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An anorectal abscess originates from an infection arising in the cryptoglandular epithelium lining the anal canal.
The internal anal sphincter is believed to serve normally as a barrier to infection passing from the gut lumen to
the deep perirectal tissues. This barrier can be breached through the crypts of Morgagni, which can penetrate
through the internal sphincter into the intersphincteric space.
Once infection gains access to the intersphincteric space, it has easy access to the adjacent perirectal spaces.
Extension of the infection can involve the intersphincteric space, ischiorectal space, or even the supralevator
space. In some instances, the abscess remains contained within the intersphincteric space. The severity and
depth of the abscess are quite variable, and the abscess cavity is often associated with formation of a fistulous
tract. For that reason, fistulas are also discussed in this article where relevant.
The variety of anatomic sequelae of the primary infection is translated into variable clinical presentations. The
relatively simple perianal abscess is to be distinguished from the more complex perirectal abscesses. Treatment
also differs according to the type of abscess present.
Anatomy
Normal anatomy demonstrates anywhere from 4-10 anal glands lying at the level of the dentate line, which
divides the squamous epithelium distally and the columnar epithelium proximally. Obstruction of these anal
glands by debris leads to stasis, bacterial overgrowth, and abscess formation that extends into the
intersphincteric groove between the internal and external anal sphincters. [1] From this space, the abscess can
spread along various potential spaces.
Anorectal abscesses are classified according to their anatomic location; the following are the most common
locations (see the image below):
Perianal
Ischiorectal
Intersphincteric
Supralevator
Illustration of major types of anorectal abscesses (submucosal type not
pictured).
Goodsall rule for anorectal fistulas. Fistulas that exit in posterior half of rectum
generally follow curved course toward posterior midline, whereas those that exit in
anterior half of rectum usually follow radial course to dentate line.
Epidemiology
United States and international statistics
Approximately 30% of patients with anorectal abscesses report a previous history of similar abscesses that
either resolved spontaneously or required surgical intervention.
The incidence of abscess formation appears to be higher in spring and summer. Whereas demographics point
to a clear disparity in the occurrence of anal abscesses with respect to age and sex, no obvious pattern exists
among various countries or regions of the world. Although it has been suggested that there is a direct relation
between the formation of anorectal abscesses and bowel habits, frequent diarrhea, and poor personal hygiene,
this relation remains unproven.
Prognosis
Overall mortality from anorectal abscesses is quite low.[2]
Early data indicated that abscess formation recurred in approximately 10% of patients, with chronic fistula-inano occurring in as many 50% of patients. [1, 2, 12]A later study found that 37% of patients developed chronic anal
fistula or recurrent sepsis.[6] In this study, risk factors were age younger than 40 years and nondiabetic status; no
difference in these complications was noted with regard to HIV status, sex, antibiotic usage, or smoking status.
Approximately two thirds of patients with rectal abscesses who are treated by incision and drainage or by
spontaneous drainage will develop a chronic anal fistula. After fistula formation, multiple complications may
develop after surgery. As many as 43% of patients may experience fecal incontinence after surgical repair for
complex fistula-in-ano.[13] Other postoperative complications include temporary postejaculation urethral irritation
and postoperative urinary retention.[14]Constipation may also occur as a result of pain on defecation.
The recurrence rate of anorectal fistulas after fistulotomy, fistulectomy, or the use of a seton is about 1.5%. The
success rate of primary surgical treatment with fistulotomy appears to be fairly good.
History
The classic locations of anorectal abscesses, listed in order of decreasing frequency, are as follows: perianal
(60%), ischiorectal (20%), intersphincteric (5%), supralevator (4%), and submucosal (1%). The clinical
presentation correlates with the anatomic location of the abscess (though it should be kept in mind that a
perianal abscess sometimes is not an isolated superficial lesion but represents the point of a more involved
perirectal abscess).
