetone is used or stored.
;
;
;
;
6 Water Solubility
The environment is at risk of exposure during transportation, storage, disposal, or destruction of acetone.
In almost every scenario, the threat of environmental
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REFERENCES
Ahlbom, A. 1993. Biostatistics for Epidemiologists. New York: CRC
Press/Lewis Publishers.
Kamrin, M. A. 1988. Toxicology: A Primer on Principles and Applications. Chelsea, Michigan: Lewis Publishers.
American Conference of Governmental Industrial Hygienists. 1988. Documentation of the Threshold Limit Values and Biological Exposure
Indices, 5th Edition (with updates). Cincinnati: ACGIH
Anthony, C. P., and N. J. Kolthoff. 1971. Textbook of Anatomy and Physiology. St. Louis: C. V. Mosby Company.
Asante-Duah, D. K. 1993. Hazardous Waste Risk Assessment. New York:
CRC Press/Lewis Publishers.
Bloom, A. D. and F. J. DeSerres. 1995. Ecotoxicity and Human Health.
New York: CRC Press/Lewis Publishers.
Brusick, D. J. 1994. Methods for Generic Risk Assessment. New York:
CRC Press/Lewis Publishers.
Landis, W. G., M. H. Yu. 1995. Introduction to Environmental Toxicology. New York: CRC Press/Lewis Publishers.
Langerman, N. 1994 Precautionary Labels for Chemical Containers. New
York: CRC Press/Lewis Publishers.
Lauwerys, R. R., P. Hoet. 1993. Industrial Chemical Exposure. New
York: CRC Press/Lewis Publishers.
Lewis, R. J., Sr. 1993. Hawley's Condensed Chemical Dictionary, 12th
Edition. New York: Van Nostrand Reinhold.
New York:
Burrell, R., D. K. Flaherty, and L. J. Sauers. 1992. Toxicology of the Immune System. New York: Van Nostrand Reinhold.
Bueche, J. R. 1972.
McGraw-Hill.
Proctor, N. H., and J. P. Hughes. 1991. Chemical Hazards of the Workplace. New York: Van Nostrand Reinhold.
U.S. Department of Health and Human Services, National Institute for Occupational Safety and Health. 1994. NIOSH Pocket Guide to Chemical
Hazards. Washington, D.C.: U.S. Government Printing Office.
U.S. Department of Health and Human Services, National Institute for Occupational Safety and Health. 1978. Criteria for a Recommended
Standard - Occupational Exposure to Ketones. DHEW Publication
Number: 78-173. Washington, D.C.: U.S. Government Printing Office.