MICROENCAPSULATION

Definition:
It is the process by which individual particles or droplets of solid or liquid material (the core)
are surrounded or coated with a continuous film of polymeric material (the shell) to produce
capsules in the micrometer to millimeter range, known as microcapsules.
Or
Microencapsulation may be defined as the process of surrounding or enveloping one
substance within another substance on a very small scale, yielding capsules ranging from less
than one micron to several hundred microns in size.
Features of Microcapsule:
Microencapsulation is the packaging of small droplets of liquid or particles with a thin film.
Size:
Typically, the lowest particle size of microcapsules is 1m and the largest size is 1mm.
Composition:
Microcapsules consist of a core and a wall (or shell).
Shape:
The configuration of the core can be a spherical or irregular particle, liquid-phase suspended
solid, solid matrix, dispersed solid and aggregates of solids or liquid forms.
Classification:
Microcapsules can be classified on three basic categories according to their morphology as
follows,
1. Mononuclear:
Mononuclear (core-shell) microcapsules contain the shell around the core.
2. Polynuclear:
Polynuclear capsules have many cores enclosed within the shell.
3. Matrix types:
In matrix encapsulation, the core material is distributed homogeneously into the shell
material.

In addition to these three basic morphologies, microcapsules can also be mononuclear with
multiple shells, or they may form clusters of microcapsules.
Generally microparticles are divided in to two components;
a) Core material.
b) Coat or wall or shell material.

Core materials:
The material to be coated. It may be liquid or solid or gas. Liquid core may be dissolved or
dispersed material.
Composition of core material:
Drug or active constituent.
Coating materials:

Gums: Gum arabic, sodium alginate, carageenan.

Carbohydrates: Starch, dextran, sucrose
Celluloses: Carboxymethylcellulose, methycellulose.
Lipids: Bees wax, stearic acid, phospholipids.
Proteins: Gelatin, albumin.

REASONS FOR ENCAPSULATION:

This technique has been widely used for masking the organoleptic properties like taste and
odor of many drugs and thus improves patient compliance e.g. Paracetamol, nitrofurantoine
for masking the bitter taste.
By using microencapsulation techniques the liquid drugs can be converted in a free flowing
powder.
The drugs can be protected by microencapsulation which is sensitive to moisture light and
oxygen, such as nifedipine is protected from photo instability.
Microencapsulation technique also helpful to prevent the incompatibility between drugs
The drugs which are volatile in nature may vaporize at room temperature like Aspirin and
peppermint oil can be prevented by microencapsulation.
Microencapsulation has also been employed to change the site of absorption. This
application has been useful for those drugs which have the toxicity at lower pH.
1. Core protection:
The core must be isolated from its surroundings, as
1. To protect reactive substances from the environment,
2. To convert liquid active components into a dry solid system,
3. To separate incompatible components for functional reasons,
2. Controlled release of drug:
1. For targeted drug delivery
2. For delayed release of drug
3. For prolong release of drug
4. To increase bioavailability of drug
TECHNIQUES TO PREPARE:
These depends on
1.0 DRUG FACTORS:

Physical properties
Chemical properties
Biological activity
Nature of drug
Stability of drug

2.0 PRODUCTION REQUIREMENT:

Entrapment efficiency
Percentage yield

PHYSICAL METHODS

Spray drying
Spray congealing
Air suspension
Fluid bed coating
Pan coating
Centrifugal extrusion
Vibration nozzle
Multi orifice centrifugation process
Spinning disk

SPRAY DRYING AND SPRAY CONGEALING

SPRAY DRYING:
Microencapsulation by spray-drying is a low-cost
commercial process which is mostly used for the
encapsulation of fragrances, oils and flavors.
Steps:
1 Core particles are dispersed in a polymer
solution and sprayed into a hot chamber.
2 The shell material solidifies onto the core
particles as the solvent evaporates.
The microcapsules obtained are of polynuclear or
matrix type.
SPRAY-CONGEALING:
- This technique can be accomplished with spray
drying equipment when the protective coating is applied as a melt.

1- The core material is dispersed in a coating material melt.

