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cobas 4000 analyzer series

The two belong together

cobas brand
Roche Diagnostics introduces the cobas brand as the umbrella
for products used to complete or expand the screening, diagnostic
and monitoring applications of the professional laboratory.

cobas brand includes:

serum work area with clinical chemisty
and immunochemistry
data management and preanalytical solutions
products for coagulation analysis and urinalysis
instruments for rapid blood and
cardiovascular testing
PCR-based applications for virology
and womens health testing

cobas modular platform

Flexibility you can build on

Todays laboratories are challenged with delivering high standards of laboratory services with fewer resources. They face
constant pressure to lower operating costs while aspiring to
grow their business in new areas. Their concern for patient care
is paramount, and they demand only the best in diagnostic
testing and services.
Just as every patient requires individualized care, every laboratory is unique. Striking the balance between high standards
and efficient operation requires tailor-made solutions. With
cobas modular platform, Roche has developed a platform
concept that delivers individualized solutions based on a common architecture for various workloads and testing requirements.

Common universal reagent carriers

Simplifies logistics
Efficient use of reagents

Common applications
and analytical technologies
Comparable patient results
Combines routine and innovative testing

Common operator interface

cobas 4000 is the second member of the new cobas modular
platform. It offers small workload laboratories a complete
solution for clinical chemistry and immunochemistry testing.

Requires less training

Promotes staff flexibility
The cobas modular platform is designed to reduce the complexity of laboratory operation and provides efficient and
compatible solutions for network cooperation.

1 Operator in

terface

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cobas 4000 analyzer series

The two belong together
N EW 7
0
in 20

Complete serum work area testing

cobas 4000 performs clinical chemistry and immunoassay
testing for laboratories processing 80-200 serum samples/day.
Its menu of over 150 routine and innovative assays satisfies
virtually all of the testing needs for small workload laboratories.

Compact yet powerful

cobas 4000 includes the cobas c 311 analyzer for clinical
chemistry and cobas e 411 analyzer for immunoassays.
The combination of the two analyzers provides true
operational integration for small workload laboratories.

A capacity of up to 63 combined onboard tests enables full

indication panels for diagnosis and therapy monitoring.

Convenience in operation
cobas reagent packs are always ready to use and highly
stable for efficient usage.

Confidence in results
Common cobas user interfaces enable users seamless
and flexible operation between analyzers.
Online updates and remote service access via
cobas e-services expedite service and support.

Roche/Hitachi in design and manufacture, cobas 4000

continues the long tradition of proven reliability.
Electrochemiluminescence (ECL) technology sets
high standards of analytical performance and time to result.

One grip handling of reagents

The unique concept of the cobas c packs and cobas e packs
allows for convenient reagent handling.
All reagents are ready to use and are closed for protection
from external elements.
Reagent stability of up to 3 months once opened guarantees
efficient usage even for esoteric assays.
Over 90% of all reagents require calibration only once per lot.
Over 70% of all reagents require a sample volume of less
than 50 microliters.
cobas c pack multi enables development channels for userdefined reagent applications.

Loading cobas c pack onto the cobas c 311 analyzer

Pippetting reagent from cobas e pack on the cobas e 411 analyzer

cobas 4000 analyzer series

The two belong together
N EW 7
0
in 20

cobas c 311 analyzer

Clinical chemistry
ISE: potassium, sodium, chloride
Homogeneous immunoassays
HbA1c whole blood measurement
Integrated with cobas e-services
Throughput up to 480 tests/hour
45 direct access assays
Color touchscreen with mouse
Contact-free ultrasonic mixing
Clot detection

cobas e 411 analyzer

Heterogeneous immunoassays
Nine minute STAT applications
Cardiac markers including proBNP
Over 50 assays for anemia, bone, cancer,
hormones and infectious diseases
cobas e-services optional
Throughput of up to 88 tests/hour
18 direct access assays
Carry-over free disposable tips
Clot detection

Three ways to unmatched performance

As the heart of the cobas e 411 analyzer, ECL technology
delivers the unique combination of nine minute STAT applications, high analytical sensitivity and wide measuring ranges
for unparalleled performance in immunochemistry.

Wide measuring ranges

High analytical sensitivity

reduces the amount of tests

rerun due to out of range results

enables the use of innovative tests and

requires less sample volume

examples:
Estradiol range of 5 - 4,300 pg/mL
Progesterone range of 0 - 60 ng/mL
total-PSA range of 0 - 100 ng/mL

examples:
Troponin T 4th gen. with <10% CV
at 95th population percentile
hCG+ and TSH requires 10 and 50 L
sample volume, respectively

Nine minutes STAT applications

deliver unmatched turnaround time for
emergency samples
hCG+, Troponin T 4th Gen., CK-MB,
Myoglobin, PTH*

Make STATs part of your routine

With cobas 4000's nine minute STAT applications, you can
seamless integrate STAT samples into your routine workload.
These applications include:
- hCG+
- Troponin T 4th Gen.
- CK-MB
- Myoglobin
- PTH*
Faster turnaround-time for these critical parameters will
increase your laboratory's responsiveness to important areas
of the hospital such as the Emergency Department and
Surgery.

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* PTH nine minute application in development for March 2007

cobas 4000 analyzer series

Preliminary Specifications

System

cobas 4000 analyzer series includes two stand-alone analyzers for serum work area
testing in small workload laboratories:
cobas c 311 is a fully automated, random access system for clinical chemistry and
homogeneous immunoassay analysis.
cobas e 411 is a fully automated, random access system for heterogeneous
immunoassay analysis. It is available as both a disk system and a rack system.

Test throughput

Up to 300 tests/hr. photometric and ISE on cobas c 311

Up to 88 tests/hr. on cobas e 411

Type of analyzers

cobas c 311: photometric measuring unit including ISE

cobas e 411: ECL technology measuring unit

Number of channels

Up to 63 channels (reagent slots) in total:

Up to 45 channels on cobas c 311
Up to 18 channels on cobas e 411

Available parameters

196 parameters in total:

117 photometric tests, 3 ISE tests, 8 formulas, 3 serum indices on cobas c 311
65 heterogeneous tests with cobas e 411

Sample types

Serum, Plasma, Urine, CSF, Whole Blood (HbA1c only)

Sample container types

Primary tubes

5-10mL; 16x100, 16x75, 13x100, 13x75mm

Sample cup

2.5mL

Micro cup

cobas c 311 only: 1.5mL

Cups on tube

Cup on top of a 16x75/100mm tube

cobas c 311 only: cup on top of one non-standard tube and
false buttom tube

Result integrity

Clot detection available on both analyzers

Disposable tips on cobas e 411
3 test-specific serum indices on cobas c 311; automatic interference flagging of
results provided by cobas IT 3000 work area manager

Rerun/reflex function

Automatic and manual rerun on cobas c 311, manual rerun only on cobas e 411
Automatic reflex is supported by both systems, reflex request to be provided by
cobas IT 3000 work area manager or LIS

Regulatory requirements

CE, UL, C-UL, CB-report and certificate

04952502001 - 1106 - X. Xx

COBAS, COBAS C, COBAS E

and LIFE NEEDS ANSWERS
are trademarks of Roche.
2006 Roche Diagnostics
Roche Diagnostics GmbH
D-68298 Mannheim
Germany
www.roche-diagnostics.com