Escolar Documentos
Profissional Documentos
Cultura Documentos
Hepatitis
Drugs (alcohol)
Chemicals
Bacteria (rarely)
RNA virus
Found in feces 2 or more weeks before the onset of symptoms and up to 1 week
after the onset of jaundice
Poor hygiene, improper handling of food, crowded situations, and poor sanitary
conditions are all factors related to hepatitis A.
Appears in the serum as the stool becomes negative for the virus
DNA virus
Transmission of HBV
Transmission occurs when infected blood or other body fluids enter the body of a
person who is not immune to the virus.
E antigen (HBeAg)
15% to 25% of chronically infected persons die from chronic liver disease.
In North America, approximately 0.5% of the population are HBV carriers; in parts
of Asia, the rate is approximately 8% to 10%.
RNA virus
Transmitted percutaneously
Risk factors
IV drug use
Blood transfusions
Hemodialysis
Occupational exposure
perinatal transmission
Pathophysiology
Acute infection
Cytotoxic cytokines
Liver cells can regenerate over time and, if no complications occur, can resume their
normal appearance and function.
Antigen-antibody complexes
Rash
Angioedema
Arthritis
Fever
Malaise
Cryoglobulinemia
Glomerulonephritis
Vasculitis
Clinical Manifestations
In patients who are asymptomatic during the acute phase, the infection may not be
detected.
Acute phase
Malaise
Anorexia
Fatigue
Nausea
Occasional vomiting
Abdominal discomfort
Headache
The patient may find food repugnant and, if a smoker, may have distaste for
cigarettes.
Low-grade fever
Arthralgias
Skin rashes
Jaundice
After the fever subsides, the GI symptoms usually remain, and some
fatigue may continue.
Clinical manifestations:
Major complaints
Malaise
Easy fatigability
Many HBV and most HCV infections result in lifelong (chronic) infection.
Many HBV infections and most HCV infections result in chronic (lifelong) viral
infection.