2- Coating solidification (and microencapsulation) is accomplished by spraying the hot
mixture into a cool air stream.
- e.g. microencapsulation of vitamins with digestible waxes for taste masking.
AIR-SUSPENSION COATING
Microencapsulation by air suspension technique consist of the dispersing of solid, particulate
core materials in a supporting air stream and the spray coating on the air suspended particles.
Within the coating chamber, particles are suspended on an upward moving airstream.
During each pass through the coating zone, the core material receives an increment of coating
material. The cyclic process is repeated, perhaps several hundred times during processing,
depending on the purpose of microencapsulation the coating thickness desired or whether the
core material particles are thoroughly encapsulated.
FLUID BED COATING
Fluid bed coating is restricted to encapsulation of solid core materials, including liquids
absorbed into porous solids. Solid particles to be encapsulated are suspended on a jet of
air and then covered by a spray of liquid coating material. The capsules are then
moved to an area where their shells are solidified by cooling or solvent vaporization.
The process of suspending, spraying, and cooling is repeated until the capsules' walls
are of the desired thickness.
Different types of fluid-bed coaters include top spray, bottom spray, and tangential spray
(a) Top spray
(b) Bottom spray
(c) Tangential spray.
In the top spray system the coating material is sprayed downwards on to the fluid bed such
that as the solid or porous particles move to the coating region they become encapsulated.
The bottom spray is also known as Wursters coater. This technique uses a coating chamber
that has a cylindrical nozzle and a perforated bottom plate. The cylindrical nozzle is used for
spraying the coating material. As the particles move upwards through the perforated bottom
plate and pass the nozzle area, they are encapsulated by the coating material.
The tangential spray consists of a rotating disc at the bottom of the coating chamber, with the
same diameter as the chamber. During the process the disc is raised to create a gap between
the edge of the chamber and the disc. The tangential nozzle is placed
Above the rotating disc through which the coating material is released. The particles move
through the gap into the spraying zone and are encapsulated. As they travel a minimum
distance there is a higher yield of encapsulated particles.

SPINNING DISK

Suspensions of core particles in liquid shell material are poured into a rotating disc.
Due to the spinning action of the disc, the core particles become coated with the shell
material.
The coated particles are then cast from the edge of the disc by centrifugal force.
After that the shell material is solidified by external means (usually cooling).
This technology is rapid, cost-effective, and relatively simple and has high production
efficiencies.

PAN COATING
When coating is liquid?
Coating is applied as a coating solution or atomized spray to the dried solid core particles in
the coating pan.
To remove the coating solvent warm air is supplied to the coated materials while coatings are
applied in the coating pan.
On some cases the solvent is removed by drying in the oven.
When coating is solid?
1- Solid particles are mixed with a dry coating material.
2- The temperature is raised so that the coating material melts and encloses the core particles,
and then is solidified by cooling.
CENTRIFUGAL EXTRUSION
As shown in Figure
The simple extrusion method utnizes a device consisting of two concentric tubes
containing aligned fluid nozzles.

The liquid material to be coated is extruded through the nozzle of the inner tube into
the coating fluid contained in the outer tube.
Initially. The fluid extrudes as a rod surrounded by the coating fluid, but the rod
ultimately breaks up into droplets which are then immersed in the coating fluid.
As the extruded droplets pass through the nozzle orifice of the outer tube.
The coating fluid forms a surface coat which encases the extruded particle.
Spherically shaped particles are formed by the surface tension of the liquid.
By suitable means the formed coat is converted to a more rigid structure. Hardening
baths are usually employed for this purpose.

VIBRATIONAL NOZZLE:
It works under the same principle as the extrusion only difference is that an additional
vibrational nozzle is used for encapsulation and flow of fluid is laminar.
Matrix-encapsulation can be done using a laminar flow through a nozzle and an additional
vibration of the nozzle or the liquid.
MULTI ORIFICE-CENTRIFUGAL PROCESS: Microencapsulation by the multi orificecentrifugal process is the mechanical process in which the centrifugal force is applied to
throw a core material particle through an enveloping microencapsulation membrane.
The factors affect the Process include the rotational speed of the cylinder, the flow rate of the
coating and core materials and the concentration, viscosity and surface tension of the core
material.
It consists of a cylinder containing three circumferential grooves (coating material inlet)
Core material inlet
Counter rotating disc
Rotating cylinder
Process:
Coating material is introduced through the inlet grooves.

The coating material under the influence of centifugational force imparted by cylinder
rotation flows outward along the immediate groove and form film on orifice.
The counter rotating disc disperses the core material towards the orifice.
Core material encounters the coating material membrane at orifice and encapsulation
occurs.