Almost all perirectal abscesses are associated with perirectal pain that is indolent in nature. Patients with a
perianal abscess typically complain of dull perianal discomfort and pruritus. The pain often is exacerbated by
movement and increased perineal pressure from sitting or defecation. Those with an ischiorectal abscess often
present with systemic fevers, chills, and severe perirectal pain and fullness consistent with the more advanced
nature of this process. External signs are minimal and may include erythema, induration, or fluctuance.
As many as 50% of patients with perirectal abscesses may present with swelling around the rectum, and as
many as one quarter may present with rectal or perirectal drainage that may be bloody, purulent, or mucoid. [2,
4]
These patients may also present with constipation, most likely due to pain on defecation, but the absence of
constipation or even diarrhea does not rule out the diagnosis. Most of them report no history of fever or chills.
In many cases, these patients delay presentation to a physician, or they have already presented to a physician
and have been given alternative diagnoses. [2, 4]Furthermore, complaints of abdominal pain are rare in these
patients.
In addition to these symptoms, various case reports in the literature describe patients with perirectal abscesses
who present with penile discharge, hip pain, or an ingested foreign body.[16, 17, 18]
Physical Examination
Patients with anorectal abscesses usually have normal vital signs on initial evaluation, with only 21% reporting
fevers or chills. Physical examination demonstrates a small, erythematous, well-defined, fluctuant,
subcutaneous mass near the anal orifice. On digital rectal examination (DRE), a fluctuant, indurated mass may
be encountered. In one study, however, clinicians were unable to identify abscesses in 10% of patients on rectal
examination; 4% of patients showed no signs of perirectal abscesses on initial examination. [2]
Optimal physical assessment of an ischiorectal abscess may require anesthesia to alleviate patient discomfort
that would otherwise limit the extent of the examination. Patients with an intersphincteric abscess present with
rectal pain and exhibit localized tenderness on DRE. Physical examination may fail to identify an
intersphincteric abscess.
Although rare, supralevator abscesses present a similar diagnostic challenge. As a result, clinical suspicion of
an intersphincteric or supralevator abscess may require confirmation by means of computed tomography (CT),
magnetic resonance imaging (MRI), or anal ultrasonography (see Workup).
Digital examination with anesthesia can be helpful in certain cases, because patient discomfort can significantly
limit physical assessment. For example, optimal evaluation for an ischiorectal abscess is performed in this
manner. A fistula tract can be injected with peroxide solution at the time of examination under anesthesia in
order to facilitate visualization of the internal opening of the fistula.
Complications
Complications of anorectal abscesses may include the following:
Fistula formation
Bacteremia and sepsis, including seeding of the infection to other areas by hematogenous spread
Fecal incontinence
Malignancy[19]
Fistulas occur in 30-60% of patients with anorectal abscesses. The intersphincteric glands lie between the
internal and external anal sphincters and are associated most commonly with abscess formation. Fistulas arise
through obstruction of anal crypts or glands and are identified by purulent drainage from the anal canal or from
the surrounding perianal skin. Other potential causes of anorectal fistulas include diverticular disease,
inflammatory bowel disease,[20]malignancy, and complicated infections (eg, tuberculosis or actinomycosis).
Differential Diagnoses
Approach Considerations
No specific laboratory studies are indicated in the evaluation of a patient with a perianal or anorectal abscess.
Certain patients, such as individuals with diabetes and those who are immunocompromised, are at high risk for
developing bacteremia and possibly sepsis, as a result of an anorectal abscess. In such cases, complete
laboratory evaluation is important. Laboratory evaluation of the septic patient is not the focus of this article.
When an anorectal abscess is not obviously apparent but a high degree of clinical suspicion exists, imaging (eg,
computed tomography [CT], ultrasonography, or magnetic resonance imaging [MRI]) may be necessary for the
diagnosis. Plain films are of little utility for this purpose and should not be obtained unless other diagnoses are
being considered.
