Synthesis Of Ibuprofen

1. Abstrack
Ibuprofen is a drug included in category AINS ( anti inflamasi non steroid ). Ibuprofen worked
by reducing hormone that causes inflammatory and. pain in your skin Ibuprofen used to relieve
fever and treat pain or inflammatory caused by many conditions like headache, sore teeth
backbone, pain arthritis ( inflammation of the joints of the body ) painful menstruation or small
cuts
1. Introduced
Ibuprofen is one of a drug that very difficult to play soluble in water and show the
solubility of bad because they have the structure of the hydrophobic ( bushra and aslam, 2010;
mansouri, et al. , 2011 ).Besides ibuprofen has its cohesiveness of high power so as to produce an
ugly alir ( bushra and aslam, 2010 )
.Ibuprofen including one of the group drug antiinflamasi non steroid ( ains ) much used as
an analgesic, antiinflamasi and antipyretic ( abraham 2005 ).
Ibuprofen low doses as effective as aspirin and paracetamol for the indication of as an
antipyretic ( wood, et al. , 2003 ), and also as effective as indometasin ( bushra and aslam,
2010 ).Ibuprofen r and s ( + ) enansiomer chiefly used in the treatment of mild pain to moderate (
rehman, et al. , 2008 ).The dentist more often give ibuprofen to handle pain in the mouth either
acute and chronicle ( moore and hersh, 2011 ).
Ibuprofen is derivat of propionic acid that introduced many countries.This medicine is an
analgesic with resources antiinflamasi that is not too strong.The effect of analgesiknya equal to
aspirin.Ibuprofen not advisable drink by a pregnant woman and lactation.

2. Shynthesis
Ibuprofen was found by the Boot Pure Drug Company and the synthesis is named after the
company as the "Boot process". In the process it starts with Friedel-Crafts acylation of
Isobutylbenzene.
Ibuprofen adalah ditemukan oleh Boot Drug Company dan sintes adalah bernama setelah
perseroan sebagai ' boot proses '.Dalam proses ini dimulai dengan friedel-crafts acylation
dariisobutylbenzene.

"The Boot Process

1. Isobutylbenzene reacted with Ethyl chloroacetate would result with ,-epoxy ester
2. Hydrolyzed
3. decarboxylated to the aldehyde
4. React with hydroxylamine gave oxime
5. Converted to nitrile,
6. hydrolyzed to the desire acid

Later on, the new Hoechst process named after the Hoechst Company undergoes a similar
acetylation, followed by a hydrogenation with (Raney nickel) catalyst. It will result in alcohol
and last reaction is palladium-catalyzed carbonylation.
Nantinya, proses Hoechst baru bernama setelah Hoechst Company mirip acetylation,
menjalani pemeriksaan diikuti oleh kata dengan( raney hydrogenation nikel ) katalis. Dapat
menghasilkan hasil dalam alcohol dan terakhir reaksi carbonylation. palladium-catalyzed

3. Ibuprofen Mechanism-COX inhibitor

Ibuprofen's function is to block an enzymes called cyclooxygenase(COX). The NSAIDs
unselectively inhibit both COX-1 and COX-2. When the COX is inhibited, arachidonic acid is
converted into H2(PGH2),then PGH2 is converted into prostaglandins and tothromboxane A2.
Prostaglandins could ease inflammation, fever and pain, and tothrombozne A2 could lead to
formation of blood clots. Since the only function desired in this brought by COX-2 (easing pain,

fever and inflammation) and COX-1 is causing unwanted side effects further researches have
been done on blocking COX-2 but not COX-1. After years of research, through X-ray
crystallography and biophysical techniques this selective blocking is achieved.
of the nature of fisik kimia ibuprofen ((+ ) -2- ( p-isobutilfenil ) propionic acid ) with
molecular formula c13h18o2 and molecular weight 206,28.
ibuprofen wake up in the form of powder hablur, white sheet nearly white, smelling
typical weak.Practical ibuprofen is insoluble in water, very easy to dissolve in ethanol, methanol,
acetone and in chloroform, difficult to dissolve in ethyl acetate ( ditjenpom, 1995 ).Soluble in
alkaline solutions hydroxide and carbonate ( reynolds, 1989 ).This compound have its melting
point 75-77 C with pka 4.4; 5.2 and log p ( oktanol / water ) 4,0 ( moffat, et al. , 2005 ).
Ibuprofen diabsorbi rapidly through the digestive tract with biovail abilitas bigger than
80%. The top of the concentration of plasma can be achieved after 1-2 hours. Ibuprofen show
tying (90%) thorough with plasma protein (Anderson, 2002). Healthy human on the volume is
low distribusi relatif (0,15 0,02 L/kg). The time of the beak of plasma ranged from 2-4 hours.
Were roughly 90% of doses diabsorbsikan direaksi through the urine as a metabolite. A
metabolite main is the result and karboksilasi (Stoelting, 2006; Katzung, 1995; Sinatra, et al.,
1992).
indications and therapeutic doses
ibuprofen can be used to reduce pain that mild to moderate , especially pain because of
inflammatory as contained in arthritis and gout ( trevor , et al . , 2005; anderson , et al . ,
2002 ) .To reduce pain mild to moderate the use of adult doses of ibuprofen is oral per 200-400
mg , to painful menstruation 400 mg per oral if need be .For rheumatoid arthritis 400-800 mg .To
a fever in children 5 mg per kg weight , untuknyeri in children of 10 mg per kg weight , to
arthritis juvenil 30-40 mg per kg body weight per day ( anderson , et al . , 2002 ) .