CHEMICAL METHODS
1. SOLVENT EVAPORATION METHOD

Process
Step I (Dispersion of Drug in Polymer Solution)
In this process microcapsule coating (polymer) is dissolved in a volatile solvent,
which is immiscible with the liquid manufacturing vehicle phase.Methylene chloride
is a preferred solvent because of its high volatility (boiling point 41C). Mixed solvents
can also be used. The mixtures used so far tend to contain a water-immiscible solvent
(e.g., CH2CI2) and a water-miscible solvent (e.g., acetone). The water immiscible
solvent is the predominant component of the mixture.

Once the desired coating polymer is dissolved in the organic solvent, the drug to be
encapsulated is added to this solution. The drug agent may be a solid (crystalline or
amorphous) or a nonvolatile liquid. The added drug may completely dissolve in the
polymer solution or it may be completely insoluble and simply form a dispersion,
suspension, or suspension-emulsion.
Step II (Emulsification)
To obtain the microcapsule of appropriate size the core and coating material mixture is
dispersed in the liquid manufacturing vehicle phase (water) with agitation.
The drug/polymer/solvent mixture (i.e., the oil phase) is emulsified in water to form an oil-inwater emulsion.
In order to aid emulsification, a surfactant (PVA) is normally dissolved in the water phase
before the oil-in-water emulsion is formed.
Step III (Evaporation)
Evaporation is carried out by heating.
Step IV (Separation)
Once solvent evaporation appears to be complete, the capsules are separated from the
suspending medium by filtration, washed, and dried.
If the core material is dispersed in the polymer solution the polymer shrinks around the core.
And if core material is dissolved in the coating solution matrix type microcapsules are
formed.
POLYMERIZATION:
Microencapsulation by polymerization involved reaction of monomeric units located at
interface between a core material substance and continuous phase in which the core material
is dispersed. In polymerization a liquid or gaseous phase is used as continuous or core
material and as a result the polymerization reaction occurs at a liquid-liquid, solid-liquid,
Liquid-gas, or solid-gas interface.
1. Interfacial polymerization (IFP)
In this technique the capsule shell will be formed on the surface of the droplet or particle by
polymerization of the reactive monomers. The substances used are multifunctional
monomers.
Generally used monomers include
Multifunctional isocyanates
Multifunctional acid chlorides
These will be used either individually or in combination.
Process
The multifunctional monomer (acid chlorides immiscible with water) dissolved in liquid core
material and it will be dispersed in aqueous phase containing dispersing agent. A co reactant
multifunctional amine will be added to the mixture. The polymerization depends on the fact
that acid halides are water insoluble and diamines have partition coefficient toward the water
immiscible organic phase and diffuse towards it and it results in rapid polymerization at
interface and generation of capsule shell takes place.
A poly urea shell will be formed when isocyanate reacts with amine
A polynylon or polyamide shell will be formed when acid chloride reacts with amine.

2. In situ polymerization (ISP)

In this process no reactive agents are added to the core material, polymerization occurs
exclusively in the continuous phase. Initially a low molecular weight pre polymer will be
formed, as time goes on the pre polymer grows in size, it deposits on the surface of the
dispersed core material there by generating a solid capsule shell.
3.0 PHYSICOCHEMICAL METHOD:
COESERVATION
A coacervate is a tiny spherical droplet of assorted organic molecules (specifically, lipid
molecules) which is held together by hydrophobic forces from a surrounding liquid.
Their name derives from the Latin coacervare, meaning to assemble together or cluster.
PROCESS
The general outline of the processes consists of three steps carried under continuous
agitation:
Step 1: Formation of three immiscible chemical phases
The immiscible chemical phases are
(i)
A liquid manufacturing vehicle phase
(ii)
A core material phase
(iii)
A coating material phase
To form the three phases, the core material is dispersed in a solution of the coating polymer,
the solvent for the polymer being the liquid manufacturing vehicle phase.
The coating material phase, an immiscible polymer in a liquid state, is formed by utilizing
one of the methods of phase separation coacervation, that is,
By changing the temperature of the polymer solution
By adding incompatible polymer to the polymer solution
By inducing a polymer-polymer interaction
Step 2: Depositing the liquid polymer coating upon the core material
This is accomplished by controlled, physical mixing of the coating material (while liquid) and
the core material in the manufacturing vehicle. Deposition of the liquid polymer coating
around the core material occurs if the polymer is adsorbed at the interface formed between
the core material and the liquid vehicle phase, and this adsorption phenomenon is a
prerequisite to effective coating. The continued deposition of the coating material is promoted
by a reduction in the total free interfacial energy of the system, brought about by the decrease
of the coating material surface area during coalescence of the liquid polymer droplets.
Step 3: Rigidizing the coating
This is usually done by
Thermal Technique
Cross linking Technique
Desolvation Technique, to form a self-sustaining microcapsule.