Laboratory Studies
Many patients with perianal abscesses present as outpatients and need no laboratory blood tests; incision and
drainage will be sufficient. For patients with such abscesses who present to the emergency department (ED)
with no signs of systemic disease, this management strategy may be adequate, in that laboratory data will yield
very little additional information of practical use.
In patients with suspected perirectal abscess or systemic disease, a complete blood count with differential may
be obtained and may show leukocytosis or a left shift, but the absence of these findings does not preclude
either of these entities. As many as 23% of patients with diagnosed perirectal abscesses have a normal
temperature and a normal white blood cell count with a normal differential. [2]
Even though presumptive antibiotics are not required with routine incision and drainage of uncomplicated
perianal abscesses,[21, 22] wound cultures should be collected in all patients in whom incision and drainage is
performed; newer strains of bacteria (eg, methicillin-resistant S aureus) are being recognized as causes of
perirectal abscesses,[8, 9] and recurrence rates are as high as 10%. [1] Blood cultures may be obtained but may
have little to no diagnostic yield; one study reported no growth on blood cultures. [2]
Endoscopy
Evidence suggests that the use of endoscopic visualization (transrectal and transanal) is an excellent way of
evaluating complex cases of perianal abscess and fistula. With the endoscopic technique, the extent and
configuration of the abscess and fistulas can be clearly visualized. Endoscopic visualization has been reported
to be as effective as fistulography.[31]
In experienced hands, endoscopic evaluation is the preferred diagnostic procedure in patients with perirectal
pathology because of the low risk of bacterial dissemination and the low incidence of patient discomfort.
Performing an endoscopic evaluation after nonsurgical treatment is also effective for documenting the patients
response to therapy.
Approach Considerations
As a rule, the presence of an abscess is an indication for incision and drainage. Watchful waiting while
administering antibiotics is inadequate. Clinical suspicion of anorectal abscess warrants aggressive
identification and surgical incision and drainage. Delaying surgical intervention results in chronic tissue
destruction, fibrosis, and stricture formation and may impair anal continence. Simple perianal abscesses may
be treated in the emergency department (ED); more complex perirectal abscesses are treated by an
experienced surgeon in an operating room.
Some surgeons advise performing a complementary colostomy to facilitate management of complex anal
fistulas. This may be of some benefit in selected cases, but the perirectal infection may continue despite a
diverting colostomy. Adequate drainage of the abscess is the most important factor in controlling progressive
perirectal infection.
A patient with a perirectal abscess should be admitted to the surgical service unless other medical conditions or
complications from the abscess necessitate a primary medical admission, with the surgeon acting as a
consultant. Consider admitting a patient with a perirectal abscess to a medical service with the surgeon as a
consultant should be considered if the patient is elderly, febrile, hypotensive, or immunocompromised or has
significant comorbidities.
Transfer, if warranted, may be safely carried out if the patient is hemodynamically stable. Instability resulting
from a concurrent condition or sepsis makes transfer to another institution inappropriate (and possibly illegal
under the Emergency Medical Treatment and Active Labor Act [EMTALA]) unless transfer to allow delivery of a
higher level of care is in the patients best interest.
Pharmacologic Therapy
The need for routine use of antibiotics in patients with anorectal abscesses has not been established; they have
not been shown to improve healing times or reduce recurrence rates. In most of these patients, therefore,
adjuvant medical therapy with antibiotics is considered unnecessary. However, concomitant use of antibiotics
may be warranted in patients with conditions such as the following [1] :
Surgical Intervention
Preparation
Because of the acute nature of anorectal abscesses, preoperative bowel preparation is not possible and
typically is unnecessary.
Tetanus immunity status should be ascertained. When acceptable immunity cannot be established, the currently
recommended guidelines for high-risk wounds should be followed.
Adequate analgesia before aspiration is mandatory. Lidocaine 2% with epinephrine injected subcutaneously
over and around the periphery of the abscess and intramuscular (IM) or intravenous (IV) narcotics are
recommended. Ethylene chloride spray applied to the suspected area immediately before aspiration may also
help decrease the discomfort of aspiration. The cooling effect of ethylene chloride renders pain receptors
temporarily unable to transmit pain signals to the cerebral cortex.
