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A. A.
Age
39 y.o
Height
52
Diagnosis
Sex
Female
Weight
53 kg
Author
M. M. Olmillo
Website
milkv.co.vu
A/N
youre welcome J
DRUG DATA
Generic name:
Mefenamic acid
CLASSIFICATION
Pharmacologic:
NSAID
Trade name/s:
Ponstel
Patients dose:
500mg q6o prn
Maximum dose:
500 mg
Therapeutic:
Analgesic,
antipyretic
Minimum dose:
125 mg
MECHANISM OF
ACTION
Anti-inflammatory;
analgesic, and
antipyretic activities
related to inhibition of
prostaglandin
synthesis; exact
mechanisms of action
are not known.
General:
> relief of
moderate pain
when therapy will
not exceed 1 wk
> treatment of
primary
dysmenorrhea
Onset: varies
Peak: 2-4 hr
Availability:
Capsules
250mg
INDICATIONS
Pregnancy Category
Risk: C
Duration: 6 hr
Metabolism: hepatic,
2-4 hr
Route:
PO
Patients actual
indications:
Mefenamic acid is
given to patient
for relief of acute
to moderately
severe pain
Distribution: crosses
placenta, enters
breast milk
Excretion: feces, urine
Source: 2011
Lippincotts NDG
Source: 2011
Lippincotts NDG
Source: 2011
Lippincotts NDG
Source: 2011
Lippincotts NDG
CONTRAINDICATI
ON
Contraindicated with
hypersensitivity to
mefenamic acid, aspirin
allergy, and as treatment
of perioperative pain with
coronary artery bypass
grafting
Precaution:
Use cautiously with
asthma, renal or hepatic
impairment, peptic ulcer
disease, GI bleeding,
hypertension, heart
failure, pregnancy,
lactation
Interactions:
> drug-drug: increased
risk of Gi bleeds with
ASA, anticoagulants,
other NSAIDs
> drug-lab test: falsepositive reaction for
urinary bile using the
Diazo tablet test
Source: 2011
Lippincotts NDG
ADVERSE
EFFECTS
CNS: headache,
dizziness,
insomnia
Dermatologic:
rash, pruritus,
sweating
GI: nausea, GI
pain, diarrhea,
constipation
GU: dysuria, renal
impairment
Hematologic:
bleeding, platelet
inhibition with
higher doses,
neutropenia
Respiratory:
dyspnea,
hemoptysis,
pharyngitis
NURSING
RESPONSIBILITIE
S
Before:
> Check doctors order
> Assess pain score
> Assess for history of allergies to
NSAIDs
> Educate patient regarding desired
and adverse effects
> Educate patient that prolonged use
of drug may damage liver
During:
> Give drug with food, milk or
antacids
> Do not increase or double the dose,
follow exactly as prescribed and
indicated
> Administer drug with full glass of
water
> Do not break, chew or crush
capsule and tablet
> Do not administer with
anticoagulants and other drug that
causes GI upset
Other: peripheral
edema,
anaphylactoid
reactions to
anaphylactic shock
After:
> Document accordingly
> Monitor for adverse effects
> Instruct discontinuation of
medication if adverse effect occurs
> Symptomatic management for Non
serious side effects
> Assess for occurrence of GI ulcers
after taking
Source: 2011
Lippincotts NDG