1. TEMPERATURE CHANGE METHOD:

Change in temperature causes separation of coating material from the solventUseful when the
solubility of the material depend on temperature
E.g. Coating mat.: Ethyl cellulose in cyclohexane (EC is insoluble in Cyclohexane at room
temp.)
Core Material: N-Acetyl P-Amino Phenol
The EC is insoluble in cyclohexane at room temperature but is soluble at elevated
temperatures. The mixture is heated to the boiling point to form a homogeneous polymer
solution. The finely divided core material is dispersed in the solution with stirring. Allowing
the mixture to cool with continued stirring, and microencapsulation of the core material
occurs.
2. INCOMPATIBLE POLYMER ADDITION:
The polymer which is chemically not compatible will be added to the coating solution
The polymer which is to be added should have
More affinity towards solvents
No interaction with the core material.
E.g: Addition of liq. Polybutadiene(Incompatible polymer) to the EC solution in toluene
(Coating sol.).
Core material: Methylene blue HCl.
Dissolves EC in toluene
disperse methylene blue with stirring
slowly add
liqpolybutadiene
solidification by addition of hexane
filtration and drying
of microcapsules.
3. SALT ADDITION:
Soluble inorganic salts can be added to aqueous solutions of certain polymers
Should be soluble in water
Should precipitate the polymer from the solution.
Eg: Addition of 20% Sod. Sulfate to the gelatin solution.
Core Mat.: Oil soluble vitamin in corn oil.
4. NON-SOLVENT ADDITION
Phase separation can be induced by addition of non-solvent for given polymer.Have
more affinity towards solvent which is usedPrecipitate the coating polymer
Eg: Addition of Isopropyl ether to Cellulose acetate butyrate (CAB) dissolved in
Methyl ethyl ketone.
Core Mat: Methyl Scopolamine HBr
solution of CAB in MEK
Add micronized methylscopolamine with stirring
heat 55 C
slowly add isopropyl ether
slowly cool to room
tempertaure
5. POLYMER- POLYMER INTERACTION (COMPLEX COACERVATION):
Core material Eg: gelatin below its isoelectric pH possess + ve charge, acacia is vely
charged.
Core mat: Methyl Salicylate.

Both polymers show attraction due to opposite charge and form coacervate, which is the
deposited around the core due by stirring.
Coacervation types on polymer solution:
1) Aqueous phase separation:
Core material hydrophobic
Cote material hydrophilic
Simple coacervation
Water-immiscible liquid
OR
Water-insoluble solids

aqueous coating solution

(gelatin in water)

O/W emulsion (or)

aqueous suspension of solid particle
Then add slowly 20% sod.sulphate solution with continuous stirring
Gel the colloid by pouring coacervate mixture in to 7% w/w sod.sulphate solution
Filter and wash coacervate with cold water and remove salt
Treat filtered material with formaldehyde to harden the coacervate
Filter and wash Particles with cold water to remove hardening agent
Dry to remove remaining solvent
a) Complex coacervation:
Water-immiscible liquid
OR
Water-insoluble solids

aqueous coating solution

(acacia in water)

O/W emulsion (or)

Aqueous suspension of solid particles
Add gelatin solution with stirring
Add warm water until coacervate is produced
Add coacervate mixture in cold water
Treat filtered material with formaldehyde to harden the coacervate

Filter and wash Particles with cold water to remove hardening agent.
Dry to remove remaining solvent

2) Organic phase separation:

This method is opposite to aqueous phase separation.
Core material hydrophilic
Cote material hydrophobic
Water-miscible liquid
OR
Water-soluble solids

polymer in organic solvent

W/O emulsion (or)