Conscious is also an option if the physician is trained and prepared to manage the airway. If this route is taken,
cardiac monitoring, pulse oximetry, and airway management equipment must be available, including suctioning
devices, bag-valve-mask, and endotracheal intubation equipment. This technique should be used only by
physicians highly skilled in cardiac and airway management.
Management of abscess
Treatment of anorectal abscesses involves early surgical drainage of the purulent collection. [32, 33, 34, 35, 36, 37,
38]
Primary antibiotic therapy alone is ineffective in resolving the underlying infection and simply postpones
surgical intervention. Any delay in surgical intervention prolongs infection and augments tissue damage, and it
may impair sphincter continence function and promote stricture or fistula formation. The ability to drain an
anorectal abscess depends on patient comfort and on the location and accessibility of the abscess.
When the abscess is perianal or superficial, drainage can usually be accomplished in the office or ED with local
anesthesia. A small incision is made over the area of fluctuance; to shorten the length of any fistula that may
form, the incision should be made as close to the anus as is compatible with safety. [1] Pus is collected and sent
for culture. Hemostasis is achieved with manual pressure, and the wound is packed with iodophor gauze.
After 24 hours, the gauze is removed, and the patient is instructed to
bowel movements. Postoperative analgesics and stool softeners are
constipation. Typically, the patient follows up with the physician in
inspection for possible fistula-in-ano. (A short fistula-in-ano coursing
sphincter is best treated with a fistulotomy.)
The formation of fistulous tracts (see below) is an important potential complication of anorectal abscess
drainage. The type of organism cultured from an anorectal abscess is an important predictor of fistula formation
after surgical incision and drainage. Underlying anal fistulas are present in 40% of abscess cultures that are
positive for intestinal bacteria; however, cultures growing Staphylococcus species are associated with perianal
skin infections and typically indicate that there is no risk of subsequent fistula formation.
Treatment of ischiorectal, intersphincteric, and supralevator abscesses typically requires general or regional
anesthesia. To drain an ischiorectal abscess, a cruciate incision is made at the site of maximal swelling. Pus is
drained and cultured. The ischiorectal fossa is probed with a finger or hemostat to disrupt loculations and
facilitate drainage. Placement of a drain is indicated only for the management of complex or bilateral
abscesses.
To drain an intersphincteric abscess, a transverse incision is made in the anal canal below the dentate line
posteriorly. The intersphincteric space is identified, and the plane between the internal and external sphincters
is exposed. The abscess is opened to allow drainage, and a small mushroom catheter is sutured in situ to assist
drainage and prevent premature wound closure.
The optimal drainage technique for a supralevator abscess is determined by the location and etiology of the
lesion. Failure to take the primary etiology into account in the management of a supralevator abscess may lead
to iatrogenic fistula formation. Evaluation with magnetic resonance imaging (MRI) or computed tomography
(CT) can exclude intra-abdominal or pelvic pathology as possible sources.
If the supralevator abscess evolved from the extension of an ischiorectal abscess, external drainage through
the ischiorectal fossa would be indicated. If the abscess resulted from an upward extension of an
intersphincteric abscess, appropriate drainage would be created through the rectal mucosa.
In cases of posterior supralevator abscess collections, a transverse incision is made in the posterior anal canal
below the dentate line. The dissection extends from the intersphincteric plane through the puborectalis sling and
into the posterior anal space. A mushroom catheter is then sutured in place to ensure adequate drainage.
Anterior supralevator abscesses are superficial and are more common in women than in men. Surgical
drainage may be accomplished via an anteriorly directed transanal incision or by way of a transvaginal
approach entering the posterior cul-de-sac. A mushroom catheter is placed to ensure adequate drainage of the
abscess collection. Patients with systemic signs of toxicity are admitted to the hospital and treated with IV
antibiotics.
If the patients clinical condition does not improve over the following 24-48 hours, reevaluation of the
supralevator abscess by means of CT or reoperation may be indicated. Some patients with recurrent, severe
supralevator abscesses may require a diverting colostomy for optimal management. [39]
Management of fistula
Although the anal fistula has been reported since the time of Hippocrates, there is little systematic evidence to
establish optimal management. Different treatment modalities have been evaluated in more than 400 reported
trials. Approaches that have been researched include the following:
Decisive management of anal fistulas relies on therapeutic interventions. Healing rarely is spontaneous, and
failure to achieve adequate treatment often results in recurrent abscess, persistent drainage, and even
malignancy. The main paradigms to follow in the management of anorectal fistulas include the following:
Postoperative care
Postoperatively, analgesics are given for pain, and stool bulking agents and stool softeners are given to prevent
constipation. After appropriate wound care, patients may be discharged home with instructions for sitz baths
and routine follow-up. Adequate outpatient analgesia (eg, codeine with acetaminophen or an oxycodonecontaining compound) should be provided. Outpatient antibiotics may be indicated and are best chosen on the
basis of culture and sensitivity testing of pathogens derived from the abscess.
Consultations
Simple perianal abscesses can generally be managed in the ED. When the diagnosis of a more complex
perirectal abscess is made or is being entertained, however, expeditious consultation with a surgeon is
mandatory. Timely and appropriate operative treatment prevents more serious complications, such as extension
of the abscess or serious systemic infection. Appropriate surgical treatment of perirectal abscess should not be
undertaken in the ED. General or spinal anesthesia is necessary to obtain the optimal result.
Long-Term Monitoring
An otherwise healthy patient with a simple isolated perianal abscess may be treated in the ED with incision and
drainage and released with timely follow-up care. If inpatient surgical treatment is required, surgical follow-up is
necessary; acute abscesses recur in 10% of patients, and chronic fistula-in-ano may occur in as many as 50%.
[1]
Typically, the patient follows up with the physician in 2-3 weeks for wound evaluation and inspection for
possible fistula-in-ano.
If any unusual symptoms arise, such as persistent pain or fever, patients should be advised to return
immediately to the ED or to another provider.
Medication Summary
Antibiotics are unnecessary in otherwise healthy individuals. The practitioner should provide appropriate empiric
intravenous (IV) antibiotic coverage for patients who are elderly or immunosuppressed, patients who have
comorbidities, patients with a heart valve abnormality or prosthetic valve who are likely to benefit from antibiotic
prophylaxis, and patients in whom infection has become systemic.
Analgesia is necessary for pain control and may be given orally (PO) or IV, in conjunction with anesthetics if
needle aspiration or incision and drainage of an abscess are performed. Anxiolytics may help certain patients
who are apprehensive about needle aspiration, incision and drainage, imaging studies, or surgery.
Antibiotics
Class Summary
Appropriate IV antibiotic coverage should be provided preoperatively and postoperatively, either on the basis of
Gram staining or on an empiric basis, as a preventive measure, for elderly patients, patients with
immunosuppression, patients with a heart valve abnormality or prosthesis, and patients with comorbid states.
Ampicillin-sulbactam (Unasyn)
Imipenem-cilastatin (Primaxin)
Imipenem-cilastatin should be used empirically for more severely ill intensive care unit (ICU) patients. Pus or
blood culture and sensitivity results, once available, should guide antibiotic selection. Predisposing and
comorbid diseases may also guide empiric antibiotic selection.
Ampicillin
Ampicillin, a broad-spectrum penicillin, interferes with bacterial cell-wall synthesis during active replication,
causing bactericidal activity against susceptible organisms. It is used as an alternative to amoxicillin when a
patient is unable to take medication PO. Patients with prosthetic heart valves who are at risk for endocarditis
should receive IV prophylactic antibiotics before any procedure. Ampicillin is preferred for this application,
unless the patient is penicillin-allergic, in which case cefazolin or clindamycin is an appropriate choice.