Suspension of solid particles (in organic solvent)
Addition of non-solvent for polymer (mineral oil)
Phase separation (microcapsules are produced)
Cooling of microcapsules to solidify coating
Filter wash and dry
5. POLYMER ENCAPSULATION BY RAPID EXPANSION OF SUPERCRITICAL
FLUIDS
Supercritical fluids are highly compressed gasses.
Properties
Possess properties of both liquids and gases
Miscible with common gases such as hydrogen (H2) and nitrogen
Commonly Used Agents
Supercritical CO2
Alkanes (C2 to C4)
Nitrous oxide (N2O)
Supercritical CO2 is widely used for its following properties: Properties
Nontoxic
Nonflammable
Readily available
Highly pure

 Cost-effective
Applications
It has found applications in encapsulating active ingredients by polymers.
Core Materials Different core materials such as pesticides, pharmaceutical ingredients,
vitamins, and dyes are encapsulated using this method.
Shell Materials A wide variety of shell materials that either dissolve (acrylates, polyethylene
glycol) or do not dissolve (proteins, polysaccharides) in supercritical CO2 are used for
encapsulating core substances.
Methods
The most widely used methods are as follows:
Rapid expansion of supercritical solution (RESS)
Gas anti-solvent (GAS)
Particles from gas-saturated solution (PGSS)
I Rapid expansion of supercritical solution (RESS)
In this process, supercritical fluid containing the active ingredient and the shell material are
maintained at high pressure and then released at atmospheric pressure through a small nozzle.
The sudden drop in pressure causes desolvation of the shell material, which is then deposited
around the active ingredient (core) and forms a coating layer.
Disadvantage
The disadvantage of this process is that both the active ingredient and the shell
material must be very soluble in supercritical fluids.
The solubility of polymers can be enhanced by using co-solvents and non-solvents.
Example
Microencapsulation of TiO2 nanoparticles with polymer by RESS using ethanol as a
non-solvent for the polymer shell such as polyethylene glycol (PEG), and polymethyl
methacrylate
A schematic of the microencapsulation process using supercritical CO2

II GAS ANTI-SOLVENT (GAS) PROCESS

This process is also called supercritical fluid anti-solvent (SAS). Here, supercritical fluid is
added to a solution of shell material andthe active ingredients and maintained at high
pressure. This leads to a volume expansion of the solution that causes super saturationsuch
that precipitation of the solute occurs. Thus, the solute must be soluble in the liquid solvent,

but should not dissolve in themixture of solvent and supercritical fluid. On the other hand, the
liquid solvent must be miscible with the supercritical fluid.
Advantage
It is alsopossible to produce submicron particles using this method.
Disadvantage
This process is unsuitable for the encapsulation of water-soluble ingredients as water
has low solubility in supercritical fluids.
IIIPARTICLES FROM A GAS-SATURATED SOLUTION (PGSS)
This process is carried out by mixing core and shell materials in supercritical fluid at high
pressure. During this process supercritical fluid penetrates the shell material, causing
swelling. When the mixture is heated above the glass transition temperature the polymer
liquefies. Upon releasing the pressure, the shell material is allowed to deposit onto the active
ingredient. In this process, the core and shell materials may not be soluble in the supercritical
fluid.
MECHANISMS AND KINETICS OF DRUG RELEASE
Major mechanisms of drug release from microcapsules include diffusion, dissolution,
osmosis and erosion.
Diffusion:
Diffusion is the most commonly involved mechanism wherein the dissolution fluid penetrates
the shell, dissolves the core and leak out through the interstitial channels or pores. Thus, the
overall release depends on, (a) the rate at which dissolution fluid penetrates the wall of
microcapsules, (b) the rate at which drug dissolves in the dissolution fluid, and (c) the rate at
which the dissolved drug leak out and disperse from the surface. The kinetics of such drug
release obeys Higuchis equation as below:
Q = [D/J(2A-CS)CSt]1/2
Where, Q is the amount of drug released per unit area of exposed surface in time t; D is the
diffusion coefficient of the solute in the solution; A is the total amount of drug per unit
volume; CS is the solubility of drug in permeating dissolution fluid; is the porosity of the
wall of microcapsule; J is the tortuosity of the capillary system in the wall. The above
equation can be simplified to Q = vt where, v is the apparent release rate.
Dissolution:
Dissolution rate of polymer coat determines the release rate of drug from the microcapsule
when the coat is soluble in the dissolution fluid. Thickness of coat and its solubility in the
dissolution fluid influence the release rate.
Osmosis:
The polymer coat of microcapsule acts as semi permeable membrane and allows the creation
of an osmotic pressure difference between the inside and the outside of the microcapsule and
drives drug solution out of the microcapsule through small pores in the coat.
Erosion:
Erosion of coat due to pH and/or enzymatic hydrolysis causes drug release with certain coat
materials like glycerylmonostearate, bees wax and stearyl alcohol.
11Attempts to model drug release from microcapsules have become complicated due to great
diversity in physical forms of microcapsules with regard to size, shape and arrangement of
the core and coat materials. The physiochemical properties of core materials such as
solubility, diffusibility and partition coefficient, and of coating materials such as variable
thickness, porosity, and inertness also makes modeling of drug release difficult.
Loading Of Drug In Microsphere:

Mechanisms For Loading Drug:

Drug can be loaded by
a. physical entrapment
b. chemical linkage
c. surface adsorption
The active components are loaded over the microsphere principally at two points
a. During the preparation of microsphere
b. After the formation of microsphere by incubating them with the drug or protein.
MAXIMUM LOADING can be achieved by incorporating drug during the time of
preperation.
Loading during preparation is avoided because during prep loading is effected by
1) Method of preparation.
2) Presence of additives e.g. crosslinking agent, surfactant stabilizer.
3) Heat of polymerization.
4) Agitation intensity.
KINETICS OF DRUG RELEASE:
In some cases, the release rateis zero-order, i.e. the release rate is constant. In this case, the
microcapsules deliver a fixed amount of drug per minute or hour during the period of their
effectiveness. This can occur as long as a solid reservoir or dissolving drug is maintained in
the microcapsule.
A more typical release pattern is first-order in which the rate decreases exponentially with
time until the drug source is exhausted. In this situation, a fixed amount of drug is in solution
inside the microcapsule. The concentration difference between the inside and the outside of
the capsule decreases continually as the drug diffuses.
APPLICATIONS OF MICROENCAPSULATION
(A) PHARMACEUTICAL APPLICATIONS:
(1) CONTROLLED DRUG RELEASE:
Many varieties of both oral and injectable pharmaceutical formulations are
microencapsulated to release the drug over longer period of time.
Aspirin controlled release version
o Zorprin CR tablet that is used for arthritis.
Niaspan CR tablets that is used for lowering cholesterol levels and it reduces the risk
of heart attack.
(2) TARGETTED DRUG RELEASE:
Certain anti-tumor drugs are microencapsulated for targeted drug delivery.
Alginate-Poly-L-Lysine-Alginate microcapsules of anti-tumor drugs are mostly used and they
bind to tumor antigen TAG72.
(3) RECOMBINANT GENE THERAPY:
Corrective gene sequence in the form of plasmids are microencapsulated to be incorporated
in the body for the treatment of genetic disorders.
(4) ENZYME AND MICROBES IMMOBILIZATION:
Enzymes have been encapsulated in cheese to accelerate ripening and flavor development.
The encapsulated enzymes are protected from low pH and high ionic strength in cheese.
Encapsulation of microbes has been used to improve stability of starter culture.

(5) IMPROVED SHELF LIFE:

Microencapsulation of drugs enhances their shelf life by preventing degradative reactions
(dehydration and oxidation).
(6) PROTECTION AGAINST ENVIRONMENTAL EFFECTS:
Microencapsulation protects the drugs against environmental effects of UV rays, heat,
oxidation, acids and bases. E.g: microencapsulation of vitamin A palmitate and vitamin K.
(7) MASKING OF BITTER TASTE AND ODOUR:
Microencapsulation masks the bitter taste of drugs like paracetamol and nitrofurantoin etc.
It also decreases the odour and volatility of certain compounds like carbon tetrachloride
(CTC).
(8) IMPROVED PROCESSING, TEXTURE AND LESS WASTAGE OF
INGREDIENTS:
Control of hygroscopy (NaCl)
Enhanced flowability and dispersibility
Microencapsulation of non-flowing multicomponent solid mixture of thiamine,
riboflavin, niacin and iron phosphate for easy tableting.
Enhanced solubility
(9) MIXING OF INCOMPATIBLE COMPOUNDS:
Microencapsulation allows mixing of incompatible compounds like for easy addition of oily
ingredients in formulations.
(10)
MICROENCAPSULATION OF INSULINE
ISLETS:
For better and prolonged therapeutic effects of insulin.
For the improvement of compromised pancreatic function.

AND

PANCREATIC