Cefazolin
Cefazolin is a first-generation semisynthetic cephalosporin that binds to one or more penicillin-binding proteins,
arresting bacterial cell wall synthesis and inhibiting bacterial replication. It has poor capacity to cross the bloodbrain barrier. Cefazolin is primarily active against skin flora, including Staphylococcus aureus, and is typically
used alone for skin and skin-structure coverage. Regimens for IV and intramuscular (IM) dosing are similar. This
agent is used in penicillin-allergic patients with prosthetic heart valves who are at risk for endocarditis.
Clindamycin (Cleocin)
Anesthetics
Class Summary
Anesthetics may help blunt the pain of a diagnostic needle aspiration but are only partially effective.
Lidocaine 1-2% with or without epinephrine (1:100,000 or 1:200,000 concentration) is used. Lidocaine is an
amide local anesthetic used in 1-2% concentration. The 1% preparation contains 10 mg of lidocaine for each 1
mL of solution; the 2% preparation contains 20 mg of lidocaine for each 1 mL of solution. Lidocaine inhibits
depolarization of type C sensory neurons by blocking sodium channels. Epinephrine prolongs the duration of
the anesthetic effects from lidocaine by causing vasoconstriction of the blood vessels surrounding the nerve
axons.
Lidocaine decreases permeability to sodium ions in neuronal membranes. This results in inhibition of
depolarization, blocking the transmission of nerve impulses. Epinephrine prolongs the duration of the anesthetic
effects from lidocaine by causing vasoconstriction of the blood vessels surrounding the nerve axons.
Ethylene chloride may be used in conjunction with lidocaine to blunt the pain of a diagnostic needle aspiration
but is only partially effective. It should be sprayed over the area to be aspirated immediately before aspiration.
Bupivacaine and epinephrine (Marcaine with Epinephrine, Vivacaine, Sensorcaine with Epinephrine)
Bupivacaine decreases permeability to sodium ions in neuronal membranes. This results in the inhibition of
depolarization, blocking the transmission of nerve impulses. Epinephrine prolongs the duration of the anesthetic
effects from bupivacaine by causing vasoconstriction of the blood vessels surrounding the nerve axons.
Pain Medications
Class Summary
Pain control is essential to quality patient care. Analgesics ensure patient comfort, promote pulmonary toilet,
and possess sedating properties, which are beneficial for patients who experience pain. These agents are used
for comfort and sedation and to blunt the discomfort of diagnostic needle aspiration.
Meperidine is an analgesic with multiple actions similar to those of morphine; it may produce less constipation,
smooth muscle spasm, and depression of cough reflex than similar analgesic doses of morphine. Meperidine
may be used in combination with promethazine to provide a synergistic effect.
Antiemetics
Class Summary
Antiemetic agents are used to treat vomiting. In combination with analgesics like meperidine, it may produce a
synergistic effect.
Promethazine (Phenergan)
Benzodiazepines
Class Summary
By binding to specific receptor sites, benzodiazepines appear to potentiate the effects of gamma-aminobutyric
acid (GABA) and to facilitate neurotransmission of GABA and other inhibitory transmitters. These agents are
anxiolytics that may help patients who are apprehensive about needle aspiration, imaging studies, or surgery.
Conscious sedation may be considered by the emergency physician with equipment and experience necessary
to manage the patients airway if spontaneous ventilation becomes compromised.
Midazolam
Midazolam is a shorter-acting benzodiazepine sedative-hypnotic that is useful in patients who require acute or
short-term sedation. It is also useful for its amnestic effects.
Lorazepam (Ativan)
Lorazepam is a sedative-hypnotic that increases the action of GABA, thereby potentially depressing all levels of
the CNS, including the limbic system and reticular formation. It has a short onset of effect and a relatively long
half-life. When patient needs to be sedated for longer than 24 hours, this medication is